CN102488874A - Method for preparing bupleurum and cassia twig freeze-dried oral preparation - Google Patents
Method for preparing bupleurum and cassia twig freeze-dried oral preparation Download PDFInfo
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Abstract
The invention discloses a method for preparing a bupleurum and cassia twig freeze-dried oral preparation, relates to a method for preparing a freeze-dried oral preparation, and aims to solve the problems that decoction decocted by the traditional decoction method for the conventional bupleurum and cassia twig decoction is inconvenient to carry and unsuitable to be massively prepared and cannot be stored for a long time. The method for preparing the bupleurum and cassia twig freeze-dried oral preparation comprises the following steps of: 1, weighing raw materials; 2, decocting in water, and extracting decoction; 3, concentrating the decoction; 4, centrifuging, and concentrating again; and 5, performing vacuum freeze-drying to prepare the bupleurum and cassia twig freeze-dried oral preparation. The product has the advantages of definite curative effect, quick response and high stability, is convenient to carry and take, and has the shelf life of 2 years, and the total effective rate is 98.6 percent through the clinical analysis of 2,650 influenza cases. The method is used for preparing the freeze-dried oral preparation.
Description
Technical field
The present invention relates to the method for preparing of lyophilized oral formulations.
Background technology
Flu is one of human commonly encountered diseases, is the disease of main clinical manifestation with headache, nasal obstruction, nasal mucus, sneeze, aversion to wind and cold, heating, floating pulse etc.Wherein influenza pandemic can be traced back to long ago, is a kind of acute viral respiratory infectious disease of serious harm human health, has become a kind of disease that is widely current of most countries in the world.Influenza is prone to periodically be very popular or is worldwide popular, brings very grave disaster to the mankind.The loss that influenza is brought can not be ignored; Report according to U.S. Science and Technology Commission; The number that the U.S. that science and technology is flourishing in recent years dies from influenza every year is 2～40,000; Influenza becomes the higher viral infectious of fatality rate, is used for the expense of flu-prevention and labour force that influenza causes loss every year above 1.2 hundred million dollars.Influenza remains serious harm human life and healthy a kind of infectious disease so far.
China is the multiple district of influenza, almost every year breaking out of some areas or popular is arranged all, and its sickness rate occupies the infectious disease first place.Annual sickness rate is 10%～30%, and its epidemic characteristic is for breaking out, and rapid spread involves wide.The child is the most important crowd of influenza morbidity, and the infection rate of child's influenza is 1.5～3 times of adult.Therefore prevention and treatment influenza are one of main public health problems of face of mankind.
" CHAIHU GUIZHI TANG " comes from doctor's treatise on Febrile Diseases that holy Zhang Zhongjing is shown.Fang Zhongjun can disperse sun pathogenic factor in the exterior with Radix Bupleuri, can let out few YANG pathogen gas again, and medicine carrying is gone into the blood chamber.Ramulus Cinnamomi, Rhizoma Zingiberis Recens principal drug assistance are dispersed and are induced sweat, and Radix Scutellariae and Radix Bupleuri are ministerial drug with treating SHAO YANG disease by mediation altogether.Assistant is with Radix Ginseng, Fructus Jujubae replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors; The joint venture of Radix Paeoniae yin fluid astringing is joined Ramulus Cinnamomi with the harmonizing yingfen and weifen QI and blood; Rhizoma Pinelliae Preparatum symphysis Rhizoma Zingiberis Recens is to take good care of gastric qi.Help the ginseng Fructus Jujubae to set upright and transfer medicine with Radix Glycyrrhizae Preparata.All medicines share, relieving exterior-interior syndrome, and harmonizing yingfen and weifen is maintained internal security and repelled foreign invasion.The cold flu of body wind syndrome caused by deficiency, influenza are commonly encountered diseases, and " CHAIHU GUIZHI TANG " is this type of sick classic prescriptions of treatment.
At present, " CHAIHU GUIZHI TANG " still boils with traditional method, takes with the form of decoction, has many weak points: 1. big, the bitter in the mouth of decocting liquid volume, take, carry inconvenience; 2. polyphyly is prepared application according to doctor formula temporarily, should not prepare in a large number, also is unfavorable in time rescuing the critical patient; 3. be prone to mouldy, fermentation, can not store for a long time.
