CN102471238B - 千日菊素的制造方法及其制造中间体 - Google Patents

千日菊素的制造方法及其制造中间体 Download PDF

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Publication number
CN102471238B
CN102471238B CN201080026898.XA CN201080026898A CN102471238B CN 102471238 B CN102471238 B CN 102471238B CN 201080026898 A CN201080026898 A CN 201080026898A CN 102471238 B CN102471238 B CN 102471238B
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CN
China
Prior art keywords
spilanthol
isobutyl
manufacturing
mol
carboxylic acid
Prior art date
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CN201080026898.XA
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English (en)
Chinese (zh)
Other versions
CN102471238A (zh
Inventor
田中茂
石田贤哉
八木健司
氏原秀雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Takasago Union Fragrances & Flavors Co ltd
Original Assignee
Takasago Perfumery Industry Co
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Publication of CN102471238A publication Critical patent/CN102471238A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/202—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0007—Aliphatic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
CN201080026898.XA 2009-07-14 2010-07-14 千日菊素的制造方法及其制造中间体 Active CN102471238B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009165530 2009-07-14
JP2009-165530 2009-07-14
PCT/JP2010/061912 WO2011007807A1 (ja) 2009-07-14 2010-07-14 スピラントールの製造法及びその製造中間体

Publications (2)

Publication Number Publication Date
CN102471238A CN102471238A (zh) 2012-05-23
CN102471238B true CN102471238B (zh) 2014-04-02

Family

ID=43449415

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080026898.XA Active CN102471238B (zh) 2009-07-14 2010-07-14 千日菊素的制造方法及其制造中间体

Country Status (7)

Country Link
US (1) US9029593B2 (enExample)
EP (1) EP2455363B1 (enExample)
JP (1) JP5587313B2 (enExample)
CN (1) CN102471238B (enExample)
ES (1) ES2512240T3 (enExample)
IN (1) IN2012DN00361A (enExample)
WO (1) WO2011007807A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986001B1 (fr) 2012-01-24 2014-08-15 Robertet Sa Nouveau procede de concentration de spilanthol et/ou de ses isomeres et/ou homologues
WO2013140973A1 (ja) * 2012-03-23 2013-09-26 大正製薬株式会社 飲料
WO2016031292A1 (ja) * 2014-08-29 2016-03-03 三栄源エフ・エフ・アイ株式会社 経口組成物用添加剤
BR102016017871B1 (pt) * 2016-07-29 2023-03-21 Universidade Estadual De Campinas - Unicamp Processo de obtenção do espilantol e análogos, espilantol e análogos obtidos

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050500A1 (en) * 2004-12-20 2008-02-28 Ogawa & Co., Ltd. Additive for Carbonated Beverage
US20080069912A1 (en) * 2004-01-15 2008-03-20 Gattefosse Sas Use of an Acmella Oleracea Extract for the Botox-Like Effect Thereof in an Anti-Wrinkle Cosmetic Composition
US20090124701A1 (en) * 2007-11-08 2009-05-14 Symrise Gmbh & Co. Kg Use of alkamides for masking an unpleasant flavor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0790294A (ja) * 1993-09-20 1995-04-04 Lion Corp スピラントール高含有精油及びその製造方法並びにスピラントール高含有精油配合口腔用組成物
CA2470935A1 (en) * 2003-06-13 2004-12-13 Ecopia Biosciences Inc. Polyene oxazoles and processes for their preparation
JP4688517B2 (ja) * 2005-02-15 2011-05-25 小川香料株式会社 高甘味度甘味料の呈味改善剤
JP4508932B2 (ja) * 2005-04-25 2010-07-21 小川香料株式会社 呈味増強剤及び該呈味増強剤を含有する香味料並びに該香味料を含有する飲食物
JP4530906B2 (ja) * 2005-04-25 2010-08-25 小川香料株式会社 飲食品の香味増強剤
CN101910116B (zh) * 2008-01-18 2013-06-19 高砂香料工业株式会社 (2e，6z，8e)-n-异丁基-2，6，8-癸三烯酰胺(千日菊酰胺)的制备方法，以及包含该化合物的食品或饮料、香料或化妆品、或药物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080069912A1 (en) * 2004-01-15 2008-03-20 Gattefosse Sas Use of an Acmella Oleracea Extract for the Botox-Like Effect Thereof in an Anti-Wrinkle Cosmetic Composition
US20080050500A1 (en) * 2004-12-20 2008-02-28 Ogawa & Co., Ltd. Additive for Carbonated Beverage
US20090124701A1 (en) * 2007-11-08 2009-05-14 Symrise Gmbh & Co. Kg Use of alkamides for masking an unpleasant flavor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Constituents of Heliopsis Species. IV. The Total Synthesis of trans-Afhin;MARTINJ ACOBSON;《J.Am.Chem.Soc.》;19550505;第77卷;第2461-2463页 *

Also Published As

Publication number Publication date
JPWO2011007807A1 (ja) 2012-12-27
JP5587313B2 (ja) 2014-09-10
US9029593B2 (en) 2015-05-12
IN2012DN00361A (enExample) 2015-05-22
US20120116116A1 (en) 2012-05-10
WO2011007807A1 (ja) 2011-01-20
ES2512240T3 (es) 2014-10-23
CN102471238A (zh) 2012-05-23
EP2455363A4 (en) 2012-12-26
EP2455363B1 (en) 2014-10-01
EP2455363A1 (en) 2012-05-23

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20220225

Address after: 456 KANGYI Road, Kangqiao Industrial Zone, Pudong New Area, Shanghai

Patentee after: Shanghai Takasago-Union Fragrances & Flavors Co.,Ltd.

Address before: Tokyo, Japan

Patentee before: TAKASAGO INTERNATIONAL Corp.

TR01 Transfer of patent right