CN102440929B - Compound wild chrysanthemum spraying agent - Google Patents
Compound wild chrysanthemum spraying agent Download PDFInfo
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- CN102440929B CN102440929B CN 201110442717 CN201110442717A CN102440929B CN 102440929 B CN102440929 B CN 102440929B CN 201110442717 CN201110442717 CN 201110442717 CN 201110442717 A CN201110442717 A CN 201110442717A CN 102440929 B CN102440929 B CN 102440929B
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- chrysanthemi indici
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Abstract
The invention discloses a compound wild chrysanthemum spraying agent which can be used for beautifying and health care of the oral cavity as well as bacterium resistance and inflammation elimination, belonging to the field of medicines. The compound wild chrysanthemum spraying agent comprises the following active components by weight percent: 10-30% of rabdosia rubescens, 10-30% of honeysuckle flower, 20-50% of liquoric root, 20-35% of wild chrysanthemum, 0.1-0.5% of peppermint camphor, 0.2-0.6% of sodium benzoate and 0.1-2% of Tween-80. The active components are prepared into the spraying agent, and the spraying agent is convenient to carry and simple and fast to take and can prevent and treat common diseases of the oral cavity and throat, thereby achieving the effects of protecting the throat and refreshing mouth smell. The spraying agent is particularly suitable for treating sore throat and preventing upper respiratory tract infection and other diseases. The spraying agent is suitable for various crowds including ethanol-sensitive crowds.
Description
Technical field
The present invention relates to the compound wild chrysanthemum flower spray, relate in particular to and a kind ofly can carry out oral cavity health, the compound wild chrysanthemum flower oral spray of anti-inflammation belongs to field of medicaments.
Background technology
In recent years, the continuous increase of upper respiratory disease cases such as swine flu, pneumonia, superbacteria, for daily life is sounded the alarm again and again, and in the face of these antibacterials and virus, antibiotic is but over and over again abused clinically, make the bacterial drug resistance case constantly occur, helpless difficult situation has appearred in existing medical skill.In view of this, people begin self-examination and strengthen prevention and health care, strengthen health self function, and diseases prevention is not in sick.The dosage forms such as tablet, buccal tablet, granule, teabag that at present with the moistening and cleaning throat are health care on the market are comparatively common, with regard to Flos Chrysanthemi Indici, and existing Wild chrysanthemum oral buccal tablet on the market, the Flos Chrysanthemi Indici teabag does not still have this dosage form of oral spray.The oral spray dosage form can make medicine contact upper respiratory tract directly, effectively, medicinal effects is good, and have easy to carry, take advantages such as simple and fast, welcome by patient and consumer, existing market is badly in need of the compound wild chrysanthemum flower spray that exploitation has inhibiting bacteria and diminishing inflammation, the oral cavity had health-care effect.
Summary of the invention
At the existing market situation, the object of the invention is to provide a kind of anti-inflammation that has, and oral cavity, throat is had the compound wild chrysanthemum flower spray of auxiliary treatment effect.
For realizing the object of the invention, technical scheme is as follows:
The following component of compound wild chrysanthemum flower spray of the present invention is prepared from:
Rabdosia rubescens 10～30%, Flos Lonicerae 10～30%, Radix Glycyrrhizae 20～50%, Flos Chrysanthemi Indici 20～35%, Mentholum 0.1～0.5%, sodium benzoate 0.2～0.6%, sweetener 0.2%, Tween 80 are 0.1～2%.
Be preferably as follows component: Rabdosia rubescens 15～20%, Flos Lonicerae 20～30%, Radix Glycyrrhizae 25～35%, Flos Chrysanthemi Indici 25～30%, Mentholum 0.3～0.5%, sodium benzoate 0.3～0.5%, Tween 80 are 0.1～2%, sweetener 0.2%; Each component by weight percentage.
Be prepared from by the following method:
With Flos Chrysanthemi Indici, Flos Lonicerae steam distillation, it is standby to collect Aromatic water; The medicinal residues of Flos Chrysanthemi Indici, Flos Lonicerae are filtered to get filtrate, and filtrate concentrates to such an extent that clear paste A is standby; Medicinal residues and Rabdosia rubescens, the Radix Glycyrrhizae of Flos Chrysanthemi Indici, Flos Lonicerae are mixed, extract after-filtration with aqueous alcohol (50～90%), filtrate concentrates to such an extent that clear paste B is standby; Clear paste A and B are mixed the back with the Aromatic water dilution of above-mentioned collection, add Mentholum, sodium benzoate, tween and sweetener again, filter, sterilize, namely.
