US3563240A - Dual unit syringe - Google Patents

Dual unit syringe Download PDF

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Publication number
US3563240A
US3563240A US3563240DA US3563240A US 3563240 A US3563240 A US 3563240A US 3563240D A US3563240D A US 3563240DA US 3563240 A US3563240 A US 3563240A
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Prior art keywords
syringe
end
cannula
chamber
body
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
Jules Silver
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SILVER INDUSTRIES Inc
JULES SILVER
SILVER JULES
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SILVER JULES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/005Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159Dose expelling manners
    • A61M5/31591Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31561Mechanically operated dose setting member using freely adjustable volume steps

Abstract

A dual unit syringe capable of supporting a plurality of isolated medicaments or pharmaceuticals separated one from the other under such circumstances that they will be maintained in stable form for long shelf life. The syringe has means using one liquid medicament and a cannula containing another and different liquid medicament under such circumstances that the medicaments can be mixed in and expelled from the cannula in blended form.

Description

United States Patent 218M, 218N, 218NV, 218?, 218PA, 218.1, 218.2, 221, 272; 222/145, 309; 128/225, 234, 235, 239, 261

ll, /0 ll [56] References Cited UNITED STATES PATENTS 2,856,925 10/1958 Helmer et a1. 128/218 3,276,632 10/1966 Stanzel 222/83.5 3,326,416 6/1967 Hayes 222/145X 3,354,883 1 H1967 Southerland 128/272X Primary Examiner- Richard A. Gaudet Assistant Examiner-Kyle L. Howell Atlorney- Rommel & Rommel ABSTRACT: A dual unit syringe capable of supporting a pluralit'y of isolated medicaments or pharmaceuticals separated one from the other under such circumstances that they will be maintained in stable form for long shelf life. The syringe has means using one liquid medicament and a cannula containing another and different liquid medicament under such circumstances that the medicaments can be mixed in and expelled from the cannula in blended form.

DUAL UNIT SYRINGE This invention relates to a dual unit syringe capable of supporting a plurality of isolated medicaments or pharmaceuticals. The medicaments are separated from one another under such circumstances that they will be maintained in stable form and properly packaged for long shelf life. The syringe parts are so associated that the medicaments can, with ease, at the time of intended use, be properly blended and applied.

The primary object of this invention is the provision of a dual unit syringe which is adapted to be used for admixing a plurality of pharmaceuticals, one of the pharmaceuticals being penicillin. Penicillin is sensitive to various bases and other drugs frequently necessary to be added thereto as a supplement. It is easily destroyed or degraded when compounded with other pharmaceuticals. it is necessary therefore to isolate penicillin and maintain it in a very stable form. Therefore, the dual unit syringe of this invention comprises means for isolating the penicillin under such circumstances that the syringe can be manipulated for expelling medicinal supplements into penicillin and applying the resultant mixture.

A further object of this invention is the provision of a dual unit syringe which consist of a main tubular body adapted to receive a pharmaceutical or pharmaceuticals, and having as sociated therewith a cannula adapted to isolate penicillin under such circumstances that at the time of use the pharmaceuticals of the tubular body may be expelled into and through the penicillin of the cannula and the resultant mixture applied as desired. I

A further object of this invention is the provision of a convenient and satisfactory means of packaging and maintaining a multiple dose syringe with medicinal ingredients thereof separated until desired to be used, and under such circumstances that the syringe may be operated to cause admixture of the ingredients and application at a desired time.

A further object of this invention is the provision of a dual unit syringe capable of handling a plurality of medicaments respectively isolated from each other within the syringe, and under such circumstances that they may be admixed at the proper time and applied. One such use would be infusing the mammary gland of a cow through the teat canal.

Other objects and advantages of this invention will be apparent during the course of the following detailed description, taken in connection with the accompanying drawing, forming portions of this specification, and in which drawing:

FIG. 1 is a side elevation of the assembled dual unit syringe.

FIG. 2 is a longitudinal cross-sectional view taken through the syringe showing the parts of the same ready for medicinal application.

FIG. 3 is a side elevation of a different form of dual unit syringe in which expulsion power is received from an aerosol container.

H6. 4 is a vertical cross-sectional view taken through a cannula adapted to isolate penicillin under such circumstances that it can be maintained for a prolonged shelf life prior to compounding.

FIG. 5 is a fragmentary view, partly in section, showing the upper end of a tubular body or container adapted to receive one or more pharmaceuticals.

FIG. 6 is a cross-sectional view taken on the line 6-6 of FIG. 2.

