CN102526634A - Traditional Chinese medicine preparation for curing hyperplasia of mammary glands - Google Patents
Traditional Chinese medicine preparation for curing hyperplasia of mammary glands Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for curing hyperplasia of mammary glands. The traditional Chinese medicine preparation comprises 3 to 100 g of bupleurum root, 3 to 100 g of white peony root, 3 to 50 g Chinese angelica root, 3 to 100 g of prunella spike, 1 to 50 g of green tangerine orange peel, 3 to 50 g of globethistle root, 3 to 100 g of tangerine seed, 3 to 100 g of seed of cowherb, 1 to 30g of ground parched pangolin scales, 3 to 100 g of pilose asiabell root, 3 to 50 g of corydalis tuber, 3 to 50 g of curcuma root, 1 to 50 g of rose, 1 to 30 g of chinaberry fruit, 1 to 30 g of burreed tuber and 1 to 30 g of zedoary; and the traditional Chinese medicine is added with water and then boiled to obtain liquid medicine. The traditional Chinese medicine preparation has the functions of soothing the liver, relieving the depressed liver, promoting the circulation of qi, preventing cancer, resolving phlegm, softening hard masses, dispersing accumulation of pathogen, promoting blood circulation, promoting the subsidence of swelling, dredging qi and blood, dispersing tumor of breast, eliminating breast lump, promoting menstrual flow, promoting blood circulation, relieving depression of the liver-qi, resolving phlegm and softening hard masses, removing blood stasis and dispersing accumulation of pathogen, and also has the effect of regulating menstruation, so that irregular menstruation and other symptoms can also be relieved or can disappear.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Chinese medicine preparation of treating cyclomastopathy.
Background technology
Cyclomastopathy (hyperplasia of mammary gland.HMG) claim breast fiber cystic hyperplasia disease, cystic hyperplasia of breast again.Comprise cyclomastopathy and chronic cystic disease on the pathomorphism; It is the cystic hyperplasia of breast of clinical common and obstinate refractory; They be again women's commonly encountered diseases, frequently-occurring disease, and age of onset is many between 20-40 year, approximately per 20 people of adult women just have 1 people to suffer from this disease before menopause.Current prevalence also has the gesture of increase gradually.HMG is a kind of pathologic precancer of a state, and national tumor office just classified this disease as precancerous lesion as far back as 1987.Primary disease has its special significance in cystic hyperplasia of breast, its status is only second to breast carcinoma.According to the clinical symptoms of HMG, belong to motherland's medical science " nodules of the breast " " nodule in the breast " category." Yangke Xinde Ji, Experience Gained in Treating External Diseases " meaning: " pain is not had a fever for nodule in the breast, shape such as ball ovum, and color of the leather is constant, and it examines the growth and decline with susceptible to anger, this nodules of the breast." etiology and pathogenesis of primary disease, available strongly fragrant, expectorant, the stasis of blood three words are summarized.Strongly fragrant is that feelings will is not smooth, spirit depressing, and disorder of movement of QI, depression of liver-QI causes Chong and Ren channel disorder; The body fluid but strongly fragrant heat-transformation for a long time, heat are burnt decocts into expectorant, or hyperactive liver-QI attacking the spleen, and dysfunction of the spleen in transportation gathers and wets into expectorant; Qi as the commander of blood, functional activity of QI being not smooth, qi-blood disharmony, capable being obstructed of blood then becomes the stasis of blood.Strongly fragrant phlegm and blood stasis blocks newborn network, then becomes nodules of the breast.In the stagnated phlegm stasis of blood, strongly fragrant is active." Waike Zhengzong, Orthodox Manual of External Diseases " cloud: " melancholy impairing the liver, worry impairing spleen long-pending want at the heart, think unappreciated person, it is puckery to cause the meridians painful abdominal mass, the coalescence nucleation." melancholy like patient's feelings will clinically, psychentonia, then mastalgia aggravation, very then lump increases, and also can prove.Modern medicine is not affirmed the cause of disease and the development mechanism of HMG as yet, it is generally acknowledged that HMG mainly is owing to progestogen and estrogen secretion disequilibrium, and the progestogen secretion level reduces, and estrogen concentrations raises.But also there are some reports to think that HMG patient's the estrogen concentrations onset of ovulation does not increase, but reduce.