Flos Chrysanthemi Indici is cold in nature in the side, and sweet in the mouth has heat-clearing toxin-expelling functions, and Flos Chrysanthemi Indici all has in various degree inhibitory action to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae; Radix Glycyrrhizae has antitussive clinically, eliminates the phlegm, and antivirus action can be used for treating the pharyngalgia pharyngitis; Rabdosia rubescens and Flos Lonicerae two herbal medicines all have heat-clearing and toxic substances removing in various degree, inhibiting bacteria and diminishing inflammation, effects such as antiviral, adjusting immunity in treatment upper respiratory tract systemic disease.Each component synergism has antibacterial and anti-inflammation functions preferably, and oral cavity, throat are had the auxiliary treatment effect.
Innovative point of the present invention is: 1, used medicine all belongs to the medicine-food two-purpose resource in the side, thereby as the daily use of health care prevention, does not worry its toxic side effect.2, do not contain antibiotic and ethanol among the present invention, can not cause the generation of the bacterial drug resistance that antibiotic causes, and be suitable for too at ethanol or the responsive crowd of ethanol.3, being compared at present is the dosage forms such as tablet, buccal tablet, granule, teabag, cream of health care on the market with the moistening and cleaning throat; the compound wild chrysanthemum flower spray; medication experience among the people and modern Chinese medicine preparation theory are combined; easy to carry; take simple and fast, can either be inhibited for antibacterial common in the oral cavity, can play the protection throat again; the effect of fresh breath has multi-efficiencies such as health and beauty, prophylactic treatment oral cavity FAQs.Be specially adapted to treat laryngopharynx swelling and pain and prevention upper respiratory tract infection.
Every bottle of 20-30ml is sprayed directly on to the oral cavity and throat affected part during use, every day three times, each 1-2 time.Has extraordinary practical reference value.
Description of drawings
Fig. 1 compound wild chrysanthemum flower spray of the present invention is to the antibacterial ring sheet of bacillus subtilis;
Fig. 2 compound wild chrysanthemum flower spray of the present invention is to the antibacterial ring sheet of staphylococcus aureus.
The specific embodiment
For a more clear understanding of the present invention and the drug effect of medicament of the present invention, the present invention is described in further detail by following specific embodiment.
Embodiment 1
The following component of compound wild chrysanthemum flower spray of the present invention is prepared from: Rabdosia rubescens 20%, and Flos Lonicerae 20%, Radix Glycyrrhizae 31.8%, Flos Chrysanthemi Indici 25%, Mentholum 0.5%, sodium benzoate 0.5%, Tween 80 are 2%, sweetener 0.2%; Each component by weight percentage.
Be prepared from by the following method: with Flos Chrysanthemi Indici, Flos Lonicerae steam distillation, it is standby to collect Aromatic water; The medicinal residues of Flos Chrysanthemi Indici, Flos Lonicerae are filtered to get filtrate, and filtrate concentrates to such an extent that clear paste A is standby; Medicinal residues and Rabdosia rubescens, the Radix Glycyrrhizae of Flos Chrysanthemi Indici, Flos Lonicerae are mixed, and with percentage 50～90% ethanol extraction after-filtration, filtrate concentrates to such an extent that clear paste B is standby; Clear paste A and B are mixed the back with the Aromatic water dilution of above-mentioned collection, add Mentholum, sodium benzoate, tween and sweetener again, filter, sterilize, namely.
Embodiment 2
The following component of compound wild chrysanthemum flower spray of the present invention is prepared from: Rabdosia rubescens 20%, and Flos Lonicerae 20%, Radix Glycyrrhizae 26.8%, Flos Chrysanthemi Indici 30%, Mentholum 0.5%, sodium benzoate 0.5%, Tween 80 are 2%, sweetener 0.2%; Each component by weight percentage.
Be prepared from by the following method: with Flos Chrysanthemi Indici, Flos Lonicerae steam distillation, it is standby to collect Aromatic water; The medicinal residues of Flos Chrysanthemi Indici, Flos Lonicerae are filtered to get filtrate, and filtrate concentrates to such an extent that clear paste A is standby; Medicinal residues and Rabdosia rubescens, the Radix Glycyrrhizae of Flos Chrysanthemi Indici, Flos Lonicerae are mixed, and with percentage 50～90% ethanol extraction after-filtration, filtrate concentrates to such an extent that clear paste B is standby; Clear paste A and B are mixed the back with the Aromatic water dilution of above-mentioned collection, add Mentholum, sodium benzoate, tween and sweetener again, filter, sterilize, namely.
