CN102397313B - Preparation method of superfine artemisia apiacea powder at normal temperature - Google Patents
Preparation method of superfine artemisia apiacea powder at normal temperature Download PDFInfo
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- CN102397313B CN102397313B CN 201110382941 CN201110382941A CN102397313B CN 102397313 B CN102397313 B CN 102397313B CN 201110382941 CN201110382941 CN 201110382941 CN 201110382941 A CN201110382941 A CN 201110382941A CN 102397313 B CN102397313 B CN 102397313B
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Abstract
The invention discloses a preparation method of superfine artemisia apiacea powder at normal temperature, which comprises the following steps of: firstly, cleaning and airing a Chinese herbal medicine, namely artemisia apiacea, cutting the artemisia apiacea into long sections, and drying the long sections until the water content is less than or equal to 10 percent; secondly, crushing the sectionedcut traditional Chinese medicine at normal temperature to obtain crude powder of which the particle size is 60 to 100 meshes; thirdly, after crushing the obtained crude powder in a rod mill, blowing the crushed powder into a special bidirectional airflow screening machine to sieve the powder with a 500-mesh sieve to obtain powder of which the particle size is less than or equal to 25 microns, andcollecting the powder by conveying the powder into a cyclone collector through airflow generated by a draught fan, namely the finished product of the superfine artemisia apiacea powder is obtained; and finally, colleting the powder which does not pass through the 500-mesh sieve with a hopper, and conveying the powder into the rod mill through a pipeline to circularly crush the power again. The preparation method has the advantages that: the whole preparation process is performed at normal temperature and the particle size of the prepared finished medical product is less than or equal to 25 microns, so the cell wall-broken rate and the bioavailability are greatly improved; and due to the bidirectional airflow screening machine used in the preparation method, the preparation process of the superfine artemisia apiacea powder is simplified, and the aim of controlling the quality standard of Chinese herba powder is fulfilled.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to the diffusing normal temperature preparation method of superfine powder Herba Artemisiae Annuae; The invention still further relates to the special-purpose two-way airflow screening machine for this method.
Background technology
Chicken coccidiosis is that the multiple coccidiosis by Eimeria parasitizes caused a kind of protozoacide in the enterocyte of chicken, and in various fowl disease, the incidence rate of coccidiosis is the highest, and its sickness rate reaches 50～70%, mortality rate 20～30%.It is reported that the direct economic loss that the whole world causes because of chicken coccidiosis every year reaches 2,000,000,000 dollars.The annual expense of anticoccidial drug that is used for of China is up to 1,000,000,000～1,800,000,000 yuans.Every plumage broiler on average consumes 0.2～0.3 yuan of anticoccidial expense.For a long time, the main means of control chicken coccidiosis are to use antibiotics and chemical synthetic drug, these medicines have played important function to the control of chicken coccidiosis, but raiser and veterinary work person are being perplexed in chemical sproof generation always, though some chicken group uses anticoccidial drug, still faces the generation of coccidiosis and even the threat that breaks out.In addition, chemicals and antibiotic control chicken coccidiosis because meat, the egg Chinese medicine of chicken are residual, have reduced the meat of chicken, quality and the safety of egg product. and both influence the foreign trade competitiveness, brought potential hazard to human health again.In recent years, the research of Immune Prevention of Avian Coccidiosis has had certain progress, but it is applied and remains in some problems.Chinese herbal medicine is the culture rarity of China, carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The Herba Artemisiae Annuae beginning is stated from the handbook of Prescription for Emergency with more than the 300 year Ge Hong of the Eastern Jin Dynasty in Christian era, and the medicinal record of Herba Artemisiae Annuae is all arranged in later successive dynasties doctor's nationality and the Compendium of Material Medica.Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae annuae, and modern study confirms that Herba Artemisiae Annuae not only has " clearing away summer-heat, hemostasis and dysentery-stopping.Control poultry heatstroke, accumulation of food in the stomach and intes tine due to indigestion, anemopyretic cold and chicken flea " effect, Herba Artemisiae Annuae have the plasmodial effect for the treatment of simultaneously.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder Herba Artemisiae Annuae normal temperature preparation method that looses, efficiently solve present production Herba Artemisiae Annuae loose have that energy consumption is big, the medicine maximum particle diameter is difficult to accurate control, can't produce continuously, difficult problems such as dust is many in the production process, make the finished medicines of preparation have rapid-action, good effect, bioavailability height, effect that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to the diffusing normal temperature preparation method of superfine powder Herba Artemisiae Annuae.
