CN102512525B - Traditional Chinese medicine composition for treating nonpregnant infertility of dairy cattle, and preparation method and use thereof - Google Patents
Traditional Chinese medicine composition for treating nonpregnant infertility of dairy cattle, and preparation method and use thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating nonpregnant infertility of dairy cattle. The composition is prepared from a constituent A and a constituent B; the constituent A is prepared from five traditional Chinese medicine materials: epimedium, fructus psoraleae, semen cuscutae, morinda officinalis and safflower, and the constituent B is prepared from two traditional Chinese medicine materials: kudzu root and seed of cowherb. The invention further relates to a preparation method of the composition and use of the composition for preparation of the drug for treating nonpregnant infertility of the dairy cattle. The product, disclosed by the invention, has the action of restarting lactation physiology function of the cattle with non-pregnancy after long-time hybridization, galactcstasis and milk drying caused by maternity diseases such as ovarian diseases, hysteritis and the like of the nonpregnant bred cows after long-time breeding and milking cow.
Description
Technical field
The invention belongs to the veterinary medicine field, specifically, is a kind of Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow and preparation method thereof, also relates to the application of said composition in the nonpregnant infertility medicine of preparation milch cow.
Background technology
Nowadays China milch cow cause develop rapidly, national milch cow total amount has reached 1,450 ten thousand according to incompletely statistics, annual milk yield 1,985 ten thousand tons of left and right, fresh milk is 14 kilograms per capita, and milk has become the nutritional necessary product in people's life.The restraining factors of puzzlement dairy development are the various diseases of milch cow, the barrenness of milk cow due to the uterus such as endometritis, ovarian cyst and ovarian disease particularly, nonpregnant for a long time, make milch cow lose production capacity (milking capacity), the annual milch cow that suffers from long-term infertility in the whole nation reaches 920,000.Account for 6.3/% of milch cow total amount, caused very large loss to dairy.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow, said composition is comprised of A component and B component, and wherein the A component is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Epimedii: 30-80 Fructus Psoraleae: 30-80 Semen Cuscutae: 30-50
Radix Morindae Officinalis: 30-80 Flos Carthami: 30-50;
Wherein the B component is prepared from by the raw material of Chinese medicine of following weight ratio:
Radix Puerariae: 20-60 Semen Vaccariae: 30-80.
Preferably, a kind of Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow, said composition is comprised of A component and B component, and wherein the A component is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Epimedii: 40-65 Fructus Psoraleae: 40-65 Semen Cuscutae: 35-45
Radix Morindae Officinalis: 40-65 Flos Carthami: 35-45;
Wherein the B component is prepared from by the raw material of Chinese medicine of following weight ratio:
Radix Puerariae: 30-50 Semen Vaccariae: 40-70.
Preferably better, a kind of Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow, said composition is comprised of A component and B component, and wherein the A component is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Epimedii: 50 Fructus Psoraleaes: 50 Semen Cuscutae: 40
Radix Morindae Officinalis: 50 Flos Carthamis: 40;
Wherein the B component is prepared from by the raw material of Chinese medicine of following weight ratio:
Radix Puerariae: 40 Semen Vaccariae: 50.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes injection or oral powder, and is preferred but be not limited to injection or oral powder.In order to prepare these preparations, can add as required conventional pharmaceutically acceptable auxiliaries in compositions of the present invention, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing powder, can add sweeting agent, flavoring agent and antiseptic in the present composition.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention is to provide a kind of preparation method of the present composition, and said composition is comprised of A component and B component, and wherein the preparation method concrete steps of A component are as follows:
1) Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Radix Morindae Officinalis, the dried medicine raw material of Flos Carthami Chinese medicine of the five flavours cleaned, clean, drying, be ground into coarse powder, weigh by weight, add in extraction pot, add the dried quality of medicinal material 10-15 of Chinese medicine purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to boil 1-3 hour, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds raw medicinal herbs quality 8-10 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds raw medicinal herbs quality 6-8 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 60-100 hour, get rid of medicinal residues.
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of A component milch cow of Chinese medicine extraction liquid.
