CN102470146B - 血管新生控制组合物以及控制血管新生的方法 - Google Patents

血管新生控制组合物以及控制血管新生的方法 Download PDF

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Publication number
CN102470146B
CN102470146B CN201080032449.6A CN201080032449A CN102470146B CN 102470146 B CN102470146 B CN 102470146B CN 201080032449 A CN201080032449 A CN 201080032449A CN 102470146 B CN102470146 B CN 102470146B
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China
Prior art keywords
angiogenesis
retinal
nitrate
μmol
nitrite
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Expired - Fee Related
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CN201080032449.6A
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English (en)
Chinese (zh)
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CN102470146A (zh
Inventor
藤森顺也
马场秀运
村田敏规
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Air Water Inc
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Air Water Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN201080032449.6A 2009-07-17 2010-07-12 血管新生控制组合物以及控制血管新生的方法 Expired - Fee Related CN102470146B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009168928 2009-07-17
JP2009-168928 2009-07-17
JP2010128057A JP5791064B2 (ja) 2009-07-17 2010-06-03 医薬用組成物
JP2010-128057 2010-06-03
PCT/JP2010/061768 WO2011007755A1 (ja) 2009-07-17 2010-07-12 血管新生制御組成物および血管新生制御方法

Publications (2)

Publication Number Publication Date
CN102470146A CN102470146A (zh) 2012-05-23
CN102470146B true CN102470146B (zh) 2014-09-10

Family

ID=43449363

Family Applications (1)

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CN201080032449.6A Expired - Fee Related CN102470146B (zh) 2009-07-17 2010-07-12 血管新生控制组合物以及控制血管新生的方法

Country Status (6)

Country Link
US (2) US20120114768A1 (https=)
EP (1) EP2455091A4 (https=)
JP (1) JP5791064B2 (https=)
CN (1) CN102470146B (https=)
IN (1) IN2012DN01285A (https=)
WO (1) WO2011007755A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6284341B2 (ja) 2012-10-24 2018-02-28 国立大学法人東京農工大学 未熟児網膜症の治療又は予防剤、未熟児網膜症の検査方法及び未熟児網膜症の治療又は予防物質のスクリーニング方法
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤
JP6153838B2 (ja) * 2013-10-04 2017-06-28 エア・ウォーター株式会社 血管透過性抑制剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043621A1 (en) * 1997-03-31 1998-10-08 The Children's Medical Center Corporation Nitrosylation to inactivate apoptotic enzymes
WO2001010406A2 (en) * 1999-08-10 2001-02-15 Board Of Regents, The University Of Texas System Facilitating the preservation of sight by increasing optic nerve, choroidal and retinal blood flow
WO2008105731A1 (en) * 2007-02-26 2008-09-04 Jon Lundberg New use of nitrites and nitrates and compositions containing these

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731294A (en) 1993-07-27 1998-03-24 Hybridon, Inc. Inhibition of neovasularization using VEGF-specific oligonucleotides
CA2176934A1 (en) * 1993-11-17 1995-05-26 Ramnath Sasisekharan Method for inhibiting angiogenesis using heparinase
JPH10273450A (ja) * 1997-03-27 1998-10-13 Toagosei Co Ltd 眼内血管新生性疾患治療薬
AU3109199A (en) * 1998-03-25 1999-10-18 Large Scale Biology Corporation Benzoates derivatives for inhibiting angiogenesis
AU3609300A (en) * 1999-03-01 2000-09-21 Human Genome Sciences, Inc. Human serpin proteins
JP4210826B2 (ja) 2001-01-19 2009-01-21 参天製薬株式会社 ウレア誘導体を有効成分とする血管新生阻害剤
US20070135380A1 (en) * 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
US20080069904A1 (en) * 2006-07-18 2008-03-20 Oronsky Bryan T Inhibition of angiogenesis through nitric oxide tachyphylaxis
JP2008110950A (ja) 2006-10-31 2008-05-15 Japan Health Science Foundation 糖尿病網膜症の治療方法
ES2442720T3 (es) * 2008-07-31 2014-02-13 Nicox S.A. Glucocorticoides unidos a ésteres de nitrato por medio de un enlazador aromático en posición 21 y su uso en oftalmología
US20100197702A1 (en) * 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043621A1 (en) * 1997-03-31 1998-10-08 The Children's Medical Center Corporation Nitrosylation to inactivate apoptotic enzymes
WO2001010406A2 (en) * 1999-08-10 2001-02-15 Board Of Regents, The University Of Texas System Facilitating the preservation of sight by increasing optic nerve, choroidal and retinal blood flow
WO2008105731A1 (en) * 2007-02-26 2008-09-04 Jon Lundberg New use of nitrites and nitrates and compositions containing these

Also Published As

Publication number Publication date
US20120114768A1 (en) 2012-05-10
JP5791064B2 (ja) 2015-10-07
WO2011007755A1 (ja) 2011-01-20
CN102470146A (zh) 2012-05-23
US20130251823A1 (en) 2013-09-26
EP2455091A4 (en) 2012-12-19
IN2012DN01285A (https=) 2015-05-15
JP2011037830A (ja) 2011-02-24
EP2455091A1 (en) 2012-05-23
US8974836B2 (en) 2015-03-10

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Granted publication date: 20140910