CN102343029B - Chinese medicinal composition preparation for treating cough and preparation method thereof - Google Patents

Chinese medicinal composition preparation for treating cough and preparation method thereof Download PDF

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CN102343029B
CN102343029B CN 201110312548 CN201110312548A CN102343029B CN 102343029 B CN102343029 B CN 102343029B CN 201110312548 CN201110312548 CN 201110312548 CN 201110312548 A CN201110312548 A CN 201110312548A CN 102343029 B CN102343029 B CN 102343029B
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李玲
王建玲
孙丰卿
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Nantong San Intellectual Property Service Co ltd
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孙丰卿
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Abstract

The invention relates to a Chinese medicinal composition preparation for treating cough and a preparation method thereof. The Chinese medicinal composition preparation comprises the following raw materials in part by weight: 10-20 parts of aster, 5-15 parts of platycodon root, 10-20 parts of dried orange peel, 10-20 parts of bitter orange, 6-10 parts of unibract fritillary bulb, 15-25 parts of white mulberry boot-bark, 15-25 parts of common coltsfoot flower, 6-10 parts of pinellia tuber, 5-15 parts of liquoric root, 10-20 parts of baikal skullcap root, 0.25-0.35 part of aminophylline and 0.05-0.15 part of phenergan. The preparation method comprises the following steps of: adding water into aster, dried orange peel, bitter orange and unibract fritillary bulb for distilling respectively, and collecting a distillate; mixing the obtained decoction dregs with the other raw materials, including platycodon root, white mulberry boot-bark, baikal skullcap root, liquoric root pinellia tuber and common coltsfoot flower, adding water for decocting twice, filtering, combining filtrates, concentrating till the volume of the filtrate is reduced by a half to obtain a concentrated solution; and combining the distillate with the concentrating solution, concentrating into thick paste of which the relative density is 1.20-1.24, drying, and adding aminophylline and phenergan for uniformly stirring to obtain a powdery medicament. In the Chinese medicinal composition preparation, monarch medicaments, ministerial medicaments, adjuvant medicaments and conductant medicaments play different roles; the preparation has small dosage, quick response and small side effect; and the aims of treating internally and externally and treating both principal and secondary aspects of a disease can be fulfilled. The preparation can be used for suppressing the development of the patient's condition and relieving clinical symptoms, and has a remarkable curative effect.

