CN102460153A - 监控神经精神疾病治疗的生物标记 - Google Patents
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| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| US8868177B2 (en) * | 2009-03-20 | 2014-10-21 | ElectroCore, LLC | Non-invasive treatment of neurodegenerative diseases |
| US8158374B1 (en) | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| JP5540000B2 (ja) * | 2008-10-15 | 2014-07-02 | リッジ ダイアグノスティックス，インコーポレイテッド | うつ病性障害のヒトバイオマーカーハイパーマッピング |
| WO2010059709A2 (en) | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
| JP5675771B2 (ja) * | 2009-04-01 | 2015-02-25 | リッジ ダイアグノスティックス，インコーポレイテッド | 精神神経疾患の治療をモニタリングするためのバイオマーカー |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| CN102573986B (zh) | 2009-06-09 | 2016-01-20 | 赛博恩特医疗器械公司 | 用于无导线刺激器的具有袋部的神经封套 |
| WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| EP2515996B1 (en) | 2009-12-23 | 2019-09-18 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| WO2011094308A2 (en) * | 2010-01-26 | 2011-08-04 | Ridge Diagnostics, Inc. | Multiple biomarker panels to stratify disease severity and monitor treatment of depression |
| WO2012081701A1 (ja) * | 2010-12-16 | 2012-06-21 | 独立行政法人産業技術総合研究所 | 髄液型糖タンパク質の富化及び分離方法、並びにその方法を用いた中枢神経系疾患用マーカーの探索方法及び中枢神経系疾患用マーカー |
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| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| US8737709B2 (en) * | 2012-04-30 | 2014-05-27 | General Electric Company | Systems and methods for performing correlation analysis on clinical outcome and characteristics of biological tissue |
| WO2015006489A1 (en) | 2013-07-11 | 2015-01-15 | University Of North Texas Health Science Center At Fort Worth | Blood-based screen for detecting neurological disease in primary care settings |
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| WO2015127476A1 (en) * | 2014-02-24 | 2015-08-27 | Setpoint Medial Corporation | Vagus nerve stimulation screening test |
| US20170161441A1 (en) * | 2014-07-02 | 2017-06-08 | Ridge Diagnostics, Inc. | Methods and materials for treating pain and depression |
| WO2016033543A1 (en) * | 2014-08-28 | 2016-03-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for assessing efficacy of renal neuromodulation and associated systems and devices |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| EP3405255B1 (en) | 2016-01-20 | 2025-12-31 | Setpoint Medical Corporation | IMPLANTABLE MICROSTIMULATORS AND INDUCTION CHARGING SYSTEMS |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| US11045126B2 (en) | 2016-10-28 | 2021-06-29 | Koa Health B.V. | System and a method for enabling responsive cognitive behavioral therapy |
| US11872371B2 (en) | 2017-04-20 | 2024-01-16 | The Feinstein Institutes For Medical Research | Systems and methods for real-time monitoring of physiological biomarkers through nerve signals and uses thereof |
| US11173307B2 (en) | 2017-08-14 | 2021-11-16 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
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| JP2023512447A (ja) | 2020-01-13 | 2023-03-27 | ザ ファインスタイン インスティチューツ フォー メディカル リサーチ | 脾臓への高密度集束超音波刺激による出血及び出血性疾患の治療 |
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| US12649059B2 (en) | 2022-08-05 | 2026-06-09 | The Feinstein Institutes For Medical Research | Methods for reducing bleeding in hemophilia by vagus nerve stimulation to prime platelets |
