CN102458531B - 两种或更多种药物通过单一剂量选择和配给接口的递送 - Google Patents

两种或更多种药物通过单一剂量选择和配给接口的递送 Download PDF

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Publication number
CN102458531B
CN102458531B CN201080033637.0A CN201080033637A CN102458531B CN 102458531 B CN102458531 B CN 102458531B CN 201080033637 A CN201080033637 A CN 201080033637A CN 102458531 B CN102458531 B CN 102458531B
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CN
China
Prior art keywords
drug
medicament
dose
reservoir
user
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080033637.0A
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English (en)
Chinese (zh)
Other versions
CN102458531A (zh
Inventor
D.T.德索斯马雷兹林特尔
M.S.博伊德
D.M.利克
C.P.基廷
D.桑德斯
E.A.马沙尔
G.杰伊
R.D.L.麦克阿瑟
M.J.D.希尔德
C.J.史密斯
E.L.奥蒂兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of CN102458531A publication Critical patent/CN102458531A/zh
Application granted granted Critical
Publication of CN102458531B publication Critical patent/CN102458531B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3294—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3142—Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN201080033637.0A 2009-06-02 2010-06-01 两种或更多种药物通过单一剂量选择和配给接口的递送 Expired - Fee Related CN102458531B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18345209P 2009-06-02 2009-06-02
US61/183,452 2009-06-02
EP09009657.9 2009-07-25
EP09009657 2009-07-25
PCT/EP2010/057571 WO2010139666A1 (en) 2009-06-02 2010-06-01 Delivery of two or more medicaments through a single dose selection and dispense interface

Publications (2)

Publication Number Publication Date
CN102458531A CN102458531A (zh) 2012-05-16
CN102458531B true CN102458531B (zh) 2014-08-20

Family

ID=41256091

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080033637.0A Expired - Fee Related CN102458531B (zh) 2009-06-02 2010-06-01 两种或更多种药物通过单一剂量选择和配给接口的递送

Country Status (12)

Country Link
US (1) US9592342B2 (enExample)
EP (1) EP2437818B1 (enExample)
JP (1) JP5823955B2 (enExample)
CN (1) CN102458531B (enExample)
AR (1) AR076623A1 (enExample)
AU (1) AU2010255841B2 (enExample)
BR (1) BRPI1012573A2 (enExample)
CA (1) CA2763613A1 (enExample)
IL (1) IL216569A (enExample)
IN (1) IN2011CN08926A (enExample)
TW (1) TW201109060A (enExample)
WO (1) WO2010139666A1 (enExample)

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WO2003068290A2 (en) 2002-02-11 2003-08-21 Antares Pharma, Inc. Intradermal injector
WO2006079064A1 (en) 2005-01-24 2006-07-27 Antares Pharma, Inc. Prefilled needle assisted jet injector
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
ES2548447T3 (es) 2008-03-10 2015-10-16 Antares Pharma, Inc. Dispositivo de seguridad para inyector
JP5611208B2 (ja) 2008-08-05 2014-10-22 アンタレス・ファーマ・インコーポレーテッド 多数回服用量の注射装置
BR112012010058A2 (pt) * 2009-10-30 2016-05-31 Duoject Inc aplicador tópico para um agente paralítico e método para aplicação do agente
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
JP6013484B2 (ja) 2011-08-30 2016-10-25 ノボ・ノルデイスク・エー／エス 流体の順次送出のための装置
CN104066468B (zh) 2011-12-01 2017-11-03 诺沃—诺迪斯克有限公司 药物填充的递送组件
EP4327849A3 (en) 2012-03-06 2024-04-24 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
KR20150011346A (ko) 2012-04-06 2015-01-30 안타레스 팔마, 인코퍼레이티드 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
EP2882478B1 (en) * 2012-08-08 2024-12-11 Sanofi-Aventis Deutschland GmbH Drug delivery device with tamper-evident closure
DK2953667T3 (da) 2013-02-11 2020-01-27 Antares Pharma Inc Nålestøttet jetinjektionsindretning med reduceret udløserkraft
EP3572108A1 (en) 2013-03-11 2019-11-27 Antares Pharma, Inc. Dosage injector with pinion system
WO2016067179A1 (en) 2014-10-29 2016-05-06 Wockhardt Limited A drug delivery device for delivery of two or more independently user selectable multiple doses of medicaments with user operable variable dose locking mechanisms
EP3106200A1 (en) 2015-06-19 2016-12-21 MedTrace A/S A system for safe radioisotope preparation and injection
US11103648B2 (en) 2016-05-06 2021-08-31 Sanofi-Aventis Deutschland Gmbh Injector assembly
JP2021522055A (ja) * 2018-05-04 2021-08-30 アドバンスド メディカル ソリューションズ イスラエル （シーランティス） リミテッド 再構成および混合システム

