CN102448314B - 获得二十碳五烯酸和二十二碳六烯酸的酯的浓缩物的方法 - Google Patents

获得二十碳五烯酸和二十二碳六烯酸的酯的浓缩物的方法 Download PDF

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CN102448314B
CN102448314B CN2010800239775A CN201080023977A CN102448314B CN 102448314 B CN102448314 B CN 102448314B CN 2010800239775 A CN2010800239775 A CN 2010800239775A CN 201080023977 A CN201080023977 A CN 201080023977A CN 102448314 B CN102448314 B CN 102448314B
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mixture
acid
temperature
phase
epa
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CN102448314A (zh
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T·F·哈挺·格莱德
M·A·迪亚兹·方泽里达
A·马考维特斯·罗杰斯
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Golden Omega SA
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Golden Omega SA
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • C11C1/025Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by saponification and release of fatty acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/02Other edible oils or fats, e.g. shortenings or cooking oils characterised by the production or working-up
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/006Refining fats or fatty oils by extraction
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/02Refining fats or fatty oils by chemical reaction
    • C11B3/04Refining fats or fatty oils by chemical reaction with acids
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00Refining fats or fatty oils
    • C11B3/02Refining fats or fatty oils by chemical reaction
    • C11B3/06Refining fats or fatty oils by chemical reaction with bases
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08Refining
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN2010800239775A 2009-06-02 2010-06-01 获得二十碳五烯酸和二十二碳六烯酸的酯的浓缩物的方法 Active CN102448314B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CL2009001343A CL2009001343A1 (es) 2009-06-02 2009-06-02 Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.
CL1343-2009 2009-06-02
PCT/CL2010/000018 WO2010139085A1 (es) 2009-06-02 2010-06-01 Proceso para la obtención de un concentrado de esteres de ácidos eicosapentaenoico y docosahexaenoico.

Publications (2)

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CN102448314A CN102448314A (zh) 2012-05-09
CN102448314B true CN102448314B (zh) 2013-10-23

