Superfine powder Radix Isatidis normal temperature preparation method and special-purpose two-way airflow screening machine thereof
Technical field
The present invention relates to veterinary additive, especially relate to superfine powder Radix Isatidis normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine that is used for this method.
Background technology
Along with the continuous expansion of livestock culture scale, the bacterial drug resistance of using antibiotic to cause in a large number constantly rises, and has become one of common difficult problem of paying close attention in the whole world.Because continuing to increase of antibiotic use amount causes fowl poultry intestinal microbial population disorderly, is prone to increase the weight of primary infection, make fowl poultry liver renal metabolism disorderly, residual increasing the weight of, harm humans is healthy.
Chinese herbal medicine additive has natural sex, and multifunctionality, the characteristics that the have no side effect advantage of holding concurrently is added and advanced the Abwehrkraft des Koepers that can improve animal in the feedstuff, makes poultry not fall ill or fall ill less.But Chinese medicine additive exists using dosage big, and dosage form is thick, appearance poor, effective ingredient can not fully discharge, the shortcoming that bioavailability is low has influenced Chinese medicine quality and clinical health-care effect, and can not with the particulate material uniform mixing.
Radix Isatidis, the beginning is stated from Compendium of Material Medica, is the dry root of Cruciferae biennial herb plant Isatis indigotica Fort..Main product is in Hebei, Jiangsu, and provinces such as Anhui are cultivation.The property of medicine is bitter. and cold. GUIXIN stomach warp. heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving. Radix Isatidis has inhibitory action to various bacteria, to bacillus subtilis; Staphylococcus aureus, sarcine, escherichia coli; Bacillus typhi, Salmonella paratyphi, dysentery bacterium; Bacillus enteritidiss etc. all have inhibitory action, and the effective ingredient of Radix Isatidis can obviously promote mouse antibodies formation cell function and mononuclear phagocyte system function, enhancing mouse boosting cell NK activity; Strengthen ConA or the LPS induced activity to the mice PBLC, improving chicken Newcastle disease NDV-IV is tiring of Seedling immune antibody.The antibiotic antitoxin of Radix Isatidis can improve the resistance of body, has safely, and toxic and side effects is little, and effective ingredient is many, and residual advantage such as few is a kind of good feedstuff health-care additive.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; It had both kept the advantage of Chinese medicine technology of preparing; Injected new vitality for the modern production of Chinese medicine again; Have a extensive future, but in actual production, remain in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.In traditional closed circuit method crushing process; When most of material has reached fineness requirement, always there is few part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly; Make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification; Influenced the quality of production of herbal medicine compound recipe superfine powder greatly; Especially when being applied to animal drinking-water or the use of particulate material spice, because a large amount of not existence of breaking cellular wall cell are difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter; Material particles surface area and surface energy increase; Adsorptivity increases, and mobile variation is prone to be gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder Radix Isatidis normal temperature preparation method; Efficiently solve have in the present Chinese medicine production that energy consumption is big, the medicine maximum particle diameter is difficult to accurate control, can't continuous production, difficult problems such as dust is many in the production process, make the Radix Isatidis superfine powder of preparation have rapid-action, good effect, bioavailability is high, additive capacity is few advantage.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder Radix Isatidis normal temperature preparation method.
Superfine powder Radix Isatidis normal temperature preparation method of the present invention comprises the steps:
The first step, get the Chinese medicine Radix Isatidis and dry, cut into the long section of 3-5cm, natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃, the Radix Isatidis of cutting is pulverized, and obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, with the second step gained coarse powder place pulverize in the rod mill after; Be fed into special-purpose two-way airflow screening machine through wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and promptly gets superfine powder Radix Isatidis finished product; The powder of not crossing 500 mesh sieves arrives circulation pulverizing once more in the said rod mill through the funnel collection and through line transportation.