Wherein the preparation method concrete steps of B component are as follows:
1) Radix Puerariae, the Semen Vaccariae two dried medicine raw materials of flavor Chinese medicine cleaned, clean, drying, be ground into coarse powder, weigh by weight, add in extraction pot, add the dried quality of medicinal material 10-15 of Chinese medicine purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to boil 1-3 hour, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds raw medicinal herbs quality 8-10 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds raw medicinal herbs quality 6-8 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 60-100 hour, get rid of medicinal residues;
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of milch cow of the B component of Chinese medicine extraction liquid.
The oral powder preparation method of the present composition, said composition is comprised of A component and B component, and wherein the preparation method concrete steps of A component are as follows:
Method for making: Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Radix Morindae Officinalis, the dried medicine of Flos Carthami Chinese medicine of the five flavours are cleaned, be placed in respectively the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, the various crude drug in whole powder that sieved are placed in mixer stir, packing, every part of 300 grams, pack, carry out product quality analysis, drug inspection A component oral powder.
Wherein the preparation method concrete steps of B component are as follows:
Method for making: Radix Puerariae, Semen Vaccariae two flavor Chinese medicine crude drug in whole are cleaned, be placed in the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, with Radix Puerariae, the Semen Vaccariae two flavor crude drug in whole powder that sieved, being placed in mixer stirs, packing, every part of 225 grams pack, carry out product quality analysis, drug inspection B component oral powder.
Character: this product is brown ceramic powder, gas perfume, puckery, little hardship.
Usage and consumption: oral: growing cattle A component oral powder once a day, was taken 8 days continuously each serving one bag (300 gram), and the interval took B component oral powder in 5 days again.Took continuously 4 days, take once every day, and front and back 17 days were a course for the treatment of.
Need to prove, method of the present invention is a kind of preferred preparation technology but is not limited to this.Product by the inventive method preparation has good stability.
Chinese medicine composition of the present invention is comprised of A component and B component, and A component and B component use respectively: the analysis of this Chinese medicine composition chemistry effective ingredient is measured:
A component wherein:
Herba Epimedii: it mainly contains the estrogen-like effective ingredient, is mainly icariine.Oral Herba Epimedii or intramuscular injection Herba Epimedii extract injection, 40-80mg detects blood plasma.Be used in conjunction once a day 5 times, can strengthen significantly anterior pituitary, the weight of ovary, in blood plasma, estrogen-like product content obviously strengthens.
Fructus Psoraleae: Fructus Psoraleae carries out chemical analysis, and it mainly contains Coryfolin, tens kinds of chemical analysis such as Fructus Psoraleae flavanone, and it contains the phospholipid composition greatly about 333.7-824.2ng.100g Fructus Psoraleae root can also be isolated trilaurin, large Gly, and coumestrol sample material, analytical proof Fructus Psoraleae are to contain the Chinese medicine that much enriches estrogen and progestogen sample material.
Semen Cuscutae: it mainly contains the flavone compounds such as alkaloid, anthraquinone, flavone, sterol, terpenes and tannic acid, and its major function is the hormones such as stimulating animal pituitary secretion prolactin antagonist, follicule-stimulating hormone (FSH), lutropin.It is regulated in addition hypothalamus to the hormonogenic information adjusting such as prolactin antagonist, auxin or affects the adenohypophysis secretion process simultaneously.
Radix Morindae Officinalis: it mainly contains Rubiadin, B-sitosterol, dimethyl alkanes, also has in addition monosaccharide, polysaccharide, flavone, steroidal triterpene, aminoacid, anthraquinone, also has 23 kinds of metallic elements.It can make the ovary Rapid development, and promotion is ripe, and the follicle ovulation promotes corpus luteum to form, and makes the enough progestogen of its generation, and it also has the generation to hypophysis cerebri, hypothalamic estrogen, progestogen simultaneously, and liquid is passed has fine conciliation effect.
Flos Carthami: mainly contain Flos Carthami quinone glycoside, Carthamus yellow etc.Stigma Croci has excited heart, and blood circulation promoting increases the effect of coronary flow and myocardial nutrition flow.Stigma Croci is to the influential effect of ovary and uterus, and it can increase the blood flow of uterus, ovary, activates the physiological function of uterus, ovary.Advance the generation of ovarioestrogen and progestogen, improve female animal genitals's physiological function.
