CN102430262A - Device and method for extracting lucid ganoderma total triterpene - Google Patents
Device and method for extracting lucid ganoderma total triterpene Download PDFInfo
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- CN102430262A CN102430262A CN2011102613571A CN201110261357A CN102430262A CN 102430262 A CN102430262 A CN 102430262A CN 2011102613571 A CN2011102613571 A CN 2011102613571A CN 201110261357 A CN201110261357 A CN 201110261357A CN 102430262 A CN102430262 A CN 102430262A
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Abstract
The invention discloses a device and a method for extracting lucid ganoderma total triterpene. The device comprises a percolating tank and a solvent tank which is positioned on a high part of the percolating tank, wherein an alcohol tank, a percolate tank and a purified water tank which are communicated with the solvent tank through a control valve respectively are arranged above the solvent tank; and an input port of the percolate tank is connected with a percolate recovery pipeline. Ethanol solution with mass fraction of 50-90 percent is formed by using a percolating device of a tower type structure; lucid ganoderma is immersed by the ethanol solution for 2-4 hours; and percolate is collected, concentrated and spray-dried to obtain the lucid ganoderma total triterpene. Each part of the device is compactly arranged, the occupied space is small, and the percolate can be repeatedly utilized after being recovered; the lucid ganoderma total triterpene is extracted comprehensively by using the ethanol solution with different mass fraction gradients; and the method has the advantages of simplicity, low cost, full extraction and obvious economic and social benefits.
Description
Technical field
The invention belongs to the traditional Chinese medicine extraction field, be specifically related to a kind of device and method that extracts Ganoderma total triterpenes.
Background technology
Glossy ganoderma just is considered to lucky, rich and honour, fine, long-lived symbol since ancient times, and the title of " celestial grass ", " auspicious grass " is arranged, and a chinese tradition medical science direct-view glossy ganoderma for a long time is strengthening by means of tonics, consolidates the precious Chinese herbal medicine of setting upright, promoting longevity.365 kinds of Chinese medicines of record are divided into the upper, middle and lower three products, in 120 kinds of top grade Chinese medicines in China's the most ancient existing traditional Chinese medicine ancient books and records Shennong's Herbal; Glossy ganoderma is arranged and is higher than genseng, is medicine-feeding, and according to the form and the color of glossy ganoderma class glossy ganoderma is divided into six sesames; Think glossy ganoderma " pacify smart soul, increase wisdom, the beneficial motive; hard muscles and bones, good color, for a long time food is made light of one's life by commiting suicide not oldly, and the angle prolongs life ".Say that glossy ganoderma is " medicine of going up very much " in " Chinese force in pass ", " and eat it, the day after tomorrow and always ".Put down in writing in the Compendium of Material Medica that the famous medical scholar's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is write: " glossy ganoderma bitter, flat, nontoxic, the beneficial motive is invigorated blood circulation, and goes into heart hyperemia; help the heart to fill arteries and veins, calm the nerves, beneficial lung qi, tonifying liver gas, bowl spares; increase wisdom, good color, sharp joint, hard muscles and bones ... " now; Glossy ganoderma was formally recorded by the Pharmacopoeia of the People's Republic of China in 2000 as medicine, and it is again the new resource food of health ministry approval simultaneously, has no side effect, can medicine-food two-purpose." U.S.'s herbal medicine pharmacopeia and treatment summary (American Herbal Pharmacopoeia and Therapeutic Compendium) " also recorded glossy ganoderma.
Glossy ganoderma and active ingredient thereof have pharmacological action widely, can be used for preventing and treating multiple diseases such as chronic bronchitis, neurasthenia, hyperlipemia, coronary heart disease, hepatitis, leukopenia, tumour.Its effect of " strengthening the body resistance to consolidate the constitution " still can be used for weakness due to chronic disease and health care for the middle and old aged, can build up health, delay senility.
Method for distilling for the glossy ganoderma effective ingredient in the prior art is more single, and the extraction of active ingredient is comprehensive inadequately.The triterpenes composition of glossy ganoderma is complicated, and kind more than 100 is arranged, and is divided into pentacyclic triterpene and tetracyclic triterpene, and different triterpenes is dissolved in the ethanol of different quality mark, the Ganodenna Lucidum P.E that adopts conventional method for distilling to extract, and triterpene content is about 2%, and polysaccharide is 20%.
