CN102325562B - 具有可重新设定的驱动机构的固定剂量注射装置 - Google Patents

具有可重新设定的驱动机构的固定剂量注射装置 Download PDF

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Publication number
CN102325562B
CN102325562B CN200980157365.2A CN200980157365A CN102325562B CN 102325562 B CN102325562 B CN 102325562B CN 200980157365 A CN200980157365 A CN 200980157365A CN 102325562 B CN102325562 B CN 102325562B
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CN
China
Prior art keywords
injection device
dose
housing
piston rod
dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980157365.2A
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English (en)
Chinese (zh)
Other versions
CN102325562A (zh
Inventor
D.普伦特里
C.J.史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
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Publication of CN102325562A publication Critical patent/CN102325562A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN200980157365.2A 2008-12-23 2009-12-18 具有可重新设定的驱动机构的固定剂量注射装置 Active CN102325562B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08022317.5 2008-12-23
EP08022317A EP2201972A1 (en) 2008-12-23 2008-12-23 Fixed dose injection device with resettable drive mechanism
PCT/EP2009/067480 WO2010072662A1 (en) 2008-12-23 2009-12-18 Fixed dose injection device with resettable drive mechanism

Publications (2)

Publication Number Publication Date
CN102325562A CN102325562A (zh) 2012-01-18
CN102325562B true CN102325562B (zh) 2014-07-16

Family

ID=40584731

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980157365.2A Active CN102325562B (zh) 2008-12-23 2009-12-18 具有可重新设定的驱动机构的固定剂量注射装置

Country Status (16)

Country Link
US (1) US8945069B2 (enExample)
EP (2) EP2201972A1 (enExample)
JP (1) JP5588998B2 (enExample)
KR (1) KR20110099051A (enExample)
CN (1) CN102325562B (enExample)
AU (1) AU2009331633A1 (enExample)
CA (1) CA2747324A1 (enExample)
DK (1) DK2381984T3 (enExample)
IL (1) IL213575A0 (enExample)
MX (1) MX2011006534A (enExample)
NZ (1) NZ593744A (enExample)
RU (1) RU2514537C2 (enExample)
SG (1) SG172319A1 (enExample)
TW (1) TW201034712A (enExample)
WO (1) WO2010072662A1 (enExample)
ZA (1) ZA201103877B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9351964B2 (en) 2009-05-27 2016-05-31 Ptc Therapeutics, Inc. Methods for treating cancer and non-neoplastic conditions
EP2475411B1 (en) * 2009-09-07 2014-12-31 Sanofi-Aventis Deutschland GmbH Drive mechanism for drug delivery device
EP2292286A1 (en) * 2009-09-07 2011-03-09 Sanofi-Aventis Deutschland GmbH Drive mechanism for a medication delivery device and medication delivery device
EP2482889B1 (en) * 2009-09-30 2016-02-10 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device
AR078457A1 (es) * 2009-09-30 2011-11-09 Sanofi Aventis Deutschland Mecanismo accionador para un dispositivo de descarga de farmacos
JP5805092B2 (ja) 2009-09-30 2015-11-04 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 注射デバイス
BR112012007310A2 (pt) * 2009-09-30 2016-04-19 Sanofi Aventis Deutschland mecanismo de acionamento para um dispositivo de entrega de fármaco e uso de um membro de reajuste para um mecanismo de acionamento
WO2011039205A2 (en) * 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Drug delivery device and drive member for a drug delivery device
GB0918145D0 (en) 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
EP2438950A1 (en) * 2010-10-06 2012-04-11 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device and drug delivery device
EP2438951A1 (en) * 2010-10-06 2012-04-11 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device and drug delivery device
TWI544941B (zh) * 2010-10-06 2016-08-11 賽諾菲阿凡提斯德意志有限公司 藥物傳送裝置的驅動機構及藥物傳送裝置
EP2438949A1 (en) 2010-10-06 2012-04-11 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device and drug delivery device
BR112013008617A2 (pt) 2010-10-13 2016-06-14 Sanofi Aventis Deutschland mecanismo de ajuste de dose e método de uso do mesmo
CN103260675B (zh) 2010-10-13 2016-01-20 赛诺菲-安万特德国有限公司 剂量设定机构和使用该剂量设定机构的方法
TWI574708B (zh) * 2011-06-17 2017-03-21 賽諾菲阿凡提斯德意志有限公司 用於藥物遞送裝置的卡匣支撐器總成
WO2014029683A1 (en) * 2012-08-20 2014-02-27 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method for electrically detecting contact between piston rod and cartridge bung
US9486586B2 (en) * 2012-08-20 2016-11-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method for detecting a contact
TW201509464A (zh) 2013-04-10 2015-03-16 Sanofi Sa 注射裝置及組裝方法
SG11201600439SA (en) 2013-08-02 2016-02-26 Becton Dickinson Co Injection pen
CN104436375A (zh) * 2014-12-30 2015-03-25 江苏华阳电器有限公司 一种注射笔
KR20200035292A (ko) 2017-08-01 2020-04-02 피티씨 테라퓨틱스, 인크. 혈액 암 치료에 사용하기 위한 dhodh 억제제
EP3836989A1 (en) 2018-09-08 2021-06-23 Shaily Engineering Plastics Limited Injection device
JP7646550B2 (ja) * 2019-01-18 2025-03-17 サノフイ 注射デバイス

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1243578C (zh) * 1998-01-30 2006-03-01 诺沃挪第克公司 注射器
WO2006079481A1 (en) * 2005-01-25 2006-08-03 Novo Nordisk A/S An injection device with an end of dose feedback mechanism
EP1923084A1 (en) * 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Dosing and drive mechanism for drug delivery device

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US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
GB9219849D0 (en) * 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
DK170604B1 (da) * 1993-12-07 1995-11-13 Niels Erik Holm Aps Doseringsenhed til dosering af afmålte mængder af en væske
US6936032B1 (en) * 1999-08-05 2005-08-30 Becton, Dickinson And Company Medication delivery pen
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
JP4964136B2 (ja) * 2004-10-14 2012-06-27 ノボ・ノルデイスク・エー／エス 用量設定機構を備えた注射器
WO2006114395A1 (en) * 2005-04-24 2006-11-02 Novo Nordisk A/S An injection device with a gearbox

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1243578C (zh) * 1998-01-30 2006-03-01 诺沃挪第克公司 注射器
WO2006079481A1 (en) * 2005-01-25 2006-08-03 Novo Nordisk A/S An injection device with an end of dose feedback mechanism
EP1923084A1 (en) * 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Dosing and drive mechanism for drug delivery device

Also Published As

Publication number Publication date
HK1161850A1 (en) 2012-08-10
EP2381984A1 (en) 2011-11-02
ZA201103877B (en) 2012-01-25
KR20110099051A (ko) 2011-09-05
RU2514537C2 (ru) 2014-04-27
JP5588998B2 (ja) 2014-09-10
RU2011130897A (ru) 2013-01-27
IL213575A0 (en) 2011-07-31
EP2201972A1 (en) 2010-06-30
CA2747324A1 (en) 2010-07-01
AU2009331633A1 (en) 2011-07-14
EP2381984B1 (en) 2022-05-11
WO2010072662A1 (en) 2010-07-01
JP2012513266A (ja) 2012-06-14
US20120046643A1 (en) 2012-02-23
US8945069B2 (en) 2015-02-03
CN102325562A (zh) 2012-01-18
DK2381984T3 (da) 2022-08-01
NZ593744A (en) 2013-11-29
MX2011006534A (es) 2011-07-13
SG172319A1 (en) 2011-07-28
TW201034712A (en) 2010-10-01

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