CN102416046A - Chinese medicinal preparation for treating osteoarthritis - Google Patents
Chinese medicinal preparation for treating osteoarthritis Download PDFInfo
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- CN102416046A CN102416046A CN2011104137620A CN201110413762A CN102416046A CN 102416046 A CN102416046 A CN 102416046A CN 2011104137620 A CN2011104137620 A CN 2011104137620A CN 201110413762 A CN201110413762 A CN 201110413762A CN 102416046 A CN102416046 A CN 102416046A
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Abstract
The invention discloses a Chinese medicinal preparation for treating osteoarthritis, which is prepared by weighing Chinese angelica, tuber fleece flower root, eucommia bark, pangolin scales, prepared astragalus, twotooth achyranthes root, notopterygium root, drynaria baronii, tuckahoe and liquoric root in a ratio, adding water in an amount which is 4 to 6 times the total weight of the medicinal materials, decocting for 3 times and 0.5 hours each time, and mixing decoction. The medicine provided by the invention has the characteristics that: the action is quick; clinic symptoms are eliminated quickly; few toxic and side effects are generated; and the like.
Description
Technical field
The present invention provides a kind of Chinese medicine preparation of treating osteoarthritis, is used for osteoarthritis patient's treatment, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
Osteoarthritis (osteoarthritis) is because the birth defect in old age or other reasons such as wound, joint, joint deformity etc. cause that the non-inflammation degeneration of articular cartilage and edge, joint hyperosteogeny form, the clinical symptoms such as arthralgia, limitation of activity and joint deformity that produce.Osteoarthritis comprises: HOA, degenerative osteoarthritis, degeneration property arthritis, hyperplastic osteoarthritis or osteoarthritis etc.Osteoarthritis is the performance that the osteoarthrosis physiological is degenerated, and at present, does not still have the medicine that reverses or end this disease progression, and the purpose of treatment is to ease the pain, and relief of symptoms stops and delays advancing of disease, and the protection function of joint is in case the maimed person.
Summary of the invention
The present invention provides a kind of Chinese medicine preparation of treating osteoarthritis, and it is rapid to have a drug effect, characteristics such as clinical symptom disappearance is fast, and toxic and side effects is little.
Technical solution of the present invention is following:
Because the pathogeny of osteoarthritis is mainly due to the hepatic and renal YIN deficiency usually, asthenia of essence and blood, blood operation is slow, and QI-blood circulation is smooth and fall ill; QI and blood condenses, thereby checks meridians, accumulate in osteoarthrosis local and send out soreness of waist and knee joint, joint motion is unfavorable.So the present invention according to understanding and the Therapeutic Principle of Chinese medicine to osteoarthritis, with liver and kidney tonifying Zhi Qiben, holds concurrently with promoting blood circulation, dredging meridian and relieving pain.
The present invention treats the Chinese medicine preparation of osteoarthritis, by following raw materials by weight portion than processing:
Radix Angelicae Sinensis 20 ~ 25g, Radix Polygoni Multiflori 30 ~ 35g, the Cortex Eucommiae 20 ~ 25g, Squama Manis 15 ~ 18 g, Radix Astragali Preparata 25 ~ 30g, Radix Achyranthis Bidentatae 10 ~ 15g, Rhizoma Et Radix Notopterygii 15 ~ 20g, drynaria baronii 15 ~ 20g, Poria 20 ~ 25g,
Radix Glycyrrhizae 15 ~ 20g.
The method for preparing of pharmaceutical preparation of the present invention is following:
Take by weighing above-mentioned each medicine in proportion, add 4 ~ 6 times water, each 0.5 hour, decoct collecting decoction 3 times.
The present invention also can adopt the traditional Chinese medicines processing procedure to process any dosage form on the pharmaceutics.
[usage and dosage] is oral; 150ml/ time; Twice-daily; 15 days courses of treatment;
[function cures mainly] HOA, degenerative osteoarthritis, degeneration property arthritis, hyperplastic osteoarthritis or osteoarthritis.
