CN103550264B - Method for extracting Ganoderma lucidum essences - Google Patents
Method for extracting Ganoderma lucidum essences Download PDFInfo
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- CN103550264B CN103550264B CN201310535022.3A CN201310535022A CN103550264B CN 103550264 B CN103550264 B CN 103550264B CN 201310535022 A CN201310535022 A CN 201310535022A CN 103550264 B CN103550264 B CN 103550264B
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Abstract
The invention discloses a method for extracting Ganoderma lucidum essences. The method comprises the steps of firstly, performing pretreatment on Ganoderma lucidum, and purifying water; secondly, extracting the pretreated Ganoderma lucidum and the purified water; thirdly, coarsely filtering the cooled Ganoderma lucidum soup and then precisely separating; fourthly, filtering the precisely filtered fluid with a microporous membrane with the bore diameter of 0.25-0.45 microns; fifthly, concentrating the refined purified fluid with a reverse osmosis membrane at normal temperature; and sixthly, concentrating the Ganoderma lucidum soup concentrated by the reverse osmosis membrane under reduced pressure, thus obtaining the extracts. Compared with the prior art, the method can be used for extracting the Ganoderma lucidum essences to improve the nutrient absorptivity greatly, has the advantages of having high efficiency, an environment protection effect and safety and ensuring the activity of effective constituents and can keep the taste and nutrients of the Ganoderma lucidum; the Ganoderma lucidum essences are convenient to carry and can completely bring out the effects of the rare Ganoderma lucidum.
Description
Technical field
The present invention relates to field of health care products, exactly refer to a kind of extracting method of Ganoderma essence substance.
Background technology
Ganoderma, also known as Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma lucidum seu Japonicum, Herba mesonae chinensis, Ganoderma, is the Herb of Polyporaceae plant Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma.Be best with Ganoderma sinense Zhao Xu et Zhang drug effect, Ganoderma originates in east Asia, distribution in China the widest in Jiangxi, Ganoderma is as the Chinese tradition valuable ingredient of Chinese medicine having thousands of years medicinal histories, possesses very high medical value, modern pharmacology research through scientific research institution's many decades confirms, Ganoderma, for enhancing body immunity, regulates blood glucose, control blood pressure, adjuvant therapy chemicotherapy, hepatoprotective, the aspects such as hypnotic all have significant curative effect.
Ganoderma can cure ten thousand diseases, and its function is come ture, the well-informed magical effect, therefore named Ganoderma, has another name called " not dead medicine " and is commonly called as " Ganoderma lucidum seu Japonicum ", Polyporaceae class, annual fungus, wherein particularly famous with Changbai Mountain red ganoderma.
Ganoderma is the general name of Basidiomycetes Polyporaceae (Polyporaceae) Ganoderma (Ganodelma) fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. G.lucidumkarst and Ganoderma G.japonicrn L loyd, has the effects such as strengthening the body resistance, is called top grade by " herbal classic ".In recent years, to the chemical composition of Ganoderma fungus and clinical research a lot of, to the sexual cell of Ganoderma---the research of spore medical value is also quite paid attention to, and summarizes the Recent Research of Ganoderma spore herein.Ganoderma spore brown, avette, one end is truncate, (8.5 ~ 11.2) μm × (5.2 ~ 6.9) μm, tool double wall.Produce many needle-like kicks at the brown internal layer of each spore, stretch into the transparent outer layer of conidial cell wall dearly, outer sporoderm is smooth.The two layers of walls of Ganoderma spore parcel is very tough and tensile, general chemistry, and physical method is difficult to be broken, therefore limits the research to its chemical composition, bioactive ingredients.Set up effective wall-breaking method, the research of extraction to its bioactive ingredients and medical value can be promoted.
Lucidum variety is kind more than 200 about, is not that often kind of Ganoderma can be medicinal, comprising the malicious sesame that can not eat.Medical evidence red ganoderma, Ganoderma, Coriolous Dersicolor (Fr.) Quel medical value are the highest.The virgin forest maximum in the whole nation, Mt. Changbai Nature Reserve Area optimum grows, but due to the excessive harvesting of the mankind for many years, the storage of wild Ganoderma is fewer and feweri.
At present, the eating method of most Ganoderma is for cooking on the market, steeps in wine or fricassee, but above directly eating method can only absorb 20 to four ten of hundred parts of ganoderma lucidum, central hundred parts 60 to eight ten will therefore to waste.
Summary of the invention
For above-mentioned defect, the technical problem that the present invention solves is the extracting method providing a kind of Ganoderma essence substance, extract the elite of Ganoderma, greatly promote nutrition absorption rate, there is high efficiency, environmental protection, safety and guarantee the advantages such as effective ingredient activity, both maintained taste and the nutrient of Ganoderma, be easy to carry again, famous and precious Ganoderma efficacy effect can have been brought into play completely.