Family Cites Families (47)
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| US5882203A (en) * | 1995-05-31 | 1999-03-16 | Correa; Elsa I. | Method of detecting depression |
| US5658802A (en) * | 1995-09-07 | 1997-08-19 | Microfab Technologies, Inc. | Method and apparatus for making miniaturized diagnostic arrays |
| US5804453A (en) * | 1996-02-09 | 1998-09-08 | Duan-Jun Chen | Fiber optic direct-sensing bioprobe using a phase-tracking approach |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| US20040110938A1 (en) * | 2000-02-24 | 2004-06-10 | Parekh Rajesh Bhikhu | Proteins, genes and their use for diagnosis and treatment of schizophrenia |
| US20030032200A1 (en) * | 2000-02-24 | 2003-02-13 | Herath Herath Mudiyanselage Athula Chandrasiri | Proteins, genes and their use for diagnosis and treatment of bipolar affective disorder (BAD) and unipolar depression |
| US7041206B2 (en) * | 2000-03-09 | 2006-05-09 | Clinical Analysis Corporation | Medical diagnostic system |
| US7118710B2 (en) * | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
| US6905816B2 (en) * | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| EP1322957B1 (en) * | 2001-05-04 | 2009-08-12 | Biosite Incorporated | Diagnostic markers of acute coronary syndromes and methods of use thereof |
| US6710877B2 (en) * | 2001-07-23 | 2004-03-23 | Corning Incorporated | Apparatus and methods for determining biomolecular interactions |
| EP1451579A4 (en) * | 2001-11-19 | 2005-12-28 | Protometrix Inc | METHOD OF USING NON-ANTIBODY PROTEIN FOR DETECTING AND MEASURING AN ANALYTE |
| US7136518B2 (en) * | 2003-04-18 | 2006-11-14 | Medispectra, Inc. | Methods and apparatus for displaying diagnostic data |
| US20040152107A1 (en) * | 2002-09-18 | 2004-08-05 | C. Anthony Altar | Gene signature of electroshock therapy and methods of use |
| KR20040032451A (ko) * | 2002-10-09 | 2004-04-17 | 삼성전자주식회사 | 생체신호 기반의 건강 관리 기능을 갖는 모바일 기기 및이를 이용한 건강 관리 방법 |
| US7490085B2 (en) * | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| US7706871B2 (en) * | 2003-05-06 | 2010-04-27 | Nellcor Puritan Bennett Llc | System and method of prediction of response to neurological treatment using the electroencephalogram |
| US7418290B2 (en) * | 2003-05-06 | 2008-08-26 | Aspect Medical Systems, Inc. | System and method of assessment of the efficacy of treatment of neurological disorders using the electroencephalogram |
| US20040228766A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| US20040228765A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| US20050084880A1 (en) * | 2003-07-11 | 2005-04-21 | Ronald Duman | Systems and methods for diagnosing & treating psychological and behavioral conditions |
| US20070092888A1 (en) * | 2003-09-23 | 2007-04-26 | Cornelius Diamond | Diagnostic markers of hypertension and methods of use thereof |
| US20050069936A1 (en) * | 2003-09-26 | 2005-03-31 | Cornelius Diamond | Diagnostic markers of depression treatment and methods of use thereof |
| US7394547B2 (en) * | 2003-11-06 | 2008-07-01 | Fortebio, Inc. | Fiber-optic assay apparatus based on phase-shift interferometry |
| JP2005312435A (ja) * | 2004-03-29 | 2005-11-10 | Kazuhito Rokutan | うつ病の評価方法 |
| US20050254065A1 (en) * | 2004-05-12 | 2005-11-17 | Stokowski Stanley E | Method and apparatus for detecting surface characteristics on a mask blank |