B component wherein:
Radix Puerariae: mainly contain puerarin in its main isoflavone-containing class Radix Puerariae, its pharmacological action is: reconcile cardiac function, resisting hypertension, arrhythmia.Its most important effect is: quickening hypophysis cerebri, hypothalamus generate prolactin antagonist, and the prolactin antagonist major function is to stimulate development of breast ripe, strengthen and recovery mammary gland milking capacity.The lactogenic peak length of milch cow depends on the content height of prolactin antagonist.
Semen Vaccariae: dredging collateral for promoting lactation, the desilting of invigorating blood circulation, galactostasis, acute mastitis, furuncle.
The present invention is directed to and join for a long time infertile growing cattle, the cattle that gives milk is because of ovarian disease, and the not conceived lactogenic of joining for a long time due to obstetrics' diseases such as metritis stops, and the milch cow of dry milk has the effect of restarting the lactogenic physiological function.Use this medicine can make the ovary Rapid development, promotion is ripe, and the follicle ovulation promotes corpus luteum formation, makes the enough progestogen of its generation, and it also has hypophysis cerebri simultaneously, hypothalamic estrogen, and the formation of progestogen strengthens and recovery mammary gland milking capacity.
Need to prove, method of the present invention is a kind of preferred preparation technology but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, obtain good curative effect, have no any toxic and side effects.Raw material of Chinese medicine of the present invention is according to " Chinese medicine voluminous dictionary " and the record of other raw material of Chinese medicine books, wherein:
Herba Epimedii-[function cures mainly]: kidney invigorating and YANG supporting, expelling wind and removing dampness.Control the sexual impotence erectile problem, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.
Fructus Psoraleae-[function cures mainly]: reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequency of micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed with cough.External curing purplish or white patches on the skin wind.
Semen Cuscutae-[function cures mainly]: invigorating the liver and kidney, beneficial marrow makes eye bright.Control soreness of waist and knee joint, seminal emission is quenched one's thirst; The dripping urination order is dark.
Radix Morindae Officinalis-[function cures mainly]: reinforcing the kidney and supporting YANG; Bone and muscle strengthening; The expelling wind and removing dampness impotence due to deficiency of the kidney; The seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; Rheumatism limb gas.
Flos Carthami-[function cures mainly]: invigorate blood circulation can through; Stasis-dispelling and pain-killing.Control amenorrhea; Difficult labour, stillborn fetus, disease that postpartum lochia can't go, congestion are had a pain, carbuncle, traumatic injury.
Radix Puerariae-[function cures mainly]: the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, and dysentery, skin eruption are not saturating, hypertension, angina pectoris, deafness.
Semen Vaccariae-[function cures mainly]: promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, the detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.
Beneficial effect of the present invention: owing to adopting the medical material in above-mentioned prescription to combine by weight proportion, have following effect:
1, pure Chinese medicinal preparation, pure green medicine, prescription is novel, unique, rationally, to the pollution-free drug residue free of milk, have no side effect, raw material sources are extensive, cost is low.
2, this product has hypothalamus, gonadotropin hormone and follicle stimulating hormone and the effect of lutropin secretory function regulated, and the heifer of dry up, dry milk is had the effect of restarting the lactogenic function.
3, curative effect is outstanding, and effect is remarkable, and cost is low, short treating period, and instant effect, cure rate is more than 90%.
4, the milch cow of this product to premature aging, have defying age, extends the give milk effect of phase of peak.
5, this product has ill curing the disease, and anosis medication can be played generation and the effect of prevention mastitis.
6, this Chinese medicine composition can replace antibiotic, and the effect of chemicals meets the requirement of food and drug safety method, and is nuisanceless to human body, improves Milk quality and milk yield, and the dairy farmer has increased economic benefit.
For this reason, another object of the present invention is to provide the application of a kind of present composition in the nonpregnant infertility medicine of preparation treatment milch cow.
The specific embodiment
Embodiment 1
Oral powder (ProductName: the milch cow dry milk lures newborn plain oral powder)
Wherein A component raw material of Chinese medicine and consumption:
Herba Epimedii 500g, Fructus Psoraleae 500g, Semen Cuscutae 400g, Radix Morindae Officinalis 500g, Flos Carthami 400g;
Method for making: above-mentioned five tastes crude drug in whole is cleaned, be placed in the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, with the various crude drug in whole powder that sieved, being placed in mixer stirs, be distributed into 8 parts, every part of 300 grams pack, then carry out product quality analysis, drug inspection A component oral powder.
