CN102458465B - 通过抑制冷诱导rna结合蛋白(cirp)治疗炎性疾病 - Google Patents

通过抑制冷诱导rna结合蛋白(cirp)治疗炎性疾病 Download PDF

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CN102458465B
CN102458465B CN201080026421.1A CN201080026421A CN102458465B CN 102458465 B CN102458465 B CN 102458465B CN 201080026421 A CN201080026421 A CN 201080026421A CN 102458465 B CN102458465 B CN 102458465B
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cirp
antibody
inflammatory
binding
antibodies
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CN102458465A (zh
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王平
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Feinstein Institutes for Medical Research
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North Shore Long Island Jewish Research Institute
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CN201080026421.1A 2009-04-13 2010-04-13 通过抑制冷诱导rna结合蛋白(cirp)治疗炎性疾病 Expired - Fee Related CN102458465B (zh)

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US21258409P 2009-04-13 2009-04-13
US61/212,584 2009-04-13
PCT/US2010/030824 WO2010120726A1 (en) 2009-04-13 2010-04-13 Treatment of inflammatory diseases by inhibiting cold- inducible rna-binding protein (cirp)

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CN102458465B true CN102458465B (zh) 2015-09-02

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US (2) US8703138B2 (https=)
EP (1) EP2419134B1 (https=)
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CN (1) CN102458465B (https=)
AU (1) AU2010236670B2 (https=)
CA (1) CA2758449C (https=)
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Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA2758449C (en) 2009-04-13 2021-11-30 The Feinstein Institute For Medical Research Treatment of inflammatory diseases by inhibiting cold-inducible rna-binding protein (cirp)
EP3049438B1 (en) * 2013-09-24 2018-07-25 The Feinstein Institute for Medical Research Peptides inhibiting cold-inducible rna binding protein activity
ES2913339T3 (es) * 2014-01-31 2022-06-01 Draka Elevator Products Inc Dispositivo sensor de detección sísmica para equipo de transporte vertical
CN105582525B (zh) * 2014-10-24 2019-08-06 佛山市龙杰生物科技有限公司 Cirp在制备端粒酶结合剂或端粒酶活性调控剂方面的应用
US11001608B2 (en) 2019-07-11 2021-05-11 King Faisal University Arid5a peptide inhibitors
CN115925997B (zh) * 2022-11-16 2023-09-12 南通大学 一种干预治疗脑出血的多肽及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009387A1 (en) * 1999-07-29 2001-02-08 Northeastern University Isolation of novel hemapoietic genes by representational difference analysis
CN1589279A (zh) * 2001-11-16 2005-03-02 尼莫克斯股份有限公司 有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽
CN1980649A (zh) * 2004-05-17 2007-06-13 康宾纳特克斯公司 治疗免疫炎性疾病的方法和试药

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919661A (en) * 1997-08-25 1999-07-06 Incyte Pharmaceuticals, Inc. Polynucleotides encoding cytokine inducible regulatory protein
JPH11199507A (ja) * 1998-01-09 1999-07-27 Chugai Pharmaceut Co Ltd 脳疾患及び神経疾患治療薬
WO2009090287A1 (es) 2008-01-17 2009-07-23 Fundació Institut de Recerca de L'Hospital Universitari Vall d'Hebron Compuestos antitumorales basados en cirp
CA2758449C (en) 2009-04-13 2021-11-30 The Feinstein Institute For Medical Research Treatment of inflammatory diseases by inhibiting cold-inducible rna-binding protein (cirp)
US20140193412A1 (en) 2013-01-10 2014-07-10 The Feinstein Institute For Medical Research Treatment of cutaneous wounds by inhibiting cold shock proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009387A1 (en) * 1999-07-29 2001-02-08 Northeastern University Isolation of novel hemapoietic genes by representational difference analysis
CN1589279A (zh) * 2001-11-16 2005-03-02 尼莫克斯股份有限公司 有效治疗肿瘤和其它需要除去或破坏细胞的疾病的肽
CN1980649A (zh) * 2004-05-17 2007-06-13 康宾纳特克斯公司 治疗免疫炎性疾病的方法和试药

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Cold Shock Response in Mammalian Cells";Jun Fujita;《J. Mol. Microbiol. Biotechnol.》;19991231;第1卷(第2期);第243-255页尤其是摘要以及第251页左栏第2段和图7 *
"Cold-Inducible RNA-Binding Protein Bypasses Replicative Senescence in Primary Cells through Extracellular Signal-Regulated Kinase 1 and 2 Activation";Ana Artero-Castro et al.,;《Molecular and Cellular Biology》;20090121;第29卷(第7期);第1855-1868页尤其是第1857页左栏第2段和第1858页左栏第2段第4-6行 *

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