CN102406917A - Antidepressive traditional Chinese medicine composition and preparation method thereof - Google Patents
Antidepressive traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an antidepressive traditional Chinese medicine composition and a preparation method thereof. The composition comprises morinda root, radix bupleuri, radix paeoniae alba, baked immature bitter orange, bighead atractylodes rhizome (fried), tuber pinellia, polygala (prepared), licorice (baked), arisaema cum bile, radix curcumae, ginger, spina date seed (fried) and poria, has the effects of soothing liver and eliminating depression as well as calming nerves and mind, and can be used for treating depression syndromes. The preparation has the advantages of rapid acting, high bioavailability, convenience in carrying and the like.
Description
Technical field
The present invention is a kind of antidepressant Chinese medicine preparation and preparation method thereof, belongs to medical technical field.
Background technology
Depression is a kind of common mental sickness, mainly shows as depressedly, and interest lowers, pessimism; Retardation of thinking, lack of initiative, the self-accusation from the crime, diet, the sleep poor; Worry oneself to suffer from various diseases, feel that the whole body many places are uncomfortable, suicidal thought and behavior can appear in severe patient.A joint study of World Health Organization (WHO), the World Bank and Harvard University shows that depression has become second serious disease of Chinese disease burden.The factor that causes depression comprises: inherited genetic factors, physical factors, Nervous and Mental Factors etc.The risk of depression is very big, and the serious symptom depression has nearly 15% homicide rate.
The traditional Chinese medical science thinks that the main diseases of depression because the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, the heart are become homeless fosterly, though that liver, spleen, three internal organs of the heart all have is relevant, emphasizes particularly on different fields.Depression of liver-QI is how relevant with gas, blood, fire, and eat, wet, expectorant mainly closes and lies in spleen, the heart shows as deficiency syndrome then more, loses void etc. like lack of preservation of spirit, deficiency of heart-blood, the heart-yin, also has some to belong to vital QI being weakened and pathogen being violent, the syndrome of simulataneous insufficiency and excessive.Depression is just sick at gas, prolonged illness and blood, so the syndrome of qi depression to blood stasis clinically ten minutes see that with the passing of time depression does not heal more, often undermine spleen, kidney, cause that yang-energy is depressed, the mental deterioration syndrome.
The used medical material Radix Morindae Officinalis of the present invention, sweet, suffering, tepor.Return kidney, Liver Channel.Kidney-replenishing.Radix Bupleuri, hardship is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.The Radix Paeoniae Alba is bitter, sour, is slightly cold.Return liver, spleen channel.The suppressing the hyperactive liver pain relieving.Process Fructus Aurantii Immaturus hardship, suffering, acid, temperature.Return spleen, stomach warp.The dispelling the stagnated QI removing food stagnancy, the diffusing painful abdominal mass of reducing phlegm.The Rhizoma Atractylodis Macrocephalae (stir-fry) is bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic.The Rhizoma Pinelliae is hot, temperature; Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm.Radix Polygalae (system) is bitter, hot, warm.GUIXIN, kidney, lung meridian.The Fructus Alpiniae Oxyphyllae of calming the nerves.Radix Glycyrrhizae (processing) is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI.Arisaema Cum Bile is bitter, little suffering, cold.Return lung, liver, spleen channel.Removing heat-phlegm.Radix Curcumae is hot, bitter, and is cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving.Rhizoma Zingiberis Recens is hot, tepor.Return lung, spleen, stomach warp.Cold expelling induces sweat.Semen Ziziphi Spinosae (stir-fry) is sweet, sour, and is flat.Return liver, gallbladder, heart channel.Tonifying liver, mind calming.Poria is sweet, light, and is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming., all medicines share, YIN nourishing nourishing the liver, invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart can be obtained good curative effect, be a kind of traditional Chinese medical science field effectively and the Chinese medicine preparation of the control depressive illness of few side effects, broad market prospect and profit margin also have great social significance.
