CN102302686A - Medicament for treating xerophthalmia - Google Patents
Medicament for treating xerophthalmia Download PDFInfo
- Publication number
- CN102302686A CN102302686A CN201110206279A CN201110206279A CN102302686A CN 102302686 A CN102302686 A CN 102302686A CN 201110206279 A CN201110206279 A CN 201110206279A CN 201110206279 A CN201110206279 A CN 201110206279A CN 102302686 A CN102302686 A CN 102302686A
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- parts
- medicament
- radix
- fructus
- xerophthalmia
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- 239000003814 drug Substances 0.000 title claims abstract description 26
- 208000005494 xerophthalmia Diseases 0.000 title claims abstract description 15
- 241001113925 Buddleja Species 0.000 claims abstract description 3
- 241000628997 Flos Species 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 7
- 239000010271 massa medicata fermentata Substances 0.000 claims description 5
- 239000003889 eye drop Substances 0.000 claims description 3
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 241000132012 Atractylodes Species 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 241000745390 Lophatherum Species 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000001745 Rheum palmatum Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 6
- 230000028327 secretion Effects 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 206010034960 Photophobia Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicament for treating xerophthalmia. The medicament is prepared from the following raw material medicaments: common lophatherum herb, charred triplet, bighead atractylodes rhizome, Chinese atractylodes, butterflybush flower, Chinese rhubarb, platycodon grandiflorus, chrysanthemum, Chinese angelica, liquorice, Chinese magnoliavine fruit and glossy privet fruit. The medicament is prepared from pure Chinese medicaments, maintains the characteristics of low toxicity and good curative effect of natural medicaments, has clear curative effect, and can effectively treat the xerophthalmia.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of medicament of treating xerophthalmia.
Background technology
Xerophthalmia is meant because the unstable and eye surface damage of tear film unusual or that the tear hydrodynamics causes unusually of the amount of tear or matter; Thereby the one type of disease that causes a malaise symptoms, clinical manifestation are sensation of dryness, foreign body sensation, burn feeling, gargalesthesia, photophobia, furious, blurred vision, vision fluctuation and asthenopia etc.Along with the raising of The development in society and economy and people's living standard, the incidence rate of xerophthalmia has the trend of increase, and the trend of rejuvenation is arranged.
The right eye drop of many clinically employing tears waits and treats xerophthalmia at present.Because organizing of eye is relatively more responsive, these medicines are bigger for the injury of part tissue of eye, and usually can produce chemical sproof problem.
Summary of the invention
The purpose of this invention is to provide a kind of medicament of treating xerophthalmia.
In order to realize the object of the invention, the present invention provides a kind of medicament of treating xerophthalmia, and it is processed by following bulk drugs by weight:
1～5 part of 1～10 part of Rhizoma Atractylodis Macrocephalae of 1～10 part of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) of Herba Lophatheri
1～5 part of 1～10 part of Radix Et Rhizoma Rhei of 1～5 portion of Flos Buddlejae of Rhizoma Atractylodis
1～10 part of 1～10 part of Radix Angelicae Sinensis of 1～5 part of Flos Chrysanthemi of Radix Platycodonis
1～10 part of 1～10 part of Fructus Ligustri Lucidi of 1～10 part of Fructus Schisandrae Chinensis of Radix Glycyrrhizae.
Preferably, it is processed by following bulk drugs by weight:
3 parts of 10 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) of Herba Lophatheri
5 parts of 10 parts of Radix Et Rhizoma Rhei of 3 portions of Flos Buddlejaes of Rhizoma Atractylodis
5 parts of 10 parts of Radix Angelicae Sinensis of 5 parts of Flos Chrysanthemis of Radix Platycodonis
10 parts of 10 parts of Fructus Ligustri Lucidi of 5 parts of Fructus Schisandrae Chinensis of Radix Glycyrrhizae.
Preferably, medicament of the present invention is tablet, dispersible tablet, decoction or eye drop.
Medicament of the present invention is prepared with pure Chinese medicine, keeps little, the eutherapeutic characteristic of natural drug toxicity, and curative effect is clear and definite, can treat xerophthalmia effectively.
