CN102327349A - Infant quick-acting antipyretic powder - Google Patents
Infant quick-acting antipyretic powder Download PDFInfo
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- CN102327349A CN102327349A CN201110285516A CN201110285516A CN102327349A CN 102327349 A CN102327349 A CN 102327349A CN 201110285516 A CN201110285516 A CN 201110285516A CN 201110285516 A CN201110285516 A CN 201110285516A CN 102327349 A CN102327349 A CN 102327349A
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Abstract
The invention relates to infant quick-acting antipyretic powder and preparation thereof. The quick-acting antipyretic powder is specifically prepared by grinding apricot kernel, peach kernel, capejasmine seed, Chinese date seed and Chinese thorowax root into powder according to a certain proportion. During treatment, 15-30 grams (increased or decreased according to the patient's condition) of medicinal powder is taken out, egg white of fresh duck eggs is used for blending the medicinal powder into paste, the paste is made into small pills, the small piles are arranged in the middle of gauze, the gauze is pasted on Yongquan acupuncture points of two feet (the left feet of a boy and the right feet of a girl) and a Dazhui acupuncture point, the gauze is fixed by an air-permeable adhesive tape, and a dressing is replaced once every 24 hours. By externally pasting, the infant quick-acting antipyretic powder can be used for treating pyrexia such as lung heat, stomach heat and the like caused by external infection cold pathogen fever and external infection heat pathogen fever of an infant without medicament taking, injecting or transfusing; and the infant quick-acting antipyretic powder has the advantages of exact curative effects, high curing rate, no toxic or side effects and no discomfort or pain.
Description
Technical field
The present invention relates to a kind of drug regimen, specifically is raw material with Chinese medicine, and the infant quick-acting defervescent of executing the theory preparation of controlling in conjunction with the traditional Chinese medical science acupuncture point Chinese herbs paste that looses belongs to the field of Chinese medicines.
Background technology
Heating is that body temperature exceeds arm's length standard, or the uncomfortable sensation of own fever of the body, also is that body antagonism pathogen a kind of resists reaction, is one of clinical common emergency of department of pediatrics.Generate heat too high or after for a long time the function of each system of human body and organ being sustained damage, infant especially, because of its internal organs tender and lovely; Shape gas does not fill, and morbidity is easy, and the change of disease is rapid; If hyperpyrexia surpasses 41 ℃, make the various regulative mechanisms of body disorderly, very easily cause cranial nerve tissue injury.Coma, convulsions even death appear in severe patient.According to statistics, infantile fever caused by exogenous pathogens is maximum in the preschool period morbidity, average out to 6-7 time/year, and child's sickness rate that 10-15 is arranged approximately is greater than 12 every year.Like untimely treatment, infection can spread to the adnexa organ through nasopharynx part, and cause of disease can be disseminated to whole body through blood circulation, brings out the body allergy, causes numerous complication.
At present, the antipyretic on the market is of a great variety, takes orally, is coated with outward, injection, nasal drop, oral liquid or the like; Be used for moroxydine commonly used, BANLANGEN CHONGJI of antiviral class etc., the acetaminophen commonly used of antipyretic analgesic, aspirin etc., and the penicillin injection liquid of anti-inflammation class etc.; Physical cooling methods such as some traditional Chinese massages, acupoint therapy are also arranged simultaneously; How because of infant can not actively cooperate, operate cumbersomely, can't normally use.External plaster application agent is a kind of mode of bringing down a fever easily, and practical.