Summary of the invention
The present invention is a kind of antidepressant Chinese medicine composition and preparation method thereof; It is by Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, processs Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria; Be active component, the preparation of processing with mixing acceptable accessories.
Described Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, consumption be per unit dosage
Radix Morindae Officinalis 50-5000 part, Radix Bupleuri 100-1000 part, Radix Paeoniae Alba 100-1000 part,
Process Fructus Aurantii Immaturus 100-1000 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 100-1000 part, Rhizoma Pinelliae 100-1000 part,
Radix Polygalae (system) 100-1000 part, Radix Glycyrrhizae (processing) 100-1000 part, Arisaema Cum Bile 100-1000 part,
Radix Curcumae 100-1000 part, Rhizoma Zingiberis Recens 100-1000 part, Semen Ziziphi Spinosae (stir-fry) 100-1000 part,
Poria 100-1000 part.
For per unit dosage is preferably
500 parts of Radix Morindae Officinaliss, 100 parts of Radix Bupleuri, 150 parts of the Radix Paeoniae Albas, process 50 parts of Fructus Aurantii Immaturuss,
50 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 40 parts of the Rhizoma Pinelliaes, 35 parts of Radix Polygalaes (system), 30 parts in Radix Glycyrrhizae (processing),
30 parts of Arisaema Cum Bile, 50 parts of Radix Curcumaes, 80 parts in Rhizoma Zingiberis Recens, 40 parts of Semen Ziziphi Spinosaes (stir-fry),
50 parts in Poria.
The preparation technology of described antidepressant Chinese medicine composition is characterized in that comprising:
Technology A: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, decocte with water, collecting decoction filters, and is condensed into extractum, and drying is pulverized;
Technology B: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria; Add 20-95% ethanol water reflux, extract,, filter, filtrating is condensed into extractum; Drying is pulverized;
Technology C: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, decocte with water, collecting decoction; Filter, concentrate, add the ethanol precipitate with ethanol; Supernatant concentration, drying is pulverized.
This technology combines with acceptable accessories, is fit to preparation drop pill, coated tablet, thin membrane coated tablet, chewable tablet, effervescent tablet, dispersible tablet, soft capsule, granule.
Said acceptable accessories is selected from drop pill substrate, filler, effervescent (acid source and alkali source), correctives, disintegrating agent, binding agent and lubricant.
The preparation process of said drop pill is following: extract obtained and volatile oil and substrate suspendible or fusion, and through the system of dripping, ball is washed in cooling, and drying is selected ball, quality inspection, packing forms.The preparation process of said coated tablet is following: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and sugar coating promptly gets coated tablet.The preparation process of said thin membrane coated tablet is following: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and the bag film-coat promptly gets thin membrane coated tablet.The preparation process of said chewable tablet is following: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets chewable tablet.The preparation process of said effervescent tablet is following: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, effervescent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets effervescent tablet.The preparation process of said dispersible tablet is following: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, disintegrating agent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets dispersible tablet.Said preparation of soft capsule step is following: the castor oil hydrogenated heating is dissolved in the medicinal soybean oil, adds extract, volatile oil mix homogeneously, be rolled into soft capsule.The preparation process of said granule is following: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulation, drying adds volatile oil, promptly gets granule.
Described drop pill substrate is selected from but is not limited only to PEG-6000, PEG-4000, sodium stearate, glycerin gelatine, one or more the mixture in stearic acid, glyceryl monostearate, hexadecanol, octadecanol, insect wax, the hydrogenated vegetable wet goods is arranged; Described filler is selected from but is not limited only to one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, xylitol, the Semen sojae atricolor wet goods; Described correctives is selected from but one of is not limited only in Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or several kinds mixture wherein; Suitable lubricant is selected from but is not limited only to wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel; Acid source is selected from but is not limited only to citric acid (aqueous or anhydride) in the described effervescent, and alkali source is selected from but is not limited only to sodium bicarbonate.Suitable disintegrating agent is selected from but is not limited only to dried starch, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose, crospolyvinylpyrrolidone.Described binding agent is selected from but is not limited only to one or more the mixture in starch slurry, hydroxypropyl cellulose, methylcellulose, gelatin, sucrose, the polyvinylpyrrolidone etc.