The specific embodiment
Below description through the specific embodiment the present invention is described further; But this is not to be limitation of the present invention; Those skilled in the art are according to basic thought of the present invention; Can make various modifications or improvement; But only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 decoction of the present invention
Get Herba Lophatheri 100 grams, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 100 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Rhizoma Atractylodis 30 grams, Flos Buddlejae 100 grams, Radix Et Rhizoma Rhei 50 grams, Radix Platycodonis 50 grams, Flos Chrysanthemi 100 grams, Radix Angelicae Sinensis 50 grams, Radix Glycyrrhizae 50 grams, Fructus Schisandrae Chinensis 100 grams, Fructus Ligustri Lucidi 100 grams; Place 1000 ml waters; 100 ℃ of following reflux 2 hours; Filter, obtain filtering residue and filtrating.Said filtrating is concentrated into 500 milliliters, promptly gets.
Experimental example
Diagnostic criteria: have that a sensation of dryness, foreign body sensation, fatigue, furious, photophobia, burn feeling, eye acid are expanded, ophthalmalgia; Tear functional check: lacrimal secretion test I (SCHERMER I)＜10mm, breakup time of tear film (BUT)＜10s.Getting rid of light nature adacrya, no lachrymal gland, the large-area eye table of neurological disorder damages the lachrymal gland pipe choking, the unsteered systemic disease that cause, wears contact lens, operated eye or trauma history etc. is arranged in the recent period.Forbidding general antihistamine, anticholinergic agent or other opthalmologicals during the medication.
Choose xerophthalmia patient's 50 examples that meet above-mentioned diagnostic criteria, wherein male 25 examples, women 25 examples, 37 years old mean age.
Take the decoction of preparation among the embodiment 1, three times on the one, each 50 milliliters.One week of treatment is 1 course of treatment continuously.Medication was checked after 1 week.Carry out the mensuration of tear basal secretion reagent paper test Schirmer test and breakup time of tear film BUT.
The therapeutic evaluation standard:
Cure transference cure, corneal dyeing reduces, and the Schinner test is mensuration＞10mm/5min repeatedly;
The improvement sx, corneal dyeing reduces, and the lacrimal secretion amount is repeatedly measured in the Schirmer test to be increased to some extent;
Invalid symptom does not have improvement, corneal dyeing no change or increase Schirmer test and repeatedly measure the secretion of tear and do not increase.
On inspection, whole 50 routine patients all meet the standard of healing after treating.
Untoward reaction: untoward reaction does not appear in 50 routine patients in therapeutic process.
Claims (3)
1. medicament of treating xerophthalmia is characterized in that it is processed by following bulk drugs by weight:
1～5 part of 1～10 part of Rhizoma Atractylodis Macrocephalae of 1～10 part of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) of Herba Lophatheri
1～5 part of 1～10 part of Radix Et Rhizoma Rhei of 1～5 portion of Flos Buddlejae of Rhizoma Atractylodis
1～10 part of 1～10 part of Radix Angelicae Sinensis of 1～5 part of Flos Chrysanthemi of Radix Platycodonis
1～10 part of 1～10 part of Fructus Ligustri Lucidi of 1～10 part of Fructus Schisandrae Chinensis of Radix Glycyrrhizae.
2. the medicament of treatment xerophthalmia according to claim 1 is characterized in that, it is processed by following bulk drugs by weight:
3 parts of 10 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) of Herba Lophatheri
5 parts of 10 parts of Radix Et Rhizoma Rhei of 3 portions of Flos Buddlejaes of Rhizoma Atractylodis
5 parts of 10 parts of Radix Angelicae Sinensis of 5 parts of Flos Chrysanthemis of Radix Platycodonis
10 parts of 10 parts of Fructus Ligustri Lucidi of 5 parts of Fructus Schisandrae Chinensis of Radix Glycyrrhizae.
