CN102459225B - Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 - Google Patents

Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Download PDF

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CN102459225B
CN102459225B CN201080027215.2A CN201080027215A CN102459225B CN 102459225 B CN102459225 B CN 102459225B CN 201080027215 A CN201080027215 A CN 201080027215A CN 102459225 B CN102459225 B CN 102459225B
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alkyl
pyridin
compound
methyl
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CN102459225A (zh
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张旭庆
H·R·赫夫奈格尔
蔡潮钟
J·兰特
T·P·马科坦
隋治华
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Janssen Pharmaceutica NV
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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CN201080027215.2A 2009-04-16 2010-04-15 Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 Expired - Fee Related CN102459225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16987609P 2009-04-16 2009-04-16
US61/169876 2009-04-16
PCT/US2010/031212 WO2010121011A1 (en) 2009-04-16 2010-04-15 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2

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CN102459225A CN102459225A (zh) 2012-05-16
CN102459225B true CN102459225B (zh) 2014-08-20

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US (1) US8269015B2 (https=)
EP (1) EP2419417B1 (https=)
JP (1) JP5685580B2 (https=)
KR (1) KR20120061060A (https=)
CN (1) CN102459225B (https=)
AR (1) AR076310A1 (https=)
AU (1) AU2010236393B2 (https=)
BR (1) BRPI1016207A2 (https=)
CA (1) CA2758918A1 (https=)
ES (1) ES2539161T3 (https=)
MX (1) MX2011010919A (https=)
NZ (1) NZ595431A (https=)
TW (1) TW201105649A (https=)
WO (1) WO2010121011A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2010068663A1 (en) * 2008-12-10 2010-06-17 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
CN102459227B (zh) * 2009-04-17 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
TW201204717A (en) 2010-06-17 2012-02-01 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
CA2852160A1 (en) 2011-10-28 2013-05-02 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
ES2904252T3 (es) 2015-05-21 2022-04-04 Chemocentryx Inc Moduladores de CCR2
CN118267479A (zh) 2017-09-25 2024-07-02 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists

Citations (2)

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US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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US6037354A (en) 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US7576117B1 (en) 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
MXPA05005660A (es) * 2002-11-27 2005-10-18 Incyte Corp Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
US20060069123A1 (en) 2004-09-28 2006-03-30 Mingde Xia Substituted dipiperidine CCR2 antagonists
UY29219A1 (es) * 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007130712A1 (en) 2006-01-31 2007-11-15 Janssen Pharmaceutica, Nv Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases
WO2009076512A1 (en) * 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
WO2010068663A1 (en) 2008-12-10 2010-06-17 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
CN102459227B (zh) 2009-04-17 2014-08-20 詹森药业有限公司 Ccr2的4-氮杂环丁烷基-1-苯基-环己烷拮抗剂
WO2010121036A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004151A1 (en) * 2000-12-20 2003-01-02 Robert Cherney Cyclic derivatives as modulators of chemokine receptor activity
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物

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Publication number Publication date
EP2419417B1 (en) 2015-03-25
BRPI1016207A2 (pt) 2016-04-26
JP2012524107A (ja) 2012-10-11
ES2539161T3 (es) 2015-06-26
EP2419417A1 (en) 2012-02-22
KR20120061060A (ko) 2012-06-12
AU2010236393B2 (en) 2014-11-13
MX2011010919A (es) 2011-11-02
US20100267688A1 (en) 2010-10-21
NZ595431A (en) 2013-12-20
CA2758918A1 (en) 2010-10-21
US8269015B2 (en) 2012-09-18
AR076310A1 (es) 2011-06-01
AU2010236393A1 (en) 2011-11-03
TW201105649A (en) 2011-02-16
JP5685580B2 (ja) 2015-03-18
CN102459225A (zh) 2012-05-16
WO2010121011A1 (en) 2010-10-21

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