CN102423463A - Liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof - Google Patents
Liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof Download PDFInfo
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- CN102423463A CN102423463A CN201110415458XA CN201110415458A CN102423463A CN 102423463 A CN102423463 A CN 102423463A CN 201110415458X A CN201110415458X A CN 201110415458XA CN 201110415458 A CN201110415458 A CN 201110415458A CN 102423463 A CN102423463 A CN 102423463A
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- 239000003814 drug Substances 0.000 title claims abstract description 73
- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 210000004185 liver Anatomy 0.000 title claims abstract description 18
- 208000011580 syndromic disease Diseases 0.000 title abstract 5
- 238000007689 inspection Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 241000124033 Salix Species 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 241000217407 Margaritifera Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 10
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 241000046585 Aristolochia clematitis Species 0.000 abstract 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 abstract 1
- 235000017491 Bambusa tulda Nutrition 0.000 abstract 1
- 240000008537 Burchellia bubalina Species 0.000 abstract 1
- 235000004415 Burchellia bubalina Nutrition 0.000 abstract 1
- NEZONWMXZKDMKF-UHFFFAOYSA-N C.I. Natural Red 20 Chemical compound C1=CC(O)=C2C(=O)C(C(O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-UHFFFAOYSA-N 0.000 abstract 1
- 235000002687 Caesalpinia echinata Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 241000208278 Hyoscyamus Species 0.000 abstract 1
- 240000004035 Lithospermum officinale Species 0.000 abstract 1
- 235000011030 Lithospermum officinale Nutrition 0.000 abstract 1
- 241000127464 Paubrasilia echinata Species 0.000 abstract 1
- 244000082204 Phyllostachys viridis Species 0.000 abstract 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 abstract 1
- 241000304432 Sedum sarmentosum Species 0.000 abstract 1
- 241000270666 Testudines Species 0.000 abstract 1
- 241000983344 Trachelospermum jasminoides Species 0.000 abstract 1
- 240000004922 Vigna radiata Species 0.000 abstract 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 abstract 1
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 abstract 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 abstract 1
- 244000126002 Ziziphus vulgaris Species 0.000 abstract 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 abstract 1
- 239000011425 bamboo Substances 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000037315 hyperhidrosis Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and a production method thereof. The liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection is prepared from 1g of mung bean, 0.5g of bamboo leaf, 1g of Radix et Rhizoma Thalictri, 1g of wild chrysanthemum flower, 0.5g of willow sprout, 1g of gromwell, 0.5g of buffalo horn, 1g of hairy birthwort, 1g of Trachelospermum jasminoides, 1g of rhizoma atractylodis, 1g of stringy stonecrop, 1g of cinnamon, 1g of radix curcumae, 1g of safflower, 1g of brazilwood, 1g of henbane, 1g of mother-of-pearl, 1g of Chinese date, 1g of turtle shell and 1g of immature-wheat. The production method comprises the following steps: mixing, cleaning, baking, sterilizing, pulverizing, breaking cells, carrying out multi-filtration, filling, filling rubber plugs, pressing covers, carrying out lamp inspection, sticking specifications, packaging, storing, and inspecting. The liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection does not need decoction, does not pass through pores, sweat pores or the like, and is suitable for treating hidrosis, diuresis and stasis patients with liver/heart-meridian tissue diseases. The production method of the liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection can maintain all the pharmaceutical components in the traditional Chinese medicine, and thus, is a production method of a liver/heart-meridian complete-component traditional Chinese medicine injection.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat liver, the heart two Chinese medicine injection and the production method through tissue disease.
Background technology is known do not need high temperature decoct, need not be through digestive tract, can treat liver, the heart two through the Chinese medicine of tissue disease inducing sweat property all; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then human liver, the heart two treated through tissue disease; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, can treat liver, the heart two Chinese medicine injection and production method through tissue disease.
Chinese medicine preparation of the present invention is: Semen phaseoli radiati 1g, Folium Bambusae 0.5g, Radix et Rhizoma Thalictri 1g, Flos Chrysanthemi Indici 1g, willow bud 0.5g, Radix Arnebiae (Radix Lithospermi) 1g, Cornu Bubali 0.5g, Herba Aristolochiae Mollissimae 1g, Caulis Trachelospermi 1g, Rhizoma Atractylodis 1g, Herba Sedi 1g, Cortex Cinnamomi 1g, Radix Curcumae 1g, Flos Carthami 1g, Lignum Sappan 1g, Semen Hyoscyami 1g, Concha Margaritifera 1g, Fructus Jujubae 1g, Carapax Et Plastrum Testudinis 1g, Fructus Tritici Levis 1g, and production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being microwave to dry by the fire in equipment such as rooms in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare through the Chinese medicine of tissue with present treatment liver, the heart two; It with non-inducing sweat property liver, the heart two through medicine, process injection and replace, make it to be applicable to treatment hyperhidrosis, polyuria, the liver that stagnates, the heart two patient through tissue disease more, decoct without high temperature; Do not pass through digestive tract; Through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production through the full medicine injection of prescription Chinese medicine of a kind of liver, the heart two.
Specific embodiment production of the present invention is the production through the full medicine injection of prescription Chinese medicine of a kind of liver, the heart two, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Semen phaseoli radiati 1g, Folium Bambusae 0.5g, Radix et Rhizoma Thalictri 1g, Flos Chrysanthemi Indici 1g, willow bud 0.5g, Radix Arnebiae (Radix Lithospermi) 1g, Cornu Bubali 0.5g, Herba Aristolochiae Mollissimae 1g, Caulis Trachelospermi 1g, Rhizoma Atractylodis 1g, Herba Sedi 1g, Cortex Cinnamomi 1g, Radix Curcumae 1g, Flos Carthami 1g, Lignum Sappan 1g, Semen Hyoscyami 1g, Concha Margaritifera 1g, Fructus Jujubae 1g, Carapax Et Plastrum Testudinis 1g, Fructus Tritici Levis 1g, and production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and mixed, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. liver, the heart two are through non-Chinese medicine injection and the production method of inducing sweat, and prescription is: Semen phaseoli radiati 1g, Folium Bambusae 0.5g, Radix et Rhizoma Thalictri 1g, Flos Chrysanthemi Indici 1g, willow bud 0.5g, Radix Arnebiae (Radix Lithospermi) 1g, Cornu Bubali 0.5g, Herba Aristolochiae Mollissimae 1g, Caulis Trachelospermi 1g, Rhizoma Atractylodis 1g, Herba Sedi 1g, Cortex Cinnamomi 1g, Radix Curcumae 1g, Flos Carthami 1g, Lignum Sappan 1g, Semen Hyoscyami 1g, Concha Margaritifera 1g, Fructus Jujubae 1g, Carapax Et Plastrum Testudinis 1g, Fructus Tritici Levis 1g, and production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching are used the room, and batching is with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110415458XA CN102423463A (en) | 2011-12-08 | 2011-12-08 | Liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110415458XA CN102423463A (en) | 2011-12-08 | 2011-12-08 | Liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN102423463A true CN102423463A (en) | 2012-04-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110415458XA Pending CN102423463A (en) | 2011-12-08 | 2011-12-08 | Liver/heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102423463A (en) |
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- 2011-12-08 CN CN201110415458XA patent/CN102423463A/en active Pending
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Application publication date: 20120425 |