In order to solve above technical problem, the extracting method of Ganoderma essence substance provided by the invention, comprises the steps:
(1) pretreatment of Ganoderma, removes the impurity staff on Ganoderma surface, and pulverize Ganoderma at the temperature pulverizer lower than 60 DEG C, fineness requirement is at 8 orders or following, and particle diameter is the smaller the better; Extraction is processed with former water, uses the pure water removing ion;
(2) Ganoderma pretreatment obtained and pure water are in the Ganoderma of 1:8-1:15 weight portion and water ratio, water temperature extracts at 20 DEG C-50 DEG C, and extraction is carried out 2-4 time, each 10-60 minute, the Ganoderma soup filtered out after extraction is several times merged, cools at ambient temperature;
(3) being separated carrying out precision after the coarse filtration of cooled Ganoderma soup, by aperture at the accurate membrane filtration of 3-10um, obtaining the secondary filter liquid of Ganoderma soup;
(4) be 0.25-0.45um micro-pore-film filtration with aperture again by secondary filter liquid, obtain the polishing purification liquid of Ganoderma soup;
(5) polishing purification liquid reverse osmosis membrane is concentrated at normal temperatures, obtain the concentrated Ganoderma soup that solid content is 8-15%;
(6) the Ganoderma soup will concentrated through reverse osmosis membrane, then carry out concentrating under reduced pressure, adopt the low temperature of 40 DEG C-50 DEG C, Ganoderma soup being concentrated to solid content is 50-70%;
(7) concentrated solution is carried out microwave vacuum low-temperature drying, vacuum lyophilization or spray-dired mode, finally obtain elite extract.
Preferably, in step (1), with pulverizer, Ganoderma is pulverized at the temperature of 20-50 DEG C.
Preferably, described elite extract makes electuary, tablet or capsule.
Preferably, the residue obtained after microwave vacuum low-temperature drying, vacuum lyophilization or spraying dry is made highland barley biscuit.
Compared with prior art, the extracting method of Ganoderma essence substance provided by the invention, the elite using low-temperature extraction isolation technics to extract Ganoderma can bring up to hundred parts 70%, low-temperature extraction isolation technics is by the low-temperature extraction technology in conjunction with shearing and vibration force effect, combined type microwave-assisted extraction technique and supercritical carbon dioxide extraction isolation technics three technology are integrated and are formed, this technology can carry out combination adjustment according to the characteristic of raw material and product demand, there is high efficiency, environmental protection, safety with guarantee the advantages such as effective ingredient is active, the scope of application is quite extensive, operative temperature is lower than 60 DEG C, the activity of effective ingredient in natural goods can be guaranteed, do not use the solvent of harmful human body, carry out extract and separate in an economical manner, can fully retain its effective ingredient and fragrance, equipment is easy to amplify, emphasizing the modern life that is healthy and health preserving, coordinate low-temperature extraction isolation technics the efficacy exertion of Ganoderma to maximum, greatly promote nutrition absorption rate, there is high efficiency, environmental protection, safety with guarantee the advantages such as effective ingredient is active, both taste and the nutrient of Ganoderma had been maintained, be easy to carry again, famous and precious Ganoderma efficacy effect can be brought into play completely.
Accompanying drawing explanation
Fig. 1 is the flow chart of the extracting method of Ganoderma essence substance in the present invention.
Detailed description of the invention
In order to those skilled in the art can understand technical scheme provided by the present invention better, set forth below in conjunction with specific embodiment.
Refer to Fig. 1, this figure is the structural representation of the extracting method of Ganoderma essence substance in the present invention.
Embodiment 1
The extracting method of the Ganoderma essence substance that the embodiment of the present invention provides, comprises the steps:
(1) pretreatment of Ganoderma, removes the impurity staff on Ganoderma surface, and pulverize Ganoderma at the temperature pulverizer of 50 DEG C, fineness requirement is at 8 orders; Extraction is processed with former water, uses the pure water removing ion;
(2) Ganoderma pretreatment obtained and pure water are in the Ganoderma of 1:8 weight portion and water ratio, and water temperature extracts at 20 DEG C, and extraction carries out 3 times, each 30 minutes, and the Ganoderma soup filtered out after extracting 4 times merges, and cools at ambient temperature;
(3) being separated carrying out precision after the coarse filtration of cooled Ganoderma soup, by aperture at the accurate membrane filtration of 8um, obtaining the secondary filter liquid of Ganoderma soup;
(4) be 0.25um micro-pore-film filtration with aperture again by secondary filter liquid, obtain the polishing purification liquid of Ganoderma soup;
(5) polishing purification liquid reverse osmosis membrane is concentrated at normal temperatures, obtain the concentrated Ganoderma soup that solid content is 10%;
(6) the Ganoderma soup will concentrated through reverse osmosis membrane, then carry out concentrating under reduced pressure, adopt the low temperature of 50 DEG C, Ganoderma soup being concentrated to solid content is 70%;
(7) concentrated solution is carried out microwave vacuum low-temperature drying, vacuum lyophilization or spray-dired mode, finally obtain elite extract, elite extract makes electuary; The residue obtained after microwave vacuum low-temperature drying, vacuum lyophilization or spraying dry is made highland barley biscuit.