Description

A kind of Chinese medicinal composition preparation for the treatment of cough and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicinal composition preparation for the treatment of cough and preparation method thereof, belong to tcm field.
Background technology
Cough is one of modal symptom of respiratory system disease, and it is a kind of protectiveness neural reflex, produces the expiration percussion action by cough, the foreign body in respiratory tract or secretion can be excreted.Cough is the protectiveness respiratory reflex action that human body is removed the interior secretions of respiratory tract or foreign body.Although its favourable one side is arranged, violent long-term cough can cause infection to increase the weight of, respiratory tract hemorrhage etc.The common disease that causes cough has upper respiratory tract infection. acute/chronic bronchitis. and pneumonia. acute laryngitis: cough mainly is divided into acute cough, subacute and chronic cough.The acute cough is the modal disease of Pneumology Department outpatient service, refer to 3 weeks with interior cough often by due to upper respiratory tract infection, other comprise rhinitis, sinusitis, acute bronchitis, acute episode of chronic bronchitis, bronchial asthma etc.Subacute cough is to surpass for 3 weeks the persistent period, is postinfectious cough (being called again postinfectious cough), bacillary sinusitis and asthma etc. in 8 weeks with the modal reason of interior cough.Usually will surpass take cough as the cardinal symptom time for 8 weeks clinically, the unknown cause cough of C-XF Non Apparent Abnormality is called chronic cough.Chronic cough is as a kind of commonly encountered diseases, 20%～30% various commonly encountered diseases of chronic cough that patient accounts for the respiratory tract special outpatient clinic are because being not quite the same in our country and other regional pathogenesis etiologies, what be presented at that the cause of disease of China's chronic cough makes number one according to the investigation of Guangzhou respiratory disease institute is Eosinophilic bronchitis, other are followed successively by the air flue cough syndrome, cough variant asthma (allergic bronchitis), gastroesophageal reflux disease.Eosinophilic bronchitis, allergia cough, chronic bronchitis, bronchial asthma.The Chinese medicine cough has certain advantage, the medicine that relieving cough and resolving phlegm is relievingd asthma is many, the Chinese medicine preparation of some relieving cough and resolving phlegm has also appearred in the market, but the Chinese medicine preparation great majority of these treatment coughs have certain curative effect to slight cough, not good enough to chronic cough and chronic cough effect, antitussive is not lasting, acts on not obvious.
Summary of the invention
For the problem of above-mentioned existence, the invention provides a kind of Chinese medicinal composition preparation for the treatment of cough and preparation method thereof
The technical solution adopted in the present invention is:
A kind of Chinese medicinal composition preparation for the treatment of cough comprises the raw material of following weight portion:
Radix Asteris 10-20 part, Radix Platycodonis 5-15 part, Pericarpium Citri Reticulatae 10-20 part, Fructus Aurantii 10-20 part, Bulbus Fritillariae Cirrhosae 6-10 part, Cortex Mori 15-25 part, Flos Farfarae 15-25 part, Rhizoma Pinelliae 6-10 part, Radix Glycyrrhizae 5-15 part, Radix Scutellariae 10-20 part and aminophylline 0.25-0.35 part, promethazine 0.05-0.15 part.
Further preferred as technique scheme, described Chinese medicinal composition preparation comprises the raw material of following weight portion:
15 parts of Radix Asteriss, 10 parts of Radix Platycodoniss, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Aurantiis, 8 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Cortex Mori, 20 parts of Flos Farfaraees, 8 parts of the Rhizoma Pinelliaes, 10 parts, Radix Glycyrrhizae, 15 parts of Radix Scutellariaes, 0.3 part of aminophylline, 0.1 part of promethazine.
The present invention treats the Chinese medicinal composition preparation of cough, and dosage form is syrup, unguentum, capsule, tablet, granule or enteric coated tablet.
A kind of preparation method for the treatment of the Chinese medicinal composition preparation of cough comprises the following steps:
A, Radix Asteris, Pericarpium Citri Reticulatae, Fructus Aurantii, Bulbus Fritillariae Cirrhosae are added respectively water distillation, collect their distillate; Gained medicinal residues and all the other raw material Radix Platycodonis, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae, the Rhizoma Pinelliae, Flos Farfarae are mixed together, and decoct with water twice, filter, and merging filtrate is concentrated into 1/2 of filtrate volume, gets concentrated solution.
B, above-mentioned distillate, concentrated solution merge, and are concentrated into the thick extractum of relative density 1.20～1.24 (80 ℃ record).Add aminophylline, promethazine in thick extractum, stirring and evenly mixing gets unguentum.
C, with the thick extractum shift-in baking oven in above-mentioned steps b, dry to moisture lower than 5% for 50-70 ℃, take out, add aminophylline, promethazine, stirring and evenly mixing is adding adjuvant to make capsule, tablet, granule or enteric coated tablet by prior art.
D, separately get 60 parts of soluble in water boiling of sucrose, filter, merge with distillate, the concentrated solution of step a, add aminophylline, promethazine, then add appropriate stevioside flavoring agent and antiseptic, add the water standardize solution; Mixing, packing namely gets syrup.
In above preparation method, what do not illustrate in detail all gets final product by state of the art.Select 2-3 step wherein to get final product in above-mentioned steps a～d according to dosage form to be prepared.For example: when only preparing syrup, only need step a and steps d; This is that those skilled in the art can confirm.