Special-purpose two-way airflow screening machine of the present invention comprises JIKE and sets within it the downward screen drum of chamber intermediate openings, the order number of said screen drum >=500 orders; The nozzle of screen drum is connected with the funnel upper shed that is arranged on the JIKE bottom mutually; Chassis cavity is connected with air-introduced machine through the negative pressure chamber on top; Be provided with the door font rotating spraying trachea that constitutes by transverse tube and standpipe in the zone between screen drum and JIKE; The puff prot of said door font rotating spraying trachea is for axially being opened in the groove on its tube wall along said transverse tube and standpipe respectively; Said groove is offered towards the screen drum direction respectively; The groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of said blast pipe passes screen drum and is connected with the transverse tube middle part of door font rotating spraying trachea and is connected through the rolling bearing rolling; The air inlet of blast pipe extends outside the said hopper side walls and is connected with the blast orifice of aerator; In screen drum, be provided with feed pipe, above the discharging opening of said feed pipe, be provided with the buffering umbrella, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of said air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of said drive motors is 155 rev/mins; The blast pressure of said aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of said powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of said screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; The finished product Radix Isatidis grain size of micropowder of preparation≤25 microns has improved cell wall breaking rate and bioavailability greatly, has strengthened the pharmacological action of medicine, thereby has reduced dosage, has practiced thrift medical material; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder Radix Isatidis greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
Clinical effectiveness according to the Radix Isatidis superfine powder of the inventive method preparation is able to checking through following test:
Test Example: the Radix Isatidis superfine powder is to the influence of broiler immune indexes
Test drug and material:
The Radix Isatidis superfine powder adopts the present invention's preparation;
The Radix Isatidis coarse powder: 80 order coarse powder, make by oneself at laboratory;
Experimental animal and packet transaction: select 100 of healthy 1 age in days, 817 broiler chicks, be divided into 2 groups at random, 50 every group.The 1st group is Radix Isatidis coarse powder group, addition 1%; The 2nd group is Radix Isatidis superfine powder group, addition 0.8%.More than 2 groups all by above-mentioned addition spice, continuous use 7 days.
Test method: preceding 3 weeks are adopted flat appearance, and 3 all backs are adopted and raised in cages the chickling free choice feeding; Freely drink water, illumination in the house, temperature and humidity requires to carry out in strict accordance with conventional feeding and management; Brood time is aided with artificial insulation, by immune programme for children chicken is carried out newcastle and fabricius bursa immunity.Carry out cleaning and sterilizing to the crib hopper every day, and the duration of test itemized record are respectively organized feed consumption and health status.
Test chicken is in 21 ages in days, and 35 ages in days and 49 ages in days are got 7 body weight at random for every group and butchered near the broiler chicken of average weight.Blood sampling when butchering, preparation serum, sample are in-20 ℃ of preservations, and be to be measured about index.Win thymus, spleen, fabricius bursa is rejected the fat back and is claimed fresh weight.
Immune organ index (%)=immune organ weight (g) * 100/ live body heavy (g).
Add the Radix Isatidis superfine powder in the diet to broiler thymus, spleen, the exponential influence of fabricius bursa
The broiler chicken immune organ outward appearance no abnormality seen that all are butchered can be known that by last table during 21 ages in days, superfine powder group thymus index all is higher than matched group, but difference is not remarkable.The index best result of 35 ages in days thymus during with 49 ages in days is not than coarse powder group high by 5.00% (P<0.05) and 15% (P<0.05), and during 21 ages in days, superfine powder group index and spleen index is significantly higher than coarse powder group (P<0.05).
The index and spleen index of superfine powder group is the highest during 35 ages in days, has improved 71.11% than coarse powder group.Superfine powder group fabricius bursa index improves 7.08% (P<0.05) than coarse powder group during 21 ages in days.
Evidence is compared with coarse powder, in feedstuff, adds the immunity that 0.8% Radix Isatidis superfine powder can obviously improve body, poultry is prevented and cured diseases play good health-care effect.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine according to the invention.
The specific embodiment
Like Fig. 1, shown in 2, superfine powder Radix Isatidis normal temperature preparation method of the present invention comprises the steps:
The first step, choose the Chinese medicine Radix Isatidis that root is long, sturdy evenly, the real mealiness of body is big and dry, cut into the long section of 3-5cm, natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃, the Radix Isatidis of cutting is pulverized, and obtaining granularity is 60-80 purpose coarse powder;
The 3rd goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins.
1, with the second step gained coarse powder place pulverize in the rod mill 16 after; Powder body to be fractionated is arranged in the downward screen drum 2 of JIKE 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16; And, powder body to be fractionated is disperseed in screen drum 2 through the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2; The order number of screen drum 2 is 500 orders;
2, dispersive powder body to be fractionated carries out classification through screen drum 2 down in air-introduced machine 5 effect in the screen drum 2, and fine powder negative pressure chamber 4 through JIKE 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to the superfine powder Radix Isatidis finished product that collection in the tornado feeder set 17 promptly gets particle diameter≤25 micron.The powder body sinking warp through screen drum 2 is collected with the funnel 3 that screen drum 2 under sheds are connected mutually and is transported in the said rod mill 16 circulation once more through pipeline 18 and pulverizes;
3, door font rotating spraying trachea rotates through rolling bearing 10 under drive motors 8 drives; The wind that aerator 11 is seen off is in blast pipe 9 gets into said transverse tube 6 and standpipe 7; And through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions; Form the evenly blowback air-flow in screen drum 2 at screen drum 2 end faces and side; Powder body in the screen drum 2 is further atomized, stop powder body on screen drum 2, to lump simultaneously and stop up sieve screen apertures, make the powder body that does not pass through screen drum 2 along with the air-flow whirlpool that forms sinks to getting in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder Radix Isatidis finished product that obtains is sub-packed in the aluminium foil bag, and every bag weighs 500g or 1000g.