CN103494771A - Production method of traditional Chinese medicine injection - Google Patents
Production method of traditional Chinese medicine injection Download PDFInfo
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- CN103494771A CN103494771A CN201310470970.3A CN201310470970A CN103494771A CN 103494771 A CN103494771 A CN 103494771A CN 201310470970 A CN201310470970 A CN 201310470970A CN 103494771 A CN103494771 A CN 103494771A
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- chinese medicine
- conveyer belt
- machine
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- 239000003814 drug Substances 0.000 title claims abstract description 77
- 238000002347 injection Methods 0.000 title claims abstract description 27
- 239000007924 injection Substances 0.000 title claims abstract description 27
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 24
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000007689 inspection Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 210000004907 gland Anatomy 0.000 claims abstract description 13
- 238000004806 packaging method and process Methods 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 238000012856 packing Methods 0.000 claims description 18
- 235000013312 flour Nutrition 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 229940126678 chinese medicines Drugs 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 230000003834 intracellular effect Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 3
- 239000002390 adhesive tape Substances 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 239000002985 plastic film Substances 0.000 claims description 3
- 229920006255 plastic film Polymers 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 210000004243 sweat Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a production method of a traditional Chinese medicine injection. The production method is a full-medicine production method of a traditional Chinese medicine. The production link comprises the following steps: burdening, clean treatment, drying sterilization, crushing, cell rapture, multi-filtering, bulking, filling of a rubber plug and a gland, light inspection, posting of a specification, packaging, preserving, testing and the like. The production method has the advantages that the traditional Chinese medicine injection does not need to be decocted at high temperature, and does not pass through digestive tracts, pores, sweat pores and the like; the traditional Chinese medicine injection is used for injection; all pharmaceutical ingredients in the traditional Chinese medicine can be preserved by production of the traditional Chinese medicine injection; the production method is production of a full-medicine injection of the traditional Chinese medicine.
Description
Technical field the present invention relates to a kind of production method of the Chinese medicine injection for the human injection.
The current Chinese medicine injection of use clinically of background technology is all the Chinese medicine injection of Chinese medicine partial elements, it not the Chinese medicine injection of the full explosive component of Chinese medicine, extraction link in this Chinese medicine partial elements injection production process, adopt dissolution method, by decocting or ethanol, carbon dioxide solubility, the Chinese medicine intracellular matter is dissolved in solvent, then extract, this method not only can make some Chinese medicine cellular material decompose, lost efficacy, the Chinese medicine intracellular matter can not be extracted fully, a large amount of Chinese medicine intracellular matters are still stayed in the Chinese medicine cell, extraction efficiency is poor.
Summary of the invention purpose of the present invention is exactly the shortcoming existed in order to solve above-mentioned Chinese medicine injection, and provide a kind of and can save whole Chinese medicinal ingredients from damage, do not need to decoct, do not need by digestive tract, can direct injection to the Chinese medicine injection production method in human body.
Production link of the present invention comprises batching, purifying processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, the filler plug, gland, lamp inspection, paste description, packing, store, check etc., house of the present invention, facility, equipment comprises: a, batching use room, prepares burden with the equipment such as electronic scale, b are arranged in room, , there are the equipment such as ultrasonic washing unit in purifying processing room, c in purifying processing room, the drying and sterilizing room, drying and sterilizing is with the equipment such as microwave drying room, d are arranged in room, the flour room, flour is with the equipment such as Chinese medicine powder beater, e are arranged in room, the cell rupture room, cell rupture is with the equipment such as ultrasonic cell disruptor, f are arranged in room, the multi-filtering room, multi-filtering has particulate filter in room, the equipment such as liquid medicine filter, g, , there are the equipment such as automatic filling machine in the fill room, h in the fill room, , there are the equipment such as automatic filler plug machine in filler plug room, i in filler plug room, , there are the equipment such as automatic capping machine in the gland room, j in the gland room, , there are the equipment such as computer lamp inspection machine in the lamp inspection room, k in the lamp inspection room, paste the explanation study, paste in the explanation study and the equipment that pastes description is arranged, l, , there are the equipment such as automatic packing machine in the packing room, m in the packing room, warehouse, n, the check room, concrete production method is: in batch house, with electronic scale, take various Chinese medicine, various Chinese medicine is placed in container, in the ultrasonic washing unit in conveyer belt reaches purifying processing room, and pour pure water in ultrasonic washing unit, Chinese medicine is fully immersed in pure water, open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into again distilled water, Chinese medicine is carried out to fine purifiation, after the Chinese medicine fine purifiation is clean, refund in clean container, in the microwave drying room in conveyer belt is sent to the drying and sterilizing room, the temperature in microwave drying room is adjusted to 60 ℃, open again, after drying and