Summary of the invention
The objective of the invention is to solve the decoction that traditional boiling method of existing " CHAIHU GUIZHI TANG " boils and have the problem of carrying inconvenience, should not prepare in a large number, can not store for a long time, and a kind of method for preparing of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations is provided.
The method for preparing of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations is carried out according to the following steps: one, take by weighing 20～35 parts of Radix Bupleuri, 9～15 parts of Ramulus Cinnamomi, 9～15 parts of Radix Ginsengs, 9～15 parts of Radix Scutellariaes, 9～15 parts of the Radix Paeoniae Albas, 15～20 parts of Rhizoma Pinelliae Preparatum, 5～10 parts of Radix Glycyrrhizae Preparatas, 9～15 parts in Rhizoma Zingiberis Recens, 9～15 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1～1.5 hour, and filtration, decocting liquid is subsequent use; For the second time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1～1.5 hour, and filtration merges decocting liquid twice; Relative density is 1.06～1.16 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.02～1.12 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 4～5 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 20～30 hours, and vacuum is 10～20Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 5～10 hours, and vacuum is 5～10Pa.
The main effect of each Chinese medicine ingredients in the Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of the present invention:
Radix Bupleuri---function cures mainly: evacuate and bring down a fever dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for cold, fever, alternate attack of chill and fever, menoxenia, uterine prolapse, proctoptosis.
Ramulus Cinnamomi---function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Ginseng---function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, palpitation with fear insomnia, sexual impotence cold womb.
Radix Scutellariae---function cures mainly: heat clearing and damp drying, and eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
The Radix Paeoniae Alba---function cures mainly: nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Be used for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, it is dizzy to have a headache.
Rhizoma Pinelliae Preparatum---function cures mainly: drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Radix Glycyrrhizae Preparata---function cures mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Rhizoma Zingiberis Recens---function cures mainly: the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.Be used for anemofrigid cold, gastrofrigid vomiting, the cold-phlegm cough, the fish Eriocheir sinensis poisons.
Fructus Jujubae---function cures mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
The invention has the beneficial effects as follows: the method for preparing of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of the present invention; Keeping the Chinese medicine traditional extraction process---on the basis with the water extraction medicine; In conjunction with modern centrifugal, filtration and freeze drying process; Summed up the preparation process parameter of mating the most, kept the experience accumulation of traditional medicine to greatest extent, can adapt to modern society's fast pace oral formulations form again with important preparation; The present invention adopts modern production technology, thereby effective component content is superior to the decoction of traditional decoction, and bacteria containing amount is little; The prepared Radix Bupleuri Ramulus Cinnamomi of the present invention lyophilized oral formulations has the advantage of determined curative effect, rapid-action, good stability; Shelf-life of the present invention will be longer than traditional decoction greatly; Tradition decoction room temperature is placed and will be produced the phenomenon of becoming sour in 2～3 days, and this shelf life of products can reach 2 years; This product taking convenience, warm boiled water, three times on the one, one time 5 gram is taken and can be cured in 3～5 days; This product has in the harmony in the exterior of separating, and the effect of the cold expelling of bringing down a fever can be used for treating diseases such as influenza, epilepsy, epidemic hemorrhagic fever.
The method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of the present invention is used to prepare lyophilized oral formulations.
The specific embodiment
Technical scheme of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of this embodiment is carried out according to the following steps: one, take by weighing 20～35 parts of Radix Bupleuri, 9～15 parts of Ramulus Cinnamomi, 9～15 parts of Radix Ginsengs, 9～15 parts of Radix Scutellariaes, 9～15 parts of the Radix Paeoniae Albas, 15～20 parts of Rhizoma Pinelliae Preparatum, 5～10 parts of Radix Glycyrrhizae Preparatas, 9～15 parts in Rhizoma Zingiberis Recens, 9～15 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1～1.5 hour, and filtration, decocting liquid is subsequent use; For the second time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1～1.5 hour, and filtration merges decocting liquid twice; Relative density is 1.06～1.16 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.02～1.12 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 4～5 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 20～30 hours, and vacuum is 10～20Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 5～10 hours, and vacuum is 5～10Pa.
In this embodiment step 4, centrifuge speed is 5000r/min, and centrifugation time is 0.5～2h.
