CN100998785B

CN100998785B - Traditional Chinese medicine composition for treating gastrointestinal disease and its preparing method

Info

Publication number: CN100998785B
Application number: CN2006100111809A
Authority: CN
Inventors: 李祖泽; 施少斌; 郑荣波; 沈军; 黄晓丹
Original assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Current assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date: 2006-01-12
Filing date: 2006-01-12
Publication date: 2012-06-13
Anticipated expiration: 2026-01-12
Also published as: CN100998785A

Abstract

A Chinese medicine in the form of pill for treating gastrointestinal disease is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of Chinese medicine composition of treating gastrointestinal disease and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicine composition of treating gastrointestinal disease and preparation method thereof.

Background technology

Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, and these symptoms can cause by multiple reason, and the double sense wind and cold of regarding sb. as an outsider of gastrointestinal disease is one of the main reasons wherein.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment that affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache are vomited and diarrhoea clinically, mainly be with stomachache, diarrhoea; The food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia; The dizzy wave of journey; Pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is the novel formulation that on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, develops, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials, general ball, coating ", thereby it is low to cause Health pill to exist the medicine effective component content, reduces at gastrointestinal dissolution rate and absorbance, and soak time prolongs, and onset is slow.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition of treating gastrointestinal disease.

Another object of the present invention is to provide a kind of method for preparing of treating the active component of gastrointestinal disease.

Another object of the present invention provides a kind of method for preparing of treating the Chinese medicine composition of gastrointestinal disease.

Medicine of the present invention can be used to prepare the application of treating cold medicine.

Medicine of the present invention can be used for preparing the application of treatment gastroenteritis medicine.

Pharmaceutical composition of the present invention is to be processed by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.

The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.

Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; (81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss.

Best each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 34.10 parts of Ramulus Uncariae Cum Uncis; 136.40 parts of Cortex Magnoliae Officinalis; 102.30 parts of Radix Trichosanthis; 272.80 parts in Poria; 136.40 parts of the Radixs Angelicae Dahuricae; 136.40 parts of Guangdong Massa Medicata Fermentata; 34.10 parts of Fructus Tribulis; 136.40 parts of Rhizoma Atractylodis; 136.40 parts of Radix Puerariaes; 68.20 parts of Exocarpium Citri Grandises; 102.30 parts of Fructus Oryzae Germinatus; 68.20 parts of Flos Chrysanthemis; 136.40 parts of the Radix Aucklandiae; 136.40 parts of Herba Pogostemonis; 68.20 parts of Herba Menthaes; 170.50 parts of Semen Coiciss.

Medicine of the present invention can be processed any preparation on the pharmaceutics; Preferably process tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, unguentum.

The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, can these crude drug pulverize mix homogeneously be processed powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, process pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.

The proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine proportioning is a dosage range provided by the present invention.

The pill method for preparing of Chinese medicine composition of the present invention comprises following several kinds of method for preparinies:

Chinese medicine composition pill method for preparing one of the present invention comprises the steps:

A. it is subsequent use to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;

B. above 16 flavor Chinese crude drugs are ground into fine powder, process pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly get.

Chinese medicine composition pill method for preparing two of the present invention comprises the steps:

B. above 16 flavor Chinese crude drugs become superfine medicated powder through micronizing, process pill.

Chinese medicine composition pill method for preparing three of the present invention comprises the steps:

B. above 16 flavor Chinese crude drugs are processed the nanometer medical material, process pill according to the pill method for preparing then.

Chinese medicine composition pill method for preparing four of the present invention comprises the steps:

B. above 16 flavor Chinese crude drugs, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Chinese medicine composition pill method for preparing five of the present invention comprises the steps:

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 1～3 time respectively of Massa Medicata Fermentata, Poria, each 1～2 hour, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 40%～60%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 1～3 time, each 0.2～1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 1～3 time, and each 1～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 50～90 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 50～80 ℃ of dryings.

Preferred Chinese medicine composition pill method for preparing five of the present invention comprises the steps:

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, Poria be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water secondary, each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～80 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 60 ℃ of dryings.

Chinese medicine composition pill method for preparing six of the present invention comprises the steps::

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 1～3 time respectively of Massa Medicata Fermentata, Poria, each 0.5～3 hour, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 40%～60%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 1～3 time, each 0.2～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 50～90 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Preferred Chinese medicine composition pill method for preparing six of the present invention comprises the steps:

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, Poria be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water secondary, each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～80 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Chinese medicine composition pill method for preparing seven of the present invention comprises the steps:

A. the hook taking rattan is 15.50～55.80 parts; 80.40～215.50 parts of Cortex Magnoliae Officinalis; 55.50～205.80 parts of Radix Trichosanthis; 155.60～423.20 parts in Poria; 80.40～215.50 parts of the Radixs Angelicae Dahuricae; 80.40～215.50 parts of Guangdong Massa Medicata Fermentata; 15.50～55.80 parts of Fructus Tribulis; 80.40～215.50 parts of Rhizoma Atractylodis; 80.40～215.50 parts of Radix Puerariaes; 36.70～125.40 parts of Exocarpium Citri Grandises; 55.50～205.80 parts of Fructus Oryzae Germinatus; 36.70～125.40 parts of Flos Chrysanthemis; 80.40～215.50 parts of the Radix Aucklandiae; 80.40～215.50 parts of Herba Pogostemonis; 36.70～125.40 parts of Herba Menthaes; 95.20～324.80 parts of Semen Coiciss are subsequent use;

