CN100998785A - Traditional Chinese medicine composition for treating gastrointestinal disease and its preparing method - Google Patents
Traditional Chinese medicine composition for treating gastrointestinal disease and its preparing method Download PDFInfo
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- CN100998785A CN100998785A CN 200610011180 CN200610011180A CN100998785A CN 100998785 A CN100998785 A CN 100998785A CN 200610011180 CN200610011180 CN 200610011180 CN 200610011180 A CN200610011180 A CN 200610011180A CN 100998785 A CN100998785 A CN 100998785A
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Abstract
A Chinese medicine in the form of pill for treating gastrointestinal disease is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicine composition for the treatment of gastrointestinal disease and preparation method thereof.
Background technology
Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, and these symptoms can cause by multiple reason, and the double sense wind and cold of regarding sb. as an outsider of gastrointestinal disease is one of the main reasons wherein.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials, general ball, coating ", thereby it is low to cause Health pill to exist the medicine effective component content, reduces at gastrointestinal dissolution rate and absorbance, and soak time prolongs, and onset is slow.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of gastrointestinal disease.
Another object of the present invention is to provide a kind of preparation method for the treatment of the active component of gastrointestinal disease.
Another object of the present invention provides a kind of preparation method for the treatment of the Chinese medicine composition of gastrointestinal disease.
Medicine of the present invention can be used to prepare the application for the treatment of cold medicine.
Medicine of the present invention can be used for preparing the application of treatment gastroenteritis medicine.
Pharmaceutical composition of the present invention is to be made by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary by groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.
Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, (81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.
Best each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.
Medicine of the present invention can be made any preparation on the pharmaceutics; Preferably make tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, unguentum.
The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, make pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.
The proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine proportioning is a dosage range provided by the present invention.
The pill preparation method of Chinese medicine composition of the present invention comprises following several preparation method:
Chinese medicine composition pill preparation method one of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs are ground into fine powder, make pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly.
Chinese medicine composition pill preparation method two of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs become superfine medicated powder through micronizing, make pill.
Chinese medicine composition pill preparation method three of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs are made the nanometer medical material, make pill according to the pill preparation method then.
Chinese medicine composition pill preparation method four of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Chinese medicine composition pill preparation method five of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～3 time, and each 1～2 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%～60%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～3 time, and each 0.2～1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～3 time, and each 1～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 50～90 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 50～80 ℃ of dryings, promptly.
Preferred Chinese medicine composition pill preparation method five of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 60 ℃ of dryings, promptly.
Chinese medicine composition pill preparation method six of the present invention comprises the steps::
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～3 time, and each 0.5～3 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%～60%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～3 time, and each 0.2～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 50～90 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Preferred Chinese medicine composition pill preparation method six of the present invention comprises the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Chinese medicine composition pill preparation method seven of the present invention comprises the steps:
A. the hook taking rattan is 15.50～55.80 parts, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 1～4 time, and each 0.5～3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 30～60%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 1～4 time, and each 0.5～3.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 30～50%, standing over night, filter, reclaim ethanol and be concentrated into certain volume, standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 1～4 time, each 0.2～2 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 20～60%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 1～4 time, each 0.2～3.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40～80%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Preferred Chinese medicine composition pill preparation method seven of the present invention comprises the steps:
A. the hook taking rattan is 27.17～41.20 parts, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 2～3 times, and each 1～2 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 40～50%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 2～3 times, and each 1～3 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 35～45%, standing over night, filter, reclaim ethanol and be concentrated into certain volume, standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 2～3 times, each 0.5～1.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 30～50%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 2～3 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 50～70%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Best Chinese medicine composition pill preparation method seven of the present invention comprises the steps:
A. 34.10 parts in hook taking rattan, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 40%, standing over night filters, and reclaims ethanol and is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water secondary, each 1 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 45%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Chinese medicine composition pill preparation method eight of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; The paste ring spermatophore that volatile oil is added 1～10 times of extract amount closes, and gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate mix homogeneously are made medicine activity component of the present invention.
Preferred Chinese medicine composition pill preparation method eight of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is made active component of the present invention.
Best Chinese medicine composition pill preparation method eight of the present invention comprises the steps:
A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is made active component of the present invention.