The beneficial effect of this embodiment is: the method for preparing of the Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of this embodiment; Keeping the Chinese medicine traditional extraction process---on the basis with the water extraction medicine; In conjunction with modern centrifugal, filtration and freeze drying process; Summed up the preparation process parameter of mating the most, kept the experience accumulation of traditional medicine to greatest extent, can adapt to modern society's fast pace oral formulations form again with important preparation; The present invention adopts modern production technology, thereby effective component content is superior to the decoction of traditional decoction, and bacteria containing amount is little; The prepared Radix Bupleuri Ramulus Cinnamomi of the present invention lyophilized oral formulations has the advantage of determined curative effect, rapid-action, good stability; Shelf-life of the present invention will be longer than traditional decoction greatly; Tradition decoction room temperature is placed and will be produced the phenomenon of becoming sour in 2～3 days, and this shelf life of products can reach 2 years; This product taking convenience, warm boiled water, three times on the one, one time 5 gram is taken and can be cured in 3～5 days; This product has in the harmony in the exterior of separating, and the effect of the cold expelling of bringing down a fever can be used for treating diseases such as influenza, epilepsy, epidemic hemorrhagic fever.
The specific embodiment two: what this embodiment and the specific embodiment one were different is: take by weighing 25～30 parts of Radix Bupleuri, 10～13 parts of Ramulus Cinnamomi, 10～13 parts of Radix Ginsengs, 10～13 parts of Radix Scutellariaes, 10～13 parts of the Radix Paeoniae Albas, 16～19 parts of Rhizoma Pinelliae Preparatum, 6～9 parts of Radix Glycyrrhizae Preparatas, 10～13 parts in Rhizoma Zingiberis Recens, 10～13 parts in Fructus Jujubae in the step 1 by ratio of weight and the number of copies.Other is identical with the specific embodiment one.
The specific embodiment three: what this embodiment was different with the specific embodiment one or two is: in the step 2 for the first time amount of water be 10.5～11.5 times of total medical material amount, decocted 1.1～1.3 hours; For the second time amount of water is 10.5～11.5 times of total medical material amount, decocts 1.1～1.3 hours.Other is identical with the specific embodiment one or two.
The specific embodiment four: what this embodiment was different with one of specific embodiment one to three is: relative density is 1.08～1.14 clear paste when in the step 3 decocting liquid of the merging of step 2 gained being condensed into 70 ℃.Other is identical with one of specific embodiment one to three.
The specific embodiment five: what this embodiment was different with one of specific embodiment one to four is: in the step 4 that step 3 gained clear paste is centrifugal, relative density was 1.04～1.10 clear paste when gained centrifugal liquid was condensed into 70 ℃.Other is identical with one of specific embodiment one to four.
The specific embodiment six: what this embodiment was different with one of specific embodiment one to five is: the lyophilization program is in the step 5: pre-freeze time phase I is 4.2～4.8 hours; The second stage distillation, the time is 22～28 hours, vacuum is 12～18Pa; The phase III parsing-desiccation, the time is 6～8 hours, vacuum is 6～9Pa.Other is identical with one of specific embodiment one to five.
Adopt following verification experimental verification beneficial effect of the present invention:
Test one: the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of this test is carried out according to the following steps: one, take by weighing 25 parts of Radix Bupleuri, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Ginsengs, 12 parts of Radix Scutellariaes, 12 parts of the Radix Paeoniae Albas, 18 parts of Rhizoma Pinelliae Preparatum, 8 parts of Radix Glycyrrhizae Preparatas, 12 parts in Rhizoma Zingiberis Recens, 12 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 12 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1.3 hours, and filtration, decocting liquid is subsequent use; For the second time amount of water is 12 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1.5 hours, and filtration merges decocting liquid twice; Relative density is 1.10 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.08 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 5 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 25 hours, and vacuum is 15Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 10 hours, and vacuum is 8Pa.
Test two: the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of this test is carried out according to the following steps: one, take by weighing 20 parts of Radix Bupleuri, 9 parts of Ramulus Cinnamomi, 9 parts of Radix Ginsengs, 9 parts of Radix Scutellariaes, 9 parts of the Radix Paeoniae Albas, 20 parts of Rhizoma Pinelliae Preparatum, 10 parts of Radix Glycyrrhizae Preparatas, 15 parts in Rhizoma Zingiberis Recens, 15 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 12 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1.5 hours, and filtration, decocting liquid is subsequent use; For the second time amount of water is 10 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1 hour, and filtration merges decocting liquid twice; Relative density is 1.15 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.10 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 5 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 30 hours, and vacuum is 20Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 5 hours, and vacuum is 5Pa.
