CN102406546B - Normal temperature preparation method of superfine asthma treatment powder - Google Patents

Normal temperature preparation method of superfine asthma treatment powder Download PDF

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Publication number
CN102406546B
CN102406546B CN 201110382929 CN201110382929A CN102406546B CN 102406546 B CN102406546 B CN 102406546B CN 201110382929 CN201110382929 CN 201110382929 CN 201110382929 A CN201110382929 A CN 201110382929A CN 102406546 B CN102406546 B CN 102406546B
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powder
semen
screen drum
radix
superfine
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CN102406546A (en
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张国祖
郭振环
杨彩霞
李中亚
张永昌
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
Henan Kangxing Pharmaceutical Co Ltd
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HENAN HEALTH STAR PHARMACEUTICAL CO Ltd
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Abstract

The invention discloses a normal temperature preparation method of superfine asthma treatment powder, which comprises the following steps of: firstly, selecting Chinese medicinal herbs comprising white mulberry rootbark, fried bitter apricot seed, radish seed, pepperweed seed, fructus perillae, codonopsis pilosula, rhizoma atractylodis macrocephalae, caulis aristolochiae manshuriensis, rheum officinale, radix curcumae, scutellaria baicalensis and cape jasmine according to proportion; crushing five Chinese herbal medicines comprising the fried bitter apricot seed, the radish seed, the pepperweed seed, the fructus perillae and the cape jasmine at normal temperature and extracting oil components; crushing other medicines into rough powder; crushing the rough powder, entering a special two-way airflow screening machine by wind for screening by using a sieve in 500 meshes to obtain powder with the particle diameter of smaller than or equal to 25 microns for being delivered into a cyclone collector for collecting by airflow generated by a draught fan; collecting powder which is not screened by the sieve in 500 meshes through a hopper and delivering the powder into a rod mill through a pipeline for carrying out circulation crushing again; and fully and uniformly stirring the superfine powder of the collected asthma treatment powder with the extracted medicine oil components to obtain the superfine asthma treatment powder finished product. The invention has the advantages of having the finished medicament particle diameter of smaller than or equal to 25 microns, improving the cell wall breaking rate and bioavailability, strengthening the pharmacological effect and saving Chinese medicinal herbs.

Description

Superfine powder ding chuan san, powder for curing asthma normal temperature preparation method
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder ding chuan san, powder for curing asthma normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine that is used for this method.
Background technology
Chinese herbal medicine is the culture rarity of China, first Shennong's Herbal that the works relevant with natural drug is China in the world, Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The ding chuan san, powder for curing asthma that is applied to poultry at present is the powder of coarse powder, there are deficiencies such as dosage is big, dosage form thick, appearance poor, effective ingredient can not fully discharge, bioavailability is low, Chinese medicine quality and clinical therapeutic efficacy have been had a strong impact on, and can not with pellet uniform mixing, the defectives such as use of can not directly drinking water.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability height, superfine powder ding chuan san, powder for curing asthma normal temperature preparation method that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder ding chuan san, powder for curing asthma normal temperature preparation method.
Superfine powder ding chuan san, powder for curing asthma normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Cortex Mori, Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (stir-fry), Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae, Fructus Gardeniae in following ratio, Cortex Mori wherein: Semen Armeniacae Amarum (parched): Semen Raphani: Semen Lepidii (Semen Descurainiae): Fructus Perillae: Radix Codonopsis: the Rhizoma Atractylodis Macrocephalae (stir-fry): Caulis Aristolochiae Manshuriensis: Radix Et Rhizoma Rhei: Radix Curcumae: Radix Scutellariae: Fructus Gardeniae=5:4:6:6:4:6:4:4:6:5:5:5, clean the Rhizoma Atractylodis Macrocephalae (stir-frys), Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae earlier, dry and cut into long section of 3-5cm and dry to moisture≤10%;
Second step, under 20 ℃~25 ℃ temperature, crude drug Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor Chinese crude drugs are pulverized, after obtaining granularity and being 60~80 purpose coarse powder, extracted wherein oil content standby; Again remaining other crude drug are crushed to granularity 60~80 purpose coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder and Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor medicinal residues mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and promptly gets the ding chuan san, powder for curing asthma superfine powder; The powder of not crossing 500 mesh sieves arrives circulation pulverizing once more in the described rod mill through the funnel collection and by line transportation;
The 5th goes on foot, the ding chuan san, powder for curing asthma superfine powder of the 4th step collection and the Chinese medicine of the five flavours oil content that extracts in second step is stirred, and obtains superfine powder ding chuan san, powder for curing asthma finished product.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that constitutes by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m 3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m 3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, also improve simultaneously the abnormal smells from the patient and the mouthfeel of medicine, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder ding chuan san, powder for curing asthma greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test drug and material:
The ding chuan san, powder for curing asthma superfine powder adopts the inventive method preparation.
Ding chuan san, powder for curing asthma:, manufacture experimently at laboratory according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010.
Avian infectious bronchitis virus O 78: Henan agricultural university fowl diseases institute provides.
Experimental animal: two A broiler in 3 ages in week, body weight 630g~670g, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 5 groups at random,
The I group adopts ding chuan san, powder for curing asthma superfine powder high-dose therapy, and consumption is 0.5g/ days/;
The II group adopts dosage treatment in the ding chuan san, powder for curing asthma superfine powder, and consumption is 0.3g/ days/;
The III group adopts ding chuan san, powder for curing asthma, and the treatment consumption is 0.4g/ days/;
The IV group is not for treating matched group.
Test method: except that the blank group, allow other respectively organize infected chicken infectious bronchitis virus O 78Take the chicken of clinical onset, make a definite diagnosis infection through laboratory, the test case of being allowed for access is evenly sneaked into trial drug in the feedstuff by above-mentioned variable concentrations and to be fed, logotype 5 days, and therapeutic effect sees Table 1.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 1 variable concentrations ding chuan san, powder for curing asthma superfine powder is to the therapeutic effect of chicken bronchitis
Group Cure rate (%) Obvious effective rate (%) Effective percentage (%) Inefficiency (%)
95.5 4.5 100 0
90.5 7.8 97 3
82.0 10.2 92.2 7.8
- - - 88.4
Result of the test shows: the ding chuan san, powder for curing asthma ultrafine preparation of different treatment consumptions all has the obvious treatment effect to infectious bronchitis of chicken, and the big more effect of consumption is good more.Compare with the ding chuan san, powder for curing asthma superfine powder that uses suitable dosage, the therapeutic effect of ding chuan san, powder for curing asthma coarse powder has big gap.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, superfine powder ding chuan san, powder for curing asthma normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Cortex Mori, Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (stir-fry), Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae, Fructus Gardeniae in following ratio, Cortex Mori wherein: Semen Armeniacae Amarum (parched): Semen Raphani: Semen Lepidii (Semen Descurainiae): Fructus Perillae: Radix Codonopsis: the Rhizoma Atractylodis Macrocephalae (stir-fry): Caulis Aristolochiae Manshuriensis: Radix Et Rhizoma Rhei: Radix Curcumae: Radix Scutellariae: Fructus Gardeniae=5:4:6:6:4:6:4:4:6:5:5:5, clean the Rhizoma Atractylodis Macrocephalae (stir-frys), Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae earlier, dry and cut into long section of 3-5cm and dry to moisture≤10%;
Second step, under 20 ℃~25 ℃ temperature, crude drug Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor Chinese crude drugs are pulverized, after obtaining granularity and being 60~80 purpose coarse powder, extracted wherein oil content standby; Again remaining other crude drug are crushed to granularity 60~80 purpose coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder and Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor medicinal residues mix homogeneously;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m 3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m 3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and, powder body to be fractionated is disperseed in screen drum 2 by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2; The order number of screen drum 2 is 500 orders;
2, dispersive powder body to be fractionated carries out classification by screen drum 2 in the screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and promptly gets the ding chuan san, powder for curing asthma superfine powder; The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing once more in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form the evenly blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body on screen drum 2, to lump simultaneously and stop up sieve screen apertures, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters;
The 5th goes on foot, the ding chuan san, powder for curing asthma superfine powder of the 4th step collection and the Chinese medicine of the five flavours oil content that extracts in second step is stirred, and obtains superfine powder ding chuan san, powder for curing asthma finished product.
The superfine powder ding chuan san, powder for curing asthma finished product of gained is sub-packed in the aluminium foil bag, every bag 500 g or 1000g storage.