Wherein B component raw material of Chinese medicine and consumption:
Radix Puerariae: 400g, Semen Vaccariae 500g;
Method for making: method for making: Radix Puerariae, Semen Vaccariae two flavor Chinese medicine crude drug in whole are cleaned, be placed in the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, with Radix Puerariae, the Semen Vaccariae two flavor crude drug in whole powder that sieved, being placed in mixer stirs, be distributed into 4 parts, every part of 225 grams pack, then carry out product quality analysis, drug inspection B component oral powder.
Character: this product is brown ceramic powder, gas perfume, puckery, little hardship.
Usage and consumption: oral: growing cattle A component oral powder once a day, was taken 8 days continuously each serving one bag (300 gram), and the interval took B component oral powder in 5 days again.Took continuously 4 days, take once every day, and front and back 17 days were a course for the treatment of.
Operative norm: two ones of Chinese veterinary pharmacopoeia versions in 2010
Embodiment 2
Injection formulation (ProductName: the milch cow dry milk lures newborn plain injection)
Wherein A component raw material of Chinese medicine and consumption:
Herba Epimedii 500g, Fructus Psoraleae 500g, Semen Cuscutae 400g, Radix Morindae Officinalis 500g, Flos Carthami 400g;
Wherein the preparation method concrete steps of A component are as follows:
1) Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Radix Morindae Officinalis, the dried medicine raw material of Flos Carthami Chinese medicine of the five flavours cleaned, clean, drying, be ground into coarse powder, weigh by weight: Herba Epimedii 500g, Fructus Psoraleae 500g, Semen Cuscutae 400g, Radix Morindae Officinalis 500g, Flos Carthami 400g add in extraction pot, add purified water 25kg, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and heating 2 hours that are heated to boil, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds purified water 19kg, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1.5 hours, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds purified water 14kg, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 80 hours, get rid of medicinal residues.
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of A component milch cow of Chinese medicine extraction liquid.
Wherein B component raw material of Chinese medicine and consumption:
Radix Puerariae 400g, Semen Vaccariae 500g;
Wherein the preparation method concrete steps of B component are as follows:
1) just Radix Puerariae, the Semen Vaccariae two dried medicine raw materials of flavor Chinese medicine clean, clean, drying, be ground into coarse powder, weigh by weight Radix Puerariae 400g, Semen Vaccariae 500g adds in extraction pot, add purified water 10kg, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and heating 2 hours that are heated to boil, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds purified water 8kg, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1.5 hours, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds purified water 6kg, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 80 hours, get rid of medicinal residues.
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of milch cow of the B component of Chinese medicine extraction liquid.
These product characteristics: this product is brown clear liquid, gas perfume, puckery, little hardship, flows slowly.
Differentiate: this product 5ml, ampulla easy to break, the machinery sealing, ampulla is as clear as crystal asks, and meets cold easy crystallization, is solubilized in 1 minute with 35-40 ℃ of warm water heating, can use.
Embodiment 3
Clinical trial
The injection formulation of the embodiment of the present invention 2 (ProductName: the milch cow dry milk lures newborn plain injection) produce to be to complete in the small-volume injection workshop of GMP standard.Get the appropriate raw material of each active ingredient, the method for the applied science such as corresponding cosolvent, stabilizing agent, synergist is mixed with semi-finished product, then is divided in the ampulla of 5ml, finally carries out high temperature sterilize, lamp inspection, packing, i.e. " the milch cow dry milk lures newborn plain injection ".
The effect observation table of " the milch cow dry milk lures newborn plain injection " clinical practice:
Lure newborn plain injection effect observation result to show from above-mentioned clinical practice milch cow dry milk, only all can use this medicine lures breast to the cattle of the different cultivars of all ages and classes, can obtain satisfied effect.The Niu Xiaoguo at 2-3 age is best, older cattle only, primiparity miscarriage cattle only, a hybrid improvement cattle weak effect is a little.
The milch cow dry milk lures succeeding in developing of newborn plain injection, solved the difficult problem of various diseases of the milch cow of the restraining factors that perplex in decades milch cow development, the disease of especially severe is the barrenness of milk cow due to the uterus such as endometritis, ovarian cyst and ovarian disease, nonpregnant for a long time, make milch cow lose production capacity (milking capacity).Can save every year because of the long-term nonpregnant dry milk of milch cow, the raiser fund input such as raises for raising nonpregnant milch cow.Succeeding in developing of this medicine solves this pertinacious disease of milch cow obstetrics, and can making every year due to illness, nonpregnant 920,000 infertile cow heads recover Milk Productions.For positive contribution has been made in the sound development of dairy.