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 1～4 time, each 0.5～3 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 30～60%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 1～4 time, each 0.5～3.5 hour, collecting decoction filtered; Filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 30～50%, hold over night; Filter, reclaim ethanol and be concentrated into certain volume, subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 1～4 time, each 0.2～2 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 20～60%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 1～4 time, each 0.2～3.5 hour, collecting decoction filtered; Filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40～80%, hold over night; Filter, reclaim ethanol, be concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Preferred Chinese medicine composition pill method for preparing seven of the present invention comprises the steps:

A. the hook taking rattan is 27.17～41.20 parts; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; 81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss are subsequent use;

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 2～3 times, each 1～2 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40～50%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 2～3 times, each 1～3 hour, collecting decoction filtered; Filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 35～45%, hold over night; Filter, reclaim ethanol and be concentrated into certain volume, subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 2～3 times, each 0.5～1.5 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 30～50%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 2～3 times, each 0.5～3 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 50～70%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Best Chinese medicine composition pill method for preparing seven of the present invention comprises the steps:

A. 34.10 parts in hook taking rattan, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are subsequent use;

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water secondary, each 1.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction; Filter, filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%; Hold over night filters, and reclaims ethanol and is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water secondary, each 1 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 45%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction; Filter, filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 60%, hold over night; Filter, reclaim ethanol, be concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Chinese medicine composition pill method for preparing eight of the present invention comprises the steps:

A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 80.40～215.50 parts of Cortex Magnoliae Officinalis; 55.50～205.80 parts of Radix Trichosanthis; 155.60～423.20 parts in Poria; 80.40～215.50 parts of the Radixs Angelicae Dahuricae; 80.40～215.50 parts of Guangdong Massa Medicata Fermentata; 15.50～55.80 parts of Fructus Tribulis; 80.40～215.50 parts of Rhizoma Atractylodis; 80.40～215.50 parts of Radix Puerariaes; 36.70～125.40 parts of Exocarpium Citri Grandises; 55.50～205.80 parts of Fructus Oryzae Germinatus; 36.70～125.40 parts of Flos Chrysanthemis; 80.40～215.50 parts of the Radix Aucklandiae; 80.40～215.50 parts of Herba Pogostemonis; 36.70～125.40 parts of Herba Menthaes; 95.20～324.80 parts of Semen Coiciss are subsequent use;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; The paste ring spermatophore that volatile oil is added 1～10 times of extract amount closes, and gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;

C. qinghuo reagent I, clear paste II, cyclodextrin clathrate mix homogeneously are processed medicine activity component of the present invention.

Preferred Chinese medicine composition pill method for preparing eight of the present invention comprises the steps:

A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; 81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss are subsequent use;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50～70 ℃;

C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is processed active component of the present invention.

Best Chinese medicine composition pill method for preparing eight of the present invention comprises the steps:

A. it is subsequent use to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;

Method for preparing nine:

Chinese medicine composition method for preparing of the present invention comprises the steps:

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;

Add ethanol to clear paste I and make and contain alcohol amount and reach 50～80%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 5000～20000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well; Earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merging ethanol elution; Being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrates; Drying is pulverized, and it is subsequent use to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2～10 times distilled water eluting of column volume 1～3 time, water liquid discards; Reuse 50～80% ethanol elutions 1～3 time; Eluting uses ethanol 2～10 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;

C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, processes active component of the present invention.

Preferred Chinese medicine composition method for preparing of the present invention comprises the steps:

B. active component preparation:

Add ethanol to clear paste I and make and contain alcohol amount and reach 60～70%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 10000～15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well; Earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merging ethanol elution; Being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrates; Drying is pulverized, and it is subsequent use to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2～8 times distilled water eluting of column volume 2～3 times, water liquid discards; Reuse 60～70% ethanol elutions 2～3 times; Eluting uses ethanol 2～8 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;

Best Chinese medicine composition method for preparing of the present invention comprises the steps:

B. active component preparation:

Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and it is subsequent use to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;

In process for preparing medicine of the present invention eight, the method for preparing nine, whether clear paste I is further purified and make dry extract I; Clear paste II further purifies and makes dry extract II, confirms according to the form of pharmaceutical preparation.

Preparation method of Chinese medicine of the present invention is mixed arbitrary active component that makes in method for preparing eight, the method for preparing nine with pill adjuvant commonly used, process pill according to the conventional method for preparing of pill.

More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The specific embodiment

In order to understand the present invention better, logical below Test Example is further set forth the beneficial effect of medicine of the present invention.These Test Example comprise that medicine of the present invention holds wet hold under the arm the stagnate flu of card, the influence of acute gastroenteritis under the arm to wind and cold, and the effect of medicine of the present invention is described through test data.Below institute's medicament for the ease of narration, below will be called for short medicine of the present invention according to the medicine that embodiment 17 obtains according to the preparation of embodiment 17 methods in the test.