In above raw material,
Radix Asteris function nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm cures mainly abundant expectoration and breathes with cough, and new chronic cough is coughed, chronic cough hemoptysis, Radix Platycodonis function lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Pericarpium Citri Reticulatae attending effectiveness regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Aurantii attending effectiveness lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
The Bulbus Fritillariae Cirrhosae attending effectiveness deficiency of the lung; Chronic cough; Cough due to consumptive disease; Cough caused by dryness-heat; Lung abscess; Scrofula; Carbuncle; Acute mastitis.
Cortex Mori cures mainly eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for the lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.
The lung moistening of Flos Farfarae effect, reduce phlegm, cough-relieving.Cure mainly acute and chronic bronchitis, pulmonary tuberculosis, cough, asthma.
Rhizoma Pinelliae effect drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; The externally used detumescence pain relieving.
Radix Glycyrrhizae effect invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Scutellariae effect heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Aminophylline has direct relexation to airway smooth muscle.The aminophylline bronchial smooth muscle that also can relax also can alleviate bronchial mucosa hyperemia, edema, is of value to and improves respiratory function. and this product is applicable to alleviate the symptoms of panting such as bronchial asthma, asthmatic bronchitis, obstructive emphysema; Also can be used for asthma.
Promethazine can be blocked the H1 receptor of the tissues such as smooth muscle, capillary wall, thereby plays emulative antagonism with histamine, and the still stable effect of maincenter significantly can be strengthened anesthetics, hypnotic and analgesic effect.And body temperature can be reduced and the town tells.
The traditional Chinese medical science thinks that cough is because of the diseases caused by exogenous pathogenic factor six climate exopathogens, and the internal organs internal injury affects the sound card that expectorant is arranged due to the lung.See " the Plain Questions the five internal organs generate a piece of writing "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi wound and also unclear; It is noiseless and expectorant arranged coughing, spleen wet moving and be expectorant also.Cough meaning has expectorant and sound, and it is wet that lid moves in spleen in lung qi due to wound, cough and for coughing also ".Because exopathogen is violated lung, or the internal organs internal injury, involve due to the lung.Cough, the traditional Chinese medical science is divided into exogenous cough and endogenous cough.Divide by pathogenic factor, the cough due to common cold, cough due to wind and cold, the cough due to dryness, cough caused by dryness-heat, cough due to fluid-retention, anemopyretic cough, cough due to heat, epidemic cough, cough of cold type, cough caused by pathogenic damp, cough due to summer-heat, cough caused by pathogenic fire, productive cough due to indigestion etc. are arranged; Divide by the internal organs QI and blood, have that the deficiency of the lung is coughed, pulmonary cough, cough referring to the heart, cough due to disorder of the liver, cough due to the spleen disease, cough caused by the kidney disorder, cough with fecal incontinence, cough due to disorder of the small intestine, cough involving the stomach, cough involving the urinary bladder, cough involving SAN JIAO, cough with vomiting of bile, chronic cough, cough due to disorder of QI, blood stasis cough etc.; Divide by cough disease time and characteristics, chronic cough, cough before dawn, nocturnal cough, dry cough, cough due to drinking, cough accompanied with hoarseness, paroxysmal cough are arranged.Radix Asteris nourishing the lung to keep the adverse QI downward in side's medicine of the present invention, stopping coughing and removing phlegm especially is good at treating new chronic cough and is coughed.Fructus Aurantii, Radix Platycodonis lung qi dispersing are regulated the flow of vital energy, eliminating phlegm and stopping cough, sore-throat relieving evacuation of pus.The Rhizoma Pinelliae, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI.The Bulbus Fritillariae Cirrhosae treatment deficiency of the lung; Chronic cough.Cortex Mori cures mainly eliminating pathogen from the lung for relieving asthma.The cough-relieving of Flos Farfarae moistening the lung and resolving phlegm.The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough.Radix Scutellariae effect heat clearing and damp drying, eliminating fire and detoxication.The aminophylline bronchial smooth muscle that relaxes alleviates bronchial mucosa hyperemia, edema, improves respiratory function.Promethazine can be blocked the H1 receptor of the tissues such as smooth muscle, capillary wall, reduces the hypersensitive state of air flue.
The present invention compared with prior art has the following advantages: monarch of the present invention, minister, helps, makes and respectively execute its effect, have a medication few, and instant effect, side effect is little, can reach inside and outside and execute, the purpose of giving consideration to both the incidental and fundamental.Can suppress the development of the state of an illness, alleviate clinical symptoms, therapeutic effect is good.Raw material of the present invention is bought convenient, and low price is easy to make, is worthy of popularization.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1,