The superfine powder Herba Artemisiae Annuae of the present invention normal temperature preparation method that looses comprises the steps:
The first step, the Chinese crude drug Herba Artemisiae Annuae is cleaned, dried, cut into the long section of 3-5cm and dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ the Chinese medicine of cutting is pulverized, and obtaining granularity is 60-100 purpose coarse powder;
The 3rd step, with the second step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the superfine powder Herba Artemisiae Annuae finished product that looses; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation have been improved cell wall breaking rate and bioavailability greatly, have strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, also improved abnormal smells from the patient and the mouthfeel of medicine simultaneously, improve drug quality, prolonged storage life; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology that the superfine powder Herba Artemisiae Annuae looses greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
Clinical therapeutic efficacy according to the superfine powder Herba Artemisiae Annuae powder preparation of the inventive method preparation is verified by following test:
Test example one: superfine powder artemisia preparation of the present invention is to the clinical efficacy of night blindness intestinal coccidiosis
Test drug and material:
The superfine powder Herba Artemisiae Annuae looses, and adopts the present invention's preparation.
The Herba Artemisiae Annuae coarse powder: 80 order coarse powder, make by oneself at laboratory.
Diclazuril: content 99%, 100g/ bag, laboratory self-control.
Coccidian oocyst: the tender eimeria tenella of chicken (
E.tenella) the spore coccidian oocyst, effluent south agriculture university parasite laboratory provides.
Experimental animal: the assorted chicken of healthy 817 meat of 13 ages in days, totally 150.Isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 5 groups at random, every group of 30 chickens.
The I group adopts the superfine powder Herba Artemisiae Annuae to loose and treats, and feeds by 0.5% spice of feedstuff total amount;
The II group adopts the treatment of Herba Artemisiae Annuae coarse powder, feeds by 0.5% spice of feedstuff total amount;
The III group adopts the diclazuril treatment, feeds by the addition spice of 1mg/Kg feedstuff;
The IV group only infects and does not treat for infecting matched group;
The V group is the blank group, does not infect and does not treat.
Test method: except blank, every equal per oral inoculation 0.2ml during other 4 group of 15 age in days
E.tenellaSpore egg capsule suspension (contains spore egg capsule 8.0 * 10
4Individual).Infect the same day of coccidian oocyst, except blank, each administration group is evenly sneaked in the feedstuff according to above-mentioned variable concentrations and is fed, and is used in conjunction 5 days.
Infecting the promoting the circulation of blood of going forward side by side of back checkout facility chicken spirit every day, appetite, feces just keeps the score.Infected after the same day and the administration the 8th day, and weighed, calculate survival rate, rate of body weight gain of each group; And chicken all catched and killed cut open inspection, observe and carry out that caecum lesion is kept the score, hemafecia is kept the score; Calculate caecum egg sac number, egg capsule value and anticoccidial index (ACI).
Criterion:
Test chicken sum in survival rate (%)=group internal memory live chickens number/group * 100
The relative weight gain rate=(average weight gain of the average weight gain of each infected group/blank group) * 100%
Feces is kept the score with reference to the standard of Morehouse and Baron.
Caecum lesion is kept the score and with reference to Johnson and Reid 0-4 branch standard caecum lesion is kept the score, again by group average lesion score * 10.