Embodiment 4
The oral powder of the embodiment of the present invention 1 (ProductName: the milch cow dry milk lures newborn plain oral powder) compares with injection formulation (ProductName: the milch cow dry milk the lures newborn plain injection) effect of inventive embodiments 2:
Clinical trial
1, get 10 of milch cows that suffer from dry up's lactation period, carry out oral with the oral powder (ProductName: the milch cow dry milk lures newborn plain oral powder) of inventive embodiments 1; The observation of 17 days course for the treatment of, lactogenic dry up's milch cow after 20 days has 8 cow breast volumes to increase not obvious, and nipple is not full, and the milk yield of extruding is few.
2, separately get 10 of milch cows that suffer from dry up's lactation period, change injection formulation (ProductName: the milch cow dry milk the lures newborn plain injection) intramuscular injection of inventive embodiments 2 into, intramuscular injection 8 days, injected again 4 days after 5 days continuously at the interval, in clinical observation, played 8 cow head breast on the 10th day and obviously increased, reddened.Nipple can be extruded red milk in the 15th day, and in the time of 21 days, expressed milk is identical with the milch cow that gives milk normally.In the time of 25 days, the 9th cattle normally gives milk; The 10th cow breast increases, nipple is full, there is no other significant change, and 65 days is again the tenth cattle medication for the second time after injection drug for the first time, and beginning is normally given milk.
Result of the test shows: drug effect and using method, dosage form, usage and dosage have substantial connection, and intramuscular injection is better than the oral powder medication.The oral powder drug cost is high, absorption is slow, can only absorb little part, and a large amount of medicines excrete with gastrointestinal peristalsis, do not have therapeutical effect.The movable body of intramuscular injection follower absorbs, medicine directly reaches focal zone, anti-inflammation and sterilization, activating machine somatic cell, and the body hormone metabolism begins development and change, the secretion of entovarial estrogen and progestogen begins to increase, and causes that reflexive the secretion of hypothalamic prolactin antagonist strengthens.Under the effect of the diversification of the estrogen that increases, progestogen, prolactin antagonist, activate mammary glandular cell, cow mammary gland germinates, and makes nonpregnant milch cow that estrogen, progestogen, the prolactin antagonist internal metabolism process of a complete conceived sample identical with calver be arranged.Make the milch cow of nonpregnant dry milk and the cow mammary gland of conceived childbirth calving same reaching full growth be arranged, the beginning lactogenic.Lactation amount is identical with the calving milch cow, and be 11 months lactation period, and lactational lactogenic total amount and this cattle milk yield of becoming pregnant after calving is similar.
The effect observation table of " the milch cow dry milk lures newborn plain oral powder " clinical practice:
From above description of test, this medicinal medicine approach is to adopt the intramuscular injection cure rate to reach more than 98%.The oral powder effect is low, cost is high, take effect slow.
Claims (5)
1. Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow, it is characterized in that: said composition is comprised of A component and B component, and wherein the A component is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Epimedii: 40-65 Fructus Psoraleae: 40-65 Semen Cuscutae: 35-45
Radix Morindae Officinalis: 40-65 Flos Carthami: 35-45;
Wherein the B component is prepared from by the raw material of Chinese medicine of following weight ratio:
Radix Puerariae: 30-50 Semen Vaccariae: 40-70.
2. a kind of Chinese medicine composition for the treatment of the nonpregnant infertility of milch cow according to claim 1, it is characterized in that: said composition is comprised of A component and B component, and wherein the A component is prepared from by the raw material of Chinese medicine of following weight ratio:
Herba Epimedii: 50 Fructus Psoraleaes: 50 Semen Cuscutae: 40
Radix Morindae Officinalis: 50 Flos Carthamis: 40;
Wherein the B component is prepared from by the raw material of Chinese medicine of following weight ratio:
Radix Puerariae: 40 Semen Vaccariae: 50.
3. the Chinese medicine compositions of according to claim 1-2 described any one group for the treatment of milch cow nonpregnant infertility, it is characterized in that: described compositions is injection or oral powder.