Test three: the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of this test is carried out according to the following steps: one, take by weighing 35 parts of Radix Bupleuri, 15 parts of Ramulus Cinnamomi, 15 parts of Radix Ginsengs, 15 parts of Radix Scutellariaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Rhizoma Pinelliae Preparatum, 5 parts of Radix Glycyrrhizae Preparatas, 9 parts in Rhizoma Zingiberis Recens, 9 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 10 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1 hour, and filtration, decocting liquid is subsequent use; For the second time amount of water is 10 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1 hour, and filtration merges decocting liquid twice; Relative density is 1.08 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.05 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 4 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 20 hours, and vacuum is 10Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 10 hours, and vacuum is 10Pa.
The beneficial effect of above-mentioned three tests is: the method for preparing of the Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations of above-mentioned test; Keeping the Chinese medicine traditional extraction process---on the basis with the water extraction medicine; In conjunction with modern centrifugal, filtration and freeze drying process; Summed up the preparation process parameter of mating the most, kept the experience accumulation of traditional medicine to greatest extent, can adapt to modern society's fast pace oral formulations form again with important preparation; The present invention adopts modern production technology, thereby effective component content is superior to the decoction of traditional decoction, and bacteria containing amount is little; The prepared Radix Bupleuri Ramulus Cinnamomi of the present invention lyophilized oral formulations has the advantage of determined curative effect, rapid-action, good stability; Shelf-life of the present invention will be longer than traditional decoction greatly; Tradition decoction room temperature is placed and will be produced the phenomenon of becoming sour in 2～3 days, and this shelf life of products can reach 2 years; This product taking convenience, warm boiled water, three times on the one, one time 5 gram is taken and can be cured in 3～5 days; This product has in the harmony in the exterior of separating, and the effect of the cold expelling of bringing down a fever can be used for treating diseases such as influenza, epilepsy, epidemic hemorrhagic fever.
Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations with test three makes, carry out clinical experimental study:
Through to 2650 routine grippal clinical analysiss, use the CHAIHU GUIZHI TANG treatment and obtain 98.6% satisfactory effect.
Criterion of therapeutical effect: recovery from illness, (3～5 days) back body temperature of taking medicine for 1 course of treatment is normal, and the simultaneous occurrence of syndromes in both YANG and YIN channels disease disappears very little, the work and taking part in the work of normally going to work; Take a turn for the better, body temperature descends and still has between 37～38 ℃ of the low grade fever or weak, poor appetite etc. is only arranged; Invalid, symptom after taking medicine does not subtract, and body temperature does not fall or has complication to occur.
Result: 2403 examples of fully recovering (90.7%); 210 examples that take a turn for the better (7.9%); Invalid 37 examples (1.4%); Total effective rate 98.6%.3 days 1560 examples of wherein taking medicine, 5 days 894 examples, 6～8 days 196 examples.Wherein 37 examples are invalid is that a complication set in because course of disease length is taken medicine lately, adds to get effect with western medicine.
Claims (6)
1. the method for preparing of a Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations is characterized in that the method for preparing of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations is carried out according to the following steps: one, take by weighing 20～35 parts of Radix Bupleuri, 9～15 parts of Ramulus Cinnamomi, 9～15 parts of Radix Ginsengs, 9～15 parts of Radix Scutellariaes, 9～15 parts of the Radix Paeoniae Albas, 15～20 parts of Rhizoma Pinelliae Preparatum, 5～10 parts of Radix Glycyrrhizae Preparatas, 9～15 parts in Rhizoma Zingiberis Recens, 9～15 parts in Fructus Jujubae by ratio of weight and the number of copies; Two, with above-mentioned medical material decocte with water twice, for the first time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, soaks after 1 hour, decocted 1～1.5 hour, and filtration, decocting liquid is subsequent use; For the second time amount of water is 10～12 times of amounts of total medical material weight of taking by weighing of step 1, decocts 1～1.5 hour, and filtration merges decocting liquid twice; Relative density is 1.06～1.16 clear paste when three, the decocting liquid of the merging of step 2 gained being condensed into 70 ℃; Four, step 3 gained clear paste is centrifugal, relative density was 1.02～1.12 clear paste when gained centrifugal liquid was condensed into 70 ℃; Five, step 4 gained clear paste is put into freezer dryer, vacuum lyophilization is prepared into lyophilized oral formulations; The lyophilization program is: phase I pre-freeze, and temperature is 4～5 hours for-40 ℃, time; The second stage distillation, temperature is-25 ℃, and the time is 20～30 hours, and vacuum is 10～20Pa; Phase III parsing-desiccation, temperature are 35 ℃, and the time is 5～10 hours, and vacuum is 5～10Pa.