Claims (2)

1. a superfine powder ding chuan san, powder for curing asthma normal temperature preparation method is characterized in that: comprise the steps:
The first step, choose crude drug Cortex Mori, Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae, Fructus Gardeniae in following ratio, Cortex Mori wherein: Semen Armeniacae Amarum (parched): Semen Raphani: Semen Lepidii (Semen Descurainiae): Fructus Perillae: Radix Codonopsis: the Rhizoma Atractylodis Macrocephalae: Caulis Aristolochiae Manshuriensis: Radix Et Rhizoma Rhei: Radix Curcumae: Radix Scutellariae: Fructus Gardeniae=5:4:6:6:4:6:4:4:6:5:5:5, clean the Rhizoma Atractylodis Macrocephalae, Caulis Aristolochiae Manshuriensis, Radix Et Rhizoma Rhei, Radix Curcumae, Radix Scutellariae earlier, dry and cut into the long section of 3-5cm and dry to moisture≤10%;
Second step, under 20 ℃~25 ℃ temperature, crude drug Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor Chinese crude drugs are pulverized, after obtaining granularity and being 60~80 purpose coarse powder, extracted wherein oil content standby; Again remaining other crude drug are crushed to granularity 60~80 purpose coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder and Semen Armeniacae Amarum (parched), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Fructus Gardeniae 5 flavor medicinal residues mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collect in the tornado feeder set (17) and promptly gets the ding chuan san, powder for curing asthma superfine powder; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing once more in the described rod mill (16) through funnel (3) collection and by pipeline (18);
The 5th goes on foot, the ding chuan san, powder for curing asthma superfine powder of the 4th step collection and the Chinese medicine of the five flavours oil content that extracts in second step is stirred, and obtains superfine powder ding chuan san, powder for curing asthma finished product;
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that constitutes by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. superfine powder ding chuan san, powder for curing asthma normal temperature preparation method according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m 3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m 3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m 3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
CN 201110382929 2011-11-28 2011-11-28 Normal temperature preparation method of superfine asthma treatment powder Active CN102406546B (en)

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CN102406688B (en) * 2011-11-28 2013-12-04 河南省康星药业股份有限公司 Normal-temperature preparation method of codonopsis pilosula submicron powder
CN104027250B (en) * 2014-04-25 2017-02-15 江苏华冠生物技术股份有限公司 Active release processing method for Chinese herbal medicine raw materials

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WO2010042151A2 (en) * 2008-10-08 2010-04-15 Kalidindi Sanyasi R Method for alternately sifting and blending powders in the same operation

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