In the drawing, wherein for the purpose of illustration are shown different forms of the invention, and wherein similar reference characters designate corresponding parts throughout the several views, the letter A may generally designate the preferred form of invention and B a modification thereof. ln both forms of invention a cannula 10 is provided, which may be of any desirable material, preferably a synthetic plastic, It comprises an elongated tubular body 11 which at the upper end thereof tapers at 12 in an upward converging relation. It is provided withan applicator nozzle inserting stem or needle 13 of uniform diameter from end to end. The body 11 has a chamber 12 therein adapted to receive penicillin, or some other pharmaceutical which is intended to be expelled through the tapered passageway 14 of the neck 12 and then through the duct 15 of the applicator tube 13. A removable cap 16 normally seals the outer end of the nozzle 13. The tubular body 11 intermediate the ends thereof is provided with a rupturable membrane 20 adapted to seal off the chamber 12 for the purpose of isolating the body of penicillin 21 in liquid form. The tubular body 11 below the membrane 20 has a socket 22 and a base flange 23; the socket 22 being adapted to receive a tubular nozzle 25 at the outer or upper end of the syringe tubular body 30.

The tubular body 30 is preferably made of plastic and is of uniform diameter from end to end. It has a chamber 31 therein adapted to receive one or more supplemental medicaments. At its outer end it is provided with an end wall 32, upon which the nozzle 25 is mounted; a duct 34 extending through the wall 32 and the nozzle 25. The tubular body 30 at the lower end thereof is provided with laterally extending handle or finger flanges 36 as shown in the drawing. The chamber 31 is of uniform diameter from end to end and opens at the same diameter at the lower end of the tubular body 30. It is adapted to receive one or more supplemental pharmaceuticals, such as neomycin, dihydrostreptomycin, hydrocortisone or sulfonamides.

ln the form of invention A the means for expelling the liquid pharmaceuticals from the tubular body 30 into the cannula and through the medicament therein may comprise a single dose plunger or a plunger 40 which consists of a body formed of a plurality of radially extending flat flanges 60, connected centrally at 61. They are notched at 62 at the outer edges thereof. The upper ends of these flanges support a slidable plunger head 64 of flexible plastic or other suitable material. lt is adapted for insertion through the bottom opening of the chamber 31 and operates in leak-proof sliding relation in the chamber 31. The flanges 61 at the lower ends thereof support a palm engaging base or flange 66. A plunger limiting nut or ring 67 is threaded in the notches 62 having a segmental rib 68 thereon for such purpose. Rotation of the nut or ring 67 enables it to be properly located along the length of the plunger so as to permit a proper dosage of the amount of the medicament or combination of medicament 70 from ,the chamber 31 to be expelled into and through the cannula 10.

In the areosol type of syringe B, the cannula 10 is similar in structure to that above described. It also includes an aerosol container adapted to receiver the medicaments in liquified gas. The container 80 has an adapter cap 81 with a nozzle 25" similar to the nozzle 25 of the form of invention A and for the same purpose. The cap 81 is provided with an operating handle 82 which may be manipulated as by tilting, as with conventional aerosol syringes to release the medicament and gas from the container 80 for the admixture with penicillin as it passes through the cannula 10.

It will be noted in the form of invention A that the syringe barrel or tube 30 has a plunger adapted to divide the combination of medicaments 70 into four doses. As before stated, the plunger may provide for a single dose or a multiple dose. In the multiple dose the assembly should include a number of loaded cannulas 10 with the medicament 21 in amount equivalent to the number of doses. to be disbursed from chamber 31. The package as sold may comprise the equipment above described and with each syringe barrel there is provided four cannulas 10, each loaded with penicillin or some other medicament. The user can remove an empty cannula after administering one dose and continue using the same syringe barrel for the application of the remaining three doses.

Various changes in the size, shape and arrangement of parts may be made to the forms of invention herein shown and described, without departing from the spirit of the invention or the scope of the claims.

lclaim:

1. in a dual unit medicament dispensing syringe the combination of a tubular body having a chamber therein containing a liquid medicament and having a reduced top discharged nozzle provided with a passageway therethrough communicating with the chamber, the chamber at the lower end of said tudischarge passage communicatng with said cannula chamber, said cannula at is its opposite end from said applicator having a sealing disc disposed inwardly a sufiicient distance from said end to provide an opened ended socket receiving the nozzle of the tubular body, said socket being of such length that when the nozzle is fully inserted therein it will rupture the disc, and a removable sealing cap for the reduced end of said cannula.