Preparation method nine:
Chinese medicine composition preparation method of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;
Adding ethanol to clear paste I makes and contains alcohol amount and reach 50～80%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.01～1.15, rotating speed with 5000～20000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～10 times distilled water eluting of first usefulness column volume 1～3 time, and water liquid discards, reuse 50～80% ethanol elutions 1～3 time, eluting ethanol is 2～10 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
Preferred Chinese medicine composition preparation method of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;
Adding ethanol to clear paste I makes and contains alcohol amount and reach 60～70%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.02～1.10, rotating speed with 10000～15000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～8 times distilled water eluting of first usefulness column volume 2～3 times, and water liquid discards, reuse 60～70% ethanol elutions 2～3 times, eluting ethanol is 2～8 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
Best Chinese medicine composition preparation method of the present invention comprises the steps:
A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
In process for preparing medicine eight of the present invention, the preparation method nine, whether further purification of clear paste I made dry extract I; Clear paste II further purifies and makes dry extract II, determines according to the form of pharmaceutical preparation.
Preparation method of Chinese medicine of the present invention, the adjuvant that arbitrary active component that makes in preparation method eight, the preparation method nine and pill is commonly used mixes, and makes pill according to the conventional preparation method of pill.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
The specific embodiment
In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.These test examples comprise that medicine of the present invention holds wet hold under the arm the stagnate flu of card, the influence of acute gastroenteritis under the arm to wind and cold, and the effect of medicine of the present invention is described by test data.Below used medicine for the ease of narration, below will be called for short medicine of the present invention according to the medicine that embodiment 17 obtains according to the preparation of embodiment 17 methods in the test.
Test example 1: Drug therapy flu of the present invention clinical research
One, qualified experimenter's selection
(1) Chinese medical discrimination standard: [working out] with reference to " new Chinese medicine clinical research guideline " and high Chinese medicine universities and colleges' teaching materials " Chinese Internal Medicine "
Wind and cold is held wet hold under the arm stagnant (flu) under the arm: nasal obstruction watery nasal discharge, cough, pharyngalgia, fever with aversion to cold, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, anorexia, or the belch acid regurgitation is arranged, stomachache is uncomfortable, stool is uncomfortable, light red tongue is fat or light red, tongue in vain, stringy and tense pulse or stringy and rolling pulse.
(2) Western medicine diagnose standard
Flu: [with reference to " practical internal medicine "]
1, the popular contact history of flu is arranged;
2, based on local symptom, General Symptoms can have or be not obvious;
Local symptom: sneeze, nasal obstruction, watery nasal discharge, cough sometimes, pharyngalgia, hoarseness, shed tears;
General Symptoms: fever with aversion to cold, general malaise, headache and dizzy, extremity aching pain in waist and back;
3, hemogram: how normal numeration of leukocyte is or on the low side.
Two, clinical implementation scheme
(1) test method: adopt the randomized controlled trial method
(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use
(3) usage and dosage
The treatment group: medicine of the present invention, oral, each 2 bottles, every day 3 times.
Matched group: HUOXIANGZHENGQI KOUFUYE, oral, each 2 bottles, every day 3 times.
(4) course of treatment: 3 days.
(5) observation index
The health giving quality observation item
Related symptoms and sign: as aversion to cold, heating, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.
Symptom scalar quantization table
| Symptom | Do not have (0 grade) | Gently (I level) | In (II level) | Heavy (III level) |
| Aversion to cold | Do not have (0 minute) | Aversion to cold need not add clothing (1 minute) | Aversion to cold need add clothing (2 minutes) | Aversion to cold need be thickeied clothing or be divided by (3) |
| Heating | Do not have (0 minute) | 37.1～37.9 ℃ of body temperature (1 minute) | 38～38.5 ℃ of body temperature (2 minutes) | Body temperature is (3 minutes) more than 38.6 ℃ |
| Nasal obstruction | Do not have (0 minute) | The sense of obstruction is arranged, low voice speaking (1 minute) | Nose cold occur now and then (2 minutes) | Nasal obstruction constant (3 minutes) |
| Watery nasal discharge | Do not have (0 minute) | Idol has watery nasal discharge (1 minute) | The time watery nasal discharge (2 minutes) arranged | Continue watery nasal discharge (3 minutes) |
| Cough | Do not have (0 minute) | Idol has (1 minute) | The time (2 minutes) arranged | Frequently (3 minutes) |