Embodiment 3
The following component of compound wild chrysanthemum flower spray of the present invention is prepared from: Rabdosia rubescens 30%, and Flos Lonicerae 15%, Radix Glycyrrhizae 33.4%, Flos Chrysanthemi Indici 20%, Mentholum 0.2%, sodium benzoate 0.2%, Tween 80 are 1%, sweetener 0.2%; Each component by weight percentage.
Also can adopt common fried prescription method to be prepared from.
The test of embodiment 4 fungistatic effects
The compound wild chrysanthemum flower spray that the embodiment of the invention is made carries out the fungistatic effect test, following strain is all available from Henan Privincial Medicaments Inspection Inst., bacillus subtilis (CMCC (B) 44102, date 2010-03-15), Candida albicans (CMCC (F) 9800, date 2010-03-03), Pseudomonas aeruginosa (CMCC (B) 44102, date 2010-03-15), staphylococcus aureus (CMCC (B) 26003, date 100315-2), escherichia coli (bacterium CMCC (B) 44102, date: G100303-2).Adopt agar diffusion method to test, the agar diffusion experimental result is the antibacterial ring meansigma methods of bacillus subtilis: 9.82mm, the antibacterial ring meansigma methods of staphylococcus aureus: 8.10mm, the antibacterial ring of escherichia coli and bacillus pyocyaneus and Candida albicans is not obvious, stipulate in the sterile products technical manual according to Department of Public Health, antibacterial circle diameter 〉=7mm namely can be considered and has fungistatic effect.Its bacteriostatic experiment effect photo is seen accompanying drawing 1,2: four solid circles are four batches of filter paper that contain medicament of the present invention around in the accompanying drawing 1, no bacillus subtilis growth in antibacterial ring around it as can be seen, and central circular is blank; Four solid circles are four batches of filter paper that contain medicament of the present invention around in the accompanying drawing 2, are not having staphylococcus aureus growth in the antibacterial ring around it as can be seen, and central circular is blank.
Conclusion: experiment shows that this invention has good fungistatic effect to gram positive bacteria staphylococcus aureus and bacillus subtilis, to the DeGrain of gram negative bacteria escherichia coli, bacillus pyocyaneus and fungus Candida albicans.For the position, oral cavity, mainly be based on gram positive bacteria, gram negative bacteria mainly is positioned at inner internal organs, so, meet the requirement of this dosage form site of action.
The test of embodiment 5 skin irritations
Cavia porcellus, male and female half and half, available from Condar experimental animal center, Henan Province, the cleaning level.According to sodium sulfide: soap powder: the ratio preparation depilatory cream 15g of solubility soap powder=3:1:7.Add and be applied in the intact Cavia porcellus spinal column both sides of skin after low amounts of water makes it become pasty state.The scope of smearing is 3cm * 3cm, behind the 5min, with gauze the hair of Cavia porcellus is cleaned, must not injured skin.Observe guinea pig skin in the 24h and have or not difference.If no difference then can be descended the step experiment.Adopt normal use amount every day, smear three times, be applied in 2.5cm * 2.5cm one side unhairing intact skin respectively, the opposite side skin of unhairing is as blank.Whenever smear back 24h observed result, continuous 14 days.But cropping in case of necessity in the meantime.
The standards of grading of table 1. skin irritation reaction
Experimental result shows that erythema and edema phenomenon all do not appear in the compound wild chrysanthemum flower spray that the above-mentioned enforcement of the present invention makes, and this invention is described to the skin gentleness, and is non-stimulated.
The test of embodiment 6 clinical applicability
Zhang, 45 years old, the man, upper respiratory tract infection, trial edition invention spray, three times on the one, spray secondary at every turn, feel after the spray that the throat is refrigerant pleasant, the throat discomfort sense alleviates, and symptom is gradually slow after three days, transference cure after five days.
Lee, 58 years old, the woman, the taste dampness is deep on ordinary days, halitosis, the oral cavity is given vent to anger not good, few and other people talk, try out this spray after, the oral cavity is salubrious, the halitosis transference cure.
The marquis, 32 years old, the woman, laryngopharynx swelling and pain, trial edition invention spray, three times on the one, each spray once feels after the spray that the throat is refrigerant pleasant, the throat discomfort sense alleviates, laryngopharynx swelling and pain transference cure after four days.
Compound wild chrysanthemum flower spray of the present invention makes medicine contact upper respiratory tract, oral cavity directly, effectively with the spray form administration, and medicinal effects is good, has satisfied patient and consumer demand.
