CN102423470A - Heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof - Google Patents
Heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof Download PDFInfo
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- CN102423470A CN102423470A CN2011104151952A CN201110415195A CN102423470A CN 102423470 A CN102423470 A CN 102423470A CN 2011104151952 A CN2011104151952 A CN 2011104151952A CN 201110415195 A CN201110415195 A CN 201110415195A CN 102423470 A CN102423470 A CN 102423470A
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- 239000003814 drug Substances 0.000 title claims abstract description 73
- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 208000011580 syndromic disease Diseases 0.000 title abstract 5
- 238000007689 inspection Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 4
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 4
- 239000004863 Frankincense Substances 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 241000746375 Andrographis Species 0.000 claims description 3
- 241000717739 Boswellia sacra Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 10
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 244000001632 Acorus gramineus Species 0.000 abstract 1
- 244000118350 Andrographis paniculata Species 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 235000002687 Caesalpinia echinata Nutrition 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 240000003915 Lophatherum gracile Species 0.000 abstract 1
- 241000127464 Paubrasilia echinata Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000000513 Santalum album Species 0.000 abstract 1
- 235000008632 Santalum album Nutrition 0.000 abstract 1
- 241000304432 Sedum sarmentosum Species 0.000 abstract 1
- 241000983344 Trachelospermum jasminoides Species 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000035619 diuresis Effects 0.000 abstract 1
- 239000010436 fluorite Substances 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000037315 hyperhidrosis Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and a production method thereof. The heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection is prepared from 1g of lophatherum gracile, 1g of coptis, 1g of creat, 0.5g of herba violae, 1g of moutan bark, 1g of Trachelospermum jasminoides, 0.5g of tuckahoe, 0.5g of stringy stonecrop, 1g of dried ginger, 1g of sandalwood, 1g of frankincense, 1g of safflower, 0.5g of brazilwood, 1g of spina date seed, 1g of Japanese sweetflag, 1g of licorice root, 1g of fluorite, 1g of Arillus Longan, 1g of radix ophiopogonis and 1g of immature-wheat. The production method comprises the following steps: mixing, cleaning, baking, sterilizing, pulverizing, breaking cells, carrying out multi-filtration, filling, filling rubber plugs, pressing covers, carrying out lamp inspection, sticking specifications, packaging, storing, and inspecting. The heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection does not need high-temperature decoction, does not pass through alimentary tracts, pores, sweat pores or the like, and is suitable for treating hidrosis, diuresis and stasis patients with heart-meridian tissue diseases. The production method of the heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection can maintain all the pharmaceutical components in the traditional Chinese medicine, and thus, is a production method of a heart-meridian complete-component traditional Chinese medicine injection.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat the Chinese medicine injection and the production method of heart channel tissue disease.Background technology is known do not need high temperature decoct, need not be through digestive tract, Chinese medicine the inducing sweat property all that can treat heart channel tissue disease; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then human body heart channel tissue disease treated; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, the Chinese medicine injection that can treat heart channel tissue disease and production method.
Chinese medicine preparation of the present invention is: Herba Lophatheri 1g, Rhizoma Coptidis 1g, Herba Andrographis 1g, Herba Violae 0.5g, Cortex Moutan 1g, Caulis Trachelospermi 1g, Poria 0.5g, Herba Sedi 0.5g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Olibanum 1g, Flos Carthami 1g, Lignum Sappan 0.5g, Semen Ziziphi Spinosae 1g, Rhizoma Acori Graminei 1g, Radix Glycyrrhizae 1g, Fluoritum 1g, Arillus Longan 1g, Radix Ophiopogonis 1g, Fructus Tritici Levis 1g, production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being equipment such as microwave drying room in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare with the Chinese medicine of present treatment heart channel tissue; It with non-inducing sweat property heart channel medicine, process injection and replace, make it to be applicable to the patient of treatment hyperhidrosis, polyuria, heart channel tissue diseases that stagnate more, decoct without high temperature; Do not pass through digestive tract; Not through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production of the full medicine injection of a kind of heart channel prescription Chinese medicine.
Specific embodiment production of the present invention is the production of the full medicine injection of a kind of heart channel prescription Chinese medicine, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Herba Lophatheri 1g, Rhizoma Coptidis 1g, Herba Andrographis 1g, Herba Violae 0.5g, Cortex Moutan 1g, Caulis Trachelospermi 1g, Poria 0.5g, Herba Sedi 0.5g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Olibanum 1g, Flos Carthami 1g, Lignum Sappan 0.5g, Semen Ziziphi Spinosae 1g, Rhizoma Acori Graminei 1g, Radix Glycyrrhizae 1g, Fluoritum 1g, Arillus Longan 1g, Radix Ophiopogonis 1g, Fructus Tritici Levis 1g, production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and mixed, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. non-Chinese medicine injection and the production method of inducing sweat of heart channel, prescription is: Herba Lophatheri 1g, Rhizoma Coptidis 1g, Herba Andrographis 1g, Herba Violae 0.5g, Cortex Moutan 1g, Caulis Trachelospermi 1g, Poria 0.5g, Herba Sedi 0.5g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Olibanum 1g, Flos Carthami 1g, Lignum Sappan 0.5g, Semen Ziziphi Spinosae 1g, Rhizoma Acori Graminei 1g, Radix Glycyrrhizae 1g, Fluoritum 1g, Arillus Longan 1g, Radix Ophiopogonis 1g, Fructus Tritici Levis 1g, production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching use the room, prepare burden with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104151952A CN102423470A (en) | 2011-12-08 | 2011-12-08 | Heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104151952A CN102423470A (en) | 2011-12-08 | 2011-12-08 | Heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
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| CN102423470A true CN102423470A (en) | 2012-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104151952A Pending CN102423470A (en) | 2011-12-08 | 2011-12-08 | Heart-meridian non-exterior syndrome relieving traditional Chinese medicine injection and production method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494771A (en) * | 2013-09-29 | 2014-01-08 | 王建友 | Production method of traditional Chinese medicine injection |
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Application publication date: 20120425 |