Claims (1)

1. In a dual unit medicament dispensing syringe the combination of a tubular body having a chamber therein containing a liquid medicament and having a reduced top discharged nozzle provided with a passageway therethrough communicating with the chamber, the chamber at the lower end of said tubular body being opened, plunger means adjustably extending through said opening into the chamber having rotatable nonremovable length adjustable means threaded thereon to variably limit the operating travel of the plunger in the chamber whereby to control the amount of liquid medicament dosage expelled from said chamber, a removable cannula having a chamber containing a liquid medicament therein provided with an outer diametrically reduced applicator with a discharge passage communicatng with said cannula chamber, said cannula at is its opposite end from said applicator having a sealing disc disposed inwardly a sufficient distance from said end to provide an opened ended socket receiving the nozzle of the tubular body, said socket being of such length that when the nozzle is fully inserted therein it will rupture the disc, and a removable sealing cap for the reduced end of said cannula.
US3563240A 1966-07-20 1966-07-20 Dual unit syringe Expired - Lifetime US3563240A (en)

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US56668866 true 1966-07-20 1966-07-20

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
DE2753609A1 (en) * 1977-06-16 1979-01-04 Silver Jules syringe
EP0022987A1 (en) * 1979-07-23 1981-01-28 Cutter Laboratories, Inc. Syringe
WO1981001104A1 (en) * 1979-10-29 1981-04-30 J Silver Adjustable dosage syringe
US4723938A (en) * 1986-12-24 1988-02-09 Schneider-Shiley (Usa) Inc. Single plunger inflation device for angioplasty catheter
US4750373A (en) * 1987-01-22 1988-06-14 Shapiro Justin J Adjustable volume, pressure-generating pipette sampler
US4874385A (en) * 1987-12-16 1989-10-17 Sherwood Medical Company Plunger lock device
EP0493639A1 (en) 1989-06-12 1992-07-08 Jules Dr. Silver Syringe for dispensing measured quantities of a material
US5320845A (en) * 1993-01-06 1994-06-14 Py Daniel C Apparatus for delivering multiple medicaments to an eye without premixing in the apparatus
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US5328486A (en) * 1991-11-19 1994-07-12 American Cyanamid Company Syringe for dispensing multiple dosages
US5344409A (en) * 1993-06-14 1994-09-06 Genesis Industries Inc. Syringe latch
US5501373A (en) * 1991-08-02 1996-03-26 R.G.S.A.S.Di Rosaria Galli & C Atomizing dispenser for endonasal drug spray administration
US5522804A (en) * 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
US5613957A (en) * 1991-12-02 1997-03-25 Daniel Py Apparatus for applying medicament to an eye
US5811061A (en) * 1992-02-10 1998-09-22 Baxter International Inc. Method and device for testing blood units for viral contamination
WO1999007421A1 (en) * 1997-08-08 1999-02-18 Genesis Industries Incorporated Incrementally adjustable dose syringe
USRE37047E1 (en) 1992-04-06 2001-02-06 Daniel Py Cartridge for applying medicament to an eye from a dispenser
US6312413B1 (en) * 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
WO2002026298A2 (en) 2000-09-28 2002-04-04 Bayer Healthcare Llc Adjustable dosage syringe
US20020177805A1 (en) * 2001-03-13 2002-11-28 Barker John M. Pre-filled safety diluent injector
WO2003057288A1 (en) * 2001-12-28 2003-07-17 Terumo Kabushiki Kaisha Pre-filled syringe
US20050131354A1 (en) * 2001-12-28 2005-06-16 Terumo Kabushiki Kaisha Syringe
US20050215957A1 (en) * 2004-03-26 2005-09-29 Mallinckrodt Inc. Calibrated pushrod for injection volume control in prefilled syringes
US20060162501A1 (en) * 2004-07-30 2006-07-27 Ragan Philip J Bottle injector
US20070225656A1 (en) * 2006-03-24 2007-09-27 Hoyle John D Jr Dosage Control Syringe
US20080114304A1 (en) * 2006-11-13 2008-05-15 Medical Components, Inc Syringe for sequential expression of different liquids and method of using same
US20080142554A1 (en) * 2006-12-14 2008-06-19 John Lafferty Multiple Drug Injection Apparatus
US20100174236A1 (en) * 2008-11-26 2010-07-08 Steven Burns Single-use auto-disable syringe
WO2010139669A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Medicated module with premix medicament
WO2010139670A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Medicated module for a drug delivery device
WO2010139666A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Delivery of two or more medicaments through a single dose selection and dispense interface
WO2011040900A1 (en) * 2009-09-29 2011-04-07 Salzman Marc J Syringe-attached topical anesthetic dispenser
WO2011117282A1 (en) * 2010-03-26 2011-09-29 Sanofi-Aventis Deutschland Gmbh Dedicated needle assembly
US9586005B2 (en) 2013-09-30 2017-03-07 Dennis L Steffen Dual syringe delivery device and method of use
US9694134B2 (en) 2013-09-16 2017-07-04 Zoetis Services Llc Assembly for sequentially delivering substances, and associated methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2856925A (en) * 1956-01-13 1958-10-21 Easton Syringe structure
US3276632A (en) * 1965-04-02 1966-10-04 George A Stanzel Repellent fluid-dispensing weapon
US3326416A (en) * 1966-01-14 1967-06-20 Du Pont Apparatus for codispensing a plurality of liquids
US3354883A (en) * 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2856925A (en) * 1956-01-13 1958-10-21 Easton Syringe structure
US3354883A (en) * 1965-03-08 1967-11-28 Southerland Elizabeth Lee Disposable syringe having frangible means for mixing plural medicaments
US3276632A (en) * 1965-04-02 1966-10-04 George A Stanzel Repellent fluid-dispensing weapon
US3326416A (en) * 1966-01-14 1967-06-20 Du Pont Apparatus for codispensing a plurality of liquids