Therapeutic Method to HMG is a lot of, but the definite square medicine of inefficacy still so far, and clinical that to advocate use hormone preparation, purpose be the vicious cycle of blocking constitutional and Secondary cases hormonal imbalance is more.Though alleviate some symptom like medicines such as bromine second shallow lake, danazol, Progesterone and tamoxifens, its side effect is bigger, and uncertain therapeutic efficacy cuts, and possibly cause disorderly endocrine function disorderly more.Therefore have the people to advocate diseased region is carried out local excision, but usually unnecessary damage or sacrifice breast are not easy for patients to accept.Effective Chinese patent medicine of treatment primary disease is less at present.
Summary of the invention
The side effect that exists to treatment cyclomastopathy hormonotherapy commonly used in the prior art is big and with the undergo surgery defective of excision of diseased region; The invention provides a kind of Chinese medicine preparation of treating cyclomastopathy; Said Chinese medicine preparation has soothing liver-QI for relieving depression circulation of qi promoting, anticancer, resolving phlegm and softening hard masses eliminating stagnation, promoting blood circulation and detumescence, venting QI-blood, and the knot of the breast that looses lump in breast, the meridian dredging arteries and veins of invigorating blood circulation that swells, disappears also has dispersing the stagnated live-QI to relieve the stagnation of QI; Resolving phlegm and softening hard masses, effects such as drastically removing blood stasis and resolving static blood.
For realizing the foregoing invention purpose, the present invention adopts following technical proposals to be achieved:
A kind of Chinese medicine preparation of treating cyclomastopathy; It comprises Radix Bupleuri 3-100g, Radix Paeoniae Alba 3-100g, Radix Angelicae Sinensis 3-50g, Spica Prunellae 3-100g, Pericarpium Citri Reticulatae Viride 1-50g, Radix Rhapontici 3-50g, Semen Citri Reticulatae 3-100g, Semen Vaccariae 3-100g, stir-baked SQUAMA MANITIS 1-30g, Radix Codonopsis 3-100g, Rhizoma Corydalis 3-50g, Radix Curcumae 3-50g, Flos Rosae Rugosae 1-50g, Fructus Toosendan 1-30g, triangular 1-30 and Rhizoma Curcumae 1-30g, above-mentioned Chinese medicine mixing back interpolation 1000-5000ml water is boiled out medicinal liquid 250-1000ml get final product.
Further improvement to technique scheme: the hard person of lump adds Pseudobulbus Cremastrae Seu Pleiones 1-100g and Nidus Vespae 1-50g.
Further improvement to technique scheme: feelings will impassable patient adds Flos Albiziae 1-50g.
Further improvement to technique scheme: the dysphoria with feverish sensation in the chest palms and soles person adds Fructus Ligustri Lucidi 1-50g and Herba Ecliptae 1-50g.
Further improvement to technique scheme: the insomnia and dreamful sleep person adds succinum 1-30g and Semen Ziziphi Spinosae (parched) 3-100g.
Further improvement to technique scheme: lump in breast is capsule sexuality person and adds Fructus Trichosanthis 3-100g and Semen Sinapis Albae 1-50g.
Further improvement to technique scheme: the few person of MBV adds Herba Leonuri 1-100g and Cortex Moutan 1-50g.
Further improvement to technique scheme: the nipple discharge person adds Herba Hedyotidis Diffusae 1-100g, Cortex Lycii 1-50g and Semen Euryales 1-50g.
Further improvement to technique scheme: weak very person adds Radix Astragali 1-200g and Radix Rehmanniae 1-100g.