| Pharyngalgia | Do not have (0 minute) | Hypodynia (1 minute) | Pharyngalgia (2 minutes) | Pain is (3 minutes) very |
| Dizziness headache | Do not have (0 minute) | Dizzy pain is light, the time end (1 minute) when doing | Heavier, continue more than (2 minutes) | Dizziness headache can not be adhered to work (3 minutes) |
| Limb aching pain | Do not have (0 minute) | Slightly ache (1 minute) | Ache obviously (2 minutes) | Ache and accompany joint stuffiness (3 minutes) |
| Fullness in the epigastrium and chest | Do not have (0 minute) | Slightly, in time, end when doing, and do not influence work and rest (1 minute) | Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes) | Distension continues the alleviation of need taking medicine (3 minutes) unbearably |
| The belch acid regurgitation | Do not have (0 minute) | Idol has belch acid regurgitation (1 minute) | The time belch acid regurgitation (2 minutes) arranged | Frequent belch acid regurgitation (3 minutes) |
| Nausea and vomiting | Do not have (0 minute) | Idol has nauseating (1 minute) | In the time, have nauseatingly, and idol has a vomiting (2 minutes) | Frequent nauseating, vomiting (3 minutes) sometimes |
| Diet reduces | Do not have (0 minute) | Appetite reduces (1 minute) | Appetite reduces by 1/3 (2 minutes) | Appetite reduces by 1/2 (3 minutes) |
| Epigastric pain | Do not have (0 minute) | Slightly, in time, end when doing, and do not influence work and rest (1 minute) | Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes) | Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably |
| Loose stool | Do not have (0 minute) | It is shapeless to defecate, every day 1～3 time (1 minute) | Loose stool, every day 4～6 times (2 minutes) | The stool water sample, every day is (3 minutes) more than 7 times |
Three, efficacy assessment standard
1, flu curative effect determinate standard
(1) clinical recovery: treat 3 days normal with interior temperature recovery, cold symptoms all disappears.Integration reduces 〉=95%.
(2) produce effects: treat 3 days normal with interior body temperature, most of transference cure of flu.Integration reduces 〉=70%.
(3) effective: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears.Integration reduces 〉=30%
(4) invalid: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have improvement.
2, flu tcm syndrome curative effect determinate standard
(1) clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%.
(2) produce effects: clinical symptoms, sign are obviously improved, and the syndrome integration reduces 〉=70%
(3) effective: clinical symptoms, sign take a favorable turn, and the syndrome integration reduces 〉=30%
(4) invalid: clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
Computational methods (nimodipine method):
Four, statistical procedures
Group data X
2Check, ranked data be with the relatively Wilcoxon rank test (corrections) of two samples, and two sample means are relatively with t check or Wilcoxon rank test, and rank test is relatively matched with paired t-test or Wilcoxon in self front and back.All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
The result
One, physical data
This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.Chinese medical discrimination is that wind and cold is held the wet card that stagnates of holding under the arm under the arm, and Western medicine diagnose is flu.All be the outpatient.
Two, comparability inspection before the treatment
1, two groups of preceding cardinal symptoms of treatment, sign total marks compare
State of an illness total mark comparison before the table 1 liang group treatment (
)
| Group | The example number | Integration | t | P |
| Treatment group matched group | 160 77 | 13.16±4.56 12.82±4.99 | 0.518 | 0.605 |
Cardinal symptom, sign total mark compare before two groups of treatments, and difference does not have significance.
2, the comparison of two groups of preceding symptoms of treatment
The comparison of symptoms such as heating before the table 2 liang group treatment, aversion to cold, sign
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| Fever with chills nasal obstruction watery nasal discharge | Treatment group treatment of control group group treatment of control group group treatment of control group group control group | 160 77 160 77 160 77 160 77 | 71 30 22 12 31 15 35 19 | 66 30 78 30 55 26 51 22 | 20 14 53 31 66 33 65 34 | 3 3 7 4 8 3 9 2 | 1.223 0.763 0.025 0.336 | 0.221 0.445 0.980 0.737 |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of cough pharyngalgia dizziness headache chest gastral cavity reduces the limb aching pain loose watery stool | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 | 56 31 59 38 47 21 57 25 114 57 84 37 84 37 21 11 29 21 88 49 | 64 25 56 26 72 35 47 26 28 14 52 23 52 23 64 34 63 23 50 21 | 39 21 40 12 41 19 51 20 17 6 24 14 24 14 66 28 62 31 19 7 | 1 0 5 1 0 2 5 6 1 0 0 3 0 3 9 4 6 2 3 0 | 0.350 2.156 0.454 0.384 0.556 1.056 1.308 0.689 0.726 1.372 | 0.726 0.031 0.650 0.701 0.578 0.291 0.191 0.491 0.468 0.170 |
The comparisons of symptoms such as heating, aversion to cold, sign before two groups of treatments except that the order of severity treatment group of pharyngalgia is higher than matched group, have outside the significant difference, all the other there are no significant differences.
Comparability detects and shows before the above-mentioned treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.Show that two groups have comparability.
