CN102309364B - Gas flow control device for assisting radiofrequency ablation and method for implementing cooling by same - Google Patents
Gas flow control device for assisting radiofrequency ablation and method for implementing cooling by same Download PDFInfo
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- CN102309364B CN102309364B CN 201010217513 CN201010217513A CN102309364B CN 102309364 B CN102309364 B CN 102309364B CN 201010217513 CN201010217513 CN 201010217513 CN 201010217513 A CN201010217513 A CN 201010217513A CN 102309364 B CN102309364 B CN 102309364B
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Abstract
The invention discloses a gas flow control device for assisting radiofrequency heating. The gas flow control device comprises a steel cylinder, a pressure reducing valve, a gas flow control system, a gas precooling system and a radiofrequency needle, wherein gas inside the steel cylinder has a positive Joule-Thomson effect, flows out from the steel cylinder, is subjected to pressure regulation through the pressure reducing valve, and then is used for throttling and refrigerating at the point of the radiofrequency needle after passing through the gas flow control system and the gas precooling system in sequence. In the invention, a thermocouple, a PID (Proportion Integration Differentiation) regulator and a flow controller constitute a flow control unit; according to the comparison between a temperature feedback signal and a set temperature at the point of the radiofrequency needle, the cold energy at the point of the radiofrequency needle is regulated automatically, the ablation temperature is controlled precisely, a damage area is effectively enlarged and is controllable, and the safety and the usability of radiofrequency ablation are increased. In addition, the invention further discloses four types of specific methods for implementing cooling by using the cooling gas flow control device.
Description
Technical field
The present invention relates to the gas flow control device of a kind of Assisted RF Plasma CVD heating usefulness and implement the method for cooling, be used for the cold of control inputs radio frequency needle point, when enlarging the radio-frequency (RF) ablation scope, so that ablation range can be controlled easily.
Background technology
It is early stage that the radiofrequency ablation therapy tumor starts from the nineties in 19th century, but utilize the thought of heat treatment tumor but can trace back to ancient Egypt and Greece period.Therefore the tumor tissues water content usually easily is heated usually more than normal surrounding tissue, thereby causes the damage of tumor tissue.For tumor cell, the low PH environment that causes owing to long-term power consumption, chronic hypoxia, malnutrition, and the new vessels hot-swap feature of tumor is poor, self blood capillary lacks the factors such as basement membrane, all can cause tumor to thermo-responsive.These are that radio-frequency (RF) ablation heats the basis that makes tumor tissue necrosis to the tumor tissues selectivity.The ultimate principle of radio-frequency (RF) ablation is by electrode needle the alternating electromagnetic waveguide of high frequency to be entered tumor tissues, forms the loop through dispersing electrode again.During radio frequency operation, conductive ion in the tissue and polarized electron are according to the change rapid movement of alternating current direction, cause frictional heat, this endogenous pyrogen raises rapidly the interior temperature of tumor tissues, when local temperature surpasses 45 ℃～50 ℃, and the albumen generation degeneration in the normal cell, the bilayer lipid membrane dissolving, cell membrane bursts apart, and the inside and outside loss of water of cell causes tissue coagulation downright bad; Simultaneously, tumor peripheral vessels tissue coagulation can not continue to tumor feeding, is conducive to prevent neoplasm metastasis; The radio frequency heat effect can also enhancing human body immunity power, suppresses the growth of residual and primary tumo(u)r tissue to reach the purpose that melts, and Here it is " original position deactivation ", it be radio frequency tumour ablation treating treat mechanism the most at all.Radio-frequency (RF) ablation has following advantage with respect to other heating ablation modes: applied range, only act on focus, and wound is little, and it is convenient to implement, and cost is low.
In the actual radio frequency ablation procedure, because square being directly proportional of ablation range and electric current, and electric current be inversely proportional to apart from the square distance of pin, therefore, most radio-frequency currents are converted into heat energy around radio frequency needle 2, in the 3mm scope, cause the local organization excess Temperature, after tissue temperature surpasses 100 ℃, can produce vaporization, dehydration and even carbonization, the impedance of tissue increases sharply, electric current is decayed rapidly, causes ablation range to diminish.How can not increase ablation range under the too high prerequisite at tissue temperature, to become the key factor of radiofrequency ablation therapy tumor.
At present, mainly increase the radio-frequency (RF) ablation zone by following two kinds of methods: the one, adopt the multiple warhead ablating electrode.Such as RitaMedical Systems, the multi-electrode ablation apparatus of Inc..Its principal character is: most advanced and sophisticated 1-3 centimetre of 6-16 piece of sub-pin conducts electricity, and the other parts of sub-pin scribble insulating barrier; When the group pin all launched, the tip of each sub-pin and the distance of shank were all less than 2 centimetres, thus the formation oblate spheroid.Knob on the lever can launch 6-16 piece of sub-pin while or grouping and withdrawal.Its major defect is: the size of electrode is larger, and need open in vivo, and wound is larger, and has greatly increased the Potential danger of the contiguous vital tissue of damage; Use the operation more complicated, be difficult to correctly be inserted into target tissue; The ablation areas of multiple warhead ablating electrode is irregular, easily causes hemorrhage and infection symptoms.
The 2nd, adopt the cooling ablating electrode.The cooling ablating electrode has the outer cold two kinds of forms of interior cold-peace.Interior cold radio frequency needle is in radio frequency needle inside the cooling medium circulation line to be set, and this cooling medium can be liquid or gas.Cooling medium produces low temperature at needle point, acts on simultaneously destination organization with radio frequency heating, delays pin wall place tissue and heats up, and avoids producing and organizes carbonization, prolongs and melts the time, makes more radio-frequency (RF) energy be applied to destination organization, reaches the purpose that increases ablation range.Existing many companies produce the cooling ablating electrode in the world, have obtained good clinical effectiveness.Such as the cool-tip electrode of Sherwood Services AG, fluid such as water or saline etc. that it injects cooling reduce needle tip temperature at by heat convection; Chinese patent CN 2689905Y has announced a kind of water-cooled radio frequency ablating electrode; US Patent No. 2008/0154258A1 has announced after a kind of gas pre-cooling in the throttling of needle point place, further reduces the cold and hot cutter system of temperature; Chinese patent CN 101209217A and CN 2579358Y have all announced a kind of air cooling radio frequency ablation system.Comparatively speaking, the liquid cooling radio frequency needle is subject to liquid inlet and outlet pipe size, and general diameter is larger, has affected the Minimally Invasive Surgery effect, and fluid liquid flow velocity in tubule is slower, flow is little, when the electrode needle temperature is higher, easily produces gasification, form biphase gas and liquid flow, flow resistance increases, and further reduces flow velocity, causes overall heat exchange efficiency not high.The air cooling radio frequency needle can improve the problems referred to above to a certain extent because gas fluidity is much better than liquid, with respect to the liquid cooling radio frequency needle, certain advantage is arranged.But gas is directly usually too small at the cold that the needle point throttling produces, and the gas chilldown system of Chinese patent CN 101209217A bulletin, complex structure, and pre-cooling is chronic, clinical use inconvenience.
Outer cold radio frequency needle is then directly poured into the solution such as saline to target tissue by electrode needle, HiTT106 tumor micro-wound system such as German Viemedic GmbH company namely adopts this filling type radio frequency needle, and Chinese patent CN 201356648Y has also announced a kind of saline perfusion RF ablation catheter.The injection of solution both can delay to organize temperature rise, can increase tissue conductivities and augmentation of heat transfer again, and therefore, this filling type radio frequency needle can allow larger ablation power, produces larger ablation range.But owing to the uncertainty that infusion liquid distributes, cause the scrambling of ablation areas in tissue, easily damage normal structure, also follow higher complication rate.
In sum, the cooled RF ablation techniques more has prospect in the pin, has become in the industry one of main direction of studying.But above-mentioned various cooled RF pins are the control problem of unresolved input cold all, the cold of input and the heat of radio-frequency current generation is well mated, thereby control ablation range easily.
Summary of the invention
Technical problem to be solved by this invention is deficiency and the actual demand for existing cooled RF technology, the refrigerating gas volume control device that provides a kind of Assisted RF Plasma CVD to melt usefulness, and propose to utilize aforementioned refrigerating gas volume control device to implement the method for cooling.Refrigerating gas volume control device overall structure of the present invention is simple, and convenient easy-to-use, the gas precooling speed is fast, and cold is large; The method of implementation cooling provided by the invention is the cold of control inputs radio frequency needle point accurately, gives full play to the advantage of this technology of cooling Assisted RF Plasma CVD, so that ablation range increases substantially and be controlled.
In order to solve the problems of the technologies described above, the refrigerating gas volume control device that the Assisted RF Plasma CVD that the present invention proposes melts usefulness comprises: steel cylinder, air relief valve, gas Flowrate Control System, gas chilldown system and radio frequency needle, gas is the gas of the positive Joule-Thomsan effect (coefficient) of tool in the steel cylinder, such as nitrogen, carbon dioxide etc., gas is flowed out by steel cylinder, after the air relief valve adjust blood pressure, successively by freezing at radio frequency needle spike knot stream behind gas Flowrate Control System and the gas chilldown system.
The gas Flowrate Control System of this device comprises gas flow controller, temperature controller, thermocouple and host computer, temperature controller has automatically and manual two kinds of control models, and be connected with host computer with flow controller respectively by data wire, pass through upper computer software, temperature controller can be controlled according to radio frequency needle point thermocouple signal automatic/hand the aperture of flow controller, thus the cold of control inputs needle point.
The gas chilldown system of this device comprises a cover or two cover semiconductor refrigerating equipments: when adopting a cover semiconductor refrigerating equipment, the air inlet copper pipe disk becomes discoid, is fixed in the cold junction upper surface of semiconductor chilling plate, covers the cotton insulation material that waits of rubber outward; When adopting two cover semiconductor refrigerating equipments, the air inlet copper pipe disk becomes discoid, the cold junction upper surface of two semiconductor chilling plates is carved with groove, the degree of depth addition of two grooves is less than air inlet pipe external diameter 1mm, have aperture to link to each other between the two ends on the same direction of cold end surface and interior grooves, the cold junction grooves docking of two cover semiconductor refrigerating equipments is fixed with rivet, the plate-like air inlet pipe places in the groove, lays the cotton heat preserving and insulating material that waits of rubber between the outer of groove.
The concrete grammar that utilizes aforementioned refrigerating gas volume control device to implement cooling provided by the invention has four kinds:
1. temperature controller is set as automatic control mode, by upper computer software target setting temperature, radio frequency needle point thermocouple is with the actual temperature input temp controller that records, temperature controller is by comparison object temperature and actual temperature value, send control signal to gas flow controller, regulate its aperture, thereby the cold of control inputs radio frequency needle point makes the temperature stabilization of radio frequency needle point in setting value.
2. temperature controller is set as automatic control mode, output signal is set as pulse and presses, and sets blanking time, and the control flow controller is interrupted switching, so that gas flows into the radio frequency needle point discontinuously, the radio frequency needle point is interrupted cooling.
3. temperature controller is set as manual control model, gas flow controller is set as any opening degree between 0%-100%, when opening radiofrequency generator, open gas cooled.
4. temperature controller is set as manual control model, gas flow controller is set as any opening degree between 0%-100%, after the radio frequency needle point reached design temperature, temperature controller transmitted control signal automatically, gas flow controller was opened to the aperture of setting.
The advantage of maximum of the present invention is, the refrigerating gas volume control device overall structure that the Assisted RF Plasma CVD that provides melts usefulness is simple, and the gas precooling speed is fast, cold is large, substantially can accomplish plug and play.Concrete cooling implementation method provided by the invention can get accurately control to the cold of input radio frequency needle point with accomplished in many ways, makes it the heat coupling that produces with radio-frequency current, increases to greatest extent and controllably ablation range.
Description of drawings
Fig. 1 is that Assisted RF Plasma CVD of the present invention melts with refrigerating gas volume control device structural representation.
Fig. 2 is semiconductor refrigerating equipment storage cold drawing top view among the present invention.
Fig. 3 is semiconductor refrigerating equipment storage cold drawing partial sectional view among the present invention.
Wherein: 1 is steel cylinder, and 2 is air relief valve, and 3 is gas flow controller, and 4 is semiconductor refrigerating equipment, and 5 is temperature controller, and 6 is radiofrequency generator, and 7 is host computer, and 8 is radio frequency needle, and 9 are the storage cold drawing, and 10 are storage cold drawing groove, and 11 is aperture.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, further set forth the present invention.These embodiment are interpreted as only being used for explanation the present invention and are not used in restriction protection scope of the present invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalences change and modification falls into claim limited range of the present invention equally.
As Figure 1-3, the gas flow control device of the Assisted RF Plasma CVD heating usefulness that one embodiment of the present invention provides, comprise steel cylinder 1, air relief valve 2, gas Flowrate Control System, gas chilldown system 4, radio frequency needle 8, gas is the gas of the positive Joule-Thomsan effect (coefficient) of tool in the steel cylinder, such as nitrogen, carbon dioxide etc., gas is flowed out by steel cylinder 1, after air relief valve 2 adjust blood pressure, successively by freezing at radio frequency needle spike knot stream behind gas Flowrate Control System and the gas chilldown system 4, wherein:
Gas Flowrate Control System comprises gas flow controller 3, temperature controller 5, thermocouple 9 and host computer 7, and temperature controller 5 has automatically and manual two kinds of control models, and is connected with host computer with flow controller 3, thermocouple 9 respectively by data wire and is connected; By upper computer software, temperature controller 5 can be according to the aperture of radio frequency needle point thermocouple 9 signals with the contrast automatic/hand control flow controller 3 that presets temperature;
When gas chilldown system 4 adopted a cover semiconductor refrigerating equipment, the air inlet copper pipe disk became discoid, is fixed in storage cold drawing 10 upper surfaces of semiconductor refrigerating equipment 4, covered the cotton heat preserving and insulating material that waits of rubber outward.
The gas flow control device of the Assisted RF Plasma CVD heating usefulness that another preferred embodiment of the present invention provides, except gas chilldown system 4 adopted two cover semiconductor refrigerating equipments 4, all the other structures were identical with last embodiment.When gas chilldown system 4 adopts two cover semiconductor refrigerating equipments, the air inlet copper pipe disk becomes discoid, storage cold drawing 10 upper surfaces of two semiconductor refrigerating equipments 4 are carved with groove 11, the degree of depth of two grooves is added up less than air inlet pipe external diameter 1mm, there is semicircle aperture 12 to link to each other between the two ends on the storage cold drawing 10 surperficial same directions and interior grooves, storage cold drawing 10 docking of two cover semiconductor refrigerating equipments 4, fix with rivet, the plate-like air inlet pipe places in the groove 11, lays the cotton heat preserving and insulating material that waits of rubber between the outer of groove 11.
As shown in Figure 1, the concrete grammar that utilizes the refrigerating gas volume control device to implement cooling that the preferred embodiment of the present invention provides has four kinds:
The method that the first is implemented cooling is set as automatic control mode with temperature controller 5, by upper computer software target setting temperature, radio frequency needle point thermocouple 9 is with the actual temperature input temp controller 5 that records, temperature controller 5 is by comparison object temperature and actual temperature value, send control signal to gas flow controller 3, regulate its aperture, thereby the cold of control inputs radio frequency needle point makes the temperature stabilization of radio frequency needle point in setting value.The advantage of this cooling means is, under the radio-frequency power of certain limit, flow control system can be controlled gas flow to a desired value automatically, with the temperature stabilization at radio frequency needle wall place in the unlikely high value of organizing carbonization that causes, such as 90 ℃, stable high temperature can increase by the heat transfer of conduction of heat to periphery, effectively increases ablation range.
The method that the second is implemented cooling is set as automatic control mode with temperature controller 5, output signal is set as pulse voltage, be set as blanking time such as 5s, 10s, 15s etc., control gas flow controller 3 is interrupted switching, so that gas flows into the radio frequency needle point discontinuously, the radio frequency needle point is interrupted cooling.
The third method of implementing cooling is set as manual control model with temperature controller 5, and gas flow controller 3 is set as any opening degree between 0%-100%, opens gas cooled when opening radiofrequency generator 6.
The 4th kind of method of implementing cooling is set as manual control model with temperature controller 5, gas flow controller 3 is set as any opening degree between 0%-100%, after the radio frequency needle point reaches design temperature, temperature controller 5 transmits control signal automatically, gas flow controller 3 is opened to the aperture of setting.
Claims (9)
1. the gas flow control device of Assisted RF Plasma CVD heating usefulness, it is characterized in that, this device comprises steel cylinder (1), air relief valve (2), gas Flowrate Control System, gas chilldown system (4) and radio frequency needle (8), gas is the gas of the positive Joule-Thomsan effect (coefficient) of tool in the steel cylinder, gas is flowed out by steel cylinder (1), after air relief valve (2) adjust blood pressure, successively by freezing at radio frequency needle spike knot stream behind gas Flowrate Control System and the gas chilldown system (4).
2. Assisted RF Plasma CVD as claimed in claim 1 heats the gas flow control device of usefulness, it is characterized in that, gas Flowrate Control System comprises gas flow controller (3), temperature controller (5), thermocouple (9) and host computer (7), temperature controller (5) has automatically and manual two kinds of control models, and is connected 7 with gas flow controller (3), thermocouple (9) with host computer respectively by data wire) be connected; By upper computer software, temperature controller (5) is according to the aperture of the contrast automatic/hand control gas flow controller (3) of thermocouple (9) signal and predefined target temperature.
3. the gas flow control device of Assisted RF Plasma CVD heating usefulness as claimed in claim 1 is characterized in that, the gas chilldown system comprises a cover or two cover semiconductor refrigerating equipments (4):
Adopt a cover semiconductor refrigerating equipment (4), the air inlet copper pipe disk becomes discoid, is fixed in storage cold drawing (10) upper surface of semiconductor refrigerating equipment (4), covers heat preserving and insulating material outward;
Adopt two cover semiconductor refrigerating equipments (4), the air inlet copper pipe disk becomes discoid, storage cold drawing (10) upper surface of two semiconductor refrigerating equipments (4) is carved with groove (11), the degree of depth addition of two grooves is less than air inlet copper pipe external diameter 1mm, there is semicircle aperture (12) to link to each other between the two ends on storage cold drawing (10) the surperficial same direction and interior grooves, storage cold drawing (10) docking of two cover semiconductor refrigerating equipments (4), fix with rivet, discoid air inlet copper pipe places in the groove (11), lays heat preserving and insulating material between the outer of groove (11).
4. the gas flow control device of Assisted RF Plasma CVD heating usefulness as claimed in claim 3 is characterized in that, heat preserving and insulating material is that rubber is cotton.
5. such as the gas flow control device of any one described Assisted RF Plasma CVD heating usefulness of claim 1-3, it is characterized in that, the gas of the positive Joule-Thomsan effect (coefficient) of tool is nitrogen or carbon dioxide.
6. a gas flow control device that utilizes Assisted RF Plasma CVD claimed in claim 2 heating usefulness is implemented the method for cooling, it is characterized in that, temperature controller (5) is set as automatic control mode, by upper computer software target setting temperature, thermocouple (9) is with the actual temperature input temp controller (5) that records, temperature controller (5) is by comparison object temperature and actual temperature value, send control signal to gas flow controller (3), regulate its aperture, thereby the cold of control inputs radio frequency needle point makes the temperature stabilization of radio frequency needle point at target temperature.
7. a gas flow control device that utilizes Assisted RF Plasma CVD claimed in claim 2 heating usefulness is implemented the method for cooling, it is characterized in that, temperature controller (5) is set as automatic control mode, output signal is set as pulse voltage, set blanking time, control gas flow controller (3) is interrupted switching, so that gas flows into the radio frequency needle point discontinuously, the radio frequency needle point is interrupted cooling.
8. a gas flow control device that utilizes Assisted RF Plasma CVD claimed in claim 2 heating usefulness is implemented the method for cooling, it is characterized in that, temperature controller (5) is set as manual control model, gas flow controller (3) is set as any opening degree between 0%-100%, when opening radiofrequency generator (6), opens gas cooled.
9. a gas flow control device that utilizes Assisted RF Plasma CVD claimed in claim 2 heating usefulness is implemented the method for cooling, it is characterized in that, temperature controller (5) is set as manual control model, gas flow controller (3) is set as any opening degree between 0%-100%, after the radio frequency needle point reaches target temperature, temperature controller (5) transmits control signal automatically, gas flow controller (3) is opened to the aperture of setting.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI564042B (en) * | 2013-02-28 | 2017-01-01 | 日本來富恩股份有限公司 | Catheter system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3209236B1 (en) | 2015-03-31 | 2020-06-10 | St. Jude Medical, Cardiology Division, Inc. | Device for delivering pulsed rf energy during catheter ablation |
| CN116269999B (en) * | 2023-02-28 | 2024-01-05 | 北京大学深圳医院 | Pipeline device, system and control method for controlling wind speed and flow of therapeutic apparatus |
| CN117017472B (en) * | 2023-08-16 | 2024-02-02 | 镇江恒生涓恩医疗器械有限公司 | Bipolar operation electrode |
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| CN2273314Y (en) * | 1996-02-13 | 1998-01-28 | 中国科学院上海技术物理研究所 | Quartz active gas generating device for vacuum system |
| WO2008077317A1 (en) * | 2006-12-26 | 2008-07-03 | Accutarget Medipharma (Shanghai) Corp. Ltd. | Radio frequency ablation system with joule-thomson cooler |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI564042B (en) * | 2013-02-28 | 2017-01-01 | 日本來富恩股份有限公司 | Catheter system |
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