Further improvement to technique scheme: increase through fore udder lump distending pain, through after alleviation of pain, the lump person of dwindling add Radix Rehmanniae 1-100g, Rhizoma Chuanxiong 1-50g and Rhizoma Cyperi 1-50g.
Compared with prior art, advantage of the present invention and good effect are:
The present invention is according to women's physiological characteristics and dialectical, and combines the experience of treating HMG for many years, adopts Chinese medicine preparation with Radix Bupleuri, Pericarpium Citri Reticulatae Viride, the circulation of qi promoting of Fructus Toosendan soothing liver-QI for relieving depression; Semen Citri Reticulatae, Spica Prunellae resolving phlegm and softening hard masses eliminating stagnation; Radix Angelicae Sinensis, Radix Paeoniae Alba nourshing blood and promoting blood circulation, regulating thoroughfare and controlling vessel; Radix Curcumae, Flos Rosae Rugosae are blood medicine in the gas, circulation of qi promoting and not being detained; Spina Gleditsiae leads to twelve regular channels QI and blood, kind promoting blood circulation and detumescence; Rhizoma Corydalis is a gas medicine in the blood, controls all up and down all over the body pains; Semen Vaccariae is walked blood system, venting QI-blood, and the knot of the breast that looses is swollen; Triangular, Rhizoma Curcumae, the kind clear Yangming Channel pyretic toxicity of Radix Rhapontici, the lump in breast that disappears is for controlling the key medicine of cystic hyperplasia of breast; The stir-baked SQUAMA MANITIS the meridian dredging arteries and veins of invigorating blood circulation is searched and is picked meridian stasis and stagnate, and gas is passed through the fluent pain of arteries and veins from ending, and the capable expectorant stasis of blood of blood is loose lump from disappearing.It is longer to consider that Chinese medicine preparation according to the invention is taken curative effect, is just probably consuming impairment of QI, so assistant Radix Codonopsis QI invigorating is set upright.Take a broad view of in the prescription tool dispersing the stagnated live-QI to relieve the stagnation of QI between the various Chinese medicinal components, resolving phlegm and softening hard masses, the effect of drastically removing blood stasis and resolving static blood has also played the effect of regulating menstruation simultaneously, so symptoms such as menoxenia also alleviate or disappear thereupon.
Fructus Toosendan has the soothing liver-QI for relieving depression circulation of qi promoting, is used for generally that side of body rib due to irritability stasis or the incoordination between the liver and stomach is had a pain, epigastric pain and hernia be painful, and is used for distending pain of the breast and cyclomastopathy is not on the books as yet.Modern pharmacological research, Fructus Toosendan, Rhizoma Curcumae, Radix Rhapontici prevent the canceration effect.Also through animal acute and chronic toxicological test, the result proves safe without toxic side effect in the present invention.Modern medicine thinks that Chinese medicine preparation possibly have regulating action to hypophysis-sex gland hormones, makes its restore cycle property secreting law; Possibly pass through the liver-smoothing, qi-regulating effect in addition, the adjustment liver is to the deactivation function of gonadal hormone.
The specific embodiment
Below in conjunction with the specific embodiment technical scheme of the present invention is done further detailed explanation.
Embodiment 1
1, clinical data
117 examples are clinic case in the present embodiment, women's 116 examples wherein, male's 1 example; Unmarried's 9 examples, the married's 108 examples; 21-30 years old 23 example of age of onset, 31-40 years old 55 example, 41-45 years old 30 example, 46-50 years old 9 example.3-11 months 43 examples of the course of disease, 1-3 years person's 59 examples, 4-6 person's 12 examples, 7-16 years person's 3 examples.
One-sided breast 30 examples of falling ill, bilateral breast 87 examples of falling ill.The inspection of molybdenum target photo belongs to 197 breast of lobulus simplex hypertrophy, wherein merges 15 breast of fibroplasia, merges 3 breast of ductal ectasia; 5 breast of cystic hyperplasia.The lumps that all can lay one's hand on and differ in size in the patient's chest or the fine granularity thing that swells.
