CN102423460A - Liver meridian nondiaphoretic traditional Chinese medicinal injection and production method thereof - Google Patents
Liver meridian nondiaphoretic traditional Chinese medicinal injection and production method thereof Download PDFInfo
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- CN102423460A CN102423460A CN2011104151859A CN201110415185A CN102423460A CN 102423460 A CN102423460 A CN 102423460A CN 2011104151859 A CN2011104151859 A CN 2011104151859A CN 201110415185 A CN201110415185 A CN 201110415185A CN 102423460 A CN102423460 A CN 102423460A
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- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 210000004185 liver Anatomy 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 67
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000007689 inspection Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 241000628997 Flos Species 0.000 claims abstract description 7
- 238000003860 storage Methods 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 10
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 2
- 241000132011 Atractylodes lancea Species 0.000 abstract 1
- 244000306301 Caesalpinia sappan Species 0.000 abstract 1
- 235000015162 Caesalpinia sappan Nutrition 0.000 abstract 1
- 241000530419 Changium smyrnioides Species 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000530115 Clerodendrum trichotomum Species 0.000 abstract 1
- 241000208689 Eucommia ulmoides Species 0.000 abstract 1
- 241001135871 Gentiana scabra Species 0.000 abstract 1
- 244000219416 Hypericum japonicum Species 0.000 abstract 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 abstract 1
- 241001071917 Lithospermum Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 abstract 1
- 235000011613 Pinus brutia Nutrition 0.000 abstract 1
- 241000018646 Pinus brutia Species 0.000 abstract 1
- 235000000664 Rosa chinensis Nutrition 0.000 abstract 1
- 240000008254 Rosa chinensis Species 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 229940097275 indigo Drugs 0.000 abstract 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000037315 hyperhidrosis Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a liver meridian nondiaphoretic traditional Chinese medicinal injection and a production method thereof. The formula of the injection comprises 1g of Flos Buddlejae, 1g of Gentiana scabra Bunge, 1g of Natural Indigo, 1g of Lithospermum erythrorhizon, 1g of Pine Nodular Branch, 1g of Clerodendrum trichotomum Thunb, 1g of Cortex Acanthopanacis, 1g of Atractylodes lancea, 1g of Hypericum japonicum Thunb., 1g of cinnamon, 1g of Green Tangerine Peel, 1g of Radix Curcumae, 1g of Rosa chinensis, 0.5g of Sappanwood, 1g of rhizoma gastrodiae, 1g of Eucommia ulmoides, 1g of white peony root, 1g of Changium smyrnioides, and 1g of Dark Plum Fruit. The production method comprises production links of burdening, cleaning, drying disinfection, crushing, cell rupture, multiple filtering, loading, rubber stopper filling, lid pressing, lamp inspection, specification plastering, packaging, storage, examination and the like. The injection which has the advantages of no need of high temperature decoction, no pass of the alimentary canal, no pass of pores and sweat pores and the like is suitable for treating patients suffering from liver meridian tissue diseases with symptoms of hidrosis, diuresis and multiple stagnation. The production of the injection, which can preserve medicinal components in above traditional Chinese medicines of the formula, is the production of a liver meridian traditional Chinese medicinal injection of the whole medicines.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat the Chinese medicine injection and the production method of Liver Channel tissue disease.Background technology is known do not need high temperature decoct, need not be through digestive tract, Chinese medicine the inducing sweat property all that can treat the Liver Channel tissue disease; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then human liver treated through tissue disease; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, the Chinese medicine injection that can treat the Liver Channel tissue disease and production method.
Chinese medicine preparation of the present invention is: Flos Buddlejae 1g, Radix Gentianae 1g, Indigo Naturalis 1g, Radix Arnebiae (Radix Lithospermi) 1g, Lignum Pini Nodi 1g, Folium et Ramulus Clerodendri Trichotomi 1g, Cortex Acanthopancis 1g, Rhizoma Atractylodis 1g, Herba Hyperici Japonici 1g, Cortex Cinnamomi 1g, Pericarpium Citri Reticulatae Viride 1g, Radix Curcumae 1g, Flos Rosae Chinensis 1g, Lignum Sappan 0.5g, Rhizoma Gastrodiae 1g, Cortex Eucommiae 1g, Radix Paeoniae Alba 1g, Radix Changii 1g, Fructus Mume 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being equipment such as microwave drying room in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare with the Chinese medicine of present treatment Liver Channel tissue; It with non-inducing sweat property Liver Channel medicine, process injection and replace, make it to be applicable to the patient of treatment hyperhidrosis, polyuria, the Liver Channel tissue diseases that stagnate more, decoct without high temperature; Do not pass through digestive tract; Not through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production of the full medicine injection of a kind of Liver Channel prescription Chinese medicine.
Specific embodiment production of the present invention is the production of the full medicine injection of a kind of Liver Channel prescription Chinese medicine, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Flos Buddlejae 1g, Radix Gentianae 1g, Indigo Naturalis 1g, Radix Arnebiae (Radix Lithospermi) 1g, Lignum Pini Nodi 1g, Folium et Ramulus Clerodendri Trichotomi 1g, Cortex Acanthopancis 1g, Rhizoma Atractylodis 1g, Herba Hyperici Japonici 1g, Cortex Cinnamomi 1g, Pericarpium Citri Reticulatae Viride 1g, Radix Curcumae 1g, Flos Rosae Chinensis 1g, Lignum Sappan 0.5g, Rhizoma Gastrodiae 1g, Cortex Eucommiae 1g, Radix Paeoniae Alba 1g, Radix Changii 1g, Fructus Mume 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and mixed, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. non-Chinese medicine injection and the production method of inducing sweat of Liver Channel, prescription is: Flos Buddlejae 1g, Radix Gentianae 1g, Indigo Naturalis 1g, Radix Arnebiae (Radix Lithospermi) 1g, Lignum Pini Nodi 1g, Folium et Ramulus Clerodendri Trichotomi 1g, Cortex Acanthopancis 1g, Rhizoma Atractylodis 1g, Herba Hyperici Japonici 1g, Cortex Cinnamomi 1g, Pericarpium Citri Reticulatae Viride 1g, Radix Curcumae 1g, Flos Rosae Chinensis 1g, Lignum Sappan 0.5g, Rhizoma Gastrodiae 1g, Cortex Eucommiae 1g, Radix Paeoniae Alba 1g, Radix Changii 1g, Fructus Mume 1g, production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching use the room, prepare burden with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104151859A CN102423460A (en) | 2011-12-08 | 2011-12-08 | Liver meridian nondiaphoretic traditional Chinese medicinal injection and production method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104151859A CN102423460A (en) | 2011-12-08 | 2011-12-08 | Liver meridian nondiaphoretic traditional Chinese medicinal injection and production method thereof |
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| CN102423460A true CN102423460A (en) | 2012-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104151859A Pending CN102423460A (en) | 2011-12-08 | 2011-12-08 | Liver meridian nondiaphoretic traditional Chinese medicinal injection and production method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
| CN108741677A (en) * | 2018-05-17 | 2018-11-06 | 阜南县富昌恒业工艺品有限公司 | A red wooden coffee table |
-
2011
- 2011-12-08 CN CN2011104151859A patent/CN102423460A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
| CN108741677A (en) * | 2018-05-17 | 2018-11-06 | 阜南县富昌恒业工艺品有限公司 | A red wooden coffee table |
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Application publication date: 20120425 |