Retrieval is in recent years about type of bringing down a fever patent of invention; Disclosed have 60 remainders; For example Chinese patent CN1049144B in the Antifebrile oral liquor of authorization on February 9th, 2000 bulletin, is a primary raw material with Radix Bupleuri, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Gypsum Fibrosum, Radix Glycyrrhizae, Radix Codonopsis, Ramulus Cinnamomi; One Chinese patent application CN 1358525A in the disclosed anti-inflammatory medicine oral liquid of bringing down a fever on July 17th, 2002, is made up of Folium Isatidis, Rhizoma Paridis, Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, Radix Scutellariae, Fructus Amomi Rotundus, Herba Ephedrae, Semen Armeniacae Amarum, Zhu's Huang, Pheretima, bulky, Cornu Bubali; One Chinese patent application CN 1509456A in disclosed a kind of Chinese medicine preparation " capsule of bringing down a fever " of persistent fever and preparation method thereof of catching a cold of treating on January 5th, 2005, is made up of Semen Coicis, Talcum, Cortex Magnoliae Officinalis, Medulla Tetrapanacis, Folium Bambusae, Semen Armeniacae Amarum; One Chinese patent application CN1615953A in bring down a fever effervescent granule and method for making thereof of disclosed children's Chai Gui on May 18th, 2005, is that crude drug and accessory drugs are processed by Radix Bupleuri, Ramulus Cinnamomi, Radix Puerariae, Herba Spirodelae, Radix Scutellariae, the Radix Paeoniae Alba, Periostracum Cicadae; Chinese patent publication number CN101279056A; In disclosed children's antipyretic granule on October 8th, 2008, the Chinese medicine granules of processing by Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Fructus Gardeniae, Cortex Moutan, Radix Scutellariae, Herba Lophatheri, Pheretima, Rhizoma Paridis, Radix Bupleuri, Radix Cynanchi Atrati etc.Chinese patent CN100515442C; Powder for external application for defervescence in authorization on July 22nd, 2009 bulletin; Be by the Chinese medicine of Gypsum Fibrosum 1.5-2.5 part, Alumen 1.5-2.5 part, Herba Artemisiae Annuae 0.5-1.5 part, Fructus Gardeniae 1.5-2.8 part, Radix Et Rhizoma Rhei 1.5-2.8 part, Matrii Sulfas Exsiccatus 0.5-1.5 part through pulverizing, levigate, sieve; Mix homogeneously, sub-dose packaging forms.Chinese patent publication number CN101584784A, in disclosed a kind of children's antipyretic Chinese medicine on November 25th, 2009, by Rhizoma Coptidis, Fructus Gardeniae, Talcum each, Radix Glycyrrhizae, Radix Isatidis, the Rhizoma Pinelliae grind and process.
The disclosed various antipyretics of above patent are different fully with composition and component that infant quick-acting defervescent of the present invention looses, and its effect is also different.
Summary of the invention
Year clinical position experience surplus the inventor sums up 40; Generate heat repeatedly to infant, the awkward situation of clinical medicine has been invented a kind of infant quick-acting defervescent and has been loose; The present invention is made up of Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri, and its each component consumption is 1: 1: 1: 1: 1.
Method for preparing of the present invention is:
(1) take by weighing equivalent Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri, with the sterilization of radioactive element cobalt irradiation, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;
(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;
Get 15～30g medicamental pulverata (according to state of an illness increase and decrease) when (3) treating, get fresh Ovum Anas domestica album mediation medicamental pulverata and become pasty state, make piller; Place in the middle of the gauze, stick double-legged Yongquan acupoint (boy's left foot, girl's right crus of diaphragm) and DAZHUI acupoint; The external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours.
Specify advantage of the present invention below in conjunction with the property of medicine:
Semen Armeniacae Amarum bitter in the mouth among the present invention is warm in nature, returns lung, spleen, large intestine channel, and is poisonous.Has the lung qi dispersing cough-relieving, lowering the adverse-rising QI to subdue asthma, loosening bowel to relieve constipation, parasite killing detoxicating functions; Cure mainly cough, dyspnea with rapid and short breath fullness in the chest, sore throat pharyngalgia, dryness of the intestine constipation, insect poison skin infection.
Semen Persicae bitter in the mouth, sweet, property is flat, and GUIXIN, liver, large intestine channel have blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.The amygdalin that it contains has antitussive effect, and Semen Persicae has the increase drug absorption.
Fructus Gardeniae bitter in the mouth cold in nature is gone into the heart, liver, lung, stomach warp, and heat clearing away is arranged, pathogenic fire purging, and the removing heat from blood effect cures mainly calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.
Semen Ziziphi Spinosae property is put down sweet in the mouth, goes into the heart, spleen, liver, gallbladder meridian, nourishing the liver, mind calming are arranged, calms the nerves, the effect of arresting sweating, cooling.Cure mainly restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.
Radix Bupleuri bitter in the mouth cold nature is returned Liver Channel, gallbladder meridian, has to evacuate to bring down a fever, and yang invigorating soothing liver-QI function cures mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, and sternal rib pain, proctoptosis, the uterus comes off, menoxenia.