Three, efficacy analysis
1, total effects analysis
This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.The curative effect of treatment flu is as follows:
Table 3-1 Syndrome in TCM marquis curative effect
| Group | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
| Treatment group matched group | 160 77 | 64 40.0％ 15 19.5％ | 76 47.5％ 39 50.6％ | 18 11.3％ 20 26.0％ | 2 1.3％ 3 3.9％ |
U＝3.863 P＝0.001
Above result shows: treat after 3 days, treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is better than matched group.
Two groups of curative effect of disease of table 3-2 relatively
| Group | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
| Treatment group matched group | 160 77 | 64 40.0％ 15 19.5％ | 76 47.5％ 39 50.6％ | 18 11.3％ 20 26.0％ | 2 1.3％ 3 3.9％ |
U＝3.863 P＝0.001
Above result shows: treat after 3 days, treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and curative effect of disease has significant difference between two groups, and treatment group curative effect is better than matched group.
Two groups of patient's total marks improvement of table 3-3 comparison (
)
| Group | The example number | Divide before treating | Treating the back divides | Difference | Compare before and after the treatment (P) |
| Treatment group matched group | 160 77 | 13.16±4.56 12.82±4.99 | 1.73±2.22 2.86±2.34 | 11.43±4.31 9.96±4.74 | 0.001 0.001 |
Treatment back treatment group and matched group total mark compare: t=3.616 P=0.001
Treatment group and matched group difference compare: t=2.381 P=0.018
By table 3-3 as seen, the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, learns by statistics and handles (paired t-test), and significant difference is all arranged; Two groups of treatment back integrations compare, and the treatment group is lower than matched group, and significant difference is arranged; The comparison of the difference of two groups of symptom and sign total mark improvement, the treatment group is better than matched group, and significant difference is arranged.
2, the comparison of two groups of treatment back state of an illness
Table 4-1 treats back 1 day symptom, sign for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| Fever with chilliness nasal obstruction runny nose cough pharyngalgia dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 160 77 160 77 160 77 160 77 160 77 160 77 160 77 | 85 37 54 24 41 20 48 26 70 31 84 45 83 34 | 70 33 84 42 83 35 79 31 59 31 54 27 65 34 | 5 7 20 11 34 20 31 19 31 15 21 5 12 9 | 0 0 2 0 2 2 2 1 0 0 1 0 0 0 | 1.087 0.332 0.605 0.094 0.386 1.202 1.271 | 0.277 0.740 0.545 0.925 0.699 0.229 0.204 |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of chest gastral cavity reduces the limb aching pain loose watery stool | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 160 77 160 77 160 77 160 77 160 77 160 77 160 77 | 77 33 128 62 104 47 125 64 37 20 53 28 103 54 | 55 29 24 12 48 21 33 13 78 41 77 34 51 21 | 26 14 8 3 8 9 2 0 44 15 30 15 6 2 | 2 1 0 0 0 0 0 0 1 1 0 0 0 0 | 0.724 0.128 0.899 0.930 1.012 0.290 0.898 | 0.469 0.898 0.369 0.352 0.312 0.772 0.369 |
Treat back 1 day symptom, sign for two groups and compare difference that there are no significant.
Table 4-2 treats back 2 days symptoms, signs for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of fever with chilliness nasal obstruction runny nose cough pharyngalgia dizziness headache chest gastral cavity reduces | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group | 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 | 131 58 117 51 75 34 88 38 88 40 124 54 124 54 107 51 146 73 136 65 147 73 82 40 111 | 28 18 39 25 73 33 59 34 63 33 35 21 35 21 49 20 13 4 24 12 13 4 72 35 47 | 1 1 3 1 12 10 13 5 9 4 1 2 1 2 4 6 1 0 0 0 0 0 6 2 2 | 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 | 1.186 1.008 0.751 0.625 0.380 0.771 1.290 0.360 0.974 0.117 0.817 0.175 0.616 | 0.236 0.314 0.453 0.532 0.704 0.441 0.197 0.719 0.330 0.907 0.414 0.861 0.538 |
| The limb aching pain loose stool | Treatment group treatment of control group group matched group | 160 77 160 77 | 111 50 135 70 | 47 27 25 7 | 2 0 0 0 | 0 0 0 0 | 0.616 1.376 | 0.538 0.169 |
Treat back 2 days symptoms, signs for two groups and compare difference that there are no significant.