Test Example 1: Drug therapy flu of the present invention clinical research

One, qualified experimenter's selection

(1) Chinese medical discrimination standard: [working out] with reference to " new Chinese medicine clinical research guideline " and high Chinese medicine universities and colleges' teaching materials " Chinese Internal Medicine "

Wind and cold is held wet hold under the arm stagnant (flu) under the arm: nasal obstruction watery nasal discharge, cough, pharyngalgia, fever with aversion to cold, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, anorexia, or the belch acid regurgitation is arranged, stomachache is uncomfortable, stool is uncomfortable, light red tongue is fat or light red, tongue in vain, stringy and tense pulse or stringy and rolling pulse.

(2) Western medicine diagnose standard

Flu: [with reference to " practical internal medicine "]

1, the popular contact history of flu is arranged;

2, be main with local symptom, General Symptoms can have or be not obvious;

Local symptom: sneeze, nasal obstruction, watery nasal discharge, cough sometimes, pharyngalgia, hoarseness, shed tears;

General Symptoms: fever with aversion to cold, general malaise, headache and dizzy, extremity aching pain in waist and back;

3, hemogram: how normal numeration of leukocyte is or on the low side.

Two, clinical implementation scheme

(1) test method: adopt the randomized controlled trial method

(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use

(3) usage and dosage

The treatment group: medicine of the present invention, oral, each 2 bottles, every day 3 times.

Matched group: HUOXIANGZHENGQI KOUFUYE, oral, each 2 bottles, every day 3 times.

(4) course of treatment: 3 days.

(5) observation index

The health giving quality observation item

Relevant symptoms and sign: like aversion to cold, heating, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.

Symptom scalar quantization table

Symptom	Do not have (0 grade)	Gently (I level)	In (II level)	Heavy (III level)
					Aversion to cold	Do not have (0 minute)	Aversion to cold need not add clothing (1 minute)	Aversion to cold need add clothing (2 minutes)	Aversion to cold need be thickeied clothing or quilt (3 minutes)
Heating	Do not have (0 minute)	37.1～37.9 ℃ of body temperature (1 minute)	38～38.5 ℃ of body temperature (2 minutes)	Body temperature is (3 minutes) more than 38.6 ℃
					Nasal obstruction	Do not have (0 minute)	The sense of obstruction is arranged, low voice speaking (1 minute)	Nose cold occur now and then (2 minutes)	Nasal obstruction constant (3 minutes)
Watery nasal discharge	Do not have (0 minute)	Idol has watery nasal discharge (1 minute)	The time watery nasal discharge (2 minutes) arranged	Continue watery nasal discharge (3 minutes)
					Cough	Do not have (0 minute)	Idol has (1 minute)	The time (2 minutes) arranged	Frequently (3 minutes)
Pharyngalgia	Do not have (0 minute)	Hypodynia (1 minute)	Pharyngalgia (2 minutes)	Pain is (3 minutes) very
					Dizziness headache	Do not have (0 minute)	Dizzy pain is light, the time end (1 minute) when doing	Heavier, continue more than (2 minutes)	Dizziness headache can not be adhered to work (3 minutes)
Limb aching pain	Do not have (0 minute)	Slightly ache (1 minute)	Ache obviously (2 minutes)	Ache and accompany joint stuffiness (3 minutes)
					Fullness in the epigastrium and chest	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes)	Distension continues the alleviation of need taking medicine (3 minutes) unbearably
The belch acid regurgitation	Do not have (0 minute)	Idol has belch acid regurgitation (1 minute)	The time belch acid regurgitation (2 minutes) arranged	Frequent belch acid regurgitation (3 minutes)
					Nausea and vomiting	Do not have (0 minute)	Idol has nauseating (1 minute)	In the time, have nauseatingly, and idol has a vomiting (2 minutes)	Frequent nauseating, vomiting (3 minutes) sometimes
Diet reduces	Do not have (0 minute)	Appetite reduces (1 minute)	Appetite reduces by 1/3 (2 minutes)	Appetite reduces by 1/2 (3 minutes)
					Epigastric pain	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes)	Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably
Loose stool	Do not have (0 minute)	It is shapeless to defecate, every day 1～3 time (1 minute)	Loose stool, every day 4～6 times (2 minutes)	The stool water sample, every day is (3 minutes) more than 7 times

Three, efficacy assessment standard

1, flu curative effect determinate standard

(1) clinical recovery: treat 3 days normal with interior temperature recovery, cold symptoms all disappears.Integration reduces >=95%.

(2) produce effects: treat 3 days normal with interior body temperature, most of transference cure of flu.Integration reduces >=70%.

(3) effective: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears.Integration reduces >=30%

(4) invalid: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have improvement.

2, flu tcm syndrome curative effect determinate standard

(1) clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces >=95%.

