CN102460153A - 监控神经精神疾病治疗的生物标记 - Google Patents
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| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| US8868177B2 (en) * | 2009-03-20 | 2014-10-21 | ElectroCore, LLC | Non-invasive treatment of neurodegenerative diseases |
| US8158374B1 (en) | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
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| EP2337866B1 (en) * | 2008-10-15 | 2014-07-30 | Ridge Diagnostics, Inc. | Human biomarker hypermapping for depressive disorders |
| WO2010059709A2 (en) | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
| US20100280760A1 (en) * | 2009-04-01 | 2010-11-04 | Ridge Diagnostics, Inc. | Biomarkers for monitoring treatment of neuropsychiatric diseases |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| US20150241447A1 (en) * | 2009-11-17 | 2015-08-27 | Ralph J. ZITNIK | Vagus nerve stimulation screening test |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| EP2515996B1 (en) | 2009-12-23 | 2019-09-18 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| EP2529222A4 (en) * | 2010-01-26 | 2013-10-09 | Ridge Diagnostics Inc | MULTIPLE BIOMARKER PANELS FOR STRATIFYING ILLNESS HEAVY GRADES AND MONITORING THE TREATMENT OF DEPRESSIONS |
| EP3279668B1 (en) * | 2010-12-16 | 2019-05-15 | National Institute of Advanced Industrial Science and Technology | Method for enrichment and separation of spinal fluid glycoprotein, method for searching for marker for central nervous system diseases which utilizes the aforementioned method, and marker for central nervous system diseases |
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| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| US8737709B2 (en) * | 2012-04-30 | 2014-05-27 | General Electric Company | Systems and methods for performing correlation analysis on clinical outcome and characteristics of biological tissue |
| EP3022560B1 (en) | 2013-07-11 | 2020-09-02 | University of North Texas Health Science Center at Fort Worth | Blood-based screen for detecting neurological diseases in primary care settings |
| JP6364488B2 (ja) * | 2013-11-26 | 2018-07-25 | ユニバーシティー オブ ノース テキサス ヘルス サイエンス センター アット フォートワースＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｔｅｘａｓ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅ Ｃｅｎｔｅｒ Ａｔ Ｆｏｒｔ Ｗｏｒｔｈ | 認知欠損を治療するための個別化医療的手法 |
| WO2016004375A2 (en) * | 2014-07-02 | 2016-01-07 | Ridge Diagnostics, Inc. | Methods and materials for treating pain and depression |
| US11154712B2 (en) * | 2014-08-28 | 2021-10-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for assessing efficacy of renal neuromodulation and associated systems and devices |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| US11406833B2 (en) | 2015-02-03 | 2022-08-09 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| WO2017127758A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| EP3518745A1 (en) | 2016-10-28 | 2019-08-07 | Telefonica Innovacion Alpha S.L | System and a method for enabling responsive cognitive behavioral therapy |
| EP3612083B8 (en) | 2017-04-20 | 2022-12-28 | The Feinstein Institutes for Medical Research | Systems and methods for real-time monitoring of physiological biomarkers through nerve signals and uses thereof |
| WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
| WO2019046814A1 (en) | 2017-09-01 | 2019-03-07 | Venn Biosciences Corporation | IDENTIFICATION AND USE OF GLYCOPEPTIDES AS BIOMARKERS FOR THE DIAGNOSIS AND MONITORING OF TREATMENT |