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US (2) US8586772B2 (cg-RX-API-DMAC7.html)
EP (1) EP2438819B9 (cg-RX-API-DMAC7.html)
JP (1) JP5721148B2 (cg-RX-API-DMAC7.html)
KR (1) KR101430318B1 (cg-RX-API-DMAC7.html)
CN (1) CN102448314B (cg-RX-API-DMAC7.html)
AR (1) AR076622A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010256274B2 (cg-RX-API-DMAC7.html)
CA (1) CA2764242C (cg-RX-API-DMAC7.html)
CL (1) CL2009001343A1 (cg-RX-API-DMAC7.html)
CO (1) CO6470849A2 (cg-RX-API-DMAC7.html)
CY (1) CY1115329T1 (cg-RX-API-DMAC7.html)
DK (1) DK2438819T4 (cg-RX-API-DMAC7.html)
ES (1) ES2411958T5 (cg-RX-API-DMAC7.html)
HR (1) HRP20130531T1 (cg-RX-API-DMAC7.html)
MA (1) MA33485B1 (cg-RX-API-DMAC7.html)
NO (1) NO2438819T3 (cg-RX-API-DMAC7.html)
PE (1) PE20121267A1 (cg-RX-API-DMAC7.html)
PL (1) PL2438819T3 (cg-RX-API-DMAC7.html)
PT (1) PT2438819E (cg-RX-API-DMAC7.html)
SI (1) SI2438819T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201300056B (cg-RX-API-DMAC7.html)
WO (1) WO2010139085A1 (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009001343A1 (es) 2009-06-02 2009-07-10 Golden Omega S A Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.
GB201001345D0 (en) * 2010-01-27 2010-03-17 Equateq Ltd Process for preparing and purifying fatty acids
CL2010001587A1 (es) * 2010-12-27 2013-01-11 Golden Omega S A Proceso de preparacion de un concentrado de etil esteres de acidos grasos omega-3 que comprende sobre el 80% en peso de dichos esteres en configuracion cis y sus dobles enlaces separados por una unidad metilenica.
US8258330B1 (en) * 2012-01-04 2012-09-04 Naturalis, S.A. Carrier fluid composition comprising fatty acids ethyl esters and process for reducing the concentration of persistent organic pollutants in fish oil
US10568858B2 (en) * 2012-05-10 2020-02-25 Solutex Na Llc Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors
CN104302615B (zh) 2012-05-14 2017-09-08 日本水产株式会社 减低了环境污染物质的高度不饱和脂肪酸或高度不饱和脂肪酸乙酯及其制造方法
FR2991337B1 (fr) * 2012-05-29 2016-09-02 Roquette Freres Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues
JP6218738B2 (ja) * 2012-10-01 2017-10-25 日清ファルマ株式会社 高度不飽和脂肪酸アルキルエステル含有組成物の製造方法
ITMI20121681A1 (it) * 2012-10-08 2014-04-09 Milanotrading Srl Metodo di produzione di esteri etilici di acidi grassi poliinsaturi e loro impiego in formulazioni per uso orale nell'uomo
US10123986B2 (en) 2012-12-24 2018-11-13 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US9629820B2 (en) 2012-12-24 2017-04-25 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
US9045698B2 (en) * 2013-06-28 2015-06-02 Uop Llc Methods for removing contaminants from oils using base washing and acid washing
ES2875965T3 (es) 2013-12-04 2021-11-11 Nippon Suisan Kaisha Ltd Aceite microbiano que contiene ácido dihomo-gamma-linolénico y biomasa microbiana que contiene ácido dihomo-gamma-linolénico
ES3042360T3 (en) * 2014-04-07 2025-11-20 Epax Norway As Long chain monounsaturated fatty acid composition and long chain polyunsaturated fatty acid and method for the production thereof
AU2016262315B2 (en) 2015-05-13 2020-09-03 Epax Norway As Very long chain polyunsaturated fatty acids from natural oils
WO2016207734A1 (en) 2015-06-26 2016-12-29 Pronova Biopharma Norge As Composition for treatment of nafld
AU2016317523B2 (en) * 2015-08-31 2019-12-12 Nippon Suisan Kaisha, Ltd. Free polyunsaturated fatty acid-containing composition and manufacturing method therefor
JP6947370B2 (ja) * 2015-10-05 2021-10-13 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. 油組成物および製造方法
IL247522A0 (en) * 2016-08-29 2016-11-30 Technion Res & Dev Foundation Removal of pollutants from organic matter
KR101722924B1 (ko) * 2016-12-28 2017-04-05 이경화학 주식회사 고순도 mct 오일을 함유하는 피부각전 제거용 화장료 조성물의 제조방법 및 그에 의해 제조된 화장료 조성물
KR101754741B1 (ko) 2016-12-28 2017-07-06 이경화학 주식회사 세라마이드 에멀젼을 함유하는 화장료 조성물의 제조방법
KR101727539B1 (ko) 2016-12-28 2017-05-02 이경화학 주식회사 유산균 발효 추출물을 유효성분으로 포함하는 화장료 조성물의 제조방법 및 그에 의해 제조된 화장료 조성물
EP3586642A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Ala enriched polyunsaturated fatty acid compositions
EP3586640A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
US10836701B2 (en) * 2019-04-04 2020-11-17 Alejandro Markovits Rojas Fish oil cholesterol
CN114540116B (zh) * 2022-02-24 2024-02-13 海南潜龙生物科技有限公司 一种鳄鱼油的精制方法
KR102865475B1 (ko) * 2022-09-27 2025-09-25 고려대학교 산학협력단 저온결정법과 에스테르 반응을 이용한 오메가­3 불포화지방산의 효율적인 농축방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204638A (zh) * 1997-07-02 1999-01-13 湖南天海林实业股份有限公司 二十二碳六烯酸的制备和酯化工艺