In the prescription of the present invention, Radix Polygoni Multiflori can be beneficial smart, can enrich blood again, and character is gentle, and is not dry oiliness, cold not hot, flat invigorating the liver and kidney.The both sweet Wen Zhirun of Radix Angelicae Sinensis enriches blood with nourishing the liver, and is good to numb limbs and tense tendons, contracture, the effect of trembling that the blood deficiency the liver failing to be nourished causes; Hot again temperature is invigorated blood circulation, and is the key medicine of blood circulation promoting and blood stasis dispelling, and holding concurrently can pain relieving, the pain due to the limbs passages through which vital energy circulates stasis of blood is stagnated, numb commonly used.Can look after the state of an illness more all sidedly for osteoarthritis.Two medicines share, and are main with tonifying kidney-yin, and it is cloudy with tonifying liver to hold concurrently, but and promoting blood circulation and stopping pain.Be monarch drug altogether.
The Cortex Eucommiae is longer than invigorating the liver and kidney and bone and muscle strengthening, and warm unit down again can pain relieving, and to control the unstrong soreness of waist and knee joint of muscles and bones of suffering from a deficiency of the kidney, flaccidity and weakness of the lower limbs is good at.The effect that tonifying both YIN and YANG is arranged.Squama Manis is good at walking to scurry, and property specially row is loose, in reach internal organs, outer the meridian dredging, blood circulation promoting and blood stasis dispelling power is strong, can the tonneau meridians, reach the joint thoroughly, be usually used in treating articular instability, numbness contracture.The sweet temperature of the Radix Astragali is apt to into taste, is the invigorating the spleen and replenishing QI key medicine, and these article are to the deficiency of vital energy and hyperamization stagnates, and the muscle arteries and veins loses the numb limbs and tense tendons of supporting and often plays the curative effect of QI invigorating with promoting the circulation of blood.The same usefulness of three medicines, but principal drug assistance is invigorated blood circulation collateral dredging with the kidney invigorating.Be ministerial drug altogether.
Radix Achyranthis Bidentatae has three with justice: the power of its blood circulation promoting and blood stasis dispelling is stronger first, and its function of promoting blood circulation to disperse blood clots has thin profit to fall the characteristics of letting out; Second liver and kidney tonifying, strengthening the tendons and bones is to control the soreness of the waist and knees that its caused by liver and kidney deficiency causes; Three property are kind descending, often are the guiding drug of lower limb disease, the kind limb disease of controling the inferior.The hot temperature of Rhizoma Et Radix Notopterygii is bitter dry, and its property hero is strong, has analgesic effect preferably, and it is better to control logical to the greatest extent all over the body person's curative effect, because of it is apt to into urinary bladder channel, so be good to remove shoulder and back ache.The sweet temperature of Rhizoma Drynariae is gone into kidney, can strong muscles and bones, and benefit is deficient, and can the promoting the circulation of blood arteries and veins, pain relieving.Three medicines share, and have both brought into play invigorating the liver and kidney, and the bone and muscle strengthening effect has can the meridian dredging sharp joint and pain relieving is adjuvant drug altogether.
The Poria sweet in the mouth is and light, and the property of medicine is gentle, inclined to one side cold and heat, and the ability air making-up and spleen enlivening is with reinforcing body resistance.The Radix Glycyrrhizae sweet taste is strong, and the flavour of rectifiable side's Chinese medicine and bringing into play is in harmonious proportion the effect of the property of medicine, but and invigorating the spleen and replenishing QI.Two medicines are messenger drug altogether.
More than all medicines share, for curing mainly it, be aided with kidney-replenishing, with the moon of invigorating the liver and kidney to reach treating YIN within YANG.The kidney being the origin of congenital constitution, and main bone is given birth to the logical brain of marrow, and kidney qi is vigorous then to enjoy excellent health; Promoting blood circulation to remove obstruction in the collateral is controlled its pain, dispels blood stasis, unfolds meridians, removes the local joint symptom.Play the kidney invigorating altogether, invigorate blood circulation, the effect of collateral dredging, pain relieving.
The clinical standard of including in
1.1 tcm diagnosis standard reference Ministry of Public Health " new Chinese medicine clinical research guideline " standard
(1) have a dull ache from the beginning of knee joint, joint stuffiness, light activity is alleviated slightly, and climate change increases the weight of, and does not touchingly repeatedly heal
(2) insidious onset, morbidity are slowly seen person in middle and old age more
(3) but the knee mild swelling, often there is clickly sound and grating in the joint when movable
(4) patient fell ill the course of disease less than 2 years, patient's dim complexion, and body of the tongue is red partially, Tai Bai or thin white, rolling pulse or string.