4. the preparation methoies of the Chinese medicine composition of according to claim 1-2 described any one group for the treatment of milch cow nonpregnant infertility is characterized in that: comprise the following steps:
1) Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Radix Morindae Officinalis, the dried medicine raw material of Flos Carthami Chinese medicine of the five flavours cleaned, clean, drying, be ground into coarse powder, weigh by weight, add in extraction pot, add the dried quality of medicinal material 10-15 of Chinese medicine purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to boil 1-3 hour, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds raw medicinal herbs quality 8-10 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds raw medicinal herbs quality 6-8 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 60-100 hour, get rid of medicinal residues;
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of A component milch cow of Chinese medicine extraction liquid;
Wherein the preparation method concrete steps of B component are as follows:
1) Radix Puerariae, the Semen Vaccariae two dried medicine raw materials of flavor Chinese medicine cleaned, clean, drying, be ground into coarse powder, weigh by weight, add in extraction pot, add the dried quality of medicinal material 10-15 of Chinese medicine purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to boil 1-3 hour, medicinal liquid is leached, get filtrate for the first time, standby;
2) decocting for Chinese herbal medicine for the second time in Chinese medicine extracting tank, adds raw medicinal herbs quality 8-10 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the second time, standby;
3) decocting for Chinese herbal medicine for the third time in Chinese medicine extracting tank, adds raw medicinal herbs quality 6-8 purified water doubly, opens the vacuum automatic switch, is decompressed to negative pressure 0.5-1MP, and is heated to boil 1-2 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) with step 1, step 2, step 3 standby for the first time, for the second time, filtrate is placed in container and mixes for the third time, utilizes the ultrasonic extraction technology, and three medicinal liquids are admixed together;
5) step 4 gained medicinal liquid is concentrated with the Chinese medicinal steaming hair device, concentrated concentration is 15% of filtrate, gets concentrated solution, and is standby;
6) with step 5 gained concentrated medicament, add the ethanol of 3 times of amount content 95%, insert in alcohol precipitation tank, heat 80 ℃, purify medicinal liquid and again filtered in 60-100 hour, get rid of medicinal residues;
7) decompression recycling ethanol is used filter paper filtering after reclaiming ethanol again, is divided in the ampulla of 5ml, carries out high temperature sterilize, and lamp inspection, packing namely get the nonpregnant infertility injection of milch cow of the B component of Chinese medicine extraction liquid.
5. the oral powder preparation methoies of the Chinese medicine composition of according to claim 1-2 described any one group for the treatment of milch cow nonpregnant infertility, said composition is comprised of A component and B component, and wherein the preparation method concrete steps of A component are as follows:
Method for making: Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Radix Morindae Officinalis, the dried medicine of Flos Carthami Chinese medicine of the five flavours are cleaned, be placed in respectively the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, the various crude drug in whole powder that sieved are placed in mixer stir, packing, every part of 300 grams, pack, then carry out product quality analysis, drug inspection A component oral powder;
Wherein the preparation method concrete steps of B component are as follows:
Method for making: Radix Puerariae, Semen Vaccariae two flavor Chinese medicine crude drug in whole are cleaned, be placed in the oven dry of hot air circulation drying baker, go out baking oven and be placed on hammer type feedstuff crasher, be ground into powder, cross 100 mesh sieves after pulverizing, weigh by weight, with Radix Puerariae, the Semen Vaccariae two flavor crude drug in whole powder that sieved, being placed in mixer stirs, packing, every part of 225 grams pack, then carry out product quality analysis, drug inspection B component oral powder.
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| CN101342353A (en) * | 2008-07-24 | 2009-01-14 | 王镇 | Traditional Chinese medicine preparation for treating barrenness and preparation method thereof |
| CN101579430A (en) * | 2008-05-13 | 2009-11-18 | 天津生机集团股份有限公司 | Veterinary drug perfusate for treating apogeny for cows and preparation method thereof |
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| CN101342353A (en) * | 2008-07-24 | 2009-01-14 | 王镇 | Traditional Chinese medicine preparation for treating barrenness and preparation method thereof |
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| 刘晓琳等.中药的激素样作用研究.《中兽医医药杂志》.2006,(第3期),第27-29页，第28页左栏倒数第3段、倒数第1段及右栏第2段，第29页左栏第2.2节第2段，. |
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