The present invention carries out compatibility with above-mentioned Chinese medicine, makes each medicine produce synergism, thereby can effectively treat calentura such as lung-heat that diseases caused by exogenous pathogenic factor cold-evil heating and the heating of diseases caused by exogenous pathogenic factor pathogenic heat cause, gastric heat; Select for use Ovum Anas domestica album to be in harmonious proportion, can promote drug absorption, the lysozyme that Ovum Anas domestica album is rich in is a kind of natural infection material; Can play effects such as antiallergic, Ovum Anas domestica album is slightly cold, and good heat-clearing toxin-expelling functions is arranged; Its contained protein, aminoacid and multiple beneficial bacterium are beneficial to the absorption of medicine in addition.Select DAZHUI acupoint and Yongquan acupoint dispenser simultaneously for use, DAZHUI acupoint is the meeting of brothers' three sun and governor vessel, cures mainly calentura, malaria, cough, dyspnea, osteopyrexia and fever; Stiffness of the nape, pain in the shoulder and back, stiffness along the spinal column, opisthotonus, infantile convulsion, demented epilepsy syndrome, five kinds of over strain is deficient; Seven kinds of impairments is weak, heatstroke, cholera, vomiting, jaundice, rubella; Yongquan acupoint is the first cave of kidney channel, and the effect of heat radiation anger is arranged, and it is linking up the most acupuncture point of sole, is the important acupuncture point of diseases prevention, health care.The present invention sticks through external, and especially, do not take medicine, do not have an injection, do not infuse infant calentura operating aspect, determined curative effect, cure rate is high, has no side effect the no any discomfort and the pain of injury.
Description of drawings
Accompanying drawing 1: different time body temperature changed after acetaminophen group and quick-acting defervescent loose and organize medication.
The specific embodiment
Further specify preparation of the present invention below in conjunction with embodiment.
Embodiment one
(1) take by weighing each 3g of Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri, with the sterilization of radioactive element cobalt irradiation, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;
(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;
(3) 15g medicamental pulverata (according to state of an illness increase and decrease) time is got in treatment, gets fresh Ovum Anas domestica album and is in harmonious proportion medicamental pulverata and becomes pasty state, makes piller, places in the middle of the gauze, sticks double-legged Yongquan acupoint (boy's left foot, girl's right crus of diaphragm) and DAZHUI acupoint, and the external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours.
Embodiment two
(1) take by weighing each 6g of Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri, with the sterilization of radioactive element cobalt irradiation, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;
(2) mixed medicamental pulverata being crossed the bottling of 100～120 mesh sieves seals subsequent use;
(3) 30g medicamental pulverata (according to state of an illness increase and decrease) time is got in treatment, gets fresh Ovum Anas domestica album and is in harmonious proportion medicamental pulverata and becomes pasty state, makes piller, places in the middle of the gauze, sticks double-legged Yongquan acupoint (boy's left foot, girl's right crus of diaphragm) and DAZHUI acupoint, and the external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours.
The Test Example 1 infant quick-acting defervescent of the present invention toxicity test that looses
(1) acute toxicity test: choose each 10 of normal skin and artificial damaged skin SD rats, stick 5 times of (15g/kg body weight) infant quick-acting defervescents respectively and loose, repeatedly stick, skin allergy and toxicity all do not occur.
(2) long term toxicity test: choose 80 of SD rats, body weight 60～80g is divided into four groups at random, and 20 every group, male and female half and half, single cage is raised.If 2 times, 5 times, 10 times three dose groups are irritated stomach SD rat with decoction respectively; Irritated stomach once in per 24 hours; After 1 week, its hemogram, liver,kidney,spleen are not seen toxic and side effects, experiment finishes the back and puts to death rat; Liver,kidney,spleen etc. is carried out histopathologic examination's (paraffin section), result of the test such as table 1.
The dirty body ratio of each treated animal of table 1 result (%)
Can find out that from table 1 all animal liver, kidney, spleen etc. are not all seen obvious pathological change, explain antiasthmatic-antitussive paste have no side effect, safe and reliable.
Test Example 2
One, physical data
1, patient source: case 180 examples are observed in this test altogether; Boy's 100 examples, girl 80, are divided into 2 groups at random; Acetaminophen group 80 examples (matched group) wherein; Infant quick-acting defervescent of the present invention looses and organizes 100 examples (test group), and the age of two groups of data, the course of disease, body temperature comparing difference not statistically significant (P＞0.05) are seen table 2.
Table 2 liang group physical data is
relatively
Two, include the case standard in
Axillaty temperature＞38.5 ℃ children with upper respiratory infections, the age is June～6 years old, 2.5 years old mean age.
