CN102428074A - α-(N-苯磺酰氨基)环烷基衍生物 - Google Patents
α-(N-苯磺酰氨基)环烷基衍生物 Download PDFInfo
- Publication number
- CN102428074A CN102428074A CN2010800222929A CN201080022292A CN102428074A CN 102428074 A CN102428074 A CN 102428074A CN 2010800222929 A CN2010800222929 A CN 2010800222929A CN 201080022292 A CN201080022292 A CN 201080022292A CN 102428074 A CN102428074 A CN 102428074A
- Authority
- CN
- China
- Prior art keywords
- compound
- chloro
- hydroxymethyl
- benzenesulfonamide
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*Cc1cccc(*)c1 Chemical compound C*Cc1cccc(*)c1 0.000 description 2
- VXTXWJNFCFNEED-LEWJYISDSA-N C=C([C@H](CCC1)[C@@H]1N(Cc(cc1)ccc1C#N)S(c(cc1)ccc1Cl)(=O)=O)O Chemical compound C=C([C@H](CCC1)[C@@H]1N(Cc(cc1)ccc1C#N)S(c(cc1)ccc1Cl)(=O)=O)O VXTXWJNFCFNEED-LEWJYISDSA-N 0.000 description 1
- ZMTKKTIGOXOQDE-RBBKRZOGSA-N C=C([C@H](CCCC1)[C@@H]1N(Cc(c(F)c1)ccc1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O)O Chemical compound C=C([C@H](CCCC1)[C@@H]1N(Cc(c(F)c1)ccc1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O)O ZMTKKTIGOXOQDE-RBBKRZOGSA-N 0.000 description 1
- XAMRAPLCZCJCTC-IAHIVXGCSA-N CC([C@H](CCCC1)C1/C=N\S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound CC([C@H](CCCC1)C1/C=N\S(c(cc1)ccc1Cl)(=O)=O)=O XAMRAPLCZCJCTC-IAHIVXGCSA-N 0.000 description 1
- IHZPLQHOFSSDSE-LSDHHAIUSA-N CC([C@H](CCCC1)[C@@H]1NC(OCc1ccccc1)=O)=O Chemical compound CC([C@H](CCCC1)[C@@H]1NC(OCc1ccccc1)=O)=O IHZPLQHOFSSDSE-LSDHHAIUSA-N 0.000 description 1
- VAEKGKONBZJFPM-UHFFFAOYSA-N CC1SC(C)=CC1 Chemical compound CC1SC(C)=CC1 VAEKGKONBZJFPM-UHFFFAOYSA-N 0.000 description 1
- QRQNZXJKWMALRM-SPLOXXLWSA-N C[C@H](CCCC1)[C@@H]1N(Cc(c(F)c1)cc(F)c1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](CCCC1)[C@@H]1N(Cc(c(F)c1)cc(F)c1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O QRQNZXJKWMALRM-SPLOXXLWSA-N 0.000 description 1
- WXHMOOPNUZMTQU-IVZQSRNASA-N C[C@H](CCCC1)[C@@H]1N(Cc(cc(c(-c1ncc[o]1)c1)F)c1F)S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](CCCC1)[C@@H]1N(Cc(cc(c(-c1ncc[o]1)c1)F)c1F)S(c(cc1)ccc1Cl)(=O)=O WXHMOOPNUZMTQU-IVZQSRNASA-N 0.000 description 1
- ADKXZONADNUIKX-OPAMFIHVSA-N C[C@H](CCCC1)[C@@H]1N(Cc(ccc(-c1ncc[o]1)c1)c1F)S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](CCCC1)[C@@H]1N(Cc(ccc(-c1ncc[o]1)c1)c1F)S(c(cc1)ccc1Cl)(=O)=O ADKXZONADNUIKX-OPAMFIHVSA-N 0.000 description 1
- BLMQVCROAUDMRN-FOIQADDNSA-N C[C@H](CCCC1)[C@@H]1N(Cc(ccc(-c1ncc[o]1)c1F)c1F)S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](CCCC1)[C@@H]1N(Cc(ccc(-c1ncc[o]1)c1F)c1F)S(c(cc1)ccc1Cl)(=O)=O BLMQVCROAUDMRN-FOIQADDNSA-N 0.000 description 1
- HRKARKYIPZRAMG-RDTXWAMCSA-N C[C@H](CCCC1)[C@@H]1N(Cc1ccc(-c2ncc[o]2)c(F)c1F)S(c1ccc(C(F)(F)F)nc1)(=O)=O Chemical compound C[C@H](CCCC1)[C@@H]1N(Cc1ccc(-c2ncc[o]2)c(F)c1F)S(c1ccc(C(F)(F)F)nc1)(=O)=O HRKARKYIPZRAMG-RDTXWAMCSA-N 0.000 description 1
- HALCBPJUGWBVBU-UHFFFAOYSA-N Cc1cnc(C(F)(F)F)cc1 Chemical compound Cc1cnc(C(F)(F)F)cc1 HALCBPJUGWBVBU-UHFFFAOYSA-N 0.000 description 1
- ZVTVHFKBWFSCJQ-UHFFFAOYSA-N O=C(CC(c(c(F)c1)ccc1-c1ncc[o]1)NS(c(cc1)ccc1Cl)(=O)=O)C1CCCCC1 Chemical compound O=C(CC(c(c(F)c1)ccc1-c1ncc[o]1)NS(c(cc1)ccc1Cl)(=O)=O)C1CCCCC1 ZVTVHFKBWFSCJQ-UHFFFAOYSA-N 0.000 description 1
