CN102311378A - 稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途 - Google Patents

稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途 Download PDF

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Publication number
CN102311378A
CN102311378A CN2011102214054A CN201110221405A CN102311378A CN 102311378 A CN102311378 A CN 102311378A CN 2011102214054 A CN2011102214054 A CN 2011102214054A CN 201110221405 A CN201110221405 A CN 201110221405A CN 102311378 A CN102311378 A CN 102311378A
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China
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group
compound
alkyl
present
tetrahydrochysene
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CN2011102214054A
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Chinese (zh)
Inventor
道格拉斯.P.博特曼
托马斯.O.施拉德尔
格雷姆.森普尔
菲利普.J.斯金纳
郑载奎
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Publication of CN102311378A publication Critical patent/CN102311378A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011102214054A 2004-12-23 2005-12-22 稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途 Pending CN102311378A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63866804P 2004-12-23 2004-12-23
US60/638,668 2004-12-23
US67652105P 2005-04-29 2005-04-29
US60/676,521 2005-04-29

Related Parent Applications (1)

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CN 200580044454 Division CN101087765A (zh) 2004-12-23 2005-12-22 稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途

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CN2011102214069A Pending CN102321024A (zh) 2004-12-23 2005-12-22 稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途
CN2011102214054A Pending CN102311378A (zh) 2004-12-23 2005-12-22 稠合吡唑衍生物和其在治疗代谢相关病症的方法中的用途

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US (3) US7241792B2 (enExample)
EP (1) EP1831178A2 (enExample)
JP (1) JP2008525476A (enExample)
KR (1) KR20070088808A (enExample)
CN (2) CN102321024A (enExample)
AR (1) AR055015A1 (enExample)
AU (1) AU2005319121A1 (enExample)
BR (1) BRPI0519262A2 (enExample)
CA (1) CA2589648A1 (enExample)
CU (1) CU23691B7 (enExample)
EA (1) EA013184B1 (enExample)
GE (1) GEP20105126B (enExample)
GT (1) GT200500379A (enExample)
HN (1) HN2005036256A (enExample)
IL (1) IL183654A0 (enExample)
MA (1) MA29148B1 (enExample)
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NO (1) NO20073766L (enExample)
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PA (1) PA8658301A1 (enExample)
PE (1) PE20060949A1 (enExample)
TN (1) TNSN07236A1 (enExample)
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Publication number Publication date
NO20073766L (no) 2007-09-21
US20090258892A1 (en) 2009-10-15
WO2006069242A3 (en) 2006-08-31
NZ555721A (en) 2011-02-25
BRPI0519262A2 (pt) 2009-01-06
CA2589648A1 (en) 2006-06-29
JP2008525476A (ja) 2008-07-17
EA013184B1 (ru) 2010-02-26
WO2006069242A2 (en) 2006-06-29
PA8658301A1 (es) 2006-10-13
IL183654A0 (en) 2007-09-20
GT200500379A (es) 2006-10-25
TNSN07236A1 (en) 2008-11-21
KR20070088808A (ko) 2007-08-29
US20070073062A1 (en) 2007-03-29
CN102321024A (zh) 2012-01-18
AR055015A1 (es) 2007-08-01
PE20060949A1 (es) 2006-10-11
AU2005319121A1 (en) 2006-06-29
MA29148B1 (fr) 2008-01-02
US20060205955A1 (en) 2006-09-14
CU23691B7 (es) 2011-09-21
US7241792B2 (en) 2007-07-10
GEP20105126B (en) 2010-12-10
EA200701361A1 (ru) 2007-12-28
US7612106B2 (en) 2009-11-03
NI200700161A (es) 2008-04-21
HN2005036256A (es) 2010-02-08
TW200635904A (en) 2006-10-16
CU20070144A7 (es) 2010-01-22
EP1831178A2 (en) 2007-09-12

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