Claims (2)
1. compound wild chrysanthemum flower spray, be prepared from by Chinese medicine, adjuvant, it is characterized in that it adopts following method to be prepared from according to following proportioning: Rabdosia rubescens 15～20%, Flos Lonicerae 20～30%, Radix Glycyrrhizae 25～35%, Flos Chrysanthemi Indici 25～30%, Mentholum 0.3～0.5%, sodium benzoate 0.3～0.5%, Tween 80 is 0.1～2%, sweetener 0.2%; Each component by weight percentage; Preparation method: with Flos Chrysanthemi Indici, Flos Lonicerae steam distillation, it is standby to collect Aromatic water; The medicinal residues of Flos Chrysanthemi Indici, Flos Lonicerae are filtered to get filtrate, and filtrate concentrates to such an extent that clear paste A is standby; Medicinal residues and Rabdosia rubescens, the Radix Glycyrrhizae of Flos Chrysanthemi Indici, Flos Lonicerae are mixed, use the hydrous alcohol extraction after-filtration, filtrate concentrates to such an extent that clear paste B is standby; Clear paste A and B are mixed the back with the Aromatic water dilution of above-mentioned collection, add Mentholum, sodium benzoate, Tween 80 and sweetener again, filter, sterilize, namely.
2. compound wild chrysanthemum flower spray as claimed in claim 1 is characterized in that, it is prepared from by following component: Rabdosia rubescens 20%, and Flos Lonicerae 20%, Radix Glycyrrhizae 31.8%, Flos Chrysanthemi Indici 25%, Mentholum 0.5%, sodium benzoate 0.5%, Tween 80 are 2%, sweetener 0.2%.
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| CN 201110442717 CN102440929B (en) | 2011-12-27 | 2011-12-27 | Compound wild chrysanthemum spraying agent |
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| CN 201110442717 CN102440929B (en) | 2011-12-27 | 2011-12-27 | Compound wild chrysanthemum spraying agent |
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| CN102440929A CN102440929A (en) | 2012-05-09 |
| CN102440929B true CN102440929B (en) | 2013-09-25 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830128A (en) * | 2012-11-21 | 2014-06-04 | 苏州鑫贝瑞药业有限公司 | Novel care solution and applications thereof |
| CN103006767A (en) * | 2013-01-22 | 2013-04-03 | 广州中医药大学第一附属医院 | Traditional Chinese medicine teabag for treating qi-deficiency and heat toxin blocking type nasopharyngitis |
| CN104840549A (en) * | 2015-04-22 | 2015-08-19 | 钟兴欢 | Throat heat clearing loquat lozenge |
| CN106860519A (en) * | 2015-12-11 | 2017-06-20 | 河南和贵恒实业有限公司 | Herbal mixture sweet osmanthus oral spray |
| CN105381207A (en) * | 2015-12-17 | 2016-03-09 | 济南舜祥医药科技有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat |
| CN106727135A (en) * | 2016-12-27 | 2017-05-31 | 郑州游爱网络技术有限公司 | A kind of mouthwash for carcinoma of mouth rehabilitation and preparation method thereof |
| CN110101805A (en) * | 2019-06-04 | 2019-08-09 | 苏州知时生物科技有限公司 | Pure plant rhinitis conditioning liquid and preparation method thereof |
| CN113616693B (en) * | 2020-05-09 | 2023-08-01 | 苏州玉森新药开发有限公司 | Traditional Chinese medicine antibacterial spray |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198065A (en) * | 2011-05-30 | 2011-09-28 | 天津天狮生物发展有限公司 | Oral spray and preparation method thereof |
| CN102258569A (en) * | 2011-07-06 | 2011-11-30 | 张海 | Chinese medicinal composition for treating stomatitis and sphagitis and preparation method thereof |
-
2011
- 2011-12-27 CN CN 201110442717 patent/CN102440929B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198065A (en) * | 2011-05-30 | 2011-09-28 | 天津天狮生物发展有限公司 | Oral spray and preparation method thereof |
| CN102258569A (en) * | 2011-07-06 | 2011-11-30 | 张海 | Chinese medicinal composition for treating stomatitis and sphagitis and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 任爱农 等.野菊花抑菌和抗病毒作用实验研究.《药物生物技术》.1999,第6卷(第4期),第241页. |
| 童巧珍 等.金银花挥发油提取工艺探讨.《湖南中医学院学报》.2002,第22卷(第4期),第24页. |
| 野菊花抑菌和抗病毒作用实验研究;任爱农 等;《药物生物技术》;19991231;第6卷(第4期);第241页 * |
| 金银花挥发油提取工艺探讨;童巧珍 等;《湖南中医学院学报》;20021231;第22卷(第4期);第24页 * |
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