Main disease has distending pain of the breast, tenderness, the preceding pain of menstruation.Most with dizzy, irritated, body is tired, insomnia, poor appetite, uncomfortable in chest, hypochondriac pain, menoxenia, dysmenorrhea etc.,, white and thin fur light red with body of the tongue, stringy and thready pulse or heavy carefully be main.
2, Therapeutic Method
All give Chinese medicine preparation according to the invention during the treatment, withdraw other drug.Said Chinese medicine preparation is by Radix Bupleuri 10g, Radix Paeoniae Alba 30g, Radix Angelicae Sinensis 12g, Spica Prunellae 15g, Pericarpium Citri Reticulatae Viride 15g, Radix Rhapontici 15g, Semen Citri Reticulatae 15g, Semen Vaccariae 20g, stir-baked SQUAMA MANITIS (grind and dash) 6g, Radix Codonopsis 15g, Rhizoma Corydalis 15g, Radix Curcumae 15g, Flos Rosae Rugosae 9g, Fructus Toosendan 6g, triangular 10g and Rhizoma Curcumae 10g; Various components add decocting medicinal liquid 250ml after mixing; 1 dose of every day; Decoct the back and divide twice clothes sooner or later, one month is a course of treatment, generally takes 2-4 the course of treatment (menstrual phase is withdrawn).
3, therapeutic outcome
The standard determination curative effect that the treatment standard is formulated by Society of Surgery of All-China Association of Traditional Chinese Medicine breast disease special topic group, specific as follows:
Criterion of cure: lump in breast dissipates, and mastalgia disappears, and does not recur in three months after the drug withdrawal;
The produce effects standard: the lump maximum gauge dwindles more than 1/2, and mastalgia disappears;
Effective standard: the lump maximum gauge dwindles less than 1/2, and mastalgia alleviates, or lump dwindles more than 1/2, and mastalgia does not alleviate;
Invalid standard: lump does not dwindle, or increases hardening on the contrary, or simple mastalgia alleviation, and lump does not dwindle.
Judge according to above-mentioned criterion of therapeutical effect, in 117 examples, clinical cure person 18 examples (15.38%), produce effects 47 examples (40.17%), effective 47 examples (40.17%), invalid 5 examples (4.27%) are cured obvious effective rate 55.56%, total effective rate 95.73%.
Chinese medicine preparation also has curative effect preferably to symptom such as dizzy, irritated, body is tired, insomnia, uncomfortable in chest, hypochondriac pain and menoxenia or dysmenorrhea.Aspect total effective rate, course of disease length and curative effect do not have obvious inner link, and the age size does not also have obvious relation with curative effect.
This treatment group is established matched group in addition and is observed.Select case according to diagnostic criteria, divide into groups, adopt the double-blind method treatment according to random sampling method.20 examples are organized in treatment, treat with Chinese medicine preparation.
Matched group 20 examples (are made up of Chinese medicine Cornu Cervi, Herba Taraxaci, Caulis Spatholobi, Radix Notoginseng, Cortex Moutan etc. with RUPIXIAO.) treatment, obey 3 at every turn, every day three times, four months is a course of treatment.Menstrual phase is withdrawn.The clinical cure of treatment group as a result 1 example, produce effects 7 examples, effective 11 examples, invalid 1 example, total effective rate 95.0%; Matched group does not have the clinical cure case, produce effects 2 examples, effective 7 examples, invalid 11 examples, total effective rate 45.0%.Treatment group total effective rate is apparently higher than matched group (P ﹤ 0.01).
Embodiment 2
Present embodiment adopts concrete case to explain.