Three, test method
The acetaminophen group, acetaminophen 10～15mg/kg that oral Dongbei Pharmaceutical General Factory is produced; The infant quick-acting defervescent group of loosing adopts powder medicated powder of the present invention (3g/kg body weight), with Ovum Anas domestica album furnishing pasty state, makes piller, places in the middle of the gauze, sticks double-legged Yongquan acupoint (boy's left foot, girl's right crus of diaphragm) and DAZHUI acupoint, the external immobilization with adhesive tape of breathing freely.Observe 40min after the medication respectively, 1h, 2h, 3h, 4h, 6h, 8h, 12h, infant body temperature changes and untoward reaction.
Four, the curative effect determinate standard infant is perspired, and body temperature drops to onset; It is effective more than 0.5 ℃ that body temperature descends.
Five, result
1. two groups of comprehensive therapeutic effects, the 1h total effective rate 65% (52/80) after the medication of acetaminophen group, and quick-acting defervescent looses, and 1h is 91% (91/100) after the group medication, and difference has highly significant meaning (P＜0.01).
2. different time body temperature changes after medication each time point quick-acting defervescent group mean body temperature of loosing and all is lower than acetaminophen after two groups of medications, sees table 3.
Different time body temperature changes
after the table 3 liang group medication
Six, conclusion
Calentura such as the lung-heat that 180 routine clinical test results demonstrations, the diffusing group of this kind quick-acting defervescent are generated heat to treatment diseases caused by exogenous pathogenic factor cold-evil and the diseases caused by exogenous pathogenic factor pathogenic heat is generated heat to be caused, gastric heat have significant curative effect, and its symptomes complice curative effect total effective rate is respectively 91%.Comprehensive this Chinese powder medicine determined curative effect of contrast, application is convenient, and in application process, does not find obvious adverse reaction and toxic and side effects.
Claims (4)
1. an infant quick-acting defervescent looses, and it is characterized in that it mainly is to be developed by the former medicine of Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri that waits weight portion.
2. the said preparation of medicaments method of claim 1, it comprises the following steps:
A) take by weighing equivalent Semen Armeniacae Amarum, Semen Persicae, Fructus Gardeniae, Semen Ziziphi Spinosae and Radix Bupleuri, with the sterilization of radioactive element cobalt irradiation, pulverization after the difference cleaning and removing impurities drying, mixing for standby use;
B) mixed medicamental pulverata being crossed the subsequent use described quick-acting defervescent of claim 1 that promptly gets of 100～120 mesh sieves bottling sealing looses.
3. get 15～30g medicamental pulverata (according to state of an illness increase and decrease) during according to Drug therapy described in the claim 1 and 2; Get fresh Ovum Anas domestica album mediation medicamental pulverata and become pasty state, make piller, place in the middle of the gauze; Stick double-legged Yongquan acupoint (boy's left foot; Girl's right crus of diaphragm) and DAZHUI acupoint, the external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours.
4. according to claim 1 or 3 described medicines, process increases adjuvant, can process to stick, and is widely used.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110285516A CN102327349A (en) | 2011-09-23 | 2011-09-23 | Infant quick-acting antipyretic powder |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110285516A CN102327349A (en) | 2011-09-23 | 2011-09-23 | Infant quick-acting antipyretic powder |
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| CN102327349A true CN102327349A (en) | 2012-01-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196351A (en) * | 2023-02-27 | 2023-06-02 | 郝锋 | Infant defervescing patch and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117388A (en) * | 1994-08-24 | 1996-02-28 | 东营市面粉厂 | Compound bupleuri liniment |
| CN1511553A (en) * | 2002-12-30 | 2004-07-14 | 龙 代 | Infantile antipyretic |
-
2011
- 2011-09-23 CN CN201110285516A patent/CN102327349A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1117388A (en) * | 1994-08-24 | 1996-02-28 | 东营市面粉厂 | Compound bupleuri liniment |
| CN1511553A (en) * | 2002-12-30 | 2004-07-14 | 龙 代 | Infantile antipyretic |
Non-Patent Citations (1)
| Title |
|---|
| 胡献国: "《小儿家庭足疗》", 30 September 2003, article "小儿家庭足疗" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196351A (en) * | 2023-02-27 | 2023-06-02 | 郝锋 | Infant defervescing patch and preparation method and application thereof |
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Application publication date: 20120125 |