(2) produce effects: clinical symptoms, sign are obviously improved, and the syndrome integration reduces >=70%

(3) effective: clinical symptoms, sign take a favorable turn, and the syndrome integration reduces >=30%

(4) invalid: clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.

Computational methods (nimodipine method):

Four, statistical procedures

Group data is used X ²Check, ranked data be with the relatively Wilcoxon rank test (corrections) of two samples, and two sample means are relatively with t check or Wilcoxon rank test, and rank test is relatively matched with paired t-test or Wilcoxon in self front and back.All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to checked has statistical significance.

The result

One, physical data

This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.Chinese medical discrimination is that wind and cold is held the wet card that stagnates of holding under the arm under the arm, and Western medicine diagnose is flu.All be the outpatient.

Two, comparability inspection before the treatment

1, two groups of preceding cardinal symptoms of treatment, sign total marks compare

State of an illness total mark comparison before the table 1 liang group treatment (x ± SD)

Cardinal symptom, sign total mark compare before two groups of treatments, and difference does not have significance.

2, the comparison of two groups of preceding symptoms of treatment

The comparison of symptoms such as heating before the table 2 liang group treatment, aversion to cold, sign

The comparisons of symptoms such as heating, aversion to cold, sign before two groups of treatments except that the order of severity treatment group of pharyngalgia is higher than matched group, have outside the significant difference, all the other there are no significant differences.

Comparability detects and shows before the above-mentioned treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.Show that two groups have comparability.

Three, efficacy analysis

1, total effects analysis

This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.The curative effect of treatment flu is following:

Table 3-1 Syndrome in TCM marquis curative effect

U＝3.863 P＝0.001

Above result shows: treat after 3 days, treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Through statistical analysis, Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is superior to matched group.

Two groups of curative effect of disease of table 3-2 relatively

U＝3.863 P＝0.001

Above result shows: treat after 3 days, treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Through statistical analysis, curative effect of disease has significant difference between two groups, and treatment group curative effect is superior to matched group.

Two groups of patient's total marks improvement of table 3-3 comparison (x ± SD)

Treatment back treatment group and matched group total mark compare: t=3.616 P=0.001

Treatment group and matched group difference compare: t=2.381 P=0.018

3-3 is visible by table, and the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, through statistical procedures (paired t-test), significant difference is arranged all; Two groups of treatment back integrations compare, and the treatment group is lower than matched group, and significant difference is arranged; The comparison of the difference of two groups of symptom and sign total mark improvement, the treatment group is superior to matched group, and significant difference is arranged.

2, the comparison of two groups of treatment back state of an illness

Table 4-1 treats back 1 day symptom, sign for two groups and compares

Treat back 1 day symptom, sign for two groups and compare difference that there are no significant.

Table 4-2 treats back 2 days symptoms, signs for two groups and compares

Treat back 2 days symptoms, signs for two groups and compare difference that there are no significant.

Table 4-3 treats back 3 days symptoms, signs for two groups and compares

Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.

Symptom, sign improvement degree such as two groups of treatment back heatings of table 4-4, aversion to cold are relatively ^*

^*Improve 1 grade of expression: reduced by 1 grade before the treatment in 3 days behind the symptom treatment

^*Improve 2 grades of expressions: reduced by 2 grades before the treatment in 3 days behind the symptom treatment

^*Improve 3 grades of expressions: reduced by 3 grades before the treatment in 3 days behind the symptom treatment

Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is superior to matched group, have outside the significant difference, all the other there are no significant differences.

Four, conclusion

Comparability detects and to show before the treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Treat that the tcm syndrome efficacy result shows after 3 days: treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Through statistical analysis, Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is superior to matched group.

Treat that the curative effect of disease result shows after 3 days: treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Through statistical analysis, curative effect of disease has significant difference between two groups, and treatment group curative effect is superior to matched group.

Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is superior to matched group, have outside the significant difference, all the other there are no significant differences.

In sum, Drug therapy flu of the present invention (wind and cold is held the wet card that stagnates of holding under the arm under the arm) has obvious curative effects, is superior to contrasting the medicine HUOXIANGZHENGQI KOUFUYE, and its clinical RD is safe.

Test Example 2: Drug therapy acute gastroenteritis of the present invention clinical research

One. qualified experimenter's selection

The wet resistance of dyspepsia (acute gastroenteritis): chest distress, belch acid regurgitation, nausea and vomiting, anorexia, the smelly or water sample in uncomfortable, the big loose stool of stomachache, light red tongue or light red, tongue is thick in vain, relaxed and soft pulse or stringy and rolling pulse.

(2) Western medicine diagnose standard: acute gastroenteritis [with reference to " modern Chinese medicine emergency case internal medicine "]

Acute gastroenteritis is because of improper diet or takes food and invade the caused digestive tract acute inflammation of gastrointestinal by the food of antibacterial, bacteriotoxin pollution and by virus.Clinical manifestation is primary symptom person with vomiting, upper abdominal pain, is called acute gastritis; Clinical manifestation is primary symptom person with diarrhoea, stomachache, is called acute enteritis; Clinical manifestation is primary symptom person with vomiting, stomachache, diarrhoea, then is called acute gastroenteritis.The person of being in a bad way can cause dehydration, acidosis even shock.

