CN102423412A - Non-exterior-syndrome-relieving Chinese medicinal injection for kidney channel and lung channel and production method thereof - Google Patents
Non-exterior-syndrome-relieving Chinese medicinal injection for kidney channel and lung channel and production method thereof Download PDFInfo
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- CN102423412A CN102423412A CN2011104150521A CN201110415052A CN102423412A CN 102423412 A CN102423412 A CN 102423412A CN 2011104150521 A CN2011104150521 A CN 2011104150521A CN 201110415052 A CN201110415052 A CN 201110415052A CN 102423412 A CN102423412 A CN 102423412A
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- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 210000003734 kidney Anatomy 0.000 title claims abstract description 15
- 210000004072 lung Anatomy 0.000 title claims abstract description 15
- 208000011580 syndromic disease Diseases 0.000 title abstract 5
- 239000003814 drug Substances 0.000 claims abstract description 70
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 241001164374 Calyx Species 0.000 claims abstract description 4
- 210000000582 semen Anatomy 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000007689 inspection Methods 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 241000255791 Bombyx Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 241001106044 Physalis Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 108010052008 colla corii asini Proteins 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 9
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 208000008454 Hyperhidrosis Diseases 0.000 abstract description 4
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 230000037315 hyperhidrosis Effects 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241001254604 Angelica pubescens Species 0.000 abstract 1
- 244000003416 Asparagus officinalis Species 0.000 abstract 1
- 235000005340 Asparagus officinalis Nutrition 0.000 abstract 1
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 240000005717 Dioscorea alata Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 244000308505 Filipendula ulmaria Species 0.000 abstract 1
- 235000016622 Filipendula ulmaria Nutrition 0.000 abstract 1
- 235000000093 Filipendula ulmaria ssp. denudata Nutrition 0.000 abstract 1
- 235000000092 Filipendula ulmaria ssp. ulmaria Nutrition 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 241000208966 Polygala Species 0.000 abstract 1
- 244000081426 Ranunculus ficaria Species 0.000 abstract 1
- 235000002226 Ranunculus ficaria Nutrition 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 244000223014 Syzygium aromaticum Species 0.000 abstract 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 abstract 1
- 239000010975 amethyst Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 230000003325 follicular Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a non-exterior-syndrome-relieving Chinese medicinal injection for a kidney channel and a lung channel and a production method thereof. According to the formulation, the non-exterior-syndrome-relieving Chinese medicinal injection comprises 1 g of rhizoma anemarrhenae, 1 g of phellodendron bark, 1 g of scandent hop , 0.5 g of winterchery fruit or calyx, 1 g of figwort, 1 g of wolfberry bark, 1 g of pubescent angelica root, 1 g of yam rhizome, 1 g of queen of the meadow, 1 g of semen plantaginis, 1 g of giant knotweed, 1 g of clove, 1 g of drynaria, 1 g of polygala root, 1 g of batryticated silkworm, 1 g of sealwort, 1 g of amethyst, 1 g of donkey-hide gelatin, 1 g of asparagus root and 1 g of magnolia vine fruit; and the production method comprises the following processes of: compounding, carrying out cleaning treatment, drying and sterilizing, crushing, carrying out cell rupture, multi-filtering, pouring, rubber stopper filling, capping, detecting by light, specification pasting, packaging, storing and inspecting. The non-exterior-syndrome-relieving Chinese medicinal injection has the advantages of no need of decoction, not passing through follicular orifice and sweat pore, and the like, and is suitable for treating patients who suffer from kidney and lung channel tissue diseases with hyperhidrosis, diuresis and sluggish; and in the production of the non-exterior-syndrome-relieving Chinese medicinal injection, all drug ingredients of prescribed Chinese medicine can be preserved, so that the production method is a production method of the full-drug injection of the prescribed Chinese medicine for the kidney channel and the lung channel.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat kidney, lung two Chinese medicine injection and the production method through tissue disease.
