CN102382080A - 一种多西他赛的制备方法 - Google Patents
一种多西他赛的制备方法 Download PDFInfo
- Publication number
- CN102382080A CN102382080A CN2011104198268A CN201110419826A CN102382080A CN 102382080 A CN102382080 A CN 102382080A CN 2011104198268 A CN2011104198268 A CN 2011104198268A CN 201110419826 A CN201110419826 A CN 201110419826A CN 102382080 A CN102382080 A CN 102382080A
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- preparation
- docetaxel
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- compound
- solvent
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- YWLXLRUDGLRYDR-SKXCCXORSA-N CC(C)([C@@](C1)([C@H](C([C@]2([C@@H](C[C@@H]3O)OC2)OC(C)=O)[C@]3(C)C([C@@H]2O)=O)OC(c3ccccc3)=O)O)C2=C(C)[C@H]1O Chemical compound CC(C)([C@@](C1)([C@H](C([C@]2([C@@H](C[C@@H]3O)OC2)OC(C)=O)[C@]3(C)C([C@@H]2O)=O)OC(c3ccccc3)=O)O)C2=C(C)[C@H]1O YWLXLRUDGLRYDR-SKXCCXORSA-N 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201110419826.8A CN102382080B (zh) | 2011-12-15 | 2011-12-15 | 一种多西他赛的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201110419826.8A CN102382080B (zh) | 2011-12-15 | 2011-12-15 | 一种多西他赛的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102382080A true CN102382080A (zh) | 2012-03-21 |
CN102382080B CN102382080B (zh) | 2014-06-18 |
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CN201110419826.8A Active CN102382080B (zh) | 2011-12-15 | 2011-12-15 | 一种多西他赛的制备方法 |
Country Status (1)
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CN (1) | CN102382080B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108997265A (zh) * | 2018-09-07 | 2018-12-14 | 江苏红豆杉药业有限公司 | 一种多西他赛中间体脱保护基团的方法 |
CN109836401A (zh) * | 2017-11-28 | 2019-06-04 | 正大天晴药业集团股份有限公司 | 一种多西他赛的纯化方法 |
CN111138386A (zh) * | 2019-12-30 | 2020-05-12 | 重庆市碚圣医药科技股份有限公司 | 一种多西他赛的半合成方法 |
CN115650882A (zh) * | 2022-11-14 | 2023-01-31 | 肇庆学院 | 一种多西他赛杂质及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1087905A (zh) * | 1992-10-05 | 1994-06-15 | 罗纳-布朗克罗莱尔股份有限公司 | 制备塔三烷衍生物的方法 |
CN101088994A (zh) * | 2006-06-12 | 2007-12-19 | 上海龙翔生物医药开发有限公司 | 一种紫杉醇和多西紫杉醇的合成方法 |
WO2008054233A2 (en) * | 2006-10-31 | 2008-05-08 | Instytut Farmaceutyczny | Process for the preparation of docetaxel |
WO2008072849A1 (en) * | 2006-12-14 | 2008-06-19 | Hanmi Pharm. Co., Ltd. | Method of preparing docetaxel and intermediates used therein |
-
2011
- 2011-12-15 CN CN201110419826.8A patent/CN102382080B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1087905A (zh) * | 1992-10-05 | 1994-06-15 | 罗纳-布朗克罗莱尔股份有限公司 | 制备塔三烷衍生物的方法 |
CN101088994A (zh) * | 2006-06-12 | 2007-12-19 | 上海龙翔生物医药开发有限公司 | 一种紫杉醇和多西紫杉醇的合成方法 |
WO2008054233A2 (en) * | 2006-10-31 | 2008-05-08 | Instytut Farmaceutyczny | Process for the preparation of docetaxel |
WO2008072849A1 (en) * | 2006-12-14 | 2008-06-19 | Hanmi Pharm. Co., Ltd. | Method of preparing docetaxel and intermediates used therein |
Non-Patent Citations (3)
Title |
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CHUAN-MIN QI,等: "A Novel Method to Synthesize Docetaxel and its Isomer With High Yields", 《J. HETEROCYCLIC CHEM.》 * |
JAE HO HEO,等: "Development of New Efficient Synthetic Methods for Docetaxel", 《BULL. KOREAN CHEM. SOC.》 * |
李鹏,等: "多西他赛的合成", 《中国医药工业杂志》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109836401A (zh) * | 2017-11-28 | 2019-06-04 | 正大天晴药业集团股份有限公司 | 一种多西他赛的纯化方法 |
CN109836401B (zh) * | 2017-11-28 | 2023-02-14 | 正大天晴药业集团股份有限公司 | 一种多西他赛的纯化方法 |
CN108997265A (zh) * | 2018-09-07 | 2018-12-14 | 江苏红豆杉药业有限公司 | 一种多西他赛中间体脱保护基团的方法 |
CN111138386A (zh) * | 2019-12-30 | 2020-05-12 | 重庆市碚圣医药科技股份有限公司 | 一种多西他赛的半合成方法 |
CN115650882A (zh) * | 2022-11-14 | 2023-01-31 | 肇庆学院 | 一种多西他赛杂质及其制备方法 |
Also Published As
Publication number | Publication date |
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CN102382080B (zh) | 2014-06-18 |
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C06 | Publication | ||
PB01 | Publication | ||
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ASS | Succession or assignment of patent right |
Owner name: YANGTZE RIVER PHARMACEUTICAL CO., LTD. Effective date: 20140508 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20140508 Address after: 225321 No. 8, Tai Tay Road, Binjiang Industrial Park, Taizhou Economic Development Zone, Jiangsu, China Applicant after: Jiangsu Haici Biological Pharmaceutical Co., Ltd. of Yangtze River Pharmaceutical Group Applicant after: Yangtze River Pharmaceutical Co., Ltd. Address before: 225321 No. 8, Tai Tay Road, Binjiang Industrial Park, Taizhou Economic Development Zone, Jiangsu, China Applicant before: Jiangsu Haici Biological Pharmaceutical Co., Ltd. of Yangtze River Pharmaceutical Group |
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C14 | Grant of patent or utility model | ||
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