A kind of Chinese medicinal composition preparation for the treatment of cough, described medicine is made by the raw material of following weight portion: Radix Asteris 10g, Radix Platycodonis 5g, Pericarpium Citri Reticulatae 10g, Fructus Aurantii 10g, Bulbus Fritillariae Cirrhosae 6g, Cortex Mori 15g, Flos Farfarae 15g, Rhizoma Pinelliae 6g, Radix Glycyrrhizae 5g, Radix Scutellariae 18g, aminophylline 250mg, promethazine 50mg.
Preparation method one comprises the following steps:
A, Radix Asteris, Pericarpium Citri Reticulatae, Fructus Aurantii, Bulbus Fritillariae Cirrhosae are added respectively water distillation, collect their distillate; Gained medicinal residues and all the other raw material Radix Platycodonis, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae, the Rhizoma Pinelliae, Flos Farfarae are mixed together, and decoct with water twice, filter, and merging filtrate is concentrated into 1/2 of filtrate volume, gets concentrated solution.
B, above-mentioned distillate, concentrated solution merge, and are concentrated into the thick extractum of relative density 1.20～1.24 (80 ℃ record), add aminophylline, promethazine, and stirring and evenly mixing gets unguentum.
Perhaps continue following steps, preparation capsule, tablet, granule or enteric coated tablet:
C, with the thick extractum shift-in baking oven of above-mentioned steps b, dry to moisture lower than 5% for 50-70 ℃, take out, add aminophylline, promethazine, stirring and evenly mixing is adding adjuvant to make capsule, tablet, granule or enteric coated tablet by prior art.
Preparation method two: the preparation of syrup comprises the following steps:
A, Radix Asteris, Pericarpium Citri Reticulatae, Fructus Aurantii, Bulbus Fritillariae Cirrhosae are added respectively water distillation, collect their distillate; Gained medicinal residues and all the other raw material Radix Platycodonis, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae, the Rhizoma Pinelliae, Flos Farfarae are mixed together, and decoct with water twice, filter, and merging filtrate is concentrated into 1/2 of filtrate volume, gets concentrated solution.
D, get that sucrose 60g is soluble in water to be boiled, filter, merge with distillate, the concentrated solution of above-mentioned steps a, add aminophylline, promethazine, then add appropriate stevioside flavoring agent and antiseptic, add the water standardize solution; Mixing, packing namely gets syrup.
Embodiment 2,
A kind of Chinese medicinal composition preparation for the treatment of cough, described medicine is made by the raw material of following weight portion: Radix Asteris 15g, Radix Platycodonis 10g, Pericarpium Citri Reticulatae 15g, Fructus Aurantii 15g, Bulbus Fritillariae Cirrhosae 8g, Cortex Mori 20g, Flos Farfarae 20g, Rhizoma Pinelliae 8g, Radix Glycyrrhizae 10g, Radix Scutellariae 15g, aminophylline 300mg, promethazine 100mg.
Preparation method is identical with embodiment 1.
Embodiment 3,
A kind of Chinese medicinal composition preparation for the treatment of cough, described medicine is made by the raw material of following weight portion: Radix Asteris 20g, Radix Platycodonis 15g, Pericarpium Citri Reticulatae 20g, Fructus Aurantii 20g, Bulbus Fritillariae Cirrhosae 10g, Cortex Mori 25g, Flos Farfarae 25g, Rhizoma Pinelliae 10g, Radix Glycyrrhizae 15g, Radix Scutellariae 20g, aminophylline 350mg, promethazine 150mg.
Preparation method is identical with embodiment 1.
Contrast test:
Criterion of therapeutical effect is drafted with reference to " tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect ": recovery from illness: the transference cure clinical signs such as cough, expectoration disappears and keep two week above produce effects: cough is even to be had and occurs or the sharp abnormal smells from the patient of being attacked by an assassin, cold, generation when overworked.Clinical sign obviously alleviates.Effectively: cough alleviates or transference cure, but recurs in the obvious inducement situation of nothing in 2 weeks after drug withdrawal.Invalid: as to treat after 3 courses for the treatment of cough, clinical sign without significant change
choosing 400 example cough patients (coughs comprising acute/chronic bronchitis, upper respiratory tract infection, pneumonia, Bronchial Asthmas), choose at random 300 examples as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3, the 100 routine patients that each treatment group treatment is chosen at random, treatment group 1 uses the syrup of the embodiment of the present invention 1 preparation to treat, treatment group 2 uses the syrup of the embodiment of the present invention 2 preparations to treat, treatment group 3 uses the syrup of the embodiment of the present invention 3 preparations to treat, each 20ml, every day 3 times, seven days is a course for the treatment of.
The patient of matched group adopts the conventional antibiotics of using, expelling phlegm for arresting cough, and spasmolytic is relievingd asthma, and supports anti symptom treatment to treat.Treatment group adds medical syrup agent of the present invention.
Therapeutic outcome such as following table:
Figure BDA0000098817100000041
Can find out from above tables of data, treatment group 2 nonresponders have 0 example, and 6 examples of improvement account for 6%, and produce effects person's 10 examples account for 10%, healing person's 84 examples, cure rate 84%, total effective 100%.The matched group nonresponder has 13 examples, account for 13%, improvement, 14 examples, account for 14%, produce effects person's 9 examples account for 9%, healing person's 64 examples, cure rate 64%, total effective 87%. treatment group effective percentage cure rates are apparently higher than matched group, and the cure rate effective percentage for the treatment of group 2 is higher than all the other treatment groups, and treatment group 2 prescriptions are the most effective in sum.