The specific embodiment
Come preparation of the present invention done further specifying through following instance, but be not limited in following instance.
Embodiment 1: drop pill (A)
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, polyethylene glycol 6000 1300g
Method for making: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters, and is condensed into extractum, and drying is pulverized.Polyethylene glycol 6000 is heated to 90～100 ℃, treats to add water extraction extract powder mix homogeneously after whole fusions, keep 85～90 ℃,, splash into and become ball in the simethicone, promptly get with the speed of 100 of per minutes.
Embodiment 2: drop pill
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, polyethylene glycol 6000 1300g
Method for making: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria and add 90% ethanol water reflux, extract; Filter; Filtrating is condensed into extractum, and drying is pulverized.Polyethylene glycol 6000 is heated to 90～100 ℃, treats to add the extract powder mix homogeneously after whole fusions, keeps 85～90 ℃, with the speed of 100 of per minutes, splashes in the liquid paraffin with thermograde and becomes ball, promptly gets.
Embodiment 3: Film coated tablets
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, dextrin 20g, low substituted hydroxy-propyl methylcellulose 5g, magnesium stearate 2.5g
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters, and is condensed into extractum; Drying is pulverized, with low substituted hydroxy-propyl methylcellulose mixing; Granulate, drying adds magnesium stearate; Tablet forming, the bag film-coat promptly gets.
Embodiment 4: effervescent tablet
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, sodium bicarbonate 100g, tartaric acid 170g, orange flavor 6g, dextrin is an amount of, PEG6000 is an amount of
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters, and is condensed into extractum, and drying is pulverized.Above-mentioned powder, dextrin, magnesium stearate, sodium bicarbonate, tartaric acid, orange flavor, PEG6000 mixing, airtight 2 hours, tablet forming promptly got.
Embodiment 5: coated tablet
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, dextrin 20g, low substituted hydroxy-propyl methylcellulose 5g, magnesium stearate 2.5g
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria and add 20-95% ethanol water reflux, extract,, filter, filtrating is condensed into extractum; Drying is pulverized, with dextrin, low substituted hydroxy-propyl methylcellulose mixing; Granulate, drying adds magnesium stearate; Tablet forming, sugar coating promptly gets.
Embodiment 6: chewable tablet
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, dextrin 20g, sucrose 100g, magnesium stearate 2.5g
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters; Be condensed into extractum, drying is pulverized; With dextrin, sucrose mixing, granulate drying; Add magnesium stearate, tablet forming promptly gets.
Embodiment 7: dispersible tablet
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, cross-linking sodium carboxymethyl cellulose 20g, microcrystalline Cellulose 100g, low substituted hydroxy-propyl methylcellulose 5g, magnesium stearate 2.5g
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters, and is condensed into extractum; Drying is pulverized, with cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, low substituted hydroxy-propyl methylcellulose mixing; Granulate, drying adds magnesium stearate; Tablet forming, the bag film-coat promptly gets.
Embodiment 8: soft capsule
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, to process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, medicinal soybean oil 20g, castor oil hydrogenated 1.0g, rubber an amount of
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria and add 80% ethanol water reflux, extract,, filter, filtrating is condensed into extractum, and drying is pulverized.The castor oil hydrogenated heating is dissolved in the medicinal soybean oil, adds extract and mix evenly, be rolled into ball.
Embodiment 9: granule
Radix Morindae Officinalis 500g, Radix Bupleuri 100g, Radix Paeoniae Alba 150g, process Fructus Aurantii Immaturus 50g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 50g, Rhizoma Pinelliae 40g, Radix Polygalae (system) 35g, Radix Glycyrrhizae (processing) 30g, Arisaema Cum Bile 30g, Radix Curcumae 50g, Rhizoma Zingiberis Recens 80g, Semen Ziziphi Spinosae (stir-fry) 40g, Poria 50g, dextrin 20g, sucrose 500g
Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria decocte with water, collecting decoction filters, and is condensed into extractum; Drying is pulverized, with dextrin, sucrose mixing; Granulate, drying promptly gets.