Background technology is known do not need high temperature decoct, need not be through digestive tract, can treat kidney, lung two through the Chinese medicine of tissue disease inducing sweat property all; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then human body kidney, lung two treated through tissue disease; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, can treat kidney, lung two Chinese medicine injection and production method through tissue disease.
Chinese medicine preparation of the present invention is: Rhizoma Anemarrhenae 1g, Cortex Phellodendri 1g, Herba humuli scandentis 1g, Calyx Seu Fructus Physalis 0.5g, Radix Scrophulariae 1g, Cortex Lycii 1g, Radix Angelicae Pubescentis 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Eupatorii 1g, Semen Plantaginis 1g, Rhizoma Polygoni Cuspidati 1g, Flos Caryophylli 1g, Rhizoma Drynariae 1g, Radix Polygalae 1g, Bombyx Batryticatus 1g, Rhizoma Polygonati 1g, Fluoritum 1g, Colla Corii Asini 1g, Radix Asparagi 1g, Fructus Schisandrae Chinensis 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being equipment such as microwave drying room in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare through the Chinese medicine of tissue with present treatment kidney, lung two; It with non-inducing sweat property kidney, lung two through medicine, process injection and replace, make it to be applicable to treatment hyperhidrosis, polyuria, the kidney that stagnates, lung two patient through tissue disease more, decoct without high temperature; Do not pass through digestive tract; Through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production through the full medicine injection of prescription Chinese medicine of a kind of kidney, lung two.
Specific embodiment production of the present invention is the production through the full medicine injection of prescription Chinese medicine of a kind of kidney, lung two, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Rhizoma Anemarrhenae 1g, Cortex Phellodendri 1g, Herba humuli scandentis 1g, Calyx Seu Fructus Physalis 0.5g, Radix Scrophulariae 1g, Cortex Lycii 1g, Radix Angelicae Pubescentis 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Eupatorii 1g, Semen Plantaginis 1g, Rhizoma Polygoni Cuspidati 1g, Flos Caryophylli 1g, Rhizoma Drynariae 1g, Radix Polygalae 1g, Bombyx Batryticatus 1g, Rhizoma Polygonati 1g, Fluoritum 1g, Colla Corii Asini 1g, Radix Asparagi 1g, Fructus Schisandrae Chinensis 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and are mixed in-rise, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. kidney, lung two are through non-Chinese medicine injection and the production method of inducing sweat, and prescription is: Rhizoma Anemarrhenae 1g, Cortex Phellodendri 1g, Herba humuli scandentis 1g, Calyx Seu Fructus Physalis 0.5g, Radix Scrophulariae 1g, Cortex Lycii 1g, Radix Angelicae Pubescentis 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Eupatorii 1g, Semen Plantaginis 1g, Rhizoma Polygoni Cuspidati 1g, Flos Caryophylli 1g, Rhizoma Drynariae 1g, Radix Polygalae 1g, Bombyx Batryticatus 1g, Rhizoma Polygonati 1g, Fluoritum 1g, Colla Corii Asini 1g, Radix Asparagi 1g, Fructus Schisandrae Chinensis 1g, and production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching are used the room, and batching is with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104150521A CN102423412A (en) | 2011-12-08 | 2011-12-08 | Non-exterior-syndrome-relieving Chinese medicinal injection for kidney channel and lung channel and production method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104150521A CN102423412A (en) | 2011-12-08 | 2011-12-08 | Non-exterior-syndrome-relieving Chinese medicinal injection for kidney channel and lung channel and production method thereof |
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| Publication Number | Publication Date |
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| CN102423412A true CN102423412A (en) | 2012-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104150521A Pending CN102423412A (en) | 2011-12-08 | 2011-12-08 | Non-exterior-syndrome-relieving Chinese medicinal injection for kidney channel and lung channel and production method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
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Application publication date: 20120425 |