Claims (2)

1. Chinese medicinal composition preparation for the treatment of cough, it is characterized in that, described medicine components is the raw material of following weight portion: Radix Asteris 10-20 part, Radix Platycodonis 5-15 part, Pericarpium Citri Reticulatae 10-20 part, Fructus Aurantii 10-20 part, Bulbus Fritillariae Cirrhosae 6-10 part, Cortex Mori 15-25 part, Flos Farfarae 15-25 part, Rhizoma Pinelliae 6-10 part, Radix Glycyrrhizae 5-15 part, Radix Scutellariae 10-20 part and aminophylline 0.25-0.35 part, promethazine 0.05-0.15 part; Make syrup, capsule, tablet or granule.
2. the Chinese medicinal composition preparation for the treatment of as claimed in claim 1 cough, it is characterized in that, described medicine components is the raw material of following weight portion: 15 parts of Radix Asteriss, 10 parts of Radix Platycodoniss, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Fructus Aurantiis, 8 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Cortex Mori, 20 parts of Flos Farfaraees, 8 parts of the Rhizoma Pinelliaes, 10 parts, Radix Glycyrrhizae, 15 parts of Radix Scutellariaes, 0.3 part of aminophylline, 0.1 part of promethazine.
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CN103947793A (en) * 2014-04-09 2014-07-30 郎溪县黄香茶叶有限公司 Tea drink formula beneficial to wind dispelling and phlegm relief and preparation method thereof
CN104547368A (en) * 2014-12-29 2015-04-29 孙丰卿 Traditional Chinese medicine composition for treating cold and cough of children and preparation of traditional Chinese medicine composition
CN106177255A (en) * 2016-08-31 2016-12-07 邹霞 A kind of Chinese medicine and western medicine compound preparation treating adult respiratory distress syndrome and preparation method