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
DE2753609A1 (en) * 1977-06-16 1979-01-04 Silver Jules syringe
EP0022987A1 (en) * 1979-07-23 1981-01-28 Cutter Laboratories, Inc. Syringe
DK156377B (en) * 1979-07-23 1989-08-14 Miles Inc Syringe
US4275729A (en) * 1979-10-29 1981-06-30 Jules Silver Adjustable dosage syringe
WO1981001104A1 (en) * 1979-10-29 1981-04-30 J Silver Adjustable dosage syringe
US4723938A (en) * 1986-12-24 1988-02-09 Schneider-Shiley (Usa) Inc. Single plunger inflation device for angioplasty catheter
US4750373A (en) * 1987-01-22 1988-06-14 Shapiro Justin J Adjustable volume, pressure-generating pipette sampler
US4874385A (en) * 1987-12-16 1989-10-17 Sherwood Medical Company Plunger lock device
EP0493639A1 (en) 1989-06-12 1992-07-08 Jules Dr. Silver Syringe for dispensing measured quantities of a material
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US5501373A (en) * 1991-08-02 1996-03-26 R.G.S.A.S.Di Rosaria Galli & C Atomizing dispenser for endonasal drug spray administration
US5328486A (en) * 1991-11-19 1994-07-12 American Cyanamid Company Syringe for dispensing multiple dosages
US5531708A (en) * 1991-11-19 1996-07-02 American Cyanamid Company Syringe for dispensing multiple dosages
US5613957A (en) * 1991-12-02 1997-03-25 Daniel Py Apparatus for applying medicament to an eye
US5685869A (en) * 1991-12-02 1997-11-11 Daniel Py Apparatus for applying medicament to an eye
US5944702A (en) * 1991-12-02 1999-08-31 Instill & Co. Method for instilling a predetermined volume of medicament into an eye
US5811061A (en) * 1992-02-10 1998-09-22 Baxter International Inc. Method and device for testing blood units for viral contamination
USRE37047E1 (en) 1992-04-06 2001-02-06 Daniel Py Cartridge for applying medicament to an eye from a dispenser
US5320845A (en) * 1993-01-06 1994-06-14 Py Daniel C Apparatus for delivering multiple medicaments to an eye without premixing in the apparatus
US5344409A (en) * 1993-06-14 1994-09-06 Genesis Industries Inc. Syringe latch
US5643218A (en) * 1994-02-15 1997-07-01 Lawrence A. Lynn Auto-flushing medical fluid injection system
US5697915A (en) * 1994-02-15 1997-12-16 Lynn; Lawrence A. Displacement-activated medical check valve
US5743886A (en) * 1994-02-15 1998-04-28 Lawrence A. Lynn Sequential medical fluid aspiration and injection system and method
US5769825A (en) * 1994-02-15 1998-06-23 Lynn; Lawrence A. Self-contained syringe and pharmaceutical packaging system for enclosed mixing of pharmaceutical and diluent
US5549569A (en) * 1994-02-15 1996-08-27 Lawrence A. Lynn Ex vivo blood isolation system
US6228065B1 (en) 1994-02-15 2001-05-08 Lawrence A. Lynn Displacement activated medical check valve
US5522804A (en) * 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
WO1999007421A1 (en) * 1997-08-08 1999-02-18 Genesis Industries Incorporated Incrementally adjustable dose syringe
US6312413B1 (en) * 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US6562007B1 (en) 2000-09-28 2003-05-13 Bayer Healthcare Llc Adjustable dosage syringe
WO2002026298A2 (en) 2000-09-28 2002-04-04 Bayer Healthcare Llc Adjustable dosage syringe
US6981963B2 (en) 2001-03-13 2006-01-03 Mdc Investment Holdings, Inc. Pre-filled safety diluent injector