1.2 the clinical criteria that doctor trained in Western medicine is recommended according to American Rheumatism Association
A few days knee-joint pain in (1) one month,
(2) there is sound the joint motion time,
(3) morning stiff 30 minutes,
(4) age>40 years old,
(5) knee joint bone property swelling companion snap,
(6) snap is not accompanied in the swelling of knee joint bone property.
The minimum existence (1)--(4) or (1)--, (3) (5) or (6) were promptly diagnosable.
The performance of iconography X line:
(1) edge, joint or ligament attachment point hyperosteogeny form
(2) little bony spur around the joint
(3) the narrow companion's subchondral bone sclerosis in joint space
(4) there is the sclerosis capsule to become in the subcartilaginous osseous lamella
2.1, case includes standard in
(1) meets knee osteoarthritis (the caused by liver and kidney deficiency muscle arteries and veins stasis type) person of above-mentioned diagnostic criteria;
(2) age 40-75 is between year, male or female;
(3) course of disease was less than 2 years
(4) the morbidity back is without other mode therapists
(5) signature Informed Consent Form
2.2, the case exclusion standard
(1) do not meet above-mentioned tcm diagnosis standard person
(2) merge knee joint tumor, tuberculosis, osteomyelitis and serious osteoporosis person; ;
(3) be associated with serious body organic disease such as serious cardiovascular and cerebrovascular vessel, liver, kidney, hemopoietic system and nervous system, as: chronic nephritis, hepatitis, heart disease etc.;
(4) hepatic and kidney function obstacle, the digestive tract ulcer person
(5) known to this ingredient allergy and allergic constitution person
(6) therapentic part has serious skin injury or serious skin patient
(7) anemia of pregnant woman and women breast-feeding their children, allergic constitution or to this medicine allergy sufferers;
2.3, end test standard
1. serious safety issue takes place in the test, should end test.
2. the experimenter is unwilling to proceed clinical trial, proposes to end the clinical trial requirement.
2.4, the case that comes off standard
1. serious adverse events, untoward reaction, complication take place, and should not accept to continue treatment.
2. withdraw from voluntarily in observing.
3. data is incomplete, influences effectiveness and safety judgement person.
Criterion of therapeutical effect and result
Criterion of therapeutical effect
" traditional Chinese medical science disease diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine's formulation in 1994.Clinical cure: knee joint swelling, pain complete obiteration, joint function recovery is normal; Produce effects: arthralgia obviously alleviates, and swelling disappears basically, and knee joint function significantly improves; Effectively: arthralgia alleviates to some extent, and knee joint function makes moderate progress; Invalid: joint swelling and pain does not have and alleviates, and knee joint function does not have improvement.
Usage: 2 doses of every days, 150ml, sub-service sooner or later.15 days is 1 course of treatment, and treatment is totally 4 courses of treatment.
The result
60 routine patients take medicine after 4 courses of treatment continuously, clinical cure 9 examples (15%), produce effects 29 examples (483%), effective 17 examples (283%), invalid 5 examples (83%), total effective rate 917%.
Good effect of the present invention is:Be with pure Chinese medicinal preparation, drug effect is rapid, and clinical symptom disappearance is fast, and toxic and side effects is little, short treating period, and painful little, expense is low.
The specific embodiment
Through following examples the present invention is described for example further; And do not limit the present invention in any way; Under the prerequisite that does not deviate from technical solution of the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope of the present invention.
Embodiment 1
Take by weighing Radix Angelicae Sinensis 20g, Radix Polygoni Multiflori 30g, Cortex Eucommiae 20g, Squama Manis 15g, Radix Astragali Preparata 25g, Radix Achyranthis Bidentatae 10g, Rhizoma Et Radix Notopterygii 15g, drynaria baronii 15g, Poria 20g, Radix Glycyrrhizae 15g, add 6 times and be decocted in water for oral dose, each decocting 0.5 hour, totally 3 times, collecting decoction 300ml.