| EP1766398B1 (en) * | 2004-06-24 | 2011-01-05 | GE Healthcare Bio-Sciences AB | Method for detecting molecular surface interactions |
| US20060063199A1 (en) * | 2004-09-21 | 2006-03-23 | Elgebaly Salwa A | Diagnostic marker |
| US7445887B2 (en) * | 2005-01-07 | 2008-11-04 | Fortebio, Inc. | Enzyme activity measurements using bio-layer interferometry |
| JP2007024822A (ja) * | 2005-07-21 | 2007-02-01 | Aska Pharmaceutical Co Ltd | 男性の更年期又はうつ病の鑑別方法 |
| JP2009516156A (ja) * | 2005-10-18 | 2009-04-16 | ケンブリッジ エンタープライズ リミティッド | 精神病性障害を診断及びモニタリングする方法及びバイオマーカー |
| US20070161042A1 (en) * | 2006-01-11 | 2007-07-12 | Fortebio, Inc. | Methods for characterizing molecular interactions |
| HRP20140673T1 (hr) * | 2006-02-17 | 2014-10-10 | Atsuo Sekiyama | Indikator biološkog materijala i postupak mjerenja biološkog materijala |
| US20080015465A1 (en) * | 2006-06-15 | 2008-01-17 | Scuderi Gaetano J | Methods for diagnosing and treating pain in the spinal cord |
| US7651836B2 (en) * | 2006-08-04 | 2010-01-26 | Hospital Santiago Apóstol | Methods for diagnosis and prognostic of psychiatric diseases |
| US8158374B1 (en) * | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US20080199866A1 (en) * | 2006-10-10 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Snp detection and other methods for characterizing and treating bipolar disorder and other ailments |
| WO2008099972A1 (ja) * | 2007-02-16 | 2008-08-21 | Shimadzu Corporation | 上皮性卵巣癌の組織型識別マーカー、及びそれを用いた組織型に基づく上皮性卵巣癌の罹患の識別法 |
| US20080281531A1 (en) * | 2007-03-15 | 2008-11-13 | Kazuhito Rokutan | Method for Diagnosing Depression |
| CN102037355A (zh) * | 2008-03-04 | 2011-04-27 | 里奇诊断学股份有限公司 | 基于多重生物标记物板块诊断和监测抑郁症 |
| EP2272044A4 (en) * | 2008-03-12 | 2011-07-06 | Ridge Diagnostics Inc | INFLAMMATORY BIOMARKING FOR MONITORING DEPRESSION DISEASES |
| JP5540000B2 (ja) * | 2008-10-15 | 2014-07-02 | リッジ ダイアグノスティックス，インコーポレイテッド | うつ病性障害のヒトバイオマーカーハイパーマッピング |
| WO2010059709A2 (en) * | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
| US20120178118A1 (en) * | 2010-12-06 | 2012-07-12 | Bo Pi | Biomarkers for monitoring treatment of neuropsychiatric diseases |
| JP5675771B2 (ja) * | 2009-04-01 | 2015-02-25 | リッジ ダイアグノスティックス，インコーポレイテッド | 精神神経疾患の治療をモニタリングするためのバイオマーカー |
| WO2011094308A2 (en) * | 2010-01-26 | 2011-08-04 | Ridge Diagnostics, Inc. | Multiple biomarker panels to stratify disease severity and monitor treatment of depression |
-
2010
- 2010-04-06 CA CA2757659A patent/CA2757659A1/en not_active Abandoned
- 2010-04-06 JP JP2012504782A patent/JP2012523009A/ja active Pending
- 2010-04-06 CN CN2010800258668A patent/CN102460153A/zh active Pending
- 2010-04-06 US US12/754,770 patent/US20100280562A1/en not_active Abandoned
- 2010-04-06 EP EP10762304A patent/EP2417448A4/en not_active Withdrawn
- 2010-04-06 WO PCT/US2010/030104 patent/WO2010118035A2/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111524596A (zh) * | 2020-04-07 | 2020-08-11 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种判断青少年双相障碍发病风险的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2417448A2 (en) | 2012-02-15 |
| WO2010118035A3 (en) | 2011-01-13 |
| CA2757659A1 (en) | 2010-10-14 |
| WO2010118035A2 (en) | 2010-10-14 |
| JP2012523009A (ja) | 2012-09-27 |
| EP2417448A4 (en) | 2012-10-24 |
| US20100280562A1 (en) | 2010-11-04 |
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