(1) acute simple gastritis

1. unclean feed, eating and drinking too much at one meal or eating cold and uncooked food excessively diet are arranged, indulge in excessive drinking, take the zest pharmacohistory;

2. morbidity is anxious, generally morbidity in several hours to 24 hours on the feed;

3. stomachache can alleviate after Upper abdominal pain, belch, loss of appetite, nausea and vomiting, the vomiting;

4. because of bacterial infection causes patient's acute enteritis that often occurs together stomachache, diarrhoea, watery stool etc. are arranged;

5. physical examination can have upper abdominal pain or all tenderness of umbilicus, bowel sounds active or hyperfunction slightly.

(2) acute enteritis

1. with diarrhoea cardinal symptom, Acute onset, diarrhoea every day for several times surplus 10 time, is yellow water sample loose stool or foam, mucus, pus and blood etc. is arranged;

2. the multidigit of suffering from abdominal pain is in umbilicus week, with tenderness in various degree;

3. epigastric discomfort can be arranged, feel sick, vomiting, abdominal distention etc.;

4. how normal body temperature is, or heating etc. is arranged.Severe patient can cause dehydration, acidosis, shock etc.;

5. stool is cultivated and often can find pathogenic bacterium.

Two. the clinical implementation scheme

(1) test method: adopt the randomized controlled trial method

(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use

(3) usage and dosage

(4) course of treatment: 3 days.

(5) observation index

The health giving quality observation item

(1) relevant symptoms and sign: like dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.

Symptom scalar quantization table

Symptom	Do not have (0 grade)	Gently (I level)	In (II level)	Heavy (III level)
					Dizziness headache	Do not have (0 minute)	Dizzy pain is light, the time end (1 minute) when doing	Heavier, continue more than (2 minutes)	Dizziness headache can not be adhered to work (3 minutes)
Limb aching pain	Do not have (0 minute)	Slightly ache (1 minute)	Ache obviously (2 minutes)	Ache and accompany joint stuffiness (3 minutes)
					Fullness in the epigastrium and chest	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes)	Distension continues the alleviation of need taking medicine (3 minutes) unbearably
The belch acid regurgitation	Do not have (0 minute)	Idol has belch acid regurgitation (1 minute)	The time belch acid regurgitation (2 minutes) arranged	Frequent belch acid regurgitation (3 minutes)
					Nausea and vomiting	Do not have (0 minute)	Idol has nauseating (1 minute)	In the time, have nauseatingly, and idol has a vomiting (2 minutes)	Frequent nauseating, vomiting (3 minutes) sometimes
Diet reduces	Do not have (0 minute)	Appetite reduces (1 minute)	Appetite reduces by 1/3 (2 minutes)	Appetite reduces by 1/2 (3 minutes)
					Epigastric pain	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes)	Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably
Loose stool	Do not have (0 minute)	It is shapeless to defecate, every day 1～3 time (1 minute)	Loose stool, every day 4～6 times (2 minutes)	The stool water sample, every day is (3 minutes) more than 7 times

Three, efficacy assessment standard

1, acute gastroenteritis curative effect determinate standard

(1) clinical recovery: clinical symptoms, sign disappear, and it is normal that physico-chemical examination recovers.Integration reduces >=95%.

(2) produce effects: clinical cardinal symptom, sign disappear basically, and integration subtracts >=and 70%, physico-chemical examination obviously improves.

(3) effective: cardinal symptom, sign alleviate, and integration reduces >=30%, and physico-chemical examination makes moderate progress.

(4) invalid: as not reach above-mentioned effective standard or deterioration person.

2, acute gastroenteritis therapeutic effect of syndrome criterion

Computational methods (nimodipine method):

Four, statistical procedures

Statistical method:

Acute gastroenteritis as a result

One, physical data

This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.Chinese medical discrimination is the dyspepsia dampness, and Western medicine diagnose is an acute gastroenteritis.Outpatient's 224 examples, inpatient's 15 examples.

Two, comparability inspection before the treatment

2, two groups of preceding state of an illness of treatment relatively

Local comparison with General Symptoms such as two groups of 2-1 of table treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation

Local comparison with General Symptoms such as two groups of treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation, difference that there are no significant.

Stool antibacterial culturing situation relatively before two groups of treatments of table 2-2

Stool antibacterial culturing situation compares there was no significant difference before two groups of treatments.

Comparability detects and shows before the above-mentioned treatment; Two groups of gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache; Aspects such as stool antibacterial culturing situation, total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Three, efficacy analysis

1, total effects analysis

This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.The curative effect of treatment acute gastroenteritis (dyspepsia dampness) is following:

Two groups of curative effect of disease of table 3-1 relatively

U＝2.631 P＝0.009

Above result shows: treat after 3 days, treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Through statistical analysis, treatment group curative effect of disease is superior to matched group, and significant difference is arranged.

Table 3-2 Syndrome in TCM marquis curative effect

U＝2.818 P＝0.005

Above result shows: treat after 3 days, treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Through statistical analysis, treatment group Syndrome in TCM marquis curative effect is superior to matched group, and significant difference is arranged.