Table 4-3 treats back 3 days symptoms, signs for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of fever with chilliness nasal obstruction runny nose cough pharyngalgia dizziness headache chest gastral cavity reduces the limb aching pain loose watery stool | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 | 154 68 147 67 118 44 130 56 109 46 133 66 151 64 147 59 155 76 155 72 159 75 125 50 145 59 155 73 | 6 9 11 10 37 28 28 18 46 27 24 9 9 12 13 16 5 1 5 5 1 2 35 27 14 18 5 4 | 0 0 1 0 5 5 2 3 5 4 3 2 0 1 0 2 0 0 0 0 0 0 0 0 1 0 0 0 | 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 | 2.346 1.142 2.604 1.556 1.317 0.473 2.809 3.297 0.836 1.206 1.269 2.159 2.879 0.779 | 0.019 0.254 0.009 0.120 0.188 0.636 0.005 0.001 0.403 0.228 0.204 0.031 0.004 0.436 |
Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.
Symptom, sign improvement degree such as two groups of treatment back heatings of table 4-4, aversion to cold are relatively
*
| Symptom, sign | Group | The example number | Increase the weight of | No change | Improve 1 grade | Improve 2 grades | Improve 3 grades | U | P |
| Heating | The treatment group | 160 | 0 | 74 | 65 | 19 | 2 | 0.670 |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of aversion to cold nasal obstruction runny nose cough pharyngalgia dizziness headache chest gastral cavity reduces the limb aching pain loose watery stool | Treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 160 77 | 0 0 0 0 0 1 0 3 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 | 33 27 13 46 26 39 25 79 47 66 45 51 26 59 30 114 57 89 38 110 59 29 19 30 22 91 51 | 31 79 35 67 39 65 32 64 22 67 21 73 38 53 31 33 15 47 26 40 16 81 43 76 35 48 21 | 12 52 28 44 12 53 20 14 6 27 10 36 12 46 15 12 5 24 10 9 2 43 13 49 18 19 5 | 1 2 1 3 0 2 0 0 0 0 0 0 1 2 1 1 0 0 3 1 0 7 2 5 1 2 0 | 0.436 1.826 1.502 1.658 2.470 0.674 0.947 0.486 0.933 1.347 1.934 2.053 1.583 | 0.503 0.663 0.068 0.133 0.097 0.014 0.500 0.344 0.627 0.351 0.178 0.053 0.040 0.113 |
*Improve 1 grade of expression: reduced by 1 grade before the treatment in 3 days behind the symptom treatment
*Improve 2 grades of expressions: reduced by 2 grades before the treatment in 3 days behind the symptom treatment
*Improve 3 grades of expressions: reduced by 3 grades before the treatment in 3 days behind the symptom treatment
Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is better than matched group, have outside the significant difference, all the other there are no significant differences.
Four, conclusion
This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.Chinese medical discrimination is that wind and cold is held the wet card that stagnates of holding under the arm under the arm, and Western medicine diagnose is flu.All be the outpatient.
Comparability detects and to show before the treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.
Treat that the tcm syndrome efficacy result shows after 3 days: treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 1 1.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is better than matched group.
Treat that the curative effect of disease result shows after 3 days: treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and curative effect of disease has significant difference between two groups, and treatment group curative effect is better than matched group.
Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is better than matched group, have outside the significant difference, all the other there are no significant differences.
In sum, Drug therapy flu of the present invention (wind and cold is held the wet card that stagnates of holding under the arm under the arm) has obvious curative effects, is better than contrasting the medicine HUOXIANGZHENGQI KOUFUYE, and its clinical recommended dose is safe.
Test example 2: Drug therapy acute gastroenteritis of the present invention clinical research
One. qualified experimenter's selection
(1) Chinese medical discrimination standard: [working out] with reference to " new Chinese medicine clinical research guideline " and high Chinese medicine universities and colleges' teaching materials " Chinese Internal Medicine "
The wet resistance of dyspepsia (acute gastroenteritis): chest distress, belch acid regurgitation, nausea and vomiting, anorexia, stomachache discomfort, the smelly or water sample in big loose stool, light red tongue or light red, tongue is thick in vain, relaxed and soft pulse or stringy and rolling pulse.
(2) Western medicine diagnose standard: acute gastroenteritis [with reference to " modern Chinese medicine emergency case internal medicine "]
Acute gastroenteritis is because of improper diet or takes food and invade the caused digestive tract acute inflammation of gastrointestinal by the food of antibacterial, bacteriotoxin pollution and by virus.Clinical manifestation is primary symptom person with vomiting, upper abdominal pain, is called acute gastritis; Clinical manifestation is primary symptom person with diarrhoea, stomachache, is called acute enteritis; Clinical manifestation is primary symptom person with vomiting, stomachache, diarrhoea, then is called acute gastroenteritis.The person of being in a bad way can cause dehydration, acidosis even shock.
