CN102335303A - Chinese medicinal effective-part composition for treating cold in children and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal effective-part composition for treating cold in children and a preparation method thereof. The Chinese medicinal effective-part composition comprises the following components in part by weight: 70 to 90 parts of wild chrysanthemum, 30 to 90 parts of bidens pilosa, 80 to 100 parts of astragalus, 50 to 80 parts of alisma plantagoaquatica, 10 to 30 parts of leonurus japonicas, 60 to 90 parts of combined spicebush root, 0.001 to 0.004 part of vitamin C, 10 to 20 parts of American ginseng, 3 to 10 parts of sucrose, 10 to 20 parts of indigowoad root and 10 to 20 parts of ephedra. The prepared product contains ginsenoside Re, Rg1, Rg2, Rh1, astragaloside IV and the like; and glycosides account for more than 50 percent based on the weight of the Chinese medicinal effective-part composition. A medicine adsorption effect and a virus killing effect are improved by compatibility of medicines, combination of various medicines, vitamin and American ginseng, and interaction between active ingredients and nutrient; and the Chinese medicinal effective-part composition has an obvious curative effect on cold in children, and greatly reduces the relapse rate of cold. Moreover, sucrose contributes to improving the effect of vitamin in the composition, and simultaneously contributes to improving dispersion degree of the medicinal composition to ensure that the bioavailability of the composition is improved.

Description

A kind of effective ingredient in Chinese composition and method of making the same that is used to treat infantile common cold

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Technical field

The invention belongs to the pharmaceutical composition technical field, specifically, relate to a kind of effective ingredient in Chinese compositions that is used to treat infantile common cold.

 

Background technology

Flu is a kind of self-healing property disease, is divided into common cold and influenza generally.Common cold, the traditional Chinese medical science are claimed " cold ", are a kind of respiratory tract commonly encountered diseases that is caused by multiple virus, and wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonal is not just the same yet.Influenza is the acute respiratory infectious disease that is caused by influenza virus.Virus is present in the patient's breath road, when patient's cough, sneeze, gives others through droplet infection.

The infectiousness of influenza is very strong, because this virus makes a variation easily, even suffered from the people of influenza, meets influenza pandemic again when next time, and he still can infect, so influenza causes that easily fulminant is popular.Generally more in the popular chance of winter-spring season, have 20～40% people at every turn and can infect influenza.

It is sporadic that the flu case distributes, and does not cause popularly, often is prone to merge bacterial infection.The common cold onset is more anxious, and early symptom has pharyngeal dried itching or burning sensation, sneeze, nasal obstruction, watery nasal discharge, begins to be clear water appearance nasal mucus, retrogradation after 2～3 days; Can be with pharyngalgia; General do not have heating and General Symptoms, or low grade fever, headache are only arranged.General through recovery from illness in 5～7 days.

Flu also is a kind of acute infection property rhinitis, is commonly called as " cold ".Being caused by Respirovirus, is main Causative virus with coronavirus and rhinovirus wherein.Virus is discharged from respiratory secretions and is propagated, when Abwehrkraft des Koepers descends, as suffer from cold, malnutrition, overtired, tobacco and wine excessively, the chronic disease of systemic disease and nose itself influences respiratory smooth etc., brings out infection easily.Flu outbreak back secondary bacterial infection.Intranasal has dry sensation and gargalesthesia, sneeze, general malaise or low grade fever is arranged during the flu onset, nasal obstruction, hyposmia, a large amount of clear water nasal mucus of stream, nasal mucosa hyperemia, edema is gradually arranged later on, a large amount of clear water appearance or purulent secretion etc. are arranged.If no complication, the course of disease is about 7～10 days.

Because virus existence does not have medicine can directly kill cold virus in human body cell in the world, effective ways rely on the human immune system exactly.So flu should be main with supporting treatment, it is light to pay special attention to rest, great quantity of water drinking, diet.This can give immune system muscle power support fully.

Child catches a cold easily, and at first with physiology, the anatomical features of their body, the immune system developmental immaturity is relevant.Child's rhinostenosis, mucosa is tender, and the mucosa glandular secretion is not enough, and dry, environmental adaptation and resistivity are relatively poor to external world, are inflamed easily.The premature infant, the child of birth defect or disease is arranged, such as pulmonary insufficiency, when particularly suffering from the natural immunity disease, nursing makes mistakes slightly and but can catch a cold.