Treatment back treatment group and matched group total mark compare: t=2.240 P=0.026

Treatment group and matched group difference compare: t=0.653 P=0.515

3-3 is visible by table, and the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, through statistical procedures (paired t-test), significant difference is arranged all; Treatment back treatment group and matched group total mark compare, and difference has significance; The comparison of the difference of two groups of symptom and sign total mark improvement, there was no significant difference.

2, the comparison of two groups of treatment back state of an illness

Table 4-1 treats back 1 day symptom, sign for two groups and compares

Treat back 1 day symptom relatively for two groups, the order of severity of treatment group nausea and vomiting, epigastric pain, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.

Table 4-2 treats back 2 days symptoms, signs for two groups and compares

Treat back 2 days symptoms relatively for two groups, the order of severity of treatment group nausea and vomiting, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.

Table 4-3 treats back 3 days symptoms, signs for two groups and compares

Treat back 3 days symptoms relatively for two groups, treatment group breast gastral cavity feeling of distension and oppression, nausea and vomiting, diet reduce, the order of severity of loose stool is lighter than matched group, significant difference are arranged, there was no significant differences such as all the other belch acid regurgitations.

Whole body and local circumstance's improvement degree comparisons such as two groups of treatments of table 4-4 metathorax gastral cavity feeling of distension and oppression ^*

Two groups of whole body and local circumstance's improvement degree comparisons such as treatment metathorax gastral cavity feeling of distension and oppression, difference that there are no significant.

The treatment group has two example stool positive bacterial culture before treating, and treats the back check and all transfers feminine gender to.

3, the situation that clinical adverse occurs

All untoward reaction does not all appear in case.

Four, conclusion

Comparability detects and shows before the treatment; Two groups of sexes, age, the course of disease, previously treatment, gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache; Aspects such as stool antibacterial culturing situation, total mark, body of the tongue, tongue fur, pulse condition relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Treat that the curative effect of disease result of study shows after 3 days: treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Through statistical analysis, treatment group curative effect of disease is superior to matched group, and significant difference is arranged.

Treat that Syndrome in TCM marquis effectiveness study result shows after 3 days: treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Through statistical analysis, treatment group Syndrome in TCM marquis curative effect is superior to matched group, and significant difference is arranged.

In sum, Drug therapy acute gastroenteritis of the present invention (dyspepsia dampness) has obvious curative effects, and its clinical RD is safe.

Below further set forth the method for preparing of medicine of the present invention through embodiment.

Embodiment 1:

A. write out a prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are subsequent use;

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 3 times respectively of Massa Medicata Fermentata, Poria, each 2 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 75% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 88～92 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 88～92 ℃ of oven dry, pulverize, sieve, use water pill; When general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol, process ball according to the pill method for preparing.

Embodiment 2:

A. write out a prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are subsequent use;

Embodiment 3:

A. write out a prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are subsequent use;

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and 3 hours for the first time, 0.5 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 2 times respectively of Massa Medicata Fermentata, Poria, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 2 times, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 65% alcohol heating reflux respectively, and 3 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 2 times with 75% alcohol heating reflux, and 3 hours for the first time, 1 hour for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 11% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80～85 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 80～85 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 70～75 ℃ of dryings.

Embodiment 4:

Prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g;

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 2 times respectively of Massa Medicata Fermentata, Poria, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 2 times, 1 hour for the first time, 0.5 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and 1 hour for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 65% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 2 times with 60% alcohol heating reflux, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 9% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 70～72 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 70～72 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 70～72 ℃ of dryings.

Embodiment 5:

Prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g;

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 2 times respectively of Massa Medicata Fermentata, Poria, each 1 hour, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 40%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 2 times, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 60% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 2 times with 75% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 8% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 70 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 70 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Embodiment 6

(a.) prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are subsequent use;

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 3 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 3 times respectively of Massa Medicata Fermentata, Poria, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 60%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and 3 hours for the first time, 2 hours for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 85% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 90 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Embodiment 7

A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;

Embodiment 8

A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;

Embodiment 9

A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;

Embodiment 10

A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;

Embodiment 11

A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;

B. manufacturing approach: Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, Poria be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water secondary, each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～80 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 60 ℃ of dryings.

Embodiment 12

A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;

B. manufacturing approach: Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, Poria be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water secondary, each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～80 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Embodiment 13

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 3 times, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, the decocte with water of Poria difference 3 times 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter; Merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 60%, hold over night; Filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, 1 hour for the first time, 0.5 hour for the second time, 0.2 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 60% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 60% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time; Filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs; Filter, filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～70 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 60～70 ℃ of dryings.

Embodiment 14

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 2 times respectively of Massa Medicata Fermentata, Poria, 1.5 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 40%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 2 times, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 2 times, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 85% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 2 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 70～80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 60～70 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; With the mixture coating of oil stone dust, carmine and red ferric oxide,, promptly get 70～80 ℃ of dryings.