- XWUQXLKDIJJKGI-UHFFFAOYSA-N OCC1(CCCCC1)N(Cc(cc1)ccc1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O Chemical compound OCC1(CCCCC1)N(Cc(cc1)ccc1-c1n[o]cn1)S(c(cc1)ccc1Cl)(=O)=O XWUQXLKDIJJKGI-UHFFFAOYSA-N 0.000 description 1
- NJAFGOLYLUCGFX-YFPLAWBCSA-N OC[C@H](CCCCC1)C1(C1)C1N(Cc(cc1)ccc1-c1ncc[o]1)S(c(cc1)ccc1Cl)(=O)=O Chemical compound OC[C@H](CCCCC1)C1(C1)C1N(Cc(cc1)ccc1-c1ncc[o]1)S(c(cc1)ccc1Cl)(=O)=O NJAFGOLYLUCGFX-YFPLAWBCSA-N 0.000 description 1
- XKMLXPSJCGPSAO-JQRITLKVSA-N OC[C@H](CCCCC1)C1(C1)C1NS(c(cc1)ccc1Cl)(=O)=O Chemical compound OC[C@H](CCCCC1)C1(C1)C1NS(c(cc1)ccc1Cl)(=O)=O XKMLXPSJCGPSAO-JQRITLKVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16185209P | 2009-03-20 | 2009-03-20 | |
| US61/161852 | 2009-03-20 | ||
| PCT/US2010/027915 WO2010108067A1 (en) | 2009-03-20 | 2010-03-19 | Alpha-(n-benzenesulfonamido)cycloalkyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102428074A true CN102428074A (zh) | 2012-04-25 |
Family
ID=42235839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800222929A Pending CN102428074A (zh) | 2009-03-20 | 2010-03-19 | α-(N-苯磺酰氨基)环烷基衍生物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7977362B2 (OSRAM) |
| EP (1) | EP2408756B1 (OSRAM) |
| JP (1) | JP2012521353A (OSRAM) |
| CN (1) | CN102428074A (OSRAM) |
| WO (1) | WO2010108067A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ533603A (en) | 2001-12-20 | 2007-02-23 | Bristol Myers Squibb Co | Alpha-(N-sulphonamido)acetamide derivatives as beta-amyloid inhibitors used for treating Alzheimer's Disease and Down's syndrome |
| US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
| US8252821B2 (en) | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| EP2471363A1 (de) | 2010-12-30 | 2012-07-04 | Bayer CropScience AG | Verwendung von Aryl-, Heteroaryl- und Benzylsulfonamidocarbonsäuren, -carbonsäureestern, -carbonsäureamiden und -carbonitrilen oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen |
| WO2013052700A1 (en) * | 2011-10-04 | 2013-04-11 | The Brigham And Women's Hospital, Inc. | Novel sulfonamides |
| WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| WO2019025153A1 (de) | 2017-07-31 | 2019-02-07 | Bayer Cropscience Aktiengesellschaft | Verwendung von substituierten n-sulfonyl-n'-aryldiaminoalkanen und n-sulfonyl-n'-heteroaryldiaminoalkanen oder deren salzen zur steigerung der stresstoleranz in pflanzen |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005042489A1 (en) * | 2003-10-29 | 2005-05-12 | Elan Pharmaceuticals, Inc. | N-substituted benzene sulfonamides |
| CN1617852A (zh) * | 2001-12-20 | 2005-05-18 | 布里斯托尔-迈尔斯斯奎布公司 | α－(N－磺酰氨基)乙酰胺衍生物作为β－淀粉样蛋白抑制剂 |
| US20060014945A1 (en) * | 2004-07-13 | 2006-01-19 | Guido Galley | Sulfonamides |
| CN1938266A (zh) * | 2004-04-01 | 2007-03-28 | 辉瑞产品有限公司 | 用于治疗神经变性疾病的磺酰胺化合物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274094A (en) | 1990-08-15 | 1993-12-28 | British Bio-Technology Limited | Production of heterobicyclic containing benzene sulfonamides |
| GB9202791D0 (en) | 1992-02-11 | 1992-03-25 | British Bio Technology | Compounds |
| US5583221A (en) | 1994-05-04 | 1996-12-10 | Eli Lilly And Company | Substituted fused and bridged bicyclic compounds as therapeutic agents |
| NZ321293A (en) | 1995-11-17 | 2001-04-27 | Warner Lambert Co | Sulfonamide inhibitors of matrix metalloproteinases |