For 10 kairine sesames, have 72% with the elite that low-temperature extraction isolation technics is extracted wherein, only remaining 28% residue.
Embodiment 2
The extracting method of the Ganoderma essence substance that the embodiment of the present invention provides, comprises the steps:
(1) pretreatment of Ganoderma, removes the impurity staff on Ganoderma surface, and pulverize Ganoderma at the temperature pulverizer of 30 DEG C, fineness requirement is at 20 orders; Extraction is processed with former water, uses the pure water removing ion;
(2) Ganoderma pretreatment obtained and pure water are in the Ganoderma of 1:15 weight portion and water ratio, and water temperature extracts at 50 DEG C, and extraction carries out 4 times, each 60 minutes, and the Ganoderma soup filtered out after extracting 4 times merges, and cools at ambient temperature;
(3) being separated carrying out precision after the coarse filtration of cooled Ganoderma soup, by aperture at the accurate membrane filtration of 10um, obtaining the secondary filter liquid of Ganoderma soup;
(4) be 0.45um micro-pore-film filtration with aperture again by secondary filter liquid, obtain the polishing purification liquid of Ganoderma soup;
(5) polishing purification liquid reverse osmosis membrane is concentrated at normal temperatures, obtain the concentrated Ganoderma soup that solid content is 15%;
(6) the Ganoderma soup will concentrated through reverse osmosis membrane, then carry out concentrating under reduced pressure, adopt the low temperature of 50 DEG C, Ganoderma soup being concentrated to solid content is 50%;
(7) concentrated solution is carried out microwave vacuum low-temperature drying, vacuum lyophilization or spray-dired mode, finally obtain elite extract, elite extract makes capsule; The residue obtained after microwave vacuum low-temperature drying, vacuum lyophilization or spraying dry is made highland barley biscuit.
For 10 kairine sesames, have 70% with the elite that low-temperature extraction isolation technics is extracted wherein, only remaining 30% residue.
Embodiment 3
The extracting method of the Ganoderma essence substance that the embodiment of the present invention provides, comprises the steps:
(1) pretreatment of Ganoderma, removes the impurity staff on Ganoderma surface, and pulverize Ganoderma at the temperature pulverizer of 20 DEG C, fineness requirement is at 100 orders; Extraction is processed with former water, uses the pure water removing ion;
(2) Ganoderma pretreatment obtained and pure water are in the Ganoderma of 1:12 weight portion and water ratio, and water temperature extracts at 40 DEG C, and extraction carries out 2 times, each 30 minutes, and the Ganoderma soup filtered out after extracting 2 times merges, and cools at ambient temperature;
(3) being separated carrying out precision after the coarse filtration of cooled Ganoderma soup, by aperture at the accurate membrane filtration of 5um, obtaining the secondary filter liquid of Ganoderma soup;
(4) be 0.35um micro-pore-film filtration with aperture again by secondary filter liquid, obtain the polishing purification liquid of Ganoderma soup;
(5) polishing purification liquid reverse osmosis membrane is concentrated at normal temperatures, obtain the concentrated Ganoderma soup that solid content is 10%;
(6) the Ganoderma soup will concentrated through reverse osmosis membrane, then carry out concentrating under reduced pressure, adopt the low temperature of 45 DEG C, Ganoderma soup being concentrated to solid content is 60%;
(7) concentrated solution is carried out microwave vacuum low-temperature drying, vacuum lyophilization or spray-dired mode, finally obtain elite extract, elite extract makes tablet; The residue obtained after microwave vacuum low-temperature drying, vacuum lyophilization or spraying dry is made highland barley biscuit.
For 10 kairine sesames, have 75% with the elite that low-temperature extraction isolation technics is extracted wherein, only remaining 25% residue.