Embodiment 2
Take by weighing Radix Angelicae Sinensis 25g, Radix Polygoni Multiflori 30g, Cortex Eucommiae 20g, Squama Manis 18 g, Radix Astragali Preparata 30g, Radix Achyranthis Bidentatae 10g, Rhizoma Et Radix Notopterygii 15g, drynaria baronii 15g, Poria 25g, Radix Glycyrrhizae 20g.Add 6 times and be decocted in water for oral dose, each decocting 0.5 hour, totally 3 times, collecting decoction 300ml.
Embodiment 3
Take by weighing Radix Angelicae Sinensis 20g, Radix Polygoni Multiflori 35g, Cortex Eucommiae 20g, Squama Manis 18g, Radix Astragali Preparata 25g, Radix Achyranthis Bidentatae 15g, Rhizoma Et Radix Notopterygii 15g, drynaria baronii 20g, Poria 25g, Radix Glycyrrhizae 15g, add 6 times and be decocted in water for oral dose, each decocting 0.5 hour, totally 3 times, collecting decoction 300ml.
Embodiment 4
Take by weighing Radix Angelicae Sinensis 25g, Radix Polygoni Multiflori 35g, Cortex Eucommiae 20g, Squama Manis 15g (smash and be decocted first 30 minutes), Radix Astragali Preparata 25g, Radix Achyranthis Bidentatae 15g, Rhizoma Et Radix Notopterygii 20g, drynaria baronii 20g, Poria 25g, Radix Glycyrrhizae 20g; Adding 6 times is decocted in water for oral dose; Each decocting 0.5 hour, totally 3 times, collecting decoction 300ml.
Embodiment 5
Take by weighing Radix Angelicae Sinensis 25g, Radix Polygoni Multiflori 30g, Cortex Eucommiae 25g, Squama Manis 15g, Radix Astragali Preparata 30g, Radix Achyranthis Bidentatae 10g, Rhizoma Et Radix Notopterygii 20g, drynaria baronii 20g, Poria 25g, Radix Glycyrrhizae 20g, add 6 times and be decocted in water for oral dose, each decocting 0.5 hour, totally 3 times, collecting decoction 300ml.
For showing the therapeutic effect of medicine of the present invention, selected below the patient of several routine osteoarthritis, take medicine of the present invention and treat, analyze through clinical observation and sum up as follows:
Case 1
The Wang, woman, 65 years old, retirement.On July 20th, 2010,, " double knee joint pain 4 months increased the weight of for 1 week " institute go to a doctor because of coming me.2 years causes of patient are tired and cause double knee joint pain, limitation of activity, alleviation after having a rest, untreated.Cause double knee joint pain, swelling, limitation of activity after the cause fatigue in 4 months, go to a doctor, be diagnosed as the double knee joint synovitis, and give Western medicine, have repeatedly during the state of an illness with reducing swelling and alleviating pain (concrete medication is not quite clear) in nearby hospitals.The movable pain of double knee joint, stretching has tangible abrasive feel when going down on one's knees the joint, obviously limited during joint motion, sleep night can, red tongue, few tongue, deep-thready pulse and puckery.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treat after 2 months that existing sb.'s illness took a favorable turn.
Case 2
Zhang, the man, 55 years old, unemployed.On May 11st, 2011,, " the right gonalgia 6 months increased the weight of for 3 weeks " institute go to a doctor because of coming me.Right knee joint activity is swollen and ache, stretch when going down on one's knees the joint obviously limited, sleep night can, dimly red tongue, tongue is white, deep-thready pulse and puckery.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treating after 3 months symptom such as pain activity obviously alleviates.
Case 3
In certain, woman, 53 years old, cleaner.On 06 11st, 2011,, " the left gonalgia 24 months increased the weight of 3 days " institute go to a doctor because of coming me.Left knee joint causes local knee joint to swell and ache because of work the time receives wound before 3 years, stretches when going down on one's knees the joint limitedly, and 3 days causes are tired and cause the left gonalgia, and limitation of activity increases the weight of recently, sleep night can, red tongue, tongue is white, stringy pulse.Oral through the present invention; 150ml/ time; Twice-daily; Drug therapy is pain relief after 2 months, and joint motion is normal.