Embodiment 10: said Chinese medicine composition (A) is to the depressed experimental study of effect of mouse anti
Experimental technique:
The experiment of mice forced swimming: normal mouse is divided into according to randomized blocks: blank group, fluoxetine group (4.1mg/kg), compositions (A) group (247.6mg/kg), 10 every group.Each is organized all by the administration of 0.2ml/10g body weight, once a day, successive administration 7d, the blank group is given deionized water.1h experimentizes after the last administration.With the single water vat of putting into 23 ± 2 ℃ of high 20cm, diameter 18cm, depth of water 10cm, water temperature of mice, observe 6min, adapt to 2min, the accumulative total dead time (S) in the 4min of record back.
Mice reserpine antagonistic experiment: normal mouse is divided into according to randomized blocks: blank group, model control group, fluoxetine group (4.1mg/kg), compositions (A) group (247.6mg/kg), 10 every group.Each is organized all by the administration of 0.2ml/10g body weight, once a day, successive administration 7d, blank group and model control group are given deionized water.Lumbar injection lmg/kg reserpine immediately after the last administration, blank group injected in mice equivalent normal saline.Carry out blepharoptosis and akinetic observation behind the 120min.Calculate antagonism percentage rate (blepharoptosis antagonism percentage rate=[1-open eyes can not number of elements/animal sum] * 100%; Motion can not resist percentage rate=[1-motion can not number of elements/animal sum] * 100%); Carry out the observation that body temperature descends behind the 180min, survey mice anus temperature.
Experimental result:
Chinese medicine composition is to the influence of mice forced swimming dead time: with the blank group relatively, the fluoxetine group, Chinese medicine composition (A) group all can significantly shorten the mice forced swimming dead time.(* * P＜0.01, * P＜0.05), the result sees table 1
The influence of table 1 pair mice forced swimming dead time (
N=10)
| Group | Dosage/mg.kg-1 | Dead time/S |
| The blank group | -- | 110.50±32.15 |
| The fluoxetine group | 4.1 | 85.30±21.36* |
| Chinese medicine composition (A) group | 247.6 | 63.40±25.38** |
Annotate: compare * * P＜0.01, * P＜0.05 with the blank group
Chinese medicine composition causes mouse temperature, blepharoptosis and akinetic influence to reserpine: show as behind the model group lumbar injection reserpine body temperature decline, blepharoptosis, motion can not, with the normal control group significant difference (P＜0.01) is arranged more all; The mouse temperature that Chinese medicine composition group and fluoxetine group all can significantly be resisted due to the reserpine descends, with remarkable (P＜0.01 of model group comparing difference; P＜0.05); The Chinese medicine composition group can significantly resist reserpine induced mice blepharoptosis and motion can not, with model group comparing difference significantly (P＜0.01); The result sees table 2
Table 2 pair reserpine causes mouse temperature, blepharoptosis and akinetic influence (
N=10)
| Group | Body temperature/℃ | Antagonism blepharoptosis/% | Resisted motion can not/% |
| The blank group | 37.01±0.52 | 100 | 100 |
| Model control group | 35.67±0.51** | 10** | 10** |
| The fluoxetine group | 36.18±0.41# | 50# | 50# |
| Chinese medicine composition (A) group | 36.75±0.39## | 80## | 80## |
Annotate: compare * * P＜0.01 with the blank group, ##P＜0.01, #P＜0.05 are compared with model control group in * P＜0.05
Claims (6)
1. the present invention is a kind of antidepressant Chinese medicine composition; It is characterized in that; It mainly by Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, be that active component forms.