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932531A (en) * 1972-07-14 1976-01-13 Nippon Shokubai Kaguku Kogyo Co., Ltd. Method of manufacturing alkylene oxide adducts of an aliphatic alcohol
JPS57149400A (en) * 1981-03-12 1982-09-14 Kureha Chemical Ind Co Ltd Manufacture of high purity long chain highly unsaturated fatty acid ester
DE3227669C1 (de) 1982-07-23 1983-07-07 Hermann Dr. 4400 Münster Stage Verfahren und Anlage zum Desodorieren und/oder Entsaeuern von Speiseoelen,Fetten und Estern
GB8314496D0 (en) 1983-05-25 1983-06-29 Unilever Plc Treating triglyceride oil
US4804555A (en) 1986-10-21 1989-02-14 General Mills, Inc. Physical process for simultaneous deodorization and cholesterol reduction of fats and oils
IT1205043B (it) 1987-05-28 1989-03-10 Innova Di Ridolfi Flora & C S Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri
US4915876A (en) 1987-07-20 1990-04-10 General Mills, Inc. Process for the deodorization and stabilization of polyunsaturated oils
US4874629A (en) 1988-05-02 1989-10-17 Chang Stephen S Purification of fish oil
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
JPH0225447A (ja) * 1988-07-13 1990-01-26 Nippon Oil & Fats Co Ltd 高度不飽和脂肪酸類の製造方法
CA2334022C (en) 1998-06-05 2008-12-02 Merck Patent Gesellschaft Mit Beschraenkter Haftung Contaminant reduced marine oil
JP2000044983A (ja) * 1998-07-31 2000-02-15 Maruha Corp 二重結合を有する脂肪酸またはその誘導体の精製法
CA2273570A1 (en) * 1999-05-31 2000-11-30 Jfs Envirohealth Ltd. Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling
GB2350610A (en) 1999-06-01 2000-12-06 Jfs Envirohealth Ltd Preparation of pure unsaturated fatty acids
PT1303580E (pt) 2000-07-19 2006-09-29 Lysi Hf Processo para a producao de oleos marinhos com niveis reduzidos de contaminantes
US6846946B2 (en) 2002-02-15 2005-01-25 Value Recovery, Inc. Process for making organic products and improving the quality of non-product streams using phase transfer catalysis
SE0202188D0 (sv) 2002-07-11 2002-07-11 Pronova Biocare As A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product
NO319194B1 (no) * 2002-11-14 2005-06-27 Pronova Biocare As Lipase-katalysert forestringsfremgangsmate av marine oljer
US6846942B2 (en) 2003-05-20 2005-01-25 David Rubin Method for preparing pure EPA and pure DHA
WO2005040318A1 (en) 2003-10-21 2005-05-06 Dsm Ip Assets B.V. Stabilisation of polyunsaturated fatty acid (pufa) ester concentrates
ITMI20032247A1 (it) * 2003-11-19 2005-05-20 Tiberio Bruzzese Interazione di derivati polari di composti insaturi con substrati inorganici
US20090221705A1 (en) 2006-02-07 2009-09-03 Pal Rongved Omega 3
WO2009009040A2 (en) * 2007-07-06 2009-01-15 Baum Seth J Fatty acid compositions and methods of use
CL2009001343A1 (es) 2009-06-02 2009-07-10 Golden Omega S A Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1204638A (zh) * 1997-07-02 1999-01-13 湖南天海林实业股份有限公司 二十二碳六烯酸的制备和酯化工艺

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US20120083616A1 (en) 2012-04-05
CN102448314A (zh) 2012-05-09
WO2010139085A1 (es) 2010-12-09
JP2012528901A (ja) 2012-11-15
SI2438819T1 (sl) 2013-07-31
PE20121267A1 (es) 2012-10-06
NO2438819T3 (cg-RX-API-DMAC7.html) 2013-09-21
DK2438819T3 (da) 2013-07-08
US20140005425A1 (en) 2014-01-02
ES2411958T3 (es) 2013-07-09
KR101430318B1 (ko) 2014-08-14
CL2009001343A1 (es) 2009-07-10
MA33485B1 (fr) 2012-08-01
PT2438819E (pt) 2013-06-12
PL2438819T3 (pl) 2013-09-30
AU2010256274A1 (en) 2012-01-12
EP2438819B2 (en) 2018-02-14
ES2411958T5 (es) 2018-06-29
DK2438819T4 (en) 2018-05-07
AU2010256274B2 (en) 2014-02-13
JP5721148B2 (ja) 2015-05-20
KR20120018219A (ko) 2012-02-29
US8981137B2 (en) 2015-03-17
EP2438819B1 (en) 2013-04-24
AR076622A1 (es) 2011-06-22
EP2438819A1 (en) 2012-04-11
CA2764242A1 (en) 2010-12-09
CO6470849A2 (es) 2012-06-29
CA2764242C (en) 2013-12-24
CY1115329T1 (el) 2017-01-04
HRP20130531T1 (en) 2013-07-31
SMT201300056B (it) 2013-07-09
EP2438819B9 (en) 2018-05-02
US8586772B2 (en) 2013-11-19

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