CN102448490B - 用于预防或治疗过敏原引起的气道疾病的疫苗 - Google Patents

用于预防或治疗过敏原引起的气道疾病的疫苗 Download PDF

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Publication number
CN102448490B
CN102448490B CN201080019636.0A CN201080019636A CN102448490B CN 102448490 B CN102448490 B CN 102448490B CN 201080019636 A CN201080019636 A CN 201080019636A CN 102448490 B CN102448490 B CN 102448490B
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pertussis
ova
bpze1
allergen
vaccine
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Chinese (zh)
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CN102448490A (zh
Inventor
卡米尔·洛赫特
伯纳德·马洪
希瑟·卡瓦纳
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NATIONAL HEALTH AND MEDICINE INST
Institut Pasteur
National University of Ireland Maynooth
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NATIONAL HEALTH AND MEDICINE INST
Institut Pasteur
National University of Ireland Maynooth
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201080019636.0A 2009-04-28 2010-04-26 用于预防或治疗过敏原引起的气道疾病的疫苗 Active CN102448490B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09305371.8 2009-04-28
EP09305371 2009-04-28
PCT/EP2010/055507 WO2010125014A1 (en) 2009-04-28 2010-04-26 Vaccine for prophylaxis or treatment of an allergen-driven airway pathology

Publications (2)

Publication Number Publication Date
CN102448490A CN102448490A (zh) 2012-05-09
CN102448490B true CN102448490B (zh) 2015-05-13

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CN201080019636.0A Active CN102448490B (zh) 2009-04-28 2010-04-26 用于预防或治疗过敏原引起的气道疾病的疫苗

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Country Link
US (7) US20120177688A1 (enExample)
EP (3) EP2424564B1 (enExample)
JP (1) JP5678034B2 (enExample)
CN (1) CN102448490B (enExample)
AU (1) AU2010243708C1 (enExample)
CA (1) CA2759280C (enExample)
DK (1) DK2424564T3 (enExample)
ES (2) ES3024937T3 (enExample)
SG (1) SG175803A1 (enExample)
WO (1) WO2010125014A1 (enExample)

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BRPI0707102B1 (pt) * 2006-03-10 2022-05-31 Institut Pasteur De Lille Composição imunogênica
CA2759280C (en) 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
JP5551774B2 (ja) 2009-06-15 2014-07-16 ナショナル ユニヴァーシティー オブ シンガポール インフルエンザワクチン、組成物、および使用方法
US9415077B2 (en) 2011-11-02 2016-08-16 Institut National De La Sante Et De La Recherche Medicale Effect of an attenuated Bordetella strain against allergic disease
EP2722338A1 (en) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
CN105722530B (zh) 2013-08-16 2020-06-02 罗切斯特大学 用于紧密连接屏障调节的设计肽
US9655959B2 (en) * 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
AU2017242541B2 (en) * 2016-03-29 2022-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutant bordetella strains and methods for use
JP6598724B2 (ja) 2016-04-07 2019-10-30 株式会社ジェイテクト ステアリング装置
CA3077428A1 (en) 2017-10-18 2019-04-25 Institut Pasteur De Lille Bordetella strains expressing serotype 3 fimbriae
EP3980054A1 (en) 2019-06-05 2022-04-13 University Of Rochester New designed inhibitors of tight junction formation
EP4208472A1 (en) * 2020-09-04 2023-07-12 Intravacc B.V. Ompa mutations enhance omv production in bordetella pertussis
EP3909971A1 (en) 2020-09-28 2021-11-17 Institute of Life Sciences (ILS) Whole cell livestock vaccine for respiratory diseases

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CN88103075A (zh) * 1987-05-22 1988-12-21 武田药品工业株式会社 一种除去百日咳内毒素的方法，一种百日咳类毒素及生产方法
WO2007104451A1 (en) * 2006-03-10 2007-09-20 Institut Pasteur De Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
CN101074442A (zh) * 2007-04-29 2007-11-21 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
CN101947323A (zh) * 2010-07-26 2011-01-19 北京绿竹生物制药有限公司 一种革兰氏阴性细菌疫苗及其制备方法

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US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB9115332D0 (en) 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
FR2840319B1 (fr) * 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
EP1617805A4 (en) * 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
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EP2134359A4 (en) 2007-02-23 2010-06-16 Penn State Res Found USE OF A NONVIRULENT BORDETELLA MUTANT AS LIVING VACCINE VECTOR
CA2759280C (en) 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
US9415077B2 (en) 2011-11-02 2016-08-16 Institut National De La Sante Et De La Recherche Medicale Effect of an attenuated Bordetella strain against allergic disease
EP2722338A1 (en) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
US9655959B2 (en) 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
AU2017242541B2 (en) 2016-03-29 2022-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutant bordetella strains and methods for use
US10799573B2 (en) 2016-03-30 2020-10-13 Regents Of The University Of Minnesota Pertussis vaccines and methods of making and using
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WO2007104451A1 (en) * 2006-03-10 2007-09-20 Institut Pasteur De Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
CN101400783A (zh) * 2006-03-10 2009-04-01 巴斯德研究院里尔分院 包特氏菌减毒活菌株作为抗百日咳的单剂量疫苗
CN101074442A (zh) * 2007-04-29 2007-11-21 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
CN101947323A (zh) * 2010-07-26 2011-01-19 北京绿竹生物制药有限公司 一种革兰氏阴性细菌疫苗及其制备方法

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does childhood immunization against infectious diseases protect from the development of atopic disease?;Martignon G,et al.;《pediatr allergy immunol》;20051231;第16卷;第194页左栏第2段第1-4行、第3段第1-4行、右栏第3段第1-6行、第5段，第196页右栏第2段第1-3行，第197页左栏第1段、图2,第199页左栏第1段第1-13行 *
live attenuated B.pertussis as a single-dose nasal vaccine against whooping cough;Nathalie mielcarek et al.;《Plos pathogenes》;20060630;第2卷(第7期);第662-670页，尤其是第663页左栏第1-3段，右栏第4段 *

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US20190358309A1 (en) 2019-11-28
US11819545B2 (en) 2023-11-21
US20200282041A1 (en) 2020-09-10
ES3024937T3 (en) 2025-06-05
EP2424564A1 (en) 2012-03-07
JP2012525346A (ja) 2012-10-22
AU2010243708A1 (en) 2011-11-03
EP2424564B1 (en) 2015-02-25
JP5678034B2 (ja) 2015-02-25
CA2759280A1 (en) 2010-11-04
US20210361759A1 (en) 2021-11-25
EP3590532C0 (en) 2025-03-19
SG175803A1 (en) 2011-12-29
US20180085450A1 (en) 2018-03-29
WO2010125014A1 (en) 2010-11-04
US20130183336A1 (en) 2013-07-18
US9839683B2 (en) 2017-12-12
US11110161B2 (en) 2021-09-07
AU2010243708C1 (en) 2014-10-02
AU2010243708B2 (en) 2014-06-12
US20150182614A1 (en) 2015-07-02
US10653765B2 (en) 2020-05-19
CN102448490A (zh) 2012-05-09
CA2759280C (en) 2016-09-20
EP3590532A1 (en) 2020-01-08
US8986709B2 (en) 2015-03-24
ES2535412T3 (es) 2015-05-11
EP2910252A1 (en) 2015-08-26
US20120177688A1 (en) 2012-07-12
EP3590532B1 (en) 2025-03-19
DK2424564T3 (en) 2015-04-27
US10420827B2 (en) 2019-09-24

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