Case 4
Lee, man, 65 years old, retirement.On 07 02nd, 2011,, " the right gonalgia 6 years increased the weight of for 4 weeks " institute go to a doctor because of coming me.Right knee joint activity is swollen and ache, stretch when going down on one's knees the joint obviously limited, sleep night can, dimly red tongue, tongue is white, deep-thready pulse and puckery.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treat pain relief after 1 month, the joint motion mild limitation.
Case 5
Take charge of certain, man, 70 years old, teacher.On 07 11st, 2011,, " double knee joint pain 15 years increased the weight of 7 days " institute go to a doctor because of coming me.Double knee joint swells and ache because of fatigue causes local knee joint before 15 years, stretches when going down on one's knees the joint limitedly, and 7 days causes are suffered from cold and caused double knee joint pain, and limitation of activity increases the weight of recently, sleep night can, pale tongue, tongue is white, a little less than the stringy pulse.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treat pain relief after 3 months, joint motion is normal.
Case 6
Lee, the woman, 63 years old, unemployed.On October 20th, 2011,, " the right gonalgia 3 months increased the weight of for 1 week " institute go to a doctor because of coming me.Right knee joint activity pain, stretch when going down on one's knees the joint limited, sleep night can, dimly red tongue, tongue is white, deep-thready pulse and puckery.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treat pain relief after 1 month, but the joint normal activity.
Case 7
Zhao, the woman, 67 years old, unemployed.On October 23rd, 2011,, " the left gonalgia 3 years increased the weight of 10 days " institute go to a doctor because of coming me.Left knee joint causes the local gonalgia because of fatigue before 3 years, the knee joint limitation of activity, 10 days causes are suffered from cold and are caused the left gonalgia, limitation of activity increases the weight of recently, sleep night can, red tongue, tongue is white, stringy pulse.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treatment 2 week back pain relief, joint motion is normal.
Case 8
Liu, man, 75 years old, retirement.On October 25th, 2011,, " the right gonalgia 4 years increased the weight of for 4 weeks " institute go to a doctor because of coming me.Right knee joint activity is ached, and stretches limitation of activity when going down on one's knees the joint, sleep night can, dimly red tongue, tongue is white, deep-thready pulse and puckery.Through drug oral of the present invention; 150ml/ time; Twice-daily; Treatment 2 week back pain relief, joint motion still can.
Claims (2)
1. Chinese medicine preparation of treating osteoarthritis, by following raw materials by weight portion than processing:
Radix Angelicae Sinensis 20 ~ 25g, Radix Polygoni Multiflori 30 ~ 35g, the Cortex Eucommiae 20 ~ 25g, Squama Manis 15 ~ 18 g,
Radix Astragali Preparata 25 ~ 30g, Radix Achyranthis Bidentatae 10 ~ 15g, Rhizoma Et Radix Notopterygii 15 ~ 20g, drynaria baronii 15 ~ 20g, Poria 20 ~ 25g,
Radix Glycyrrhizae 15 ~ 20g.
2. the method for preparing according to the Chinese medicine preparation of the said treatment osteoarthritis of claim 1 is following:
Take by weighing above-mentioned each medicine in proportion, wherein, add 4 ~ 6 times water, each 0.5 hour, decoct collecting decoction 3 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104137620A CN102416046A (en) | 2011-12-13 | 2011-12-13 | Chinese medicinal preparation for treating osteoarthritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104137620A CN102416046A (en) | 2011-12-13 | 2011-12-13 | Chinese medicinal preparation for treating osteoarthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102416046A true CN102416046A (en) | 2012-04-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104137620A Pending CN102416046A (en) | 2011-12-13 | 2011-12-13 | Chinese medicinal preparation for treating osteoarthritis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926878A (en) * | 2010-06-03 | 2010-12-29 | 陕西中医学院 | Chinese medicinal composition for treating osteoarthritis and preparation method thereof |
-
2011
- 2011-12-13 CN CN2011104137620A patent/CN102416046A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 周舒心，张英: "膝关节骨性关节炎中医治疗概况", 《中西医结合研究》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926878A (en) * | 2010-06-03 | 2010-12-29 | 陕西中医学院 | Chinese medicinal composition for treating osteoarthritis and preparation method thereof |
| CN101926878B (en) * | 2010-06-03 | 2014-10-29 | 陕西中医学院 | Chinese medicinal composition for treating osteoarthritis and preparation method thereof |
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Application publication date: 20120418 |