Compared with prior art, the extracting method of Ganoderma essence substance provided by the invention, the elite using low-temperature extraction isolation technics to extract Ganoderma can bring up to hundred parts 70%, low-temperature extraction isolation technics is by the low-temperature extraction technology in conjunction with shearing and vibration force effect, combined type microwave-assisted extraction technique and supercritical carbon dioxide extraction isolation technics three technology are integrated and are formed, this technology can carry out combination adjustment according to the characteristic of raw material and product demand, there is high efficiency, environmental protection, safety with guarantee the advantages such as effective ingredient is active, the scope of application is quite extensive, operative temperature is lower than 60 DEG C, the activity of effective ingredient in natural goods can be guaranteed, do not use the solvent of harmful human body, carry out extract and separate in an economical manner, can fully retain its effective ingredient and fragrance, equipment is easy to amplify, emphasizing the modern life that is healthy and health preserving, coordinate low-temperature extraction isolation technics the efficacy exertion of Ganoderma to maximum, greatly promote nutrition absorption rate, there is high efficiency, environmental protection, safety with guarantee the advantages such as effective ingredient is active, both taste and the nutrient of Ganoderma had been maintained, be easy to carry again, famous and precious Ganoderma efficacy effect can be brought into play completely.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (4)
1. an extracting method for Ganoderma essence substance, is characterized in that, comprises the steps:
(1) pretreatment of Ganoderma, removes the impurity staff on Ganoderma surface, and pulverize Ganoderma at the temperature pulverizer lower than 60 DEG C, fineness requirement is at 8 orders or following; Extraction is processed with former water, uses the pure water removing ion;
(2) Ganoderma pretreatment obtained and pure water are in the Ganoderma of 1:8-1:15 weight portion and water ratio, water temperature extracts at 20 DEG C-50 DEG C, and extraction is carried out 2-4 time, each 10-60 minute, the Ganoderma soup filtered out after extraction is several times merged, cools at ambient temperature;
(3) being separated carrying out precision after the coarse filtration of cooled Ganoderma soup, by aperture at 3-10 μm of accurate membrane filtration, obtaining the secondary filter liquid of Ganoderma soup;
(4) be 0.25-0.45 μm of micro-pore-film filtration with aperture again by secondary filter liquid, obtain the polishing purification liquid of Ganoderma soup;
(5) polishing purification liquid reverse osmosis membrane is concentrated at normal temperatures, obtain the concentrated Ganoderma soup that solid content is 8-15%;
(6) the Ganoderma soup will concentrated through reverse osmosis membrane, then carry out concentrating under reduced pressure, adopt the low temperature of 40 DEG C-50 DEG C, Ganoderma soup being concentrated to solid content is 50-70%;
(7) concentrated solution is carried out microwave vacuum low-temperature drying, vacuum lyophilization or spray-dired mode, finally obtain elite extract.
2. the extracting method of Ganoderma essence substance according to claim 1, is characterized in that, in step (1), pulverizes at the temperature of 20-50 DEG C with pulverizer to Ganoderma.
3. the extracting method of Ganoderma essence substance according to claim 1, is characterized in that, described elite extract makes electuary, tablet or capsule.
4. the extracting method of Ganoderma essence substance according to claim 1, is characterized in that, the residue obtained after microwave vacuum low-temperature drying, vacuum lyophilization or spraying dry is made highland barley biscuit.
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| CN106265772B (en) * | 2015-06-12 | 2019-05-17 | 广州沣芝生物科技有限公司 | A kind of ganoderma lucidum concentrated extract preparation method |
| CN105079325A (en) * | 2015-09-23 | 2015-11-25 | 成都艾比科生物科技有限公司 | Method for extracting essence substances of saffron crocus |
| CN107115304B (en) * | 2017-04-10 | 2019-02-26 | 浙江寿仙谷医药股份有限公司 | One kind removing wall lucidum spore powder tablet and preparation method thereof |
| CN113768141B (en) * | 2021-09-18 | 2022-10-18 | 广东粤微食用菌技术有限公司 | Anti-oxidation repairing ganoderma lucidum extract and preparation method thereof |
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| CN101348513A (en) * | 2007-07-18 | 2009-01-21 | 澳门药物及健康应用研究所 | Ganoderic acid extraction method and preparation of soft capsule of ganoderic acid |
| CN101410129A (en) * | 2006-03-23 | 2009-04-15 | 草药科学新加坡私人有限公司 | Extracts and methods comprising ganoderma species |
| CN101416652A (en) * | 2008-04-30 | 2009-04-29 | 北京奥腾讯达科技有限公司 | Ganoderma lucidum polysaccharide coarse grains biscuit |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1759710A (en) * | 2005-11-09 | 2006-04-19 | 云南省农业机械研究所 | 'Puer' caffeine and processing method |
| CN101410129A (en) * | 2006-03-23 | 2009-04-15 | 草药科学新加坡私人有限公司 | Extracts and methods comprising ganoderma species |
| CN101348513A (en) * | 2007-07-18 | 2009-01-21 | 澳门药物及健康应用研究所 | Ganoderic acid extraction method and preparation of soft capsule of ganoderic acid |
| CN101416652A (en) * | 2008-04-30 | 2009-04-29 | 北京奥腾讯达科技有限公司 | Ganoderma lucidum polysaccharide coarse grains biscuit |
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