3. the medicament of treatment xerophthalmia according to claim 1 and 2 is characterized in that, said medicament is tablet, dispersible tablet, decoction or eye drop.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110206279 CN102302686B (en) | 2011-07-22 | 2011-07-22 | Medicament for treating xerophthalmia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110206279 CN102302686B (en) | 2011-07-22 | 2011-07-22 | Medicament for treating xerophthalmia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102302686A true CN102302686A (en) | 2012-01-04 |
| CN102302686B CN102302686B (en) | 2013-02-27 |
Family
ID=45376668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110206279 Expired - Fee Related CN102302686B (en) | 2011-07-22 | 2011-07-22 | Medicament for treating xerophthalmia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102302686B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657703A (en) * | 2012-06-04 | 2012-09-12 | 韦东波 | New application of traditional Chinese medicine buddleja officinalis |
| CN102698079A (en) * | 2012-06-19 | 2012-10-03 | 成都中医药大学附属医院 | Medicine composition for treating xerophthalmia and preparation method and application thereof |
| CN104324139A (en) * | 2014-11-07 | 2015-02-04 | 王磊 | Medicine composition for treating xerophthalmia |
| CN109758533A (en) * | 2019-03-18 | 2019-05-17 | 陈培培 | A kind of pharmaceutical composition for eyeshield and preparation method thereof and purposes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515291A (en) * | 2003-01-07 | 2004-07-28 | 程晓氢 | Oral liquor for curing ophthalmokopia |
| CN1781492A (en) * | 2005-09-29 | 2006-06-07 | 李广中 | Use of zijing in preparing preparation for treating shortsightedness |
-
2011
- 2011-07-22 CN CN 201110206279 patent/CN102302686B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515291A (en) * | 2003-01-07 | 2004-07-28 | 程晓氢 | Oral liquor for curing ophthalmokopia |
| CN1781492A (en) * | 2005-09-29 | 2006-06-07 | 李广中 | Use of zijing in preparing preparation for treating shortsightedness |
Non-Patent Citations (1)
| Title |
|---|
| 陈晨: "中医对干眼病因病机的认识及治疗概况", 《国际中医中药杂志》, vol. 29, no. 4, 30 July 2007 (2007-07-30), pages 236 - 238 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657703A (en) * | 2012-06-04 | 2012-09-12 | 韦东波 | New application of traditional Chinese medicine buddleja officinalis |
| CN102698079A (en) * | 2012-06-19 | 2012-10-03 | 成都中医药大学附属医院 | Medicine composition for treating xerophthalmia and preparation method and application thereof |
| CN104324139A (en) * | 2014-11-07 | 2015-02-04 | 王磊 | Medicine composition for treating xerophthalmia |
| CN109758533A (en) * | 2019-03-18 | 2019-05-17 | 陈培培 | A kind of pharmaceutical composition for eyeshield and preparation method thereof and purposes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102302686B (en) | 2013-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: TIANJIANG PHARMACEUTICAL INDUSTRY CO., LTD., JIANG Free format text: FORMER OWNER: CHEN CHAO Effective date: 20130731 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 272000 JINING, SHANDONG PROVINCE TO: 214400 WUXI, JIANGSU PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20130731 Address after: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee after: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin Address before: 272000 Department of Ophthalmology, the first people's Hospital of Jining, 6 health Road, Shizhong District, Shandong, Jining Patentee before: Chen Chao |
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| TR01 | Transfer of patent right |
Effective date of registration: 20170419 Address after: 150599 Harbin City, Heilongjiang province Hulan District happy street 17-1 Patentee after: Wang Kai Address before: 214400 Jiangyin Economic Development Zone, Jiangsu, Qin Shan Road, No. 8 Patentee before: Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin |
|
| TR01 | Transfer of patent right | ||
| CP02 | Change in the address of a patent holder |
Address after: 266000 Shandong city of Qingdao Province Pingdu Dazeshan town the road Patentee after: Wang Kai Address before: 150599 Harbin City, Heilongjiang province Hulan District happy street 17-1 Patentee before: Wang Kai |
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| CP02 | Change in the address of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130227 Termination date: 20180722 |
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| CF01 | Termination of patent right due to non-payment of annual fee |