(1) acute simple gastritis
1. unclean feed, eating and drinking too much at one meal or eating cold and uncooked food excessively diet are arranged, indulge in excessive drinking, take the zest pharmacohistory;
2. morbidity is anxious, generally morbidity in a few hours to 24 hour on the feed;
3. stomachache can alleviate after Upper abdominal pain, belch, loss of appetite, nausea and vomiting, the vomiting;
4. because of bacterial infection causes patient's acute enteritis that often occurs together stomachache, diarrhoea, watery stool etc. are arranged;
5. physical examination can have upper abdominal pain or all tenderness of umbilicus, bowel sounds active or hyperfunction slightly.
(2) acute enteritis
1. with diarrhoea cardinal symptom, Acute onset, diarrhoea every day for several times surplus 10 time, is yellow water sample loose stool or foam, mucus, pus and blood etc. is arranged;
2. the multidigit of suffering from abdominal pain is in umbilicus week, with tenderness in various degree;
3. epigastric discomfort can be arranged, feel sick, vomiting, abdominal distention etc.;
4. how normal body temperature is, or heating etc. is arranged.Severe patient can cause dehydration, acidosis, shock etc.;
5. stool is cultivated and often can find pathogenic bacterium.
Two. the clinical implementation scheme
(1) test method: adopt the randomized controlled trial method
(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use
(3) usage and dosage
The treatment group: medicine of the present invention, oral, each 2 bottles, every day 3 times.
Matched group: HUOXIANGZHENGQI KOUFUYE, oral, each 2 bottles, every day 3 times.
(4) course of treatment: 3 days.
(5) observation index
The health giving quality observation item
(1) related symptoms and sign: as dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.
Symptom scalar quantization table
| Symptom | Do not have (0 grade) | Gently (I level) | In (II level) | Heavy (III level) |
| Dizziness headache | Do not have (0 minute) | Dizzy pain is light, the time end (1 minute) when doing | Heavier, continue more than (2 minutes) | Dizziness headache can not be adhered to work (3 minutes) |
| Limb aching pain | Do not have (0 minute) | Slightly ache (1 minute) | Ache obviously (2 minutes) | Ache and accompany joint stuffiness (3 minutes) |
| Fullness in the epigastrium and chest | Do not have (0 minute) | Slightly, in time, end when doing, and do not influence work and rest (1 minute) | Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes) | Distension continues the alleviation of need taking medicine (3 minutes) unbearably |
| The belch acid regurgitation | Do not have (0 minute) | Idol has belch acid regurgitation (1 minute) | The time belch acid regurgitation (2 minutes) arranged | Frequent belch acid regurgitation (3 minutes) |
| Nausea and vomiting | Do not have (0 minute) | Idol has nauseating (1 minute) | In the time, have nauseatingly, and idol has a vomiting (2 minutes) | Frequent nauseating, vomiting (3 minutes) sometimes |
| Diet reduces | Do not have (0 minute) | Appetite reduces (1 minute) | Appetite reduces by 1/3 (2 minutes) | Appetite reduces by 1/2 (3 minutes) |
| Epigastric pain | Do not have (0 minute) | Slightly, in time, end when doing, and do not influence work and rest (1 minute) | Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes) | Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably |
| Loose stool | Do not have (0 minute) | It is shapeless to defecate, every day 1～3 time (1 minute) | Loose stool, every day 4～6 times (2 minutes) | The stool water sample, every day is (3 minutes) more than 7 times |
Three, efficacy assessment standard
1, acute gastroenteritis curative effect determinate standard
(1) clinical recovery: clinical symptoms, sign disappear, and it is normal that physico-chemical examination recovers.Integration reduces 〉=95%.
(2) produce effects: clinical cardinal symptom, sign disappear substantially, and integration subtracts 〉=and 70%, physico-chemical examination obviously improves.
(3) effective: cardinal symptom, sign alleviate, and integration reduces 〉=30%, and physico-chemical examination makes moderate progress.
(4) invalid: as not reach above-mentioned effective standard or deterioration person.
2, acute gastroenteritis therapeutic effect of syndrome criterion
(1) clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%.
(2) produce effects: clinical symptoms, sign are obviously improved, and the syndrome integration reduces 〉=70%
(3) effective: clinical symptoms, sign take a favorable turn, and the syndrome integration reduces 〉=30%
(4) invalid: clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
Computational methods (nimodipine method):
Four, statistical procedures
Statistical method:
Group data X
2Check, ranked data be with the relatively Wilcoxon rank test (corrections) of two samples, and two sample means are relatively with t check or Wilcoxon rank test, and rank test is relatively matched with paired t-test or Wilcoxon in self front and back.All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
Acute gastroenteritis as a result
One, physical data
This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.Chinese medical discrimination is the dyspepsia dampness, and Western medicine diagnose is an acute gastroenteritis.Outpatient's 224 examples, inpatient's 15 examples.
Two, comparability inspection before the treatment
1, two groups of preceding cardinal symptoms of treatment, sign total marks compare
State of an illness total mark comparison before the table 1 liang group treatment (
)
| Group | The example number | Integration | t | P |
| Treatment group matched group | 161 78 | 11.70±3.15 12.15±3.69 | 0.996 | 0.320 |
Cardinal symptom, sign total mark compare before two groups of treatments, and difference does not have significance.
2, two groups of preceding state of an illness of treatment relatively
Local comparison with General Symptoms such as two groups of 2-1 of table treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of chest gastral cavity reduces loose watery stool limb aching pain dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 161 78 161 78 161 78 161 78 161 78 161 78 161 78 161 78 | 11 6 42 14 30 9 9 4 7 5 1 1 81 27 89 33 | 46 16 66 33 39 14 20 12 51 23 28 15 51 41 54 35 | 83 40 41 24 69 43 95 44 64 35 75 41 25 10 15 9 | 21 16 12 7 23 12 37 1 8 39 15 57 21 4 0 3 1 | 1.405 1.390 1.689 0.229 0.511 1.182 1.357 1.688 | 0.160 0.165 0.091 0.819 0.609 0.237 0.175 0.091 |
Local comparison with General Symptoms such as two groups of treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation, difference that there are no significant.
Stool antibacterial culturing situation relatively before two groups of treatments of table 2-2
| Group | The example number | Negative | Positive | X 2 | P |
| Treatment group matched group | 161 78 | 61 19 | 2 0 | 0.000 | 1.000 |
Stool antibacterial culturing situation compares there was no significant difference before two groups of treatments.
Comparability detects and shows before the above-mentioned treatment, two groups of gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache, aspects such as stool antibacterial culturing situation, total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.
Three, efficacy analysis
1, total effects analysis
This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.The curative effect of treatment acute gastroenteritis (dyspepsia dampness) is as follows:
Two groups of curative effect of disease of table 3-1 relatively
| Group | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
| Treatment group matched group | 161 78 | 117 72.7％ 43 55.1％ | 33 20.5％ 26 33.3％ | 5 3.1％ 7 9.0％ | 6 3.7％ 2 2.6％ |
U＝2.631 P＝0.009
Above result shows: treat after 3 days, treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group curative effect of disease is better than matched group, and significant difference is arranged.
Table 3-2 Syndrome in TCM marquis curative effect
| Group | The example number | Clinical recovery (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
| Treatment group matched group | 161 78 | 119 73.9％ 43 55.1％ | 31 19.3％ 26 33.3％ | 5 3.1％ 7 9.0％ | 6 3.7％ 2 2.6％ |
U＝2.818 P＝0.005
Above result shows: treat after 3 days, treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group Syndrome in TCM marquis curative effect is better than matched group, and significant difference is arranged.
Two groups of patient's total marks improvement of table 3-3 comparison (
)
| Group | The example number | Divide before treating | Treating the back divides | Difference | Compare P before and after the treatment |
| Treatment group matched group | 161 78 | 11.70±3.15 12.15±3.69 | 1.11±2.45 1.88±2.60 | 10.58±3.44 10.27±3.60 | 0.001 0.001 |
Treatment back treatment group and matched group total mark compare: t=2.240 P=0.026
Treatment group and matched group difference compare: t=0.653 P=0.515
By table 3-3 as seen, the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, learns by statistics and handles (paired t-test), and significant difference is all arranged; Treatment back treatment group and matched group total mark compare, and difference has significance; The comparison of the difference of two groups of symptom and sign total mark improvement, there was no significant difference.
2, the comparison of two groups of treatment back state of an illness
Table 4-1 treats back 1 day symptom, sign for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of chest gastral cavity reduces loose watery stool limb aching pain dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 161 78 161 78 161 78 161 78 161 78 161 78 161 78 161 78 | 25 8 81 30 56 20 32 12 22 10 11 7 115 43 125 46 | 81 35 47 30 80 35 80 31 66 35 84 37 37 32 31 27 | 49 31 30 15 25 23 44 30 61 29 57 28 8 3 5 4 | 6 4 3 3 0 0 5 5 12 4 9 6 1 0 0 1 | 1.717 1.495 2.289 2.056 0.401 0.258 2.247 3.003 | 0.086 0.135 0.022 0.040 0.688 0.796 0.025 0.003 |
Treat back 1 day symptom relatively for two groups, the order of severity of treatment group nausea and vomiting, epigastric pain, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.
Table 4-2 treats back 2 days symptoms, signs for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| Breast gastral cavity feeling of distension and oppression belch acid regurgitation nausea and vomiting epigastric pain | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group | 161 78 161 78 161 78 161 78 161 | 67 30 113 47 115 44 83 35 56 | 82 34 40 24 43 30 72 34 86 | 9 14 7 7 3 4 4 8 17 | 3 0 1 0 0 0 2 1 2 | 1.207 1.606 2.386 1.425 0.387 | 0.227 0.108 0.017 0.154 0.698 |
| Diet reduces loose stool limb aching pain dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group control group | 161 78 161 78 161 78 161 78 | 56 28 76 28 137 58 149 64 | 86 36 71 38 22 19 11 14 | 17 14 11 11 1 1 1 0 | 2 0 3 1 1 0 0 0 | 0.387 1.891 1.976 2.412 | 0.698 0.059 0.048 0.016 |
Treat back 2 days symptoms relatively for two groups, the order of severity of treatment group nausea and vomiting, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.
Table 4-3 treats back 3 days symptoms, signs for two groups and compares
| Symptom, sign | Group | The example number | 0 grade | The I level | The II level | The III level | U | P |
| The swollen vexed belch sour regurgitation n and V epigastric pain diet of chest gastral cavity reduces loose watery stool limb aching pain dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 161 78 161 78 161 78 161 78 161 78 161 78 161 78 161 78 | 133 55 135 61 152 66 146 64 122 48 137 57 151 68 156 71 | 23 17 22 16 9 11 11 12 31 25 17 20 9 9 4 7 | 3 6 4 1 0 1 3 1 6 5 7 0 0 1 1 0 | 2 0 0 0 0 0 1 1 2 0 0 1 1 0 0 0 | 2.182 0.998 2.520 1.867 2.183 2.046 1.724 1.925 | 0.029 0.318 0.012 0.062 0.029 0.041 0.085 0.054 |
Treat back 3 days symptoms relatively for two groups, treatment group breast gastral cavity feeling of distension and oppression, nausea and vomiting, diet reduce, the order of severity of loose stool is lighter than matched group, significant difference are arranged, there was no significant differences such as all the other belch acid regurgitations.
Whole body and local circumstance's improvement degree comparisons such as two groups of treatments of table 4-4 metathorax gastral cavity feeling of distension and oppression
*
| Symptom, sign | Group | The example number | Increase the weight of | No change | Improve 1 grade | Improve 2 grades | Improve 3 grades | U | P |
| Breast gastral cavity feeling of distension and oppression belch acid regurgitation nausea and vomiting | Treatment group treatment of control group group treatment of control group group treatment of control group group | 161 78 161 78 161 78 161 | 0 0 0 0 0 0 0 | 18 11 49 15 32 10 13 | 56 23 76 45 41 24 25 | 77 40 30 15 68 33 93 | 10 4 6 3 20 11 30 | 0.004 1.254 0.702 1.183 | 0.997 0.210 0.483 |
| The epigastric pain diet reduces loose stool limb aching pain dizziness headache | Treatment group treatment of control group group treatment of control group group treatment of control group group treatment of control group group control group | 161 78 161 78 161 78 161 78 161 78 | 0 0 0 1 0 0 0 0 0 1 | 13 6 18 13 5 5 86 35 94 35 | 25 20 59 31 35 22 51 36 50 35 | 93 39 64 26 80 38 22 7 14 6 | 30 13 20 7 41 13 2 0 3 1 | 1.183 1.689 1.954 0.608 1.333 | 0.237 0.091 0.051 0.543 0.183 |
*Improve 1 grade of expression: reduced by 1 grade before the treatment in 3 days behind the symptom treatment
*Improve 2 grades of expressions: reduced by 2 grades before the treatment in 3 days behind the symptom treatment
*Improve 3 grades of expressions: reduced by 3 grades before the treatment in 3 days behind the symptom treatment
Two groups of whole body and local circumstance's improvement degree comparisons such as treatment metathorax gastral cavity feeling of distension and oppression, difference that there are no significant.
The treatment group has two example stool positive bacterial culture before treating, and treats the back check and all transfers feminine gender to.
3, the situation that clinical adverse occurs
All untoward reaction does not all appear in case.
Four, conclusion
This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.Chinese medical discrimination is the dyspepsia dampness, and Western medicine diagnose is an acