Background technology
It comprises the oral disease of stomatitis, thrush, herpetic stomatitis, recurrent stomatitis etc. oral ulcer, is commonly called as: " aphtha ", also claim " getting angry in the oral cavity ", be that a kind of periodicity shows effect repeatedly be the local ulcerative lesions disease of oral mucosa of characteristics.Cardinal symptom: the circular or oval ulcer that single or a plurality of grain of rices, Semen Glycines differ in size takes place in the mucosa of locating at lip, cheek, soft palate or the gums etc. in oral cavity; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, the local causalgia of ulcer.Characteristic with periodicity, recurrent, self limiting.The cause of disease possibly be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency.Systemic disease, heredity, immunity and microorganism possibly play an important role in its generation, development.
Motherland's medical science thinks that oral ulcer is mainly blamed in the heart, taste, kidney, and because of mouth is a key outside the spleen, tongue is the Seedling of the heart, the kidney pulse clip tongue basis, and gingiva belongs to taste.Mainly be that heart spleen two is gone up inflammation through long-pending fire, fire belongs with yang is evil, consumption of body fluid by heat; Stomach-Yin consumption wound, hyperactivity of deficient fire, or the prolonged illness impairment of the spleen is empty, damage of spleen-QI, and water is wet not to be transported, or strongly fragrant heat-transformation of a specified duration, and damp and hot going up steamed; Or emotional stress, excessive thinking, dysphoria and insomnia, so that disarmony between the heart and kidney, the smoked dispute of burning of hyperactivity of deficient fire, or heart-fire moving downward is in small intestinal, follow through on attack Yu Kou, or, cause the endogenous fire formation of heart spleen because of the article of the pungent plumpness of surfeit, follow through on attack stifling dispute; Or consume cloudy Tianjin of sad lung kidney, follow to attack on the kidney pulse and burn the dispute gingiva and cause in tongue, gingiva; Or stagnation of QI due to depression of the liver, strongly fragrant and fire-transformation secretly consumes cloudy blood, cause to dash and appoint passages through which vital energy circulates uncomfortable, in row, to hold back more very through the stagnation of QI, liver-fire is vigorous, upward burns dispute and causes aphtha.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire in a word, interior impairment of ZANG FU-organs intenseness of heat are the main causes of causing a disease, the main sick dirty heart and the spleen (stomach) of being.Cardinal symptom: the circular or oval ulcer that single or a plurality of grain of rices, Semen Glycines differ in size takes place in the mucosa of locating at lip, cheek, soft palate or the gums etc. in oral cavity; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, the local causalgia of ulcer.Have can concurrent halitosis, General Symptoms such as chronic pharyngitis, constipation, headache, dizziness, nauseating, weak, irritated, heating, lymph node.At present, the medicine of treatment oral ulcer is very many on the market, and effect is extremely undesirable, and cure rate is low.As: BINGPENG SAN.For another example: State Patent Office is at disclosed application number 03108592x on April 12nd, 2004, and the effect of denomination of invention " a kind of medicine of treating oral ulcer " treatment oral ulcer is more undesirable, cures slowly the shortcoming that cure rate is low.Doctor trained in Western medicine is mainly used antibiotic, vitaminization, and effect is also undesirable.Of the present inventionly just provide a kind of treatment oral ulcer and have the cure rate height, effect is remarkable, and the medicine source is easy to get, no poisoning, and compound medicine is used in inexpensive a kind of oral cavity of treating oral ulcer.
Summary of the invention
The object of the invention just provides a kind of treatment oral ulcer and has the cure rate height, and effect is remarkable, and the medicine source is easy to get, no poisoning, and compound medicine is used in inexpensive a kind of oral cavity of treating oral ulcer.
Technical scheme of the present invention is to realize like this; Compound medicine is used in a kind of oral cavity of treating oral ulcer; It is characterized in that: it is made up of following medicaments in part by weight raw material, fries Cortex Garciniae 12, Semen Descurainiae (parched) 15, Semen Plantaginis (parched) 12, Gypsum Fibrosum Preparatum 12, Borax(calcined) 12, Calamina (calcined and quenched) 12, calamitas urinae hominis(calcined) 12, dried Alumen 10, Calx 9, Talcum 12, Borneolum Syntheticum 3, streptomycin 0.2, erythromycin 0.2.At first will fry Cortex Garciniae 12, Semen Descurainiae (parched) 15, Semen Plantaginis (parched) 12, Gypsum Fibrosum Preparatum 12, Borax(calcined) 12, Calamina (calcined and quenched) 12, calamitas urinae hominis(calcined) 12, dried Alumen 10, Calx 9, Talcum 12, Borneolum Syntheticum 3 pulverized altogether medicated powder and streptomycin 0.2, the erythromycin 0.2 of 150 mesh sieves mix fully grind and the plastics watering can of receiving nontoxic sterilization that stirs in subsequent use.
Drug action mechanism of the present invention is following:
Fry Cortex Garciniae: bitter in the mouth, puckery, cool in nature.Have heat-clearing and toxic substances removing, convergence granulation promoting, the effect of astringing to arrest diarrhea.Be used for mucosal ulcer, like oral ulcer.Reference: (middle hospital pharmacy, the Guangdong college of traditional Chinese medicine compiles, and the Guangdong People's Press publishes, the 755-756 page or leaf is seen in June, the 1973 front page first impression)
Semen Descurainiae (parched): acrid in the mouth, hardship.Property Great Cold.Go into lung, spleen channel.Have lowering the adverse-rising QI and dispelling phlegm, let out the effect of the capable water of lung.(the same, as to see 421 pages)
Semen Plantaginis (parched): sweet in the mouth, light, cold in nature.Go into liver, kidney, small intestinal, lung meridian.Has relieving stranguria by diuresis, the effect of liver heat removing and eyesight improving.After these article were fried, its powder had the effect of treatment ulcer.(the same, as to see the 306-307 page or leaf)
Gypsum Fibrosum Preparatum: sweet in the mouth, suffering, cold in nature.Go into lung, stomach warp.Have the removing dampness granulation promoting after forging, the effect of protection skin ulcer face is used for the many pus of skin infection, diseases such as eczema, burn more.(simultaneously, seeing 118 pages)
Borax(calcined): sweet in the mouth, salty, cool in nature.Go into lung, stomach warp.It is anticorrosion to have detoxifcation, heat clearing away expectorant, the effect of convergence moisture absorption.(the same, as to see the 752-753 page or leaf)
Calamina (calcined and quenched): sweet in the mouth, property is flat.Go into the stomach warp.Has the nebula of dispelling that makes eye bright, the effect of removing dampness granulation promoting.(the same, as to see 752 pages)
Dried Alumen: sour in the mouth, cold in nature.Go into spleen channel.Effect with killing parasites for relieving itching.The external of these article can be used for hemostasis and dermatosis.Dried Alumen can be combined to the albumen chemical combination that is insoluble in water with albumen and precipitate, so it is hemorrhage to can be used for local wound.(the same, as to see 748 pages)
Talcum: sweet in the mouth, light, cold in nature.Go into stomach, urinary bladder channel.Has relieving stranguria by diuresis, clearing away heat and removing summer-heat, the effect of external heat clearing away removing dampness.Getting it has the heat clearing away effect wet with absorbing water to control skin eczema etc.Modern pharmacological research is spread on wound surface and can forms tunicle, can play a protective role, and can absorb secretions again simultaneously, promotes dry incrustation, so the skin eczema of can be used for and ulcer are arranged.(the same, as to see the 307-308 page or leaf)
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature.Go into the heart, spleen, lung meridian.Has causing resuscitation with aromatic drugs, the effect of clearing away heat to alleviate pain.(simultaneously, seeing 719 pages)
Calamitas urinae hominis(calcined): salty in the mouth, cold in nature.Go into lung, liver, urinary bladder channel.Has heat-clearing and toxic substances removing, the effect of hemostasis by removing blood stasis.Be used for laryngopharynx swelling and pain, aphtha of the mouth and tongue, ulcerative gingivitis.With reference to (simple and clear traditional Chinese medical science dictionary, " traditional Chinese medical science dictionary " editorial board compiles, People's Health Publisher, the 1st edition the 2nd printing March in 1980.See 20 pages)
Calx: acrid in the mouth, warm in nature, poisonous.Calx: have detoxifcation, hemostasis, astringent effect.Be used for scalding wound hemorrhage, ulcer of the lower limb.(the same, as to see 212 pages)
Streptomycin: streptomycin has powerful antibacterial or bactericidal action to tubercule bacillus; Most Gram-negative bacillus, Bacillus proteus, hemophilus influenza, pneumobacillus, bacillus pestis, dysentery bacterium, bordetella pertussis and Brucella etc. all there are antibacterial action preferably.Be mainly used in the actute infection due to treatment tuberculosis and the various sensitive bacterial clinically.With reference to (pharmacology, volume two, Shanghai first medical college chief editor, the People's Health Publisher publishes, national high medical college teaching material on probation the 1st edition the 2nd printing January in 1981 " supply pharmacy, Chinese medicine specialty with " be 374 pages of volumes as follows).,
Erythromycin: erythromycin all has stronger antibacterial action to gram positive bacteria like staphylococcus, streptococcus, streptococcus pneumoniae, diphtheria corynebacterium, anthrax bacillus, clostridium etc.Responsive gram-negative bacteria, hemophilus influenza, bordetella pertussis, meningococcus, gonorrhea diplococcus, Brucella etc.Also there is the part bacterial strain responsive in the dysentery bacterium to these article.In addition, rickettsia, ameba, infusorian, mycoplasma pneumoniae etc. there is stronger inhibitory action.(the same, as to see the 369-370 page or leaf)
Press: Fang Zhongyong fries Cortex Garciniae, calamitas urinae hominis(calcined), Calamina (calcined and quenched), Gypsum Fibrosum Preparatum, Borax(calcined) heat-clearing and toxic substances removing; Eliminating stasis to stop pain, convergence granulation promoting are main, and the circular or oval ulcer that single or a plurality of grain of rices, Semen Glycines differ in size, ulcer surface concavity take place the mucosa of locating with lip, cheek, soft palate or the gums etc. of controlling the oral cavity; Greyish white or the yellow pseudomembrane of surface coverage; Clear border, mucosa is red and little swollen on every side, the local causalgia of ulcer; Be aided with Semen Descurainiae (parched), Semen Plantaginis (parched), Talcum, Calx, dried Alumen diuretic, removing dampness impels the acceleration incrustation of ulcer surface with the liquid that the treating dental ulcer face oozes out; Strengthen stir-fry Cortex Garciniae, calamitas urinae hominis(calcined), Calamina (calcined and quenched), Gypsum Fibrosum Preparatum, Borax(calcined) detoxifcation, antibacterial, antiinflammatory, pain relieving with streptomycin, erythromycin person, impel the effect of the granulation promoting of ulcer surface; Strengthen the analgesic effect with Borneolum Syntheticum, its fragrance of distinguishing the flavor of so have fragrant antihalitosis after medicinal, is unlikely to have other flavour of a drug.All medicines are harmonious, and bring out the best in each other, and have the effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, convergence, damp eliminating granulation promoting, so the effect of rapid healing of canker sores is arranged.
Medicine of the present invention has the effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, convergence, damp eliminating granulation promoting.
Medicine of the present invention is applicable to the oral ulcer disease that adult, child suffer from; Clinical cardinal symptom: the lip in oral cavity, cheek, soft palate, gums etc. are located the circular or oval ulcer that mucosa has single or a plurality of grain of rices, Semen Glycines to differ in size; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, the local causalgia of ulcer.
Treating the course of treatment: 1-3 days is 1 course of treatment, and the lighter can cure 1 course of treatment; Weight person 2-3 can cure a course of treatment.
Therapeutic effect: effective percentage 95%, cure rate 92.5%.
Method for using: aim at the ulcer surface thin one deck that gushs, spray 3-4 time with watering can.
Streptomycin of the present invention is the white powder of streptomycin sulfate.
Erythromycin of the present invention is white powder.
Calx of the present invention is Calx.
All Chinese medicine pharmacy of Tongrentang buys above raw material of Chinese medicine in Beijing.
Anti-pharmaceutical factory buys streptomycin in the Shandong.
Anti-pharmaceutical factory buys erythromycin in the Shandong.
Theory of Chinese medical science thinks that oral ulcer is mainly blamed in the heart, taste, kidney, and because of mouth is a key outside the spleen, tongue is the Seedling of the heart, the kidney pulse clip tongue basis, and gingiva belongs to taste.Mainly be that heart spleen two is gone up inflammation through long-pending fire, fire belongs with yang is evil, consumption of body fluid by heat; Stomach-Yin consumption wound, hyperactivity of deficient fire, or the prolonged illness impairment of the spleen is empty, damage of spleen-QI, and water is wet not to be transported, or strongly fragrant heat-transformation of a specified duration, and damp and hot going up steamed; Or emotional stress, excessive thinking, dysphoria and insomnia, so that disarmony between the heart and kidney, the smoked dispute of burning of hyperactivity of deficient fire, or heart-fire moving downward is in small intestinal, follow through on attack Yu Kou, or, cause the endogenous fire formation of heart spleen because of the article of the pungent plumpness of surfeit, follow through on attack stifling dispute; Or consume cloudy Tianjin of sad lung kidney, follow to attack on the kidney pulse and burn the dispute gingiva and cause in tongue, gingiva; Or stagnation of QI due to depression of the liver, strongly fragrant and fire-transformation secretly consumes cloudy blood, cause to dash and appoint passages through which vital energy circulates uncomfortable, in row, to hold back more very through the stagnation of QI, liver-fire is vigorous, upward burns dispute and causes aphtha.Diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire in a word, interior impairment of ZANG FU-organs intenseness of heat are the main causes of causing a disease, the main sick dirty heart and the spleen (stomach) of being.Cardinal symptom: the single or a plurality of grain of rices of mucosa generation that the lip in oral cavity, cheek, soft palate or gums etc. are located, the circular or oval ulcer that Semen Glycines is differed in size; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, the local causalgia of ulcer.Have can concurrent halitosis, General Symptoms such as chronic pharyngitis, constipation, headache, dizziness, nauseating, weak, irritated, heating, lymph node.
The specific embodiment
Below in conjunction with embodiment effect of the present invention is further specified:
Embodiment: get and fry Cortex Garciniae 12, Semen Descurainiae (parched) 15, Semen Plantaginis (parched) 12, Gypsum Fibrosum Preparatum 12, Borax(calcined) 12, Calamina (calcined and quenched) 12, calamitas urinae hominis(calcined) 12, dried Alumen 10, Calx 9, Talcum 12, Borneolum Syntheticum 3, streptomycin 0.2, erythromycin 0.2.At first will fry Cortex Garciniae 12, Semen Descurainiae (parched) 15, Semen Plantaginis (parched) 12, Gypsum Fibrosum Preparatum 12, Borax(calcined) 12, Calamina (calcined and quenched) 12, calamitas urinae hominis(calcined) 12, dried Alumen 10, Calx 9, Talcum 12, Borneolum Syntheticum 3 pulverized altogether medicated powder and streptomycin 0.2, the erythromycin 0.2 of 150 mesh sieves mix fully grind and the plastics watering can of receiving nontoxic sterilization that stirs in subsequent use.
Treating the course of treatment: 1-3 days is 1 course of treatment, and the lighter can cure 1 course of treatment; Weight person 2-3 can cure a course of treatment.
Therapeutic effect: effective percentage 95%.Cure rate 92.5%.
Method for using: aim at the ulcer surface thin one deck that gushs, spray 3-4 time with watering can.
Medicine of the present invention has the effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, convergence, damp eliminating granulation promoting.
Medicine of the present invention is applicable to the oral ulcer disease that adult, child suffer from; Clinical cardinal symptom: the lip in oral cavity, cheek, soft palate, gums etc. are located the circular or oval ulcer that mucosa has single or a plurality of grain of rices, Semen Glycines to differ in size; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, the local causalgia of ulcer.