Therefore, for infantile common cold, reasonable care is wanted in its medication, and its medication and general flu medication are different.Existing cold medicine kind is a lot, but its therapeutic effect is unsatisfactory.

Summary of the invention

The objective of the invention is to overcome the deficiency of prior art, provide a kind of treat the infantile common cold effect significantly, can prevent Chinese patent medicine of repeated cold and preparation method thereof.

The present invention realizes above-mentioned purpose through following technical scheme:

A kind of effective ingredient in Chinese compositions that is used to treat infantile common cold, form by the component of following parts by weight:

90 parts of Radix Astragali 80-100 of Flos Chrysanthemi Indici 70-90 part Herba Bidentis Bipinnatae 30-part

Rhizoma Alismatis 50-80 part Herba Leonuri 10-30 part Radix Linderae 60-90 part

Vitamin C 0.001-0.004 part Radix Panacis Quinquefolii 10-20 part sucrose 3-10 part

Radix Isatidis 10-20 part Herba Ephedrae 10-20 part.

In above-mentioned composition, be preferably:

Flos Chrysanthemi Indici 70-75 part Herba Bidentis Bipinnatae 75-80 part Radix Astragali 90-95 part

Rhizoma Alismatis 60-70 part Herba Leonuri 20-25 part Radix Linderae 75-85 part

Vitamin C 0.002-0.003 part Radix Panacis Quinquefolii 15-20 part sucrose 6-8 part

Radix Isatidis 15-20 part Herba Ephedrae 12-20 part.

Obtained product comprises ginsenoside Re, Rg1, Rg2, Rh1 and astragaloside, and glycoside weight ratio of constituents example surpasses 50%.

Ginsenoside Re's molecular formula is C ₄₈H ₈₂O ₁₈, its structural formula is shown in formula I.Ginsenoside Rg1's molecular formula is C ₄₂H ₇₂O ₁₄, its structural formula is shown in formula II.The molecular formula of ginsenoside Rg2 is C ₄₂H ₇₂O ₁₃, its structural formula is shown in formula III.The molecular formula of ginsenoside Rh1 is C ₃₆H ₆₂O ₉, its structural formula is shown in formula IV.The molecular formula of astragaloside is C ₄₁H ₆₈O ₁₄, its structural formula is suc as formula shown in (V).

 

（Ⅰ）

（Ⅱ）

（Ⅲ）

（Ⅳ）

（Ⅴ）

Compared with prior art, the present invention has following beneficial effect:

The present invention is through the compatibility of medicine, and multiple medicine and vitamin, Radix Panacis Quinquefolii exist simultaneously, the interaction between effective ingredient and nutrient, and the assimilation effect that has promoted medicine reaches the therapeutic effect to virus; Treat the evident in efficacy of infantile common cold, and greatly reduce the flu relapse rate.Remove this, sucrose helps increasing the action effect of vitamin in the compositions, helps promoting the dispersion of pharmaceutical composition simultaneously, makes its bioavailability high.

 

The specific embodiment

Below further specify technical scheme of the present invention through concrete embodiment.

Following percent is percentage by volume.

Embodiment 1

With Flos Chrysanthemi Indici 70g, Herba Bidentis Bipinnatae 80 g, the Radix Astragali 90 g, Rhizoma Alismatis 60 g, Herba Leonuri 25 g, the Radix Linderae 75 g, vitamin C 0.003 g, Radix Panacis Quinquefolii 20 g, sucrose 8 g, Radix Isatidis 10, Herba Ephedrae 15.Alcohol reflux twice with 70%, each 1.5h filters, merging filtrate, and to be evaporated to relative density be 1.15 clear paste.Add 95% ethanol and make the alcohol amount of containing reach 75% to carry out precipitate with ethanol, filter behind the cold preservation 12h, filtrate decompression is recycled to does not have the alcohol flavor, and adding 300ml water liquid and regulating pH value is 4.5, stirs to filter filtrate for later use after leaving standstill 18h.Get gelatin 25g and join in the 1L distilled water, be heated to whole dissolvings, promptly be made into the gelatin flocculating agent; Get chitosan 30g and join the 1L1% acetum, be stirred to clear solution, promptly be made into chitosan flocculant.In aforementioned filtrating, add water to 500ml, add the chitosan flocculant that makes: the composite flocculation agent 5ml of gelatin flocculating agent=3:1, under 60 ℃ of temperature; Rotating speed is 600rpm; Leave standstill behind the 3h centrifugal, obtain upper strata liquid and the above-mentioned volatile oil solution mixing that makes after, add antiseptic and correctives again; Add water to 1000ml, promptly get oral liquid.The gained oral liquid comprises ginsenoside Re, Rg1, Rg2, Rh1 and astragaloside etc., and the ratio that the glycoside composition accounts for total extract is above 50%.