US20020177805A1 (en) * 2001-03-13 2002-11-28 Barker John M. Pre-filled safety diluent injector
US20050131354A1 (en) * 2001-12-28 2005-06-16 Terumo Kabushiki Kaisha Syringe
WO2003057288A1 (en) * 2001-12-28 2003-07-17 Terumo Kabushiki Kaisha Pre-filled syringe
US7261704B2 (en) 2001-12-28 2007-08-28 Terumo Kabushiki Kaisha Syringe
US20070265580A1 (en) * 2001-12-28 2007-11-15 Terumo Kabushiki Kaisha Syringe
US7427276B2 (en) 2001-12-28 2008-09-23 Terumo Kabushiki Kaisha Syringe
US20050215957A1 (en) * 2004-03-26 2005-09-29 Mallinckrodt Inc. Calibrated pushrod for injection volume control in prefilled syringes
US7159490B2 (en) * 2004-07-30 2007-01-09 Ragan Philip J Bottle injector
US20060162501A1 (en) * 2004-07-30 2006-07-27 Ragan Philip J Bottle injector
US20070225656A1 (en) * 2006-03-24 2007-09-27 Hoyle John D Jr Dosage Control Syringe
US7470259B2 (en) 2006-03-24 2008-12-30 Hoyle Jr John D Dosage control syringe
US8021349B2 (en) 2006-11-13 2011-09-20 Medical Components, Inc. Method of using a syringe
US8771254B2 (en) 2006-11-13 2014-07-08 Medical Components, Inc. Method of using a syringe
US8771234B2 (en) 2006-11-13 2014-07-08 Medical Components, Inc. Syringe for sequential expression of different liquids
US20100152668A1 (en) * 2006-11-13 2010-06-17 Medical Components, Inc Method of Using a Syringe
US20080114304A1 (en) * 2006-11-13 2008-05-15 Medical Components, Inc Syringe for sequential expression of different liquids and method of using same
US8021343B2 (en) * 2006-11-13 2011-09-20 Medical Components, Inc. Syringe for sequential expression of different liquids
US7753890B2 (en) * 2006-12-14 2010-07-13 Dragon Drug Gun, Inc. Multiple drug injection apparatus
US20080142554A1 (en) * 2006-12-14 2008-06-19 John Lafferty Multiple Drug Injection Apparatus
US20080171996A1 (en) * 2006-12-14 2008-07-17 John Peter Lafferty Multiple Drug Injection Apparatus
US7935086B2 (en) * 2006-12-14 2011-05-03 L M M Global Innovations, Inc. Multiple drug injection apparatus
US8287491B2 (en) 2008-11-26 2012-10-16 Becton, Dickinson And Company Single-use auto-disable syringe
US9205205B2 (en) 2008-11-26 2015-12-08 Becton, Dickinson And Company Single-use auto-disable syringe
US20100174236A1 (en) * 2008-11-26 2010-07-08 Steven Burns Single-use auto-disable syringe
US9089648B2 (en) 2009-06-02 2015-07-28 Sanofi-Aventis Deutschland Gmbh Medicated module with premix medicament
US9089649B2 (en) 2009-06-02 2015-07-28 Sanofi-Aventis Detuschland Gmbh Medicated module for a drug delivery device
US20120136334A1 (en) * 2009-06-02 2012-05-31 Sanofi-Aventis Deutschland Gmbh Delivery of Two or More Medicaments Through a Single Dose Selection and Dispense Interface
US9592342B2 (en) * 2009-06-02 2017-03-14 Sanofi-Aventis Deutschland Gmbh Delivery of two or more medicaments through a single dose selection and dispense interface
JP2012528634A (en) * 2009-06-02 2012-11-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Delivery of two or more agents via a single dose selection and dose (dispense) interface
WO2010139669A1 (en) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Medicated module with premix medicament
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