The egg capsule value is got and is respectively organized feces, fully mixing, weigh, count the egg sac number (OPG) of every gram feces with the Maxwell, and be converted into the egg capsule value by angle Sesbania cannabina (Retz.) Pers. method.
Anticoccidial index (ACI)=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value)
Effect assessment is judged anticoccidial effect according to ACI: ACI＞180, and anticoccidial is efficient; ACI is 160-180, imitates in the anticoccidial; ACI is 120-160, the anticoccidial poor efficiency; ACI＜120, anticoccidial is invalid.
The tender eimeria tenella effect assessments of anti-chicken such as table 1 Herba Artemisiae Annuae superfine powder
Result of the test sees Table 1: compare with matched group, the diffusing group of superfine powder Herba Artemisiae Annuae, Herba Artemisiae Annuae coarse powder group and diclazuril group all have positive effect to the treatment of the tender eimeria tenella of chicken, the anticoccidial index is respectively 188,178 and 179, and the curative effect of the diffusing group of superfine powder Herba Artemisiae Annuae obviously is better than Herba Artemisiae Annuae coarse powder group and diclazuril group.In view of the Chinese medicine Herba Artemisiae Annuae be difficult for to produce chemical sproof characteristics, it is better to loose to treat the chicken cecal coccidiosis effect with the superfine powder Herba Artemisiae Annuae.And when Isodose used, the superfine powder Herba Artemisiae Annuae loose and has the incomparable superiority of Herba Artemisiae Annuae coarse powder.
Test example two: the superfine powder Herba Artemisiae Annuae looses to the clinical efficacy of chicken small intestinal coccidiosis
Test drug and material:
The superfine powder Herba Artemisiae Annuae looses, and adopts the present invention's preparation.
The Herba Artemisiae Annuae coarse powder: 80 order coarse powder, make by oneself at laboratory.
Diclazuril: content 99%, 100g/ bag, laboratory self-control.
Coccidian oocyst: the huge eimeria tenella egg capsule of chicken, effluent south agriculture university parasite laboratory provides.
Experimental animal: 1 age in days Luo Man egg is raised with non-ball worm feedstuff and drinking-water with public young, and the full price of the feeding pellet of brooding does not wherein add any medicine, and the mode of adopt free choice feeding, freely drinking water is raised.During 11 ages in days, it is close to choose the body constitution amount, and confirms as 150 of healthy chickling through observation, is divided into 5 groups at random, and 30 every group, the situation of specifically dividing into groups is as follows:
The I group adopts the superfine powder Herba Artemisiae Annuae to loose and treats, and feeds by 1% spice of forage volume;
The II group adopts the treatment of Herba Artemisiae Annuae coarse powder, feeds by 1% spice of forage volume;
The III group adopts the diclazuril treatment, feeds by the addition spice of 1mg/Kg feedstuff;
The IV group only infects and does not treat for infecting matched group;
The V group is the blank group, does not infect and does not treat.
Test method: except blank, every chickling infects huge eimeria tenella spore egg capsule 1.0 * 10 during other 4 group of 14 age in days
5Individual/only.Infect the same day of coccidian oocyst, except blank, each administration group is evenly sneaked in the feedstuff according to above-mentioned variable concentrations and is fed, and is used in conjunction 5 days.Infect the back and slaughtered the Total Test chicken on the 8th day.And infecting the coccidiosis same day and infecting the back and weighed on an empty stomach in the 8th day.
Incidence, the clinical symptoms of chicken respectively organized in observation every day and record behind the inoculation coccidiosis.Infect the back and check feces the 4th, 5,6,7 day every day, record hemafecia situation is carried out the egg capsule counting, and dead chicken is in time cutd open inspection, finds out the cause of death.
Criterion:
Survival rate (%)=survival chicken number/(test chicken sum-Yin Fei coccidium infection factor and die unexpectedly chicken number) * 100%.
The relative weight gain rate=administration group or infect the rate of body weight gain of not administration group/infect rate of body weight gain * 100% of not administration group.