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| IL298193B2 (en) | 2020-05-21 | 2024-01-01 | Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| US12444497B2 (en) | 2021-05-17 | 2025-10-14 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
Family Cites Families (47)
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|---|---|---|---|---|
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| US5882203A (en) * | 1995-05-31 | 1999-03-16 | Correa; Elsa I. | Method of detecting depression |
| US5658802A (en) * | 1995-09-07 | 1997-08-19 | Microfab Technologies, Inc. | Method and apparatus for making miniaturized diagnostic arrays |
| US5804453A (en) * | 1996-02-09 | 1998-09-08 | Duan-Jun Chen | Fiber optic direct-sensing bioprobe using a phase-tracking approach |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| US20040110938A1 (en) * | 2000-02-24 | 2004-06-10 | Parekh Rajesh Bhikhu | Proteins, genes and their use for diagnosis and treatment of schizophrenia |
| US20030032200A1 (en) * | 2000-02-24 | 2003-02-13 | Herath Herath Mudiyanselage Athula Chandrasiri | Proteins, genes and their use for diagnosis and treatment of bipolar affective disorder (BAD) and unipolar depression |
| IL151477A0 (en) * | 2000-03-09 | 2003-04-10 | Clinical Analysis Corp | Medical diagnostic system |
| US7094595B2 (en) * | 2000-10-30 | 2006-08-22 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US6905816B2 (en) * | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| DE60233301D1 (de) * | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| US6710877B2 (en) * | 2001-07-23 | 2004-03-23 | Corning Incorporated | Apparatus and methods for determining biomolecular interactions |
| WO2003043487A2 (en) * | 2001-11-19 | 2003-05-30 | Protometrix, Inc. | Method of using a non-antibody protein to detect and measure an analyte |
| US7136518B2 (en) * | 2003-04-18 | 2006-11-14 | Medispectra, Inc. | Methods and apparatus for displaying diagnostic data |
| US20040152107A1 (en) * | 2002-09-18 | 2004-08-05 | C. Anthony Altar | Gene signature of electroshock therapy and methods of use |
| KR20040032451A (ko) * | 2002-10-09 | 2004-04-17 | 삼성전자주식회사 | 생체신호 기반의 건강 관리 기능을 갖는 모바일 기기 및이를 이용한 건강 관리 방법 |
| US7490085B2 (en) * | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| MXPA05011913A (es) * | 2003-05-06 | 2006-02-17 | Aspect Medical Systems Inc | Sistema y metodo para valorar la eficacia del tratamiento de trastornos neurologicos utilizando el electroencefalograma. |
| US7706871B2 (en) * | 2003-05-06 | 2010-04-27 | Nellcor Puritan Bennett Llc | System and method of prediction of response to neurological treatment using the electroencephalogram |
| US20040228766A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| US20040228765A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| WO2005017203A2 (en) * | 2003-07-11 | 2005-02-24 | Yale University | Systems and methods for diagnosing and treating psychological and behavioral conditions |
| US20070092888A1 (en) * | 2003-09-23 | 2007-04-26 | Cornelius Diamond | Diagnostic markers of hypertension and methods of use thereof |
| US20050069936A1 (en) * | 2003-09-26 | 2005-03-31 | Cornelius Diamond | Diagnostic markers of depression treatment and methods of use thereof |
| US7394547B2 (en) * | 2003-11-06 | 2008-07-01 | Fortebio, Inc. | Fiber-optic assay apparatus based on phase-shift interferometry |
| JP2005312435A (ja) * | 2004-03-29 | 2005-11-10 | Kazuhito Rokutan | うつ病の評価方法 |