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563240A (en) * 1966-07-20 1971-02-16 Jules Silver Dual unit syringe
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
CN1507360A (zh) * 2000-05-22 2004-06-23 �ź㴫 医用装置
US20040133163A1 (en) * 2001-06-20 2004-07-08 Frank Schiffmann Device for administering an injectable product in doses

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US3911916A (en) * 1971-10-29 1975-10-14 Peter A Stevens Sequential injection syringe
AT341649B (de) * 1975-08-07 1978-02-27 Immuno Ag Injektionsspritze
US4055177A (en) * 1976-05-28 1977-10-25 Cohen Milton J Hypodermic syringe
JPS5898932U (ja) * 1981-12-28 1983-07-05 市川　今朝登 注射筒
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4857056A (en) 1988-07-06 1989-08-15 Sherwood Medical Company Auto-flush syringe pump
US5114411A (en) * 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
US5147323A (en) * 1991-03-08 1992-09-15 Habley Medical Technology Corporation Multiple cartridge syringe
US5423752A (en) * 1992-07-31 1995-06-13 Habley Medical Technology Corporation Variable proportion dispenser with cartridge replacement assembly
JP2586883B2 (ja) 1992-12-01 1997-03-05 哲郎 東川 注射器
US5584815A (en) * 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
US5681279A (en) * 1996-11-04 1997-10-28 Roper; David H. Pill dispensing syringe
WO2000048662A1 (en) * 1999-02-16 2000-08-24 Prismedical Corporation Single dose delivery device
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WO2005000384A1 (en) * 2003-06-05 2005-01-06 University Of Florida Auto-injection devices and methods for intramuscular administration of medications
US7645264B2 (en) * 2005-04-11 2010-01-12 Becton, Dickinson And Company Injection device with secondary reservoir
ITPD20060419A1 (it) * 2006-11-13 2008-05-14 Federico Nalesso Dispositivo per il trattamento manutentivo di cateteri venosi centrali
CN101626794A (zh) 2007-03-07 2010-01-13 诺沃-诺迪斯克有限公司 包括多个贮存器的药物输送装置
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JP5898932B2 (ja) 2011-11-29 2016-04-06 株式会社イトーキ 二重床パネル構造

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563240A (en) * 1966-07-20 1971-02-16 Jules Silver Dual unit syringe
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
CN1507360A (zh) * 2000-05-22 2004-06-23 �ź㴫 医用装置
US20040133163A1 (en) * 2001-06-20 2004-07-08 Frank Schiffmann Device for administering an injectable product in doses

Also Published As

Publication number Publication date
CA2763613A1 (en) 2010-12-09
IL216569A (en) 2015-07-30
EP2437818B1 (en) 2019-12-11
AU2010255841A1 (en) 2011-12-22
JP2012528634A (ja) 2012-11-15
AU2010255841B2 (en) 2015-05-28
IL216569A0 (en) 2012-03-01
BRPI1012573A2 (pt) 2016-03-29
JP5823955B2 (ja) 2015-11-25
IN2011CN08926A (enExample) 2015-08-21
CN102458531A (zh) 2012-05-16
TW201109060A (en) 2011-03-16
US20120136334A1 (en) 2012-05-31
EP2437818A1 (en) 2012-04-11
US9592342B2 (en) 2017-03-14
WO2010139666A1 (en) 2010-12-09
AR076623A1 (es) 2011-06-22

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140820

Termination date: 20200601