Summary of the invention
The object of the present invention is to provide a kind of device and method that extracts Ganoderma total triterpenes; This device each several part is arranged compact; Institute takes up space few; Percolate can reuse after reclaiming, and the method for the comprehensive extraction Ganoderma total triterpenes of ethanolic solution of employing different quality mark gradient is simple, cost is low, extraction is complete, have remarkable economical and social benefit.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
Extract the device of Ganoderma total triterpenes, comprise diacolation jar and the solvent tank that is positioned at diacolation jar eminence, above solvent tank, be provided with the alcohol container, diacolation flow container and the purifying water pot that communicate with solvent tank through control valve respectively; The input port of described diacolation flow container is connected with the percolate reclaim line.Alcohol container, diacolation flow container and purifying water pot are stacked to constitute tower tank body, and said tower tank body is alcohol container, diacolation flow container, purifying water pot from top to bottom successively.Diacolation pot bottom delivery outlet is connected with diacolation flow container input port through percolate retracting device, percolate storage tank.
Adopt said apparatus to extract the method for Ganoderma total triterpenes; Utilize the diacolation device of tower structure to form the ethanolic solution of mass fraction 50-90%, make ethanolic solution submergence glossy ganoderma 2 ~ 4 hours, collect percolate (within 24 ~ 48 hours, normal temperature, speed 3 ~ 10mL/ second); Decompression concentrates (normal temperature, pressure :-0.08MPa, time: 1 ~ 3 hour; Being concentrated to proportion is 1.03), spray-drying (temperature 100-200 ℃) promptly gets Ganoderma total triterpenes; The ethanolic solution of described mass fraction 50-90% be in the diacolation process for the first time diacolation with the ethanolic solution of mass fraction 90%; After collecting the liquid of diacolation recovery for the first time; With the ethanolic solution and the purified water of mass fraction 95%, the ethanolic solution that is mixed with mass fraction 85% begins diacolation, this process repeatedly for the second time; The mass fraction of each ethanolic solution successively decreases 5%, till the ethanolic solution diacolation with mass fraction 50%.The quality of the ethanolic solution that each diacolation is required is 8 times of glossy ganoderma quality.Described glossy ganoderma is the mixture of ganoderma lucidum fruitbody and lucidum spore powder; Said ganoderma lucidum fruitbody is got cap more than 8 centimetres, and is dry, do not have the glossy ganoderma coarse crushing processing of going mouldy in 2 centimetres of the stems, to the glossy ganoderma fineness be 20～60 orders; Said lucidum spore powder is crossed 120 mesh sieves through purifying, and control moisture is at 3%-9%, and broken wall is processed, and sporoderm-broken rate requires 99%, obtains glossy ganoderma spore powder with crushed sporoderm.Behind the ethanolic solution diacolation with mass fraction 50%, once with the purified water diacolation.Adopting the content of the Ganoderma total triterpenes of the method extraction is 20-23%.
Remarkable advantage of the present invention is:
(1) the device each several part is arranged compact; Institute takes up space few; Percolate can reuse after reclaiming, and the method for the comprehensive extraction Ganoderma total triterpenes of ethanolic solution of employing different quality mark gradient is simple, cost is low, extraction is complete, have remarkable economical and social benefit.
The medicinal powder that (2) will pass through after suiting to process is loaded in the percolator; Utilize tower structure to form the leaching solvent quality mark of different gradients; The leaching solvent of each gradient adds from percolator top, and solvent infiltrate medicinal material layer down leaches the method for various effective ingredients in the flow process.
(3) the tower-type gradient percolation is to the having relatively high expectations of medicinal material granularity and process conditions, and the triterpenes composition that relatively is suitable for the extraction of rare medicinal herbs, particularly glossy ganoderma is a lot, needs to adopt the comprehensive extraction active ingredient of edible alcohol of different quality mark.
(4) can under normal temperature or cryogenic conditions, carry out, therefore can not destroy the active ingredient of medicine, extraction is complete, and effective component content is high.The triterpene content of Ganodenna Lucidum P.E is at 20-23%, and polysaccharide can reach 10-30% simultaneously.
Description of drawings
Fig. 1 is the sketch map of tower-type gradient percolation.
Wherein 1 is the diacolation jar, the 2nd, and solvent tank, the 3rd, alcohol container, the 4th, diacolation flow container, the 5th, purifying water pot, the 6th, percolate storage tank, the 7th, percolate retracting device.