Embodiment 15

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 3 times, and 3 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, the decocte with water of Poria difference 3 times 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter; Merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 50%～55%, hold over night; Filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, 2 hours for the first time, 1 hour for the second time, 0.2 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and 3 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 60%～65% alcohol heating reflux respectively, and 3 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 70%～75% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 0.5 hour for the third time; Filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs; Filter, filtrating is concentrated into the thick paste shape with 8%～10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 70～80 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Embodiment 16

B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 2 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 3 times respectively of Massa Medicata Fermentata, Poria, each 3 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 40%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 85% alcohol heating reflux respectively, and each 1 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 1 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 85～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing; In 85～90 ℃ of oven dry, pulverize, sieve; Use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol; After processing pill according to the pill method for preparing, carry out film coating, process coated pill with macromolecular material and pigment.

Embodiment 17

Embodiment 18

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 4 times, each 3 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 60%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 4 times, each 3.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and reclaims ethanol and also is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 4 times, each 2 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 60%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 4 times, each 3.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 80%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 19

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 1 time was extracted 0.5 hour, and collecting decoction filters, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 30%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 1 time extracted 0.5 hour, and collecting decoction filters, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 30%, and hold over night filters, and reclaims ethanol and also is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 1 time, extracted 2 hours, collecting decoction filters, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 20%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 1 time was extracted 0.2 hour, and collecting decoction filters, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 40%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 20

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 3 times, each 2 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 3 times, each 3 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and reclaims ethanol and also is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 3 times, each 1.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 50%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 3 times, each 3 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 20

B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 2 times, each 1 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 2 times, each 1 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 35%, and hold over night filters, and reclaims ethanol and also is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 2 times, each 0.5 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 30%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 2 times, each 0.5 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 21

Embodiment 22

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 10 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 100 ℃ with 12 times of water gagings, and each 5 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 12 times of amount ethanol of 80%, and each 5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 80 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, processes ball according to the pill method for preparing.

Embodiment 23

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 35 ℃ with 2 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35 ℃; Medicinal residues after the extraction extract 2 times at 100 ℃ with 2 times of amount ethanol of 30%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 70～75 ℃ of dryings, promptly gets.

Embodiment 24

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 6 times of water gagings, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 8 times of amount ethanol of 50%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 70 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds the required adjuvant of micropill, according to microsphere and its preparation, processes micropill.

Embodiment 25

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 90 ℃ with 8 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 70 ℃; Medicinal residues after the extraction extract 2～3 times at 80 ℃ with 8 times of amount ethanol of 70%, and each 3 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 70 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds Mel, according to the honeyed pill method, processes honeyed pill.

Embodiment 26

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 50 ℃ with 3 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 3 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 27

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 60 ℃ with 7 times of water gagings, and 2.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 4 times of amount ethanol of 60%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 60 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is processed pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly gets.

Embodiment 28

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 65 ℃ with 3 times of water gagings, and 1.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 65 ℃; Medicinal residues after the extraction extract 2 times at 59 ℃ with 4 times of amount ethanol of 65%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 65 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds pill adjuvant commonly used, according to the pill conventional method, processes pill.

Embodiment 29

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;

C. clear paste I, clear paste II are merged, concentrate, drying, with the cyclodextrin clathrate mix homogeneously, water is processed pill.

Embodiment 30

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 9 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 100 ℃ with 10 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 5 times of amount ethanol of 80%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 80%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 20000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 5 times of column volumes 3 times; 80% ethanol elution of 8 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.01～1.15, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 10 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 80% ethanol elution 3 times; Eluting uses ethanol 10 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing.

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, process active component of the present invention, use water pill, process pill according to the pill method for preparing after, carry out film coating with macromolecular material and pigment, process coated pill.

Embodiment 31

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1 time at 35 ℃ with 2 times of water gagings, extract 5 hours, and merge extractive liquid, filters, and the relative density when being concentrated into 35 ℃ of filtrating is that 1.05～1.30 clear paste I is subsequent use; Medicinal residues after the extraction extract 1 time at 100 ℃ with 2 times of amount ethanol of 30%, extract 5 hours, and merge extractive liquid, filters, extracting solution recovery ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 50%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 5000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 2 times; 20% ethanol elution of 3 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I;

C. dry extract I, clear paste II are merged, concentrate, drying adds sucrose, according to the pill conventional method, processes pill.

Embodiment 32

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 55 ℃ with 5.5 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 55 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 5.5 times of amount ethanol of 55%, and each 2.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃; Clear paste II adds water to and is diluted to density is 1.01～1.15, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5.5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. clear paste I, dry extract II are merged, concentrate, drying is mixed with lactose, according to the pill conventional method, processes pill.

Embodiment 33

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 85 ℃ with 3 times of water gagings, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 75 ℃; Medicinal residues after the extraction extract 2 times at 75 ℃ with 7 times of amount ethanol of 75%, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 75 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 60%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 10000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2 times of column volumes 3 times; 70% ethanol elution of 6 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 8 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 70% ethanol elution 3 times; Eluting uses ethanol 8 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, starch is processed pill with 5% starch slurry.