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Address after: 222, A2 Building, Jianghai Zhihui Park, 1188 New Century Avenue, Nantong Hi tech Industrial Development Zone, Jiangsu Province, 226000

Patentee after: Nantong San Intellectual Property Service Co.,Ltd.

Address before: 226300 No.8, Jinqiao West Road, Nantong high tech Zone, Nantong City, Jiangsu Province

Patentee before: JIANGSU MEIZHONG MEDICAL TECHNOLOGY Co.,Ltd.

TR01 Transfer of patent right
EE01 Entry into force of recordation of patent licensing contract
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Application publication date: 20120208

Assignee: Nantong Jingxuan Textile Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048319

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231127

Application publication date: 20120208

Assignee: Nantong Huanlian Textile Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048315

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231127

Application publication date: 20120208

Assignee: Nantong Huase Space Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048606

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Anergu New Material Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048605

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Laiou Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048604

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Yitong Intelligent Control Technology (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048603

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Ouchen Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048602

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Laishang Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048601

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Lingde Pharmaceutical Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048600

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Chujie Electronic Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048597

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Jiaerjie Labor Care Products Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048596

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: JIANGSU KANGFEITE POWER TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048594

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Tuoerpu Surveying and Mapping Information Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048583

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong TongZhou Jinfeng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048582

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Weiai Home Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048563

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Qiju Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048556

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Juguang Trading Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048551

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Chenghui Pharmacy Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048548

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tongzhou Kangxintang Drugstore Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048542

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuanpinhui E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048537

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Koushun E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048506

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuoda Machinery Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048494

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Weizhi New Material Technology (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048487

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG FEIHAI ELECTRONIC TECHNOLOGY CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048483

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Haoshi new material technology Nantong Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048475

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Steel Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048466

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG YUQI METAL PRODUCTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048459

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG KYLIN MACHINERY LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048456

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG LILIAN MACHINE TOOL MANUFACTURING CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048450

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yuma Electromechanical Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048446

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Dongdong Steel Structure Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048444

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Huaxin Price Evaluation Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048443

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yaocheng mechanical equipment manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048440

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Xinxin Pharmaceutical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048425

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Jiangsu Yichuang Packaging Materials Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048413

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231129

EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Nantong Yijialai Woolen Knitting Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049377

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG BEITE PHARMACEUTICAL MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049199

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG HAIGUO MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049196

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Qiaojiang packaging materials Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049191

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Bairun Catering Management Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049185

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Nongchaoer Food Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048976

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Xingren Tank Farm of Nantong Xinhai Liquefied Gas Service Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048969

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG SHUANGHE FOOD Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048967

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Jiangsu guanan electromechanical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048961

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Runyuan structural parts Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048952

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Jinbao Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048947

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Juntai motor vehicle testing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048942

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Honglei mechanical equipment (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048782

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: American Antelope Home Textile (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048774

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Ansheng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048765

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: NANTONG YA TAI CANDLE ARTS & CRAFTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048764

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: Nantong Jianwei Metal Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048759

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: JIANGSU YATAI FITNESS CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048748

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231202

EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Nantong Zhili Machinery Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049698

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20231205

EE01 Entry into force of recordation of patent licensing contract
OL01 Intention to license declared
OL01 Intention to license declared
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: JIANGSU HAOHAN INFORMATION TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2024980003183

Denomination of invention: A traditional Chinese medicine combination preparation for treating cough and its preparation method

Granted publication date: 20130619

License type: Common License

Record date: 20240322

EE01 Entry into force of recordation of patent licensing contract