Liu XX, the woman, 39 years old, the peasant is married.First visit on November 2 in 2009.Patient's chest distending pain 2 years is surplus, finds right lump in breast 2 months, and menstruation is delayed, blockage of menstruation, and the color purple accompanies clot, and is obvious through preceding mastalgia.Give birth to a tire, from suckling.Fat, dizzy, lumbago, body are tired, irritated sometimes, and sleep, food are received not good enough.Do during stool, urine is normal.Body of the tongue is light red, white and thin fur, stringy and thready pulse.Inspection: irascible temperament, the outer upward quadrant of right breast is laid one's hand on and 3.4* 3cm size lump, and breast outer upward quadrant in a left side is laid one's hand on and 2.3* 0.5cm size lump, and matter is medium firmly, tenderness, edge clear, what push away can move.Nipple does not have depression, and skin is normal.Does not lay one's hand on and lump oxter, the left and right sides.The molybdenum target photo: nipple and mammary areola form, skin of breast thickness are all normal.Breast top is the performance of cloud sheet shape shade, and the breast bottom has streak shade to change, and does not see lump calcification shadow in it.Be reported as cyclomastopathy, more remarkable with the right side.Card belongs to stagnation of QI due to depression of the liver, phlegm stagnation in collateral, disharmony of Chong and Conception Channels.Control the logical stasis of blood of suitable suppressing the hyperactive liver, resolving phlegm and softening hard masses.Use Chinese medicine preparation, 1 dose of every day, decoct the back and divide 2 one after each meals sooner or later.The menstrual phase drug withdrawal, period in a medicine has no adverse reaction.Take 15 doses, distending pain of the breast disappears, and lump dwindles, deliquescing, treats three months, and lump disappears.Check two breasts and do not lay one's hand on and lump, the soft activity of matter is good, and mastalgia disappears, eumenorrhea, disease disappearances such as giddy, lumbago, body are tired, agitation.The body of gland shadow is tapered in the molybdenum target photo check, breast, and density is still even, and girder is arranged rule still, does not see the tuberosity shadow, and breast, skin are normal.Curative effect is judged as clinical cure.Visited 2 years, and do not see recurrence.
Embodiment 3
Present embodiment all gives Chinese medicine preparation to the hard person of treatment lump during the treatment, withdraw other drug.Used Chinese medicine preparation comprises that still other adds Pseudobulbus Cremastrae Seu Pleiones 20g, Nidus Vespae 10g like embodiment 1 described Radix Bupleuri 10g, Radix Paeoniae Alba 30g, Radix Angelicae Sinensis 12g, Spica Prunellae 15g, Pericarpium Citri Reticulatae Viride 15g, Radix Rhapontici 15g, Semen Citri Reticulatae 15g, Semen Vaccariae 20g, stir-baked SQUAMA MANITIS (grind and dash) 6g, Radix Codonopsis 15g, Rhizoma Corydalis 15g, Radix Curcumae 15g, Flos Rosae Rugosae 9g, Fructus Toosendan 6g, triangular 10g and Rhizoma Curcumae 10g.
Method of administration is with embodiment 1: various components add decocting medicinal liquid 250ml after mixing, and decoct the back and divide twice clothes sooner or later 1 dose of every day, and one month is a course of treatment, generally takes 2-4 the course of treatment (menstrual phase is withdrawn).
Embodiment 4
Present embodiment all gives Chinese medicine preparation to treatment feelings will impassable patient during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Flos Albiziae 12g in addition.Method of administration is the same.
Embodiment 5
Present embodiment all gives Chinese medicine preparation to treatment dysphoria with feverish sensation in the chest palms and soles person during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Fructus Ligustri Lucidi 12g and Herba Ecliptae 12g in addition; Method of administration is the same.
Embodiment 6
Present embodiment all gives Chinese medicine preparation to Cure for insomnia dreaminess person during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add succinum 10g and Semen Ziziphi Spinosae (parched) 15g in addition; Method of administration is the same.
Embodiment 7
Present embodiment is capsule sexuality person to the treatment lump in breast, all gives Chinese medicine preparation during the treatment, withdraws other drug.On like embodiment 1 said prescription basis, add Fructus Trichosanthis 30g, Semen Sinapis Albae 12g in addition; Method of administration is the same.