Embodiment 34

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 7 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 7 times of water gagings, and each 2.5 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 70 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 4 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 70%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 40～70% ethanol elution of 5 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 60% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, dextrin is processed pill with 8% starch slurry.

Embodiment 35

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 4.5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 80 ℃ with 4.5 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 7.5 times of amount ethanol of 45%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 65 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 75%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 12000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 1 time; 60% ethanol elution of 6 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 7 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, use water pill, process pill according to the pill method for preparing.

Embodiment 36

Clear paste I adds ethanol to be made and contains alcohol amount and reach 65%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.08, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of crospovidone, use water pill, process pill according to the pill method for preparing.

Embodiment 37 active component method for preparinies of the present invention

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Get part clear paste I and add ethanol and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and it is subsequent use to get dry extract I;

Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃; Get part clear paste II and add water to that to be diluted to density be 1.02～1.08, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;

C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II with the cyclodextrin clathrate mix homogeneously, is processed active component of the present invention.

Embodiment 38

B. the clear paste I, dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are subsequent use;

C. with clear paste I 1g, dry extract I 1g, clear paste II 1g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Use water pill, process pill according to the pill method for preparing.

Embodiment 39

B. the clear paste I, dry extract I, the dry extract II that get the acquisition of embodiment 37 methods are subsequent use;

C. with clear paste I 15g, dry extract I 0.5g, dry extract II 0.5g and cyclodextrin clathrate mix homogeneously, add 50g starch, use water pill, process pill according to the pill method for preparing.

Embodiment 40

B. the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are subsequent use;

C. with dry extract I 20g, clear paste II 2g, dry extract II 3g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 250g hydroxypropyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.

Embodiment 41

C. with clear paste I 3g, dry extract I 1g, clear paste II 8g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add the 65g micropowder silica gel, use water pill, process pill according to the pill method for preparing.

Embodiment 42

B. the clear paste I, the clear paste II that get the acquisition of embodiment 37 methods are subsequent use;

C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, use water pill, process pill according to the pill method for preparing.

Embodiment 43

B. the dry extract I, the dry extract II that get the acquisition of embodiment 37 methods are subsequent use;

C. with dry extract I 15g, dry extract II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, mixing is used water pill, processes pill according to the pill method for preparing.

Embodiment 44

C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, mixing with the general ball of ethanol, is processed pill according to the pill method for preparing.

Embodiment 45

B. the dry extract I, the clear paste II that get the acquisition of embodiment 37 methods are subsequent use;

C. with dry extract I 15g, clear paste II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, use water pill, process pill according to the pill method for preparing.

Embodiment 46

B. the clear paste I that gets the acquisition of embodiment 37 methods is subsequent use;

C. with clear paste I 100g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, use water pill, process pill according to the pill method for preparing.

Embodiment 47

B. the dry extract I that gets the acquisition of embodiment 37 methods is subsequent use;

C. with dry extract I 15g and cyclodextrin clathrate mix homogeneously, add proper honey, process pill according to the pill method for preparing.

Embodiment 48

B. the dry extract II that gets the acquisition of embodiment 37 methods is subsequent use;

C. with dry extract II 4g and cyclodextrin clathrate mix homogeneously, add 30g starch, proper honey, mixing is processed pill according to the pill method for preparing.

Embodiment 49

B. the clear paste II that gets the acquisition of embodiment 37 methods is subsequent use;

C. with clear paste II 13g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 150g hydroxypropyl cellulose is used water pill, processes pill according to the pill method for preparing.

Embodiment 50

B. the clear paste I, the dry extract I that get the acquisition of embodiment 37 methods are subsequent use;

C. with clear paste I 15g, dry extract I 2g and cyclodextrin clathrate mix homogeneously, add the 30g dextrin, mixing is used water pill, processes pill according to the pill method for preparing.

Embodiment 51

B. the clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are subsequent use;

C. with clear paste II 3g, dry extract II 25g and cyclodextrin clathrate mix homogeneously, add 240g starch, mixing is used water pill, processes pill according to the pill method for preparing.

Embodiment 52

C. with clear paste I 14g, dry extract I 3g, clear paste II 5g, dry extract II 29g and cyclodextrin clathrate mix homogeneously, add 1000g starch, mixing is used water pill, processes pill according to the pill method for preparing.

Claims

1. a method for preparing of treating the gastrointestinal disease Chinese medicine composition comprises the steps:

B. active component preparation:

C. get a kind of or combination among dry extract I, the dry extract II, mix, process active component with cyclodextrin clathrate.

2. treat the method for preparing of gastrointestinal disease Chinese medicine composition according to claim 1, it is characterized in that comprising the steps:

B. active component preparation:

3. like the method for preparing of the said treatment gastrointestinal disease of claim 2 Chinese medicine composition, it is characterized in that comprising the steps:

B. active component preparation:

4. like the method for preparing of the arbitrary said treatment gastrointestinal disease Chinese medicine composition of claim 1-3, it is characterized in that the medicine activity component that makes among the step c mixes with pill adjuvant commonly used, processes pill according to the conventional method for preparing of pill.