Illustrate: for showing the curative effect of medicine of the present invention, get 80 routine patients " wherein 40 routine adults, 40 routine children ", clinical symptoms: the lip in oral cavity, cheek, soft palate, gums etc. are located the circular or oval ulcer that mucosa has single or a plurality of grain of rices, Semen Glycines to differ in size; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side; The local causalgia of ulcer is diagnosed as patient's average mark of oral ulcer and gives two groups of first, second, first group 20 routine adults, 20 routine children; Second group 20 routine adults, 20 routine children; At disclosed application number 03108592x on April 12nd, 2004, denomination of invention " a kind of medicine of treating oral ulcer " is treated with State Patent Office for 20 routine adults of first group treatment, 20 routine children, and 1-3 the course of treatment treated in medication every day 4 times; 20 routine adults, the 20 routine children of the treatment of second group use Drug therapy of the present invention, and 1-3 the course of treatment treated in medication every day 4 times; All locate the circular or oval ulcer that mucosa has single or a plurality of grain of rices, Semen Glycines to differ in size with the lip in symptom oral cavity, cheek, soft palate, gums etc.; The ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage, clear border; Mucosa is red and little swollen on every side, and the local causalgia of ulcer alleviates to effectively; All locate the circular or oval ulcer that mucosa has single or a plurality of grain of rices, Semen Glycines to differ in size, ulcer surface concavity, the greyish white or yellow pseudomembrane of surface coverage with the lip in symptom oral cavity, cheek, soft palate, gums etc.; Clear border; Mucosa is red and little swollen on every side, and the local causalgia complete obiteration of ulcer is recovery from illness, and therapeutic outcome shows: 20 routine adults, the 20 routine children of the treatment of first group; Effective 18 routine adults, 15 routine children, total 33 examples of imitating; Cure 16 routine adults, 14 routine children, cure 30 examples altogether, total effective rate 82.5%, cure rate 75%; 20 routine adults, the 20 routine children of the treatment of second group, effective 19 routine adults, 19 routine children, total 38 examples of imitating; Cure 18 routine adults, 19 routine children, cure 38 examples altogether, total effective rate 95%, cure rate 92.5%.
Therapeutic outcome shows that the effect of Drug therapy oral ulcer of the present invention is superior to State Patent Office at disclosed application number 03108592x on April 12nd, 2004, and the therapeutic effect of denomination of invention " a kind of medicine of treating oral ulcer " is worth develop and spread.
Model case: the West Lake, Yanggu County township Lao Dong village Dong XX, the man, 44 years old, in the clinic readme morning on the 2nd August in 2008, lip, the bicker that burn because of flu in October, 2007 were got blister; Mashed back flowing water, basic good through smearing several days with gentian voiet, later on, in the tip of the tongue, the cheek, begin to get blister on the gingiva; The mashed back of blister is scorching hot painful, also dare not eat hard thing, through treating over one year with BINGPENG SAN, antibiotic medicine, gently very, is exactly bad; Disease is seen: in the lip, the cheek, soft palate, gums etc. locate the circular or oval ulcer that mucosa has a plurality of Semen Glyciness to differ in size, and the ulcer surface concavity, surface coverage canescence pseudomembrane, clear border, mucosa is red and little swollen on every side; There is mild hyperaemia at the larynx place, thready pulse, number, and the little Huang of tongue fur, big dry stool, clinical diagnosis is an oral ulcer; Tell its all medicines of stopping using, use medicine of the present invention instead, day medication 4 times is sprayed onto medicine on the ulcer surface with watering can, and medication comes after 3 days again; It comes again after 3 days, readme, and behind personal this 3 days medicines, ulcer surface is painful in mouthful, and it is also painful to eat hard thing; Stool is also bowed out, and disease is seen: in the lip, the cheek, soft palate, gums etc. locate mucosa ulcer surface to take a turn for the better, ulcer surface has not had canescence pseudomembrane, not congested, has new granulation to grow, the hyperemia of larynx place is good; Tongue fur is normal, and arteries and veins is gentle, tells its reuse medicine and comes in 3 days again, comes readme after 3 days again; All is right, asks whether also medication, and disease is seen: in the lip, that the cheek, soft palate, gums etc. are located the ulcer surface place of mucosa is red a little, tells 3 days medicines of reuse, follows up a case by regular visits to so far recurrence.