Embodiment 8
Present embodiment all gives Chinese medicine preparation to the few person of treatment MBV during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Herba Leonuri 30g, Cortex Moutan 10g in addition; Method of administration is the same.
Embodiment 9
Present embodiment all gives Chinese medicine preparation to treatment nipple discharge person during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Herba Hedyotidis Diffusae 30g, Cortex Lycii 15g, Semen Euryales 15g in addition; Method of administration is the same.
Embodiment 10
Present embodiment all gives Chinese medicine preparation to the weak very person of treatment during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Radix Astragali 30g, Radix Rehmanniae 15g in addition; Method of administration is the same.
Embodiment 11
Present embodiment increases through fore udder lump distending pain to treatment, through after alleviation of pain, the lump person of dwindling, all give Chinese medicine preparation during the treatment, withdraw other drug.On like embodiment 1 said prescription basis, add Radix Rehmanniae 15g, Rhizoma Chuanxiong 10g, Rhizoma Cyperi 12g in addition; Method of administration is the same.
Above embodiment is only in order to explaining technical scheme of the present invention, but not limits it; Although the present invention has been carried out detailed explanation with reference to previous embodiment, for the person of ordinary skill of the art, still can make amendment to the technical scheme that previous embodiment is put down in writing, perhaps part technical characterictic wherein is equal to replacement; And these modifications or replacement do not make the essence of relevant art scheme break away from the spirit and the scope of the present invention's technical scheme required for protection.
Claims (10)
1. Chinese medicine preparation of treating cyclomastopathy; It is characterized in that it comprises Radix Bupleuri 3-100g, Radix Paeoniae Alba 3-100g, Radix Angelicae Sinensis 3-50g, Spica Prunellae 3-100g, Pericarpium Citri Reticulatae Viride 1-50g, Radix Rhapontici 3-50g, Semen Citri Reticulatae 3-100g, Semen Vaccariae 3-100g, stir-baked SQUAMA MANITIS 1-30g, Radix Codonopsis 3-100g, Rhizoma Corydalis 3-50g, Radix Curcumae 3-50g, Flos Rosae Rugosae 1-50g, Fructus Toosendan 1-30g, triangular 1-30 and Rhizoma Curcumae 1-30g, above-mentioned Chinese medicine mixing back interpolation 1000-5000ml water is boiled out medicinal liquid 250-1000ml get final product.
2. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that the hard person of lump adds Pseudobulbus Cremastrae Seu Pleiones 1-100g and Nidus Vespae 1-50g.
3. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that feelings will impassable patient adds Flos Albiziae 1-50g.
4. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1, the person adds Fructus Ligustri Lucidi 1-50g and Herba Ecliptae 1-50g to it is characterized in that the dysphoria with feverish sensation in the chest palms and soles.
, a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1, the person adds succinum 1-30g and Semen Ziziphi Spinosae (parched) 3-100g to it is characterized in that the insomnia and dreamful sleep.
6. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that lump in breast is capsule sexuality person and adds Fructus Trichosanthis 3-100g and Semen Sinapis Albae 1-50g.
7. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that the few person of MBV adds Herba Leonuri 1-100g and Cortex Moutan 1-50g.
8. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1, the person adds Herba Hedyotidis Diffusae 1-100g, Cortex Lycii 1-50g and Semen Euryales 1-50g to it is characterized in that nipple discharge.
9. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that weak very person adds Radix Astragali 1-200g and Radix Rehmanniae 1-100g.
10. a kind of Chinese medicine preparation of treating cyclomastopathy according to claim 1 is characterized in that increasing through fore udder lump distending pain, through after alleviation of pain, the lump person of dwindling add Radix Rehmanniae 1-100g, Rhizoma Chuanxiong 1-50g and Rhizoma Cyperi 1-50g.
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| CN102908603A (en) * | 2012-10-30 | 2013-02-06 | 王凤 | Chinese medicament for treating hyperplasia of mammary glands |
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