| US20050254065A1 (en) * | 2004-05-12 | 2005-11-17 | Stokowski Stanley E | Method and apparatus for detecting surface characteristics on a mask blank |
| AU2005257705A1 (en) * | 2004-06-24 | 2006-01-05 | Ge Healthcare Bio-Sciences Ab | Method for detecting molecular surface interactions |
| US20060063199A1 (en) * | 2004-09-21 | 2006-03-23 | Elgebaly Salwa A | Diagnostic marker |
| US7445887B2 (en) * | 2005-01-07 | 2008-11-04 | Fortebio, Inc. | Enzyme activity measurements using bio-layer interferometry |
| JP2007024822A (ja) * | 2005-07-21 | 2007-02-01 | Aska Pharmaceutical Co Ltd | 男性の更年期又はうつ病の鑑別方法 |
| JP2009516156A (ja) * | 2005-10-18 | 2009-04-16 | ケンブリッジ エンタープライズ リミティッド | 精神病性障害を診断及びモニタリングする方法及びバイオマーカー |
| US20070161042A1 (en) * | 2006-01-11 | 2007-07-12 | Fortebio, Inc. | Methods for characterizing molecular interactions |
| BRPI0707958B8 (pt) * | 2006-02-17 | 2021-07-27 | Sekiyama Atsuo | composição e kit para testar condições mentais por uma análise de regressão logística e método de medição de condições mentais |
| US20080015465A1 (en) * | 2006-06-15 | 2008-01-17 | Scuderi Gaetano J | Methods for diagnosing and treating pain in the spinal cord |
| US7651836B2 (en) * | 2006-08-04 | 2010-01-26 | Hospital Santiago Apóstol | Methods for diagnosis and prognostic of psychiatric diseases |
| US8158374B1 (en) * | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US20080199866A1 (en) * | 2006-10-10 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Snp detection and other methods for characterizing and treating bipolar disorder and other ailments |
| JP5298858B2 (ja) * | 2007-02-16 | 2013-09-25 | 株式会社島津製作所 | 上皮性卵巣癌の組織型識別マーカー、及びそれを用いた組織型に基づく上皮性卵巣癌の罹患の識別法 |
| JP5442208B2 (ja) * | 2007-03-15 | 2014-03-12 | 株式会社日立ハイテクノロジーズ | うつ病の検査方法 |
| EP2329260A4 (en) * | 2008-03-04 | 2011-08-03 | Ridge Diagnostics Inc | DIAGNOSIS AND MONITORING OF DEPRESSIVE DISORDERS BASED ON A PLURALITY OF BIOMARKER PANELS |
| JP5658571B2 (ja) * | 2008-03-12 | 2015-01-28 | リッジ ダイアグノスティックス，インコーポレイテッド | うつ障害をモニタリングするための炎症バイオマーカー |
| EP2337866B1 (en) * | 2008-10-15 | 2014-07-30 | Ridge Diagnostics, Inc. | Human biomarker hypermapping for depressive disorders |
| WO2010059709A2 (en) * | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
| US20100280760A1 (en) * | 2009-04-01 | 2010-11-04 | Ridge Diagnostics, Inc. | Biomarkers for monitoring treatment of neuropsychiatric diseases |
| EP2529222A4 (en) * | 2010-01-26 | 2013-10-09 | Ridge Diagnostics Inc | MULTIPLE BIOMARKER PANELS FOR STRATIFYING ILLNESS HEAVY GRADES AND MONITORING THE TREATMENT OF DEPRESSIONS |
| CN103370624A (zh) * | 2010-12-06 | 2013-10-23 | 里奇诊断学股份有限公司 | 监控神经精神疾病治疗的生物标记 |
-
2010
- 2010-04-06 US US12/754,770 patent/US20100280562A1/en not_active Abandoned
- 2010-04-06 WO PCT/US2010/030104 patent/WO2010118035A2/en not_active Ceased
- 2010-04-06 CA CA2757659A patent/CA2757659A1/en not_active Abandoned
- 2010-04-06 CN CN2010800258668A patent/CN102460153A/zh active Pending
- 2010-04-06 JP JP2012504782A patent/JP2012523009A/ja active Pending
- 2010-04-06 EP EP10762304A patent/EP2417448A4/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111524596A (zh) * | 2020-04-07 | 2020-08-11 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种判断青少年双相障碍发病风险的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2757659A1 (en) | 2010-10-14 |
| EP2417448A2 (en) | 2012-02-15 |
| WO2010118035A3 (en) | 2011-01-13 |
| WO2010118035A2 (en) | 2010-10-14 |
| JP2012523009A (ja) | 2012-09-27 |
| US20100280562A1 (en) | 2010-11-04 |
| EP2417448A4 (en) | 2012-10-24 |
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