CN102325530A - 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮 - Google Patents

用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮 Download PDF

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Publication number
CN102325530A
CN102325530A CN201080008363XA CN201080008363A CN102325530A CN 102325530 A CN102325530 A CN 102325530A CN 201080008363X A CN201080008363X A CN 201080008363XA CN 201080008363 A CN201080008363 A CN 201080008363A CN 102325530 A CN102325530 A CN 102325530A
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China
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fev1
patient
chemical compound
present
acid
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CN201080008363XA
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English (en)
Chinese (zh)
Inventor
托尔斯滕·鲁夫
埃里克·马萨纳·蒙特霍
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Almirall SA
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Almirall SA
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Priority to CN201510629441.2A priority Critical patent/CN105326838A/zh
Publication of CN102325530A publication Critical patent/CN102325530A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
CN201080008363XA 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮 Pending CN102325530A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510629441.2A CN105326838A (zh) 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09382020A EP2221055A1 (en) 2009-02-18 2009-02-18 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP09382020.7 2009-02-18
PCT/EP2010/001026 WO2010094483A1 (en) 2009-02-18 2010-02-18 5- (2-{ [6- (2, 2-difluoro-2-phenylethoxy) hexyl] amino} -1-hydroxyethyl) -8-hydroxyquinolin-2 (ih)-one for the treatment of lung function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510629441.2A Division CN105326838A (zh) 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮

Publications (1)

Publication Number Publication Date
CN102325530A true CN102325530A (zh) 2012-01-18

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201080008363XA Pending CN102325530A (zh) 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮
CN201510629441.2A Pending CN105326838A (zh) 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮

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CN201510629441.2A Pending CN105326838A (zh) 2009-02-18 2010-02-18 用于治疗肺功能的5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]胺基}-1-羟乙基)-8-羟基喹啉-2(1h)-酮

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US (2) US20120029014A1 (enExample)
EP (2) EP2221055A1 (enExample)
JP (1) JP2012518019A (enExample)
KR (1) KR20110123742A (enExample)
CN (2) CN102325530A (enExample)
AR (1) AR075432A1 (enExample)
AU (1) AU2010214854A1 (enExample)
CA (1) CA2749059C (enExample)
CL (1) CL2011002001A1 (enExample)
CO (1) CO6361939A2 (enExample)
CY (1) CY1114484T1 (enExample)
DK (1) DK2398473T3 (enExample)
EA (1) EA022442B1 (enExample)
EC (1) ECSP11011336A (enExample)
ES (1) ES2430596T3 (enExample)
HR (1) HRP20130917T1 (enExample)
IL (1) IL213979A0 (enExample)
ME (1) ME01757B (enExample)
MX (1) MX2011008577A (enExample)
MY (1) MY155657A (enExample)
NZ (1) NZ593727A (enExample)
PE (1) PE20120419A1 (enExample)
PL (1) PL2398473T3 (enExample)
PT (1) PT2398473E (enExample)
RS (1) RS52951B (enExample)
SG (2) SG173091A1 (enExample)
SI (1) SI2398473T1 (enExample)
TW (2) TW201031408A (enExample)
UA (1) UA103370C2 (enExample)
UY (1) UY32414A (enExample)
WO (1) WO2010094483A1 (enExample)
ZA (1) ZA201104654B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2302447B1 (es) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2306595B1 (es) * 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2668941A1 (en) * 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992474A (en) * 1983-04-18 1991-02-12 Glaxo Group Ltd. Phenethanolamine derivatives
WO2006122788A1 (en) * 2005-05-20 2006-11-23 Laboratorios Almirall, S.A. DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR
WO2008095720A1 (en) * 2007-02-09 2008-08-14 Almirall, S.A. Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one as agonist of the beta 2 adrenergic receptor

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7920688U1 (it) 1979-02-05 1980-08-05 Chiesi Paolo Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore
DE3274065D1 (de) 1981-07-08 1986-12-11 Draco Ab Powder inhalator
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI69963C (fi) 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DE3927170A1 (de) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
ATE209938T1 (de) 1990-09-26 2001-12-15 Pharmachemie Bv Wirbelkammer-pulverinhalator
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
UA27961C2 (uk) 1992-12-18 2000-10-16 Шерінг Корпорейшн Інгалятор для порошкових ліків
EP1908488A3 (en) 1995-04-14 2008-04-16 SmithKline Beecham Corporation Metered dose inhaler for salmeterol
AU719449B2 (en) 1995-06-21 2000-05-11 Astrazeneca Ab Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
ES2195785B1 (es) 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2232306B1 (es) 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
FR2903168B1 (fr) * 2006-06-30 2008-08-22 Fayard Eliane Bruleur pour realiser la combustion de substances reputees difficilement combustibles
UY32297A (es) * 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992474A (en) * 1983-04-18 1991-02-12 Glaxo Group Ltd. Phenethanolamine derivatives
WO2006122788A1 (en) * 2005-05-20 2006-11-23 Laboratorios Almirall, S.A. DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR
WO2008095720A1 (en) * 2007-02-09 2008-08-14 Almirall, S.A. Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one as agonist of the beta 2 adrenergic receptor

Also Published As

Publication number Publication date
UA103370C2 (uk) 2013-10-10
DK2398473T3 (da) 2013-10-21
AR075432A1 (es) 2011-03-30
WO2010094483A1 (en) 2010-08-26
EP2398473B1 (en) 2013-07-24
AU2010214854A1 (en) 2011-07-21
PL2398473T3 (pl) 2013-12-31
RS52951B (sr) 2014-02-28
CY1114484T1 (el) 2016-10-05
US20120029014A1 (en) 2012-02-02
CN105326838A (zh) 2016-02-17
EA022442B1 (ru) 2016-01-29
EP2398473A1 (en) 2011-12-28
SG173091A1 (en) 2011-08-29
MY155657A (en) 2015-11-13
MX2011008577A (es) 2011-09-06
ZA201104654B (en) 2012-02-29
KR20110123742A (ko) 2011-11-15
NZ593727A (en) 2013-07-26
CA2749059A1 (en) 2010-08-26
US20140343097A1 (en) 2014-11-20
PE20120419A1 (es) 2012-05-09
CL2011002001A1 (es) 2011-11-11
PT2398473E (pt) 2013-09-30
EA201101210A1 (ru) 2012-03-30
TW201031408A (en) 2010-09-01
HRP20130917T1 (hr) 2013-11-08
CA2749059C (en) 2017-08-01
HK1159990A1 (en) 2012-08-10
ME01757B (me) 2014-09-20
TW201442711A (zh) 2014-11-16
ECSP11011336A (es) 2011-10-31
ES2430596T3 (es) 2013-11-21
IL213979A0 (en) 2011-08-31
UY32414A (es) 2010-07-30
JP2012518019A (ja) 2012-08-09
SI2398473T1 (sl) 2013-11-29
EP2221055A1 (en) 2010-08-25
SG2014012827A (en) 2014-04-28
CO6361939A2 (es) 2012-01-20

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Address after: Spain Barcelona

Applicant after: Almirall SA

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Application publication date: 20120118