CN102397452B - Submicron powder cough powder normal temperature preparation method - Google Patents

Submicron powder cough powder normal temperature preparation method Download PDF

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Publication number
CN102397452B
CN102397452B CN 201110382912 CN201110382912A CN102397452B CN 102397452 B CN102397452 B CN 102397452B CN 201110382912 CN201110382912 CN 201110382912 CN 201110382912 A CN201110382912 A CN 201110382912A CN 102397452 B CN102397452 B CN 102397452B
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powder
screen drum
air
cough
semen
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CN102397452A (en
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马仲彬
郭振环
李中亚
冯永健
温士杰
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
Henan Kangxing Pharmaceutical Co Ltd
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
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Abstract

The invention discloses a submicron powder cough powder normal temperature preparation method, which comprises the following steps that: rhizoma anemarrhenae, bitter orange, herba ephedra, balloon flower, bitter almond, lepidium seeds, cortex mori radicis, dried orange peel, gypsum, peucedanum root, blackberry lily, folium eriobotryae and liquorice are weighed according to proportion, dried and pulverized, and oil in the bitter almond and the lepidium seeds is extracted; the coarse powder and the dregs of the bitter almond and the lepdium seeds are mixed and are placed inside a rod mill to bepulverized, then the mixed powder is blown into a special two-way airflow screen grader to be screened to obtain the powder with the granularity being less than or equal to 25nm, and the powder is conveyed by the airflow produced by a draught fan into a cyclone collector to be collected and to obtain the cough submicron powder; the powder cannot pass through a 500-mesh sieve is collected by a funnel and is conveyed into the rod mill through a pipeline to be circularly pulverized; and the cough submicron powder finished product is obtained by adequately mixing the cough submicron powder and the bitter almond oil and the lepdium seed oil. The preparation method has the advantages that: the entire preparation process is carried out under the normal temperature, and the granularity of the finished product medicine is less than or equal to 25nm; and the two-way airflow screen grader which is utilized in the method can simplify the preparation process of the submicron powder cough powder.

Description

Superfine powder ZHIKE SAN normal temperature preparation method
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder ZHIKE SAN normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine for this method.
Background technology
Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The ZHIKE SAN that is used for birds at present is the powder of coarse pulverization, there are deficiencies such as dosage is big, dosage form thick, appearance poor, effective ingredient can not fully discharge, bioavailability is low, Chinese medicine quality and clinical therapeutic efficacy have been had a strong impact on, and can not evenly mix with pellet, can not directly add drinking-water and use.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability height, superfine powder ZHIKE SAN normal temperature preparation method that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder ZHIKE SAN normal temperature preparation method.
Superfine powder ZHIKE SAN normal temperature preparation method of the present invention comprises the steps:
The first step, take by weighing the Rhizoma Anemarrhenae, Fructus Aurantii, Herba Ephedrae, Radix Platycodonis, Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae), Cortex Mori, Pericarpium Citri Reticulatae, Gypsum Fibrosum, Radix Peucedani, Rhizoma Belamcandae, Folium Eriobotryae, Radix Glycyrrhizae successively according to the weight portion ratio of 5:4:3:6:5:5:5:5:6:5:5:4:3, clean, dry, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃ temperature above-mentioned Chinese medicine is pulverized respectively, obtains granularity 60~80 purpose Chinese medicine coarse powder; Extract the oil content in Semen Armeniacae Amarum, the Semen Lepidii (Semen Descurainiae) standby;
The 3rd step, with the coarse powder mix homogeneously of above-mentioned raw materials medicine, and then add Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae) medicinal residues, fully mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the ZHIKE SAN superfine powder; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation;
The 5th step, with the abundant mix homogeneously of Semen Armeniacae Amarum oil, tansymustard seed oil that the 4th step gained ZHIKE SAN superfine powder and second step extract, obtain superfine powder ZHIKE SAN finished product.The ZHIKE SAN superfine powder finished product of above-mentioned gained is sub-packed in the aluminium foil bag every bag heavy 100g, 200g, 500g, 1000g, 2000g etc.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m 3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m 3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, abnormal smells from the patient and the mouthfeel of medicine have also been improved simultaneously, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and takes, the ZHIKE SAN of ultra micro powder can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder ZHIKE SAN greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test drug and material:
The ZHIKE SAN superfine powder adopts the present invention's preparation.
ZHIKE SAN: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010, manufacture experimently at laboratory.
Staphylococcus aureus O 78: China Veterinary Drugs Supervisory Inst. provides.
Experimental animal: the chicken in 3 ages in week, body weight 640g~670g, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 5 groups at random, every group each 50.
The I group adopts ZHIKE SAN superfine powder high-dose therapy, and consumption is 1.0g/ days/;
The II group adopts dosage treatment in the ZHIKE SAN superfine powder, and consumption is 0.5g/ days/;
The III group adopts ZHIKE SAN superfine powder low dose treatment, and consumption is 0.25g/ days/;
The IV group adopts ZHIKE SAN, and the treatment consumption is 1.0g/ days/;
The V group is that counteracting toxic substances is not treated matched group.
Test method: with the staphylococcus aureus O that preserves 78Strain is cultivated, and the concentration of measuring bacterium liquid with colony counting method is 6 * 10 9CFU/mL.Except the blank group, other respectively organizes the counteracting toxic substances amount is every chicken intramuscular injection 1mL bacterium liquid.Take the sick chicken of clinical onset, make a definite diagnosis infection through laboratory, the test case of being allowed for access is evenly sneaked into trial drug in the feedstuff by above-mentioned variable concentrations and to be fed, and is used in conjunction 5 days, and therapeutic effect sees Table 1.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 1 variable concentrations ZHIKE SAN superfine powder is to the therapeutic effect of chicken staphylococcus aureus disease
Group Cure rate (%) Obvious effective rate (%) Effective percentage (%) Inefficiency (%)
98.1 1.9 100 0
92.5 7.5 98.3 1.7
86 5 89.1 11.9
82.0 10.2 92.5 7.5
- - - 85.5
The result of the test of table 1 shows: the ZHIKE SAN superfine powder of different treatment consumptions all has the obvious treatment effect to chicken staphylococcus aureus disease, and the more big effect of consumption is more good, and the therapeutic effect of ZHIKE SAN superfine powder high dose and middle dosage group all obviously is better than the ZHIKE SAN group.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, superfine powder ZHIKE SAN normal temperature preparation method of the present invention comprises the steps:
The first step, take by weighing the Rhizoma Anemarrhenae, Fructus Aurantii, Herba Ephedrae, Radix Platycodonis, Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae), Cortex Mori, Pericarpium Citri Reticulatae, Gypsum Fibrosum, Radix Peucedani, Rhizoma Belamcandae, Folium Eriobotryae, Radix Glycyrrhizae successively according to the weight portion ratio of 5:4:3:6:5:5:5:5:6:5:5:4:3, clean, dry, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃ temperature above-mentioned Chinese medicine is pulverized respectively, obtains granularity 60~80 purpose Chinese medicine coarse powder; Extract wherein oil content standby with No. 6 solvent naphtha extractions the oil content in Semen Armeniacae Amarum, the Semen Lepidii (Semen Descurainiae);
The 3rd step, with the coarse powder mix homogeneously of above-mentioned raw materials medicine, and then add Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae) medicinal residues, fully mix homogeneously;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m 3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m 3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated that disperses in the screen drum 2 carries out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the ZHIKE SAN superfine powder.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters;
The 5th step, with the abundant mix homogeneously of Semen Armeniacae Amarum oil, tansymustard seed oil that the 4th step gained ZHIKE SAN superfine powder and second step extract, obtain superfine powder ZHIKE SAN finished product.
The superfine powder ZHIKE SAN finished product of preparation is sub-packed in the aluminium foil bag and stores, every bag heavy 500g or 1000g.

