CN102459154B - 用于制备羟胺类和药物的新方法 - Google Patents

用于制备羟胺类和药物的新方法 Download PDF

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Publication number
CN102459154B
CN102459154B CN201080025116.0A CN201080025116A CN102459154B CN 102459154 B CN102459154 B CN 102459154B CN 201080025116 A CN201080025116 A CN 201080025116A CN 102459154 B CN102459154 B CN 102459154B
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China
Prior art keywords
formula
compound
reaction
group
solvent
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Expired - Fee Related
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CN201080025116.0A
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English (en)
Chinese (zh)
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CN102459154A (zh
Inventor
拉斯·O·汉森
安德斯·伯格
拉斯·埃克隆德
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Nobel Chemicals AB
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Cambrex Karlskoga AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CN201080025116.0A 2009-04-08 2010-04-06 用于制备羟胺类和药物的新方法 Expired - Fee Related CN102459154B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20281309P 2009-04-08 2009-04-08
US61/202,813 2009-04-08
PCT/GB2010/000709 WO2010116140A1 (en) 2009-04-08 2010-04-06 New process for preparing hydroxylamines and medicaments

Publications (2)

Publication Number Publication Date
CN102459154A CN102459154A (zh) 2012-05-16
CN102459154B true CN102459154B (zh) 2015-12-02

Family

ID=42676911

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080025116.0A Expired - Fee Related CN102459154B (zh) 2009-04-08 2010-04-06 用于制备羟胺类和药物的新方法

Country Status (8)

Country Link
US (2) US20120122971A1 (enExample)
EP (1) EP2417099B1 (enExample)
JP (1) JP5788381B2 (enExample)
CN (1) CN102459154B (enExample)
BR (1) BRPI1010300B8 (enExample)
ES (1) ES2562004T3 (enExample)
PL (1) PL2417099T3 (enExample)
WO (1) WO2010116140A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) * 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140989A2 (en) * 2006-06-07 2007-12-13 Cambrex Karlskoga Ab Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169446A (ja) * 1984-02-15 1985-09-02 Mitsui Petrochem Ind Ltd ニトロフエノキシアミン類の製造方法
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JPH06145131A (ja) * 1992-11-11 1994-05-24 Mitsui Petrochem Ind Ltd シアノアリールオキシアミン類の製造方法
DE4244390A1 (de) * 1992-12-29 1994-06-30 Basf Ag Verfahren zur Herstellung von Oximino-Derivaten und neue Oximino-Derivate
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
JP2002371076A (ja) * 2001-06-14 2002-12-26 Sumitomo Seika Chem Co Ltd ２−アルキル−３−アシルベンゾフラン類の製造方法
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
JP5654994B2 (ja) * 2008-10-02 2015-01-14 カンブレックス カルルスクーガ アクチ ボラケットＣａｍｂｒｅｘ Ｋａｒｌｓｋｏｇａ Ａｂ ジケトン及び薬剤を製造するための新しいプロセス
CN102171199A (zh) * 2008-10-10 2011-08-31 隆萨有限公司 制备2-烷基-3-芳酰基-5-硝基-苯并呋喃类的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140989A2 (en) * 2006-06-07 2007-12-13 Cambrex Karlskoga Ab Process for the manufacture of 2-butyl-3- (4-methoxybenzoyl) -5-nitrobenzofurane and use thereof in the production of of medicaments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
0-(2,4-Dinitrophenyl) Oximes. Synthesis and Cyclization to 5,7-Dinitrobenzofurans;Tuvia Sheradsky;《Notes》;19670930;第4卷;第413-414页 *
Efficient Synthesis of Benzofurans Utilizing [3,3]-Sigmatropic Rearrangement;Norihiko Takeda等;《Eur. J. Org. Chem.》;20071231;第1491-1509页 *

Also Published As

Publication number Publication date
BRPI1010300B1 (pt) 2021-03-02
JP2012523401A (ja) 2012-10-04
US20140206761A1 (en) 2014-07-24
US20120122971A1 (en) 2012-05-17
EP2417099A1 (en) 2012-02-15
EP2417099B1 (en) 2015-12-23
HK1167134A1 (zh) 2012-11-23
JP5788381B2 (ja) 2015-09-30
BRPI1010300B8 (pt) 2021-05-25
PL2417099T3 (pl) 2016-06-30
ES2562004T3 (es) 2016-03-02
WO2010116140A1 (en) 2010-10-14
BRPI1010300A2 (pt) 2017-05-16
WO2010116140A8 (en) 2011-11-03
CN102459154A (zh) 2012-05-16

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Granted publication date: 20151202

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CF01 Termination of patent right due to non-payment of annual fee