The specific embodiment
Utilize the ethanolic solution of the diacolation device formation mass fraction 50-90% of tower structure; The ethanolic solution submergence glossy ganoderma of each mass fraction 2 hours; Collect percolate (24 hours, normal temperature, speed 10mL/ second), decompression concentrates (normal temperature, pressure :-0.08MPa, time: 1 hour, being concentrated to proportion was 1.03); Spray-drying (100 ℃ of temperature) promptly gets Ganoderma total triterpenes; The ethanolic solution of described mass fraction 50-90% be in the diacolation process for the first time diacolation with the ethanolic solution of mass fraction 90%; After collecting the percolate first time; With the ethanolic solution and the purified water of mass fraction 95%, the ethanolic solution that is mixed with mass fraction 85% begins diacolation, this process repeatedly for the second time; The mass fraction of each ethanolic solution successively decreases 5%, till the ethanolic solution diacolation with mass fraction 50%.The quality of the ethanolic solution that each diacolation is required is 8 times of glossy ganoderma quality.Described glossy ganoderma is the mixture of ganoderma lucidum fruitbody and lucidum spore powder; Said ganoderma lucidum fruitbody is got cap more than 8 centimetres, and is dry, do not have the glossy ganoderma coarse crushing processing of going mouldy in 2 centimetres of the stems, to the glossy ganoderma fineness be 20 orders; Said lucidum spore powder is crossed 120 mesh sieves through purifying, and control moisture is 3%, and broken wall is processed, and sporoderm-broken rate requires 99%, obtains glossy ganoderma spore powder with crushed sporoderm.Behind the ethanolic solution diacolation with mass fraction 50%, once with the purified water diacolation.Adopting the content of the Ganoderma total triterpenes of the method extraction is 22%.
Utilize the ethanolic solution of the diacolation device formation mass fraction 50-90% of tower structure; The ethanolic solution submergence glossy ganoderma of each mass fraction 4 hours; Collect percolate (48 hours, normal temperature, speed 3mL/ second), decompression concentrates (normal temperature, pressure :-0.08MPa, time: 3 hours, being concentrated to proportion was 1.03); Spray-drying (200 ℃ of temperature) promptly gets Ganoderma total triterpenes; The ethanolic solution of described mass fraction 50-90% be in the diacolation process for the first time diacolation with the ethanolic solution of mass fraction 90%; After collecting the percolate first time; With the ethanolic solution and the purified water of mass fraction 95%, the ethanolic solution that is mixed with mass fraction 85% begins diacolation, this process repeatedly for the second time; The mass fraction of each ethanolic solution successively decreases 5%, till the ethanolic solution diacolation with mass fraction 50%.The quality of the ethanolic solution that each diacolation is required is 8 times of glossy ganoderma quality.Described glossy ganoderma is the mixture of ganoderma lucidum fruitbody and lucidum spore powder; Said ganoderma lucidum fruitbody is got cap more than 8 centimetres, and is dry, do not have the glossy ganoderma coarse crushing processing of going mouldy in 2 centimetres of the stems, to the glossy ganoderma fineness be 60 orders; Said lucidum spore powder is crossed 120 mesh sieves through purifying, and control moisture is 9%, and broken wall is processed, and sporoderm-broken rate requires 99%, obtains glossy ganoderma spore powder with crushed sporoderm.Behind the ethanolic solution diacolation with mass fraction 50%, once with the purified water diacolation.Adopting the content of the Ganoderma total triterpenes of the method extraction is 21.5%.
Utilize the ethanolic solution of the diacolation device formation mass fraction 50-90% of tower structure; The ethanolic solution submergence glossy ganoderma of each mass fraction 3 hours; Collect percolate (36 hours, normal temperature, speed 5mL/ second), decompression concentrates (normal temperature, pressure :-0.08MPa, time: 2 hours, being concentrated to proportion was 1.03); Spray-drying (150 ℃ of temperature) promptly gets Ganoderma total triterpenes; The ethanolic solution of described mass fraction 50-90% be in the diacolation process for the first time diacolation with the ethanolic solution of mass fraction 90%; After collecting the percolate first time; With the ethanolic solution and the purified water of mass fraction 95%, the ethanolic solution that is mixed with mass fraction 85% begins diacolation, this process repeatedly for the second time; The mass fraction of each ethanolic solution successively decreases 5%, till the ethanolic solution diacolation with mass fraction 50%.The quality of the ethanolic solution that each diacolation is required is 8 times of glossy ganoderma quality.Described glossy ganoderma is the mixture of ganoderma lucidum fruitbody and lucidum spore powder; Said ganoderma lucidum fruitbody is got cap more than 8 centimetres, and is dry, do not have the glossy ganoderma coarse crushing processing of going mouldy in 2 centimetres of the stems, to the glossy ganoderma fineness be 40 orders; Said lucidum spore powder is crossed 120 mesh sieves through purifying, and control moisture is 6%, and broken wall is processed, and sporoderm-broken rate requires 99%, obtains glossy ganoderma spore powder with crushed sporoderm.Behind the ethanolic solution diacolation with mass fraction 50%, once with the purified water diacolation.Adopting the content of the Ganoderma total triterpenes of the method extraction is 23%.
The above is merely preferred embodiment of the present invention, and all equalizations of doing according to claim of the present invention change and modify, and all should belong to covering scope of the present invention.