2. antidepressant Chinese medicine composition as claimed in claim 1 is characterized in that:
Radix Morindae Officinalis 50-5000 part, Radix Bupleuri 100-1000 part, Radix Paeoniae Alba 100-1000 part,
Process Fructus Aurantii Immaturus 100-1000 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 100-1000 part, Rhizoma Pinelliae 100-1000 part,
Radix Polygalae (system) 100-1000 part, Radix Glycyrrhizae (processing) 100-1000 part, Arisaema Cum Bile 100-1000 part,
Radix Curcumae 100-1000 part, Rhizoma Zingiberis Recens 100-1000 part, Semen Ziziphi Spinosae (stir-fry)
100-1000 part, Poria 100-1000 part.
3. antidepressant Chinese medicine composition as claimed in claim 1 is characterized in that, for per unit dosage is preferably:
500 parts of Radix Morindae Officinaliss, 100 parts of Radix Bupleuri, 150 parts of the Radix Paeoniae Albas, process 50 parts of Fructus Aurantii Immaturuss,
50 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 40 parts of the Rhizoma Pinelliaes, 35 parts of Radix Polygalaes (system), 30 parts in Radix Glycyrrhizae (processing),
30 parts of Arisaema Cum Bile, 50 parts of Radix Curcumaes, 80 parts in Rhizoma Zingiberis Recens, 40 parts of Semen Ziziphi Spinosaes (stir-fry),
50 parts in Poria.
4. the described antidepressant Chinese medicine composition of claim 1, it is characterized in that: its preparation technology comprises
Technology A: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, decocte with water, collecting decoction filters, and is condensed into extractum, and drying is pulverized;
Technology B: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria; Add 20-95% ethanol water reflux, extract,, filter, filtrating is condensed into extractum; Drying is pulverized;
Technology C: Radix Morindae Officinalis, Radix Bupleuri, the Radix Paeoniae Alba, process Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae (stir-fry), the Rhizoma Pinelliae, Radix Polygalae (system), Radix Glycyrrhizae (processing), Arisaema Cum Bile, Radix Curcumae, Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae (stir-fry), Poria, decocte with water, collecting decoction; Filter, concentrate, add the ethanol precipitate with ethanol; Supernatant concentration, drying is pulverized.
5. antidepressant Chinese medicine composition as claimed in claim 4 is characterized in that this technology combines with acceptable accessories, is fit to preparation drop pill, coated tablet, thin membrane coated tablet, chewable tablet, effervescent tablet, dispersible tablet, soft capsule, granule.
6. be selected from drop pill substrate, filler, effervescent, correctives, disintegrating agent, binding agent and lubricant like the said acceptable accessories of claim 5.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716460A (en) * | 2012-06-30 | 2012-10-10 | 李承平 | Evil-expelling and depression-resolving combined tablet |
| CN103251757A (en) * | 2013-05-29 | 2013-08-21 | 南京中医药大学 | Borneol-containing compound preparation as well as preparation method and application thereof |
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| CN101433645A (en) * | 2008-09-09 | 2009-05-20 | 中国人民解放军第二军医大学 | Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof |
| CN101530599A (en) * | 2009-04-20 | 2009-09-16 | 高新华 | A pharmaceutical composition for treating mental depression |
| CN101773641A (en) * | 2009-01-12 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition preparation for liver soothing and depression relief and quality control method |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433645A (en) * | 2008-09-09 | 2009-05-20 | 中国人民解放军第二军医大学 | Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof |
| CN101773641A (en) * | 2009-01-12 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition preparation for liver soothing and depression relief and quality control method |
| CN101530599A (en) * | 2009-04-20 | 2009-09-16 | 高新华 | A pharmaceutical composition for treating mental depression |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716460A (en) * | 2012-06-30 | 2012-10-10 | 李承平 | Evil-expelling and depression-resolving combined tablet |
| CN103251757A (en) * | 2013-05-29 | 2013-08-21 | 南京中医药大学 | Borneol-containing compound preparation as well as preparation method and application thereof |
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