| CZ16899A3 (cs) | 1996-07-22 | 1999-08-11 | Monsanto Company | Thiolsulfonamidové inhibitory metaloproteázy |
| JPH11343279A (ja) | 1998-03-16 | 1999-12-14 | Shionogi & Co Ltd | スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤 |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| JP2002535386A (ja) | 1999-01-27 | 2002-10-22 | アメリカン・サイアナミド・カンパニー | アセチレンスルホンアミドチオールｔａｃｅインヒビター |
| NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| RU2342374C2 (ru) | 2003-03-31 | 2008-12-27 | Уайт | Фтор- и трифторалкилсодержащие гетероциклические сульфонамидные ингибиторы образования бета-амилоида и их производные |
| US7144894B2 (en) | 2004-09-23 | 2006-12-05 | Bristol-Myers Squibb Company | Sulfonamide bicyclic compounds |
| PE20080169A1 (es) | 2006-02-17 | 2008-04-11 | Wyeth Corp | Metodo para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios |
| TW200732295A (en) | 2006-02-17 | 2007-09-01 | Wyeth Corp | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
| US8633179B2 (en) | 2007-03-13 | 2014-01-21 | The Trustees Of Columbia University In The City Of New York | Synergistic interaction of NOTCH-1 inhibitors with glucocorticoids |
| WO2009005688A2 (en) | 2007-06-29 | 2009-01-08 | Trustees Of Columbia University In The City Of New York | Activating mutations in notch-1 |
| US8084477B2 (en) | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
| WO2009137657A1 (en) | 2008-05-08 | 2009-11-12 | Bristol-Myers Squibb Company | 2-aryl glycinamide derivatives |
| KR20110133046A (ko) | 2009-03-19 | 2011-12-09 | 브리스톨-마이어스 스큅 컴퍼니 | 베타 아밀로이드 펩티드 생성의 억제제로서의 신규 알파-(ｎ-술폰아미도)아세트아미드 화합물 |
| US8044077B2 (en) | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
| US20110071199A1 (en) | 2009-03-20 | 2011-03-24 | Bristol-Myers Squibb Company | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease |
| US8252821B2 (en) | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| TW201043269A (en) | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
-
2010
- 2010-03-17 US US12/725,810 patent/US7977362B2/en active Active
- 2010-03-19 WO PCT/US2010/027915 patent/WO2010108067A1/en not_active Ceased
- 2010-03-19 EP EP10709946.7A patent/EP2408756B1/en not_active Not-in-force
- 2010-03-19 CN CN2010800222929A patent/CN102428074A/zh active Pending
- 2010-03-19 JP JP2012500985A patent/JP2012521353A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1617852A (zh) * | 2001-12-20 | 2005-05-18 | 布里斯托尔-迈尔斯斯奎布公司 | α－(N－磺酰氨基)乙酰胺衍生物作为β－淀粉样蛋白抑制剂 |
| WO2005042489A1 (en) * | 2003-10-29 | 2005-05-12 | Elan Pharmaceuticals, Inc. | N-substituted benzene sulfonamides |
| CN1938266A (zh) * | 2004-04-01 | 2007-03-28 | 辉瑞产品有限公司 | 用于治疗神经变性疾病的磺酰胺化合物 |
| US20060014945A1 (en) * | 2004-07-13 | 2006-01-19 | Guido Galley | Sulfonamides |
Non-Patent Citations (1)
| Title |
|---|
| SCOTT C. MAYER，等: "Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease", 《J. MED. CHEM.》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US7977362B2 (en) | 2011-07-12 |
| WO2010108067A1 (en) | 2010-09-23 |
| EP2408756B1 (en) | 2013-05-15 |
| EP2408756A1 (en) | 2012-01-25 |
| JP2012521353A (ja) | 2012-09-13 |
| US20100240708A1 (en) | 2010-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120425 |