CN102439146A - 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物 - Google Patents

适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物 Download PDF

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Publication number
CN102439146A
CN102439146A CN2010800225471A CN201080022547A CN102439146A CN 102439146 A CN102439146 A CN 102439146A CN 2010800225471 A CN2010800225471 A CN 2010800225471A CN 201080022547 A CN201080022547 A CN 201080022547A CN 102439146 A CN102439146 A CN 102439146A
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CN
China
Prior art keywords
cyaa
polypeptide
adenylate cyclase
cell
amino acid
Prior art date
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Pending
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CN2010800225471A
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English (en)
Chinese (zh)
Inventor
P.塞博
A.奥西科瓦
J.马辛
C.法约尔
J.克鲁塞克
M.巴斯勒
C.莱克勒克
R.奥西卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Institute Of Physiology
Instityut Of Majkrobajolodzhi Of Ze Astsr VVI
Institut Pasteur
Original Assignee
Czech Institute Of Physiology
Instityut Of Majkrobajolodzhi Of Ze Astsr VVI
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09155929.4A external-priority patent/EP2233569B1/en
Priority claimed from US12/409,324 external-priority patent/US8017132B2/en
Application filed by Czech Institute Of Physiology, Instityut Of Majkrobajolodzhi Of Ze Astsr VVI, Institut Pasteur filed Critical Czech Institute Of Physiology
Priority to CN201510983155.6A priority Critical patent/CN105602924A/zh
Publication of CN102439146A publication Critical patent/CN102439146A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01001—Aodenylate cyclase (4.6.1.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN2010800225471A 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物 Pending CN102439146A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510983155.6A CN105602924A (zh) 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/409,324 2009-03-23
EP09155929.4 2009-03-23
EP09155929.4A EP2233569B1 (en) 2009-03-23 2009-03-23 Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell
US12/409,324 US8017132B2 (en) 2009-03-23 2009-03-23 Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell
PCT/EP2010/053795 WO2010136231A1 (en) 2009-03-23 2010-03-23 MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510983155.6A Division CN105602924A (zh) 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物

Publications (1)

Publication Number Publication Date
CN102439146A true CN102439146A (zh) 2012-05-02

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ID=42224889

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510983155.6A Pending CN105602924A (zh) 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物
CN2010800225471A Pending CN102439146A (zh) 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物

Family Applications Before (1)

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CN201510983155.6A Pending CN105602924A (zh) 2009-03-23 2010-03-23 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物

Country Status (7)

Country Link
EP (1) EP2411513B1 (enExample)
JP (1) JP5770711B2 (enExample)
CN (2) CN105602924A (enExample)
CA (1) CA2755694A1 (enExample)
ES (1) ES2612945T3 (enExample)
RU (1) RU2585216C2 (enExample)
WO (1) WO2010136231A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2690172A1 (en) * 2012-07-23 2014-01-29 Genticel CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses
EP2975120A1 (en) 2014-07-17 2016-01-20 Institut Pasteur Monomeric and functional adenylate cyclase CyaA toxin
WO2018091613A1 (en) * 2016-11-17 2018-05-24 Ecole Nationale Vétérinaire de Toulouse Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection
EP3323426A1 (en) * 2016-11-17 2018-05-23 Ecole Nationale Vétérinaire de Toulouse Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection
EP3381931A1 (en) 2017-03-29 2018-10-03 Mikrobiologicky ustav AV CR, v.v.i. Adenylate cyclase toxoid with reduced cytolytic activity
DE102018215551A1 (de) 2018-09-12 2020-03-12 Virolutions Biotech Gmbh Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366549A1 (fr) * 1988-10-25 1990-05-02 Institut Pasteur Dérivés d'adényl cyclase et leurs utilisations biologiques
WO2005035557A2 (en) * 2003-10-14 2005-04-21 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease
CN1839152A (zh) * 2003-06-18 2006-09-27 巴斯德研究院 包含或缺乏CD11b/CD18相互作用结构域的修饰的博德特氏菌腺苷酸环化酶及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86583A0 (en) * 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
EP1715047A3 (en) 1992-04-21 2008-08-27 Institut Pasteur Recombinant mutants for inducing specific immune responses
FR2805544B1 (fr) * 2000-02-28 2004-07-16 Pasteur Institut Adenylcyclase recombinante et procede de tri de molecules a activite proteolytique utilisant cette adenylcyclase
ES2331348T3 (es) * 2000-09-15 2009-12-30 Pasteur Institut Vectores proteinicos para el suministro de moleculas a las celulas que expresan cd11b.
PT1576967E (pt) * 2004-03-18 2007-12-03 Pasteur Institut Proteína recombinante que transporta epitopos do virús do papilloma humano inseridos numa proteína adenilato ciclase, ou no seu fragmento, e seus usos terapêuticos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366549A1 (fr) * 1988-10-25 1990-05-02 Institut Pasteur Dérivés d'adényl cyclase et leurs utilisations biologiques
CN1839152A (zh) * 2003-06-18 2006-09-27 巴斯德研究院 包含或缺乏CD11b/CD18相互作用结构域的修饰的博德特氏菌腺苷酸环化酶及其用途
WO2005035557A2 (en) * 2003-10-14 2005-04-21 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADRIANA OSICKOVA ET AL: "Adenylate cyclase toxin translocates across target cell", 《MOLECULAR MICROBIOLOGY》 *
MAREK BASLER ET AL: "Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *

Also Published As

Publication number Publication date
EP2411513A1 (en) 2012-02-01
WO2010136231A1 (en) 2010-12-02
JP2012521207A (ja) 2012-09-13
RU2585216C2 (ru) 2016-05-27
RU2011138706A (ru) 2013-04-27
CN105602924A (zh) 2016-05-25
ES2612945T3 (es) 2017-05-19
EP2411513B1 (en) 2016-11-09
CA2755694A1 (en) 2010-12-02
JP5770711B2 (ja) 2015-08-26

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Application publication date: 20120502