Claims (9)
1. a device that extracts Ganoderma total triterpenes comprises diacolation jar and the solvent tank that is positioned at diacolation jar eminence, it is characterized in that: above solvent tank, be provided with the alcohol container, diacolation flow container and the purifying water pot that communicate with solvent tank through control valve respectively; The input port of described diacolation flow container is connected with the percolate reclaim line.
2. the device of extraction Ganoderma total triterpenes according to claim 1 is characterized in that: alcohol container, diacolation flow container and purifying water pot are stacked to constitute tower tank body, and said tower tank body is alcohol container, diacolation flow container, purifying water pot from top to bottom successively.
3. the device of extraction Ganoderma total triterpenes according to claim 1 is characterized in that: diacolation pot bottom delivery outlet is connected with diacolation flow container input port through percolate retracting device, percolate storage tank.
4. method that adopts device as claimed in claim 1 to extract Ganoderma total triterpenes; It is characterized in that: utilize the diacolation device of tower structure to form the ethanolic solution of mass fraction for 50-90%; Make ethanolic solution submergence glossy ganoderma 2 ~ 4 hours, collect percolate, decompression concentrates; Spray-drying promptly gets Ganoderma total triterpenes; Described mass fraction be the ethanolic solution of 50-90% be in the diacolation process for the first time diacolation with the ethanolic solution of mass fraction 90%; After collecting the percolate effective component extracting first time; The ethanolic solution of percolate and mass fraction 95% and purified water, the ethanolic solution that is mixed with mass fraction 85% begins diacolation, this process repeatedly for the second time; The mass fraction of each ethanolic solution successively decreases 5%, till the ethanolic solution diacolation with mass fraction 50%.
5. the method for extraction Ganoderma total triterpenes according to claim 4 is characterized in that: described percolate is at normal temperatures, collects with the flow velocity of 3 ~ 10mL/ second, and acquisition time is 24 ~ 48 hours; It is to carry out at normal temperatures that described decompression concentrates, and pressure-0.08MPa, time 1 ~ 3 hour, being concentrated to proportion is 1.03; Described spray-dired temperature is at 100-200 ℃.
6. the method for extraction Ganoderma total triterpenes according to claim 4 is characterized in that: the quality of the ethanolic solution that each diacolation is required is 8 times of glossy ganoderma quality.
7. the method for extraction Ganoderma total triterpenes according to claim 4 is characterized in that: described glossy ganoderma is the mixture of ganoderma lucidum fruitbody and lucidum spore powder; Said ganoderma lucidum fruitbody is got cap more than 8 centimetres, and is dry, do not have the glossy ganoderma coarse crushing processing of going mouldy in 2 centimetres of the stems, to the glossy ganoderma fineness be 20～60 orders; Said lucidum spore powder is crossed 120 mesh sieves through purifying, and control moisture is at 3%-9%, and broken wall is processed, and sporoderm-broken rate requires to obtain glossy ganoderma spore powder with crushed sporoderm more than 99%.
8. the method for extraction Ganoderma total triterpenes according to claim 4 is characterized in that: behind the ethanolic solution diacolation with mass fraction 50%, with the purified water diacolation once.
9. the method for extraction Ganoderma total triterpenes according to claim 4 is characterized in that: the content of the Ganoderma total triterpenes that described method is extracted is 20-23%.
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Cited By (5)
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| CN103623753A (en) * | 2013-11-27 | 2014-03-12 | 大兴安岭嘉迪欧营养原料有限公司 | Novel preparation method of Great khingan wild potentilla fruticosa total triterpenes extractive |
| CN106901325A (en) * | 2017-03-15 | 2017-06-30 | 福建农林大学 | A kind of preparation and application of ganoderma lucidum full agonist |
| CN107569870A (en) * | 2017-09-29 | 2018-01-12 | 芜湖杨燕制药有限公司 | A kind of improved traditional Chinese medicine diacolation aftertreatment technology |
| CN107602351A (en) * | 2017-08-30 | 2018-01-19 | 芜湖杨燕制药有限公司 | Ethanol recovery process in a kind of traditional Chinese medicine diacolation process |
| CN112048418A (en) * | 2020-07-28 | 2020-12-08 | 武夷山元生泰生物科技有限公司 | Lucid ganoderma health-preserving wine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103623753A (en) * | 2013-11-27 | 2014-03-12 | 大兴安岭嘉迪欧营养原料有限公司 | Novel preparation method of Great khingan wild potentilla fruticosa total triterpenes extractive |
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| CN107569870A (en) * | 2017-09-29 | 2018-01-12 | 芜湖杨燕制药有限公司 | A kind of improved traditional Chinese medicine diacolation aftertreatment technology |
| CN112048418A (en) * | 2020-07-28 | 2020-12-08 | 武夷山元生泰生物科技有限公司 | Lucid ganoderma health-preserving wine and preparation method thereof |
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