sterilizing 24 hours, Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicinal powder, be sent to cell rupture with in the ultrasonic cell disruptor in room by conveyer belt again, and pour in a small amount distilled water into, open ultrasonic cell disruptor, after 24 hours, the Chinese medicine cell rupture, intracellular matter dissolves in water, pour again the distilled water of requirement into, make By Chinese Medicines, by pipeline, be sent in the multi-filtering room again, through particulate filter, the multi-filtering of liquid medicine filter, filtered the granule in the By Chinese Medicines, broken cell wall, and some antibacterials, virus, insoluble substance, By Chinese Medicines has just become Chinese medicine injection, again in pipeline is sent to the fill room, carry out fill by automatic filling machine, after the Chinese medicine injection fill is interior to bottle, bottleneck is by plastic film sealing, by conveyer belt, transferred in filler plug room again, fill in plug by automatic filler plug machine on plastic sheeting, and then be sent to the gland room by conveyer belt, by automatic capping machine, easy-open lid is covered on plug, by conveyer belt, be sent in the lamp inspection room again, carry out lamp inspection by computer lamp inspection machine, qualified products are reached and are pasted in the explanation study by conveyer belt again, adhesive tape has the Traditional Chinese medicine instruction of lot number, by conveyer belt, reached in the packing room again, after vanning, by automatic packing machine, packed, send into again storehouse reservation after packaging, inspection machine in the check room is tested to each link in this process, each link in this process all meets the requirement of GMP.
With current Chinese medicine, compare, its production can be saved whole Chinese medicinal ingredients from damage, does not need to decoct, and or not by digestive tract, it is not the production method of the full medicine injection of a kind of Chinese medicine.
Specific embodiment production of the present invention is the production of the full medicine injection of a kind of Chinese medicine, production of the present invention is the improvement of current Chinese medicine injection production on extracting method, production link of the present invention comprises batching, purifying processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, the filler plug, gland, lamp inspection, paste description, packing, store, check etc., house of the present invention, facility, equipment comprises: a, the batching room, batching is with the equipment such as electronic scale is arranged in room, b, purifying processing room, the equipment such as ultrasonic washing unit are arranged in purifying processing room, c, the drying and sterilizing room, drying and sterilizing is with the equipment such as microwave drying room are arranged in room, d, the flour room, flour is with the equipment such as Chinese medicine powder beater are arranged in room, e, the cell rupture room, cell rupture is with the equipment such as ultrasonic cell disruptor are arranged in room, f, the multi-filtering room, multi-filtering has particulate filter in room, aperture is less than the equipment such as liquid medicine filter of 2um, g, the fill room, the equipment such as automatic filling machine are arranged in the fill room, h, filler plug room, the equipment such as automatic filler plug machine are arranged in filler plug room, i, the gland room, the equipment such as automatic capping machine are arranged in the gland room, j, the lamp inspection room, the equipment such as computer lamp inspection machine are arranged in the lamp inspection room, k, paste the explanation study, paste in the explanation study equipment that pastes description is arranged, l, the packing room, the equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, the check room, these rooms are all clean rooms, structure meets the related request of GMP, take various Chinese medicine with electronic scale in batch house, various Chinese medicine is placed in container, in the ultrasonic washing unit in conveyer belt reaches purifying processing room, and pour pure water in ultrasonic washing unit, Chinese medicine is fully immersed in pure water, open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into again distilled water, Chinese medicine is carried out to fine purifiation, after the Chinese medicine fine purifiation is clean, refund in clean container, in the microwave drying room in conveyer belt is sent to the drying and sterilizing room, the temperature in microwave drying room is adjusted to 60 ℃, open again, after drying and sterilizing 24 hours, Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicinal powder, be sent to cell rupture with in the ultrasonic cell disruptor in room by conveyer belt again, and pour in a small amount distilled water into, open ultrasonic cell disruptor, after 24 hours, the Chinese medicine cell rupture, intracellular matter dissolves in water, pour again the distilled water of requirement into, make By Chinese Medicines, by pipeline, be sent in the multi-filtering room again, through particulate filter, the multi-filtering of liquid medicine filter, filtered the granule in the By Chinese Medicines, broken cell wall, and some antibacterials, virus, insoluble substance, By Chinese Medicines has just become Chinese medicine injection, again in pipeline is sent to the fill room, carry out fill by automatic filling machine, after the Chinese medicine injection fill is interior to bottle, bottleneck is by plastic film sealing, by conveyer belt, transferred in filler plug room again, fill in plug by automatic filler plug machine on plastic sheeting, and then be sent to the gland room by conveyer belt, by automatic capping machine, easy-open lid is covered on plug, by conveyer belt, be sent in the lamp inspection room again, carry out lamp inspection by computer lamp inspection machine, qualified products are reached and are pasted in the explanation study by conveyer belt again, adhesive tape has the Traditional Chinese medicine instruction of lot number, by conveyer belt, reached in the packing room again, after vanning, by automatic packing machine, packed, send into again storehouse reservation after packaging, inspection machine in the check room is tested to each link in this process, each link in this process all meets the requirement of GMP.