2. the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations according to claim 1 is characterized in that taking by weighing by ratio of weight and the number of copies in the step 1 25～30 parts of Radix Bupleuri, 10～13 parts of Ramulus Cinnamomi, 10～13 parts of Radix Ginsengs, 10～13 parts of Radix Scutellariaes, 10～13 parts of the Radix Paeoniae Albas, 16～19 parts of Rhizoma Pinelliae Preparatum, 6～9 parts of Radix Glycyrrhizae Preparatas, 10～13 parts in Rhizoma Zingiberis Recens, 10～13 parts in Fructus Jujubae.
3. the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations according to claim 1 and 2 is characterized in that in the step 2 that amount of water for the first time is 10.5～11.5 times of total medical material amount, decocts 1.1～1.3 hours; For the second time amount of water is 10.5～11.5 times of total medical material amount, decocts 1.1～1.3 hours.
4. the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations according to claim 3 is characterized in that in the step 3 that relative density when decocting liquid with the merging of step 2 gained is condensed into 70 ℃ is 1.08～1.14 clear paste.
5. the method for preparing of a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations according to claim 3 is characterized in that in the step 4 step 3 gained clear paste is centrifugal, and relative density was 1.04～1.10 clear paste when gained centrifugal liquid was condensed into 70 ℃.
6. according to the method for preparing of claim 1,4 or 5 described a kind of Radix Bupleuri Ramulus Cinnamomi lyophilized oral formulations, it is characterized in that the lyophilization program is in the step 5: pre-freeze time phase I is 4.2～4.8 hours; The second stage distillation, the time is 22～28 hours, vacuum is 12～18Pa; The phase III parsing-desiccation, the time is 6～8 hours, vacuum is 6～9Pa.
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| CN102824617A (en) * | 2012-07-20 | 2012-12-19 | 李承平 | Compound radix bupleuri tablet |
| CN103494983A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating influenza |
| CN103920125A (en) * | 2014-04-30 | 2014-07-16 | 蚌埠明日欣医药有限公司 | Chinese herbal preparation for treating wind-heat type common cold |
| CN104189879A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Formula for treating immunocom promise |
| CN108434432A (en) * | 2018-06-22 | 2018-08-24 | 首都医科大学附属北京友谊医院 | A kind of pharmaceutical applications of bupleuri and Ramuli Cinnamomi Decoction |
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| CN102824617A (en) * | 2012-07-20 | 2012-12-19 | 李承平 | Compound radix bupleuri tablet |
| CN103494983A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating influenza |
| CN103920125A (en) * | 2014-04-30 | 2014-07-16 | 蚌埠明日欣医药有限公司 | Chinese herbal preparation for treating wind-heat type common cold |
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| CN108434432A (en) * | 2018-06-22 | 2018-08-24 | 首都医科大学附属北京友谊医院 | A kind of pharmaceutical applications of bupleuri and Ramuli Cinnamomi Decoction |
| CN108434432B (en) * | 2018-06-22 | 2021-01-29 | 首都医科大学附属北京友谊医院 | Pharmaceutical application of radix bupleuri and cassia twig decoction |
| CN110464746A (en) * | 2019-08-28 | 2019-11-19 | 贵州景诚制药有限公司 | A kind of sweet pharmaceutical composition of Siberian cocklebur osmanthus art, preparation method and detection method |
| CN110464746B (en) * | 2019-08-28 | 2021-10-08 | 贵州景诚制药有限公司 | Linggui shugan medicinal composition, preparation method and detection method |
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