Claims (2)

1. a superfine powder ZHIKE SAN normal temperature preparation method is characterized in that: comprise the steps:
The first step, take by weighing the Rhizoma Anemarrhenae, Fructus Aurantii, Herba Ephedrae, Radix Platycodonis, Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae), Cortex Mori, Pericarpium Citri Reticulatae, Gypsum Fibrosum, Radix Peucedani, Rhizoma Belamcandae, Folium Eriobotryae, Radix Glycyrrhizae successively according to the weight portion ratio of 5:4:3:6:5:5:5:5:6:5:5:4:3, clean, dry, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃ temperature above-mentioned Chinese medicine is pulverized respectively, obtains granularity 60~80 purpose Chinese medicine coarse powder; Extract the oil content in Semen Armeniacae Amarum, the Semen Lepidii (Semen Descurainiae) standby;
The 3rd step, with the coarse powder mix homogeneously of above-mentioned raw materials medicine, and then add Semen Armeniacae Amarum, Semen Lepidii (Semen Descurainiae) medicinal residues, fully mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to that collection namely gets the ZHIKE SAN superfine powder in the tornado feeder set (17); The powder of not crossing 500 mesh sieves is transported to circulation pulverizing again in the described rod mill (16) through funnel (3) collection and by pipeline (18);
The 5th step, with the abundant mix homogeneously of Semen Armeniacae Amarum oil, tansymustard seed oil that the 4th step gained ZHIKE SAN superfine powder and second step extract, obtain superfine powder ZHIKE SAN finished product;
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. superfine powder ZHIKE SAN normal temperature preparation method according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m 3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m 3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
CN 201110382912 2011-11-28 2011-11-28 Submicron powder cough powder normal temperature preparation method Active CN102397452B (en)

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CN102671175B (en) * 2012-05-23 2017-09-29 天津生机集团股份有限公司 A kind of traditional Chinese medicine oral liquid for preventing and treating chicken respiratory tract disease and preparation method thereof
CN103156983A (en) * 2013-03-12 2013-06-19 山东春雪药业有限公司 Feed traditional Chinese medicine additive for preventing broiler chicken respiratory diseases and production method thereof
CN104922412A (en) * 2015-07-08 2015-09-23 李学军 Traditional Chinese medicine for treating laying hen respiratory tract diseases

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CN102512582B (en) * 2011-11-28 2013-08-28 河南省康星药业股份有限公司 Normal-temperature preparation method for ultrafine lung-regulating and cough-relieving powder and special bilateral airflow sieving machine thereof
CN102512520B (en) * 2011-11-28 2013-08-21 河南省康星药业股份有限公司 Normal-temperature preparation method for ultrafine powder hawthorn
CN102512514B (en) * 2011-11-28 2013-08-28 河南省康星药业股份有限公司 Normal-temperature preparation method for ultrafine coccidia powder and special bilateral airflow sieving machine thereof
CN102512509B (en) * 2011-11-28 2013-08-28 河南省康星药业股份有限公司 Normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder and special bidirectional airflow sieving machine thereof
CN102488720B (en) * 2011-11-28 2013-08-28 河南省康星药业股份有限公司 Preparation method for submicron pine needle powder at normal temperature and special bidirectional air-flow screening machine
CN102512545B (en) * 2011-11-28 2013-08-28 河南省康星药业股份有限公司 Submicron powder bazheng powder normal temperature preparation method and special bidirectional airflow sieving machine thereof

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