Claims (1)
1. Chinese medicine injection production method, production link comprises: batching, purifying processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, the filler plug, gland, lamp inspection, paste description, packing, store, check, house and equipment comprise: a, the batching room, batching is with electronic scale, b are arranged in room, purifying processing room, purifying processing has ultrasonic washing unit, c in room, the drying and sterilizing room, drying and sterilizing is with microwave drying room, d are arranged in room, the flour room, flour is with Chinese medicine powder beater, e are arranged in room, the cell rupture room, cell rupture is with ultrasonic cell disruptor, f are arranged in room, the multi-filtering room, multi-filtering has particulate filter in room, liquid medicine filter, g, the fill room, fill has automatic filling machine in room, h, , there is automatic filler plug machine in filler plug room, i in filler plug room, the gland room, gland has automatic capping machine in room, j, , there is computer lamp inspection machine in the lamp inspection room, k in the lamp inspection room, paste the explanation study, paste in the explanation study and the equipment that pastes description is arranged, l, the packing room, packing has automatic packing machine, m in room, warehouse, n, the check room, it is characterized in that: in batch house, with electronic scale, take various Chinese medicine, various Chinese medicine is placed in container, in the ultrasonic washing unit in conveyer belt reaches purifying processing room, and pour pure water in ultrasonic washing unit, Chinese medicine is fully immersed in pure water, open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into again distilled water, Chinese medicine is carried out to fine purifiation, after the Chinese medicine fine purifiation is clean, refund in clean container, in the microwave drying room in conveyer belt is sent to the drying and sterilizing room, the temperature in microwave drying room is adjusted to 60 ℃, open again, after drying and sterilizing 24 hours, Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicinal powder, be sent to cell rupture with in the ultrasonic cell disruptor in room by conveyer belt again, and pour in a small amount distilled water into, open ultrasonic cell disruptor, after 24 hours, the Chinese medicine cell rupture, intracellular matter dissolves in water, pour again the distilled water of requirement into, make By Chinese Medicines, by pipeline, be sent in the multi-filtering room again, through particulate filter, the multi-filtering of liquid medicine filter, filtered the granule in the By Chinese Medicines, broken cell wall, and some antibacterials, virus, insoluble substance, By Chinese Medicines has just become Chinese medicine injection, again in pipeline is sent to the fill room, carry out fill by automatic filling machine, after the Chinese medicine injection fill is interior to bottle, bottleneck is by plastic film sealing, by conveyer belt, transferred in filler plug room again, fill in plug by automatic filler plug machine on plastic sheeting, and then be sent to the gland room by conveyer belt, by automatic capping machine, easy-open lid is covered on plug, by conveyer belt, be sent in the lamp inspection room again, carry out lamp inspection by computer lamp inspection machine, qualified products are reached and are pasted in the explanation study by conveyer belt again, adhesive tape has the Traditional Chinese medicine instruction of lot number, by conveyer belt, reached in the packing room again, after vanning, by automatic packing machine, packed, send into again storehouse reservation after packaging, inspection machine in the check room is tested to each link, each link all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470970.3A CN103494771A (en) | 2013-09-29 | 2013-09-29 | Production method of traditional Chinese medicine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470970.3A CN103494771A (en) | 2013-09-29 | 2013-09-29 | Production method of traditional Chinese medicine injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103494771A true CN103494771A (en) | 2014-01-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310470970.3A Pending CN103494771A (en) | 2013-09-29 | 2013-09-29 | Production method of traditional Chinese medicine injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103494771A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107572017A (en) * | 2017-07-31 | 2018-01-12 | 芜湖杨燕制药有限公司 | A kind of filling process of traditional Chinese medicine |
| CN107585372A (en) * | 2017-08-30 | 2018-01-16 | 芜湖杨燕制药有限公司 | A kind of traditional Chinese medicine embedding pre-treating technology |
| CN111317874A (en) * | 2020-03-05 | 2020-06-23 | 北京圣途安科技开发有限责任公司 | Production method of sterile vacuum bottle |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140108 |
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| WD01 | Invention patent application deemed withdrawn after publication |