Lesion score and pathological changes value lesion score are kept the score according to the order of severity of cuing open inspection rear intestinal pathological changes by 5 fens systems of Johnson etc. standard of keeping the score.Pathological changes value=every group of average lesion score * 10.
The egg capsule value converts according to the gram feces egg capsule value method of angle Sesbania cannabina (Retz.) Pers..
The anticoccidial index is with the criterion calculation anticoccidial index of Merck company.Anticoccidial index (ACI)=(the relative weight gain rate+survival rate)-(pathological changes value+egg capsule value+hemafecia is kept the score).
Drug effect criterion: when ACI＜120, be judged to be weak curative effect; When ACI is 120-160, it is medium to be judged to be curative effect; When ACI is 160-180, it is good to be judged to be curative effect; When ACI＞180, it is outstanding to be judged to be curative effect.
Feces is kept the score and is observed the 4th, 5,6 day the feces in inoculation back, keeps the score with reference to the method for Morehouse etc.
The huge eimeria tenella effect assessments of anti-chicken such as table 2 chicken coccidia powder superfine powder
Result of the test sees Table 2: compare with matched group, the superfine powder Herba Artemisiae Annuae looses to organize chicken coccidiosis is had the obvious treatment effect, and the anticoccidial index is 188.9, belongs to the outstanding medicine of curative effect.And the anticoccidial index of Herba Artemisiae Annuae coarse powder group and diclazuril group is respectively 177.6 and 176.8, and therapeutic effect all slightly is worse than the diffusing group of superfine powder Herba Artemisiae Annuae.This shows, loose to treat the sick better effects if of the huge eimeria tenella of chicken with the superfine powder Herba Artemisiae Annuae, not only can avoid the chemical sproof generation of antibiotic and chemical synthetic drug, and with the Herba Artemisiae Annuae coarse powder when waiting dosage use, have the advantage that the Herba Artemisiae Annuae coarse powder can not be substituted.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, the superfine powder Herba Artemisiae Annuae of the present invention normal temperature preparation method that looses comprises the steps:
The first step, the Chinese crude drug Herba Artemisiae Annuae is cleaned, dried, cut into the long section of 3-5cm and dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ the Chinese medicine of cutting is pulverized, and obtaining granularity is 60-100 purpose coarse powder;
The 3rd goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins.
1, the second step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the screen drum 2 interior powder body to be fractionated that disperse carry out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the diffusing finished product of superfine powder Herba Artemisiae Annuae.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The diffusing finished product of superfine powder Herba Artemisiae Annuae that obtains is sub-packed in the aluminium foil bag, and every bag weighs 500g or 1000g.
Claims (2)
1. the diffusing normal temperature preparation method of superfine powder Herba Artemisiae Annuae is characterized in that: comprise the steps:
The first step, the Chinese crude drug Herba Artemisiae Annuae is cleaned, dried, cut into the long section of 3-5cm and dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ the Chinese medicine of cutting is pulverized, and obtaining granularity is 60-100 purpose coarse powder;
The 3rd step, with the second step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported in the tornado feeder set (17) collection and namely gets the superfine powder Herba Artemisiae Annuae finished product that looses; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing again in the described rod mill (16) through funnel (3) collection and by pipeline (18);
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. the superfine powder Herba Artemisiae Annuae according to claim 1 normal temperature preparation method that looses, it is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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Non-Patent Citations (4)
| Title |
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| 中药青蒿的历史沿革及药理临床新进展;任振宇;《天津药学》;19930228;第5卷(第1期);32－34页 * |
| 任振宇.中药青蒿的历史沿革及药理临床新进展.《天津药学》.1993,第5卷(第1期),32－34页. |
| 分级技术在中药超细粉体生产中的应用;王劲等;《中国粉体技术》;20080225(第1期);第36-38页 * |
| 王劲等.分级技术在中药超细粉体生产中的应用.《中国粉体技术》.2008,(第1期),第36-38页. |
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