Embodiment 2

Pharmaceutical formulation is: Flos Chrysanthemi Indici 90g, Herba Bidentis Bipinnatae 30g, Radix Astragali 80g, Rhizoma Alismatis 50g, Herba Leonuri 20g, Radix Linderae 70g, vitamin C 0.001g, Radix Panacis Quinquefolii 10g, sucrose 10g, Radix Isatidis 10g, Herba Ephedrae 15g.

Method for preparing is identical with embodiment 1.

Embodiment 3

Pharmaceutical formulation is: Flos Chrysanthemi Indici 80g, Herba Bidentis Bipinnatae 50g, Radix Astragali 90g, Rhizoma Alismatis 70g, Herba Leonuri 20g, Radix Linderae 80g, vitamin C 0.002g, Radix Panacis Quinquefolii 20g, sucrose 4g, Radix Isatidis 20g, Herba Ephedrae 20g.Method for preparing is identical with embodiment 1.

Embodiment 4 clinical experiments

Experimental subject is the infant that is diagnosed as upper respiratory tract infection; Experimental group is taken the Chinese medicine preparation of embodiment of the invention 1-3.

The clinical experiment result is following:

(1) upper respiratory tract infection: observe pathology 200 examples altogether, result such as table 1.

Table 1

Group

The example number

Recovery from illness

Produce effects

Effectively

Invalid

Total effective rate

The compositions of embodiment 1

200

130（65%）

40（20%）

20（10%）

10（5%）

95%

The compositions of embodiment 2

200

140（70%）

30（15%）

18（9%）

12（6%）

94%

The compositions of embodiment 3

200

128（64%）

32（16%）

32（16%）

8（4%）

96%

(2) children's often catches a cold: experimental group is observed 200 examples, result such as table 2 altogether.

Table 2

Group

The example number

Recovery from illness

Produce effects

Effectively

Invalid

Total effective rate

The compositions of embodiment 1

200

120（60%）

38（19%）

18（9%）

24（12%）

88%

The compositions of embodiment 2

200

112（56%）

24（12%）

28（14%）

36（18%）

82%

The compositions of embodiment 3

200

128（64%）

27（13.5%）

30（15%）

15（7.5%）

92.5%

Visible by table 1 and table 2, compositions of the present invention can be used to treat infant upper respiratory tract infection, and effect is remarkable.To infantile recurrent common cold also is evident in efficacy.

Claims (3)

1. effective ingredient in Chinese compositions that is used to treat infantile common cold is characterized in that being processed by the component of following parts by weight:

90 parts of Radix Astragali 80-100 of Flos Chrysanthemi Indici 70-90 part Herba Bidentis Bipinnatae 30-part

Rhizoma Alismatis 50-80 part Herba Leonuri 10-30 part Radix Linderae 60-90 part

Vitamin C 0.001-0.004 part Radix Panacis Quinquefolii 10-20 part sucrose 3-10 part

Radix Isatidis 10-20 part Herba Ephedrae 10-20 part.

2. compositions according to claim 1 is characterized in that being processed by the component of following parts by weight:

Flos Chrysanthemi Indici 70-75 part Herba Bidentis Bipinnatae 75-80 part Radix Astragali 90-95 part

Rhizoma Alismatis 60-70 part Herba Leonuri 20-25 part Radix Linderae 75-85 part

Vitamin C 0.002-0.003 part Radix Panacis Quinquefolii 15-20 part sucrose 6-8 part

Radix Isatidis 15-20 part Herba Ephedrae 12-20 part.

3. compositions according to claim 1 and 2 is characterized in that obtained product comprises ginsenoside Re, Rg1, Rg2, Rh1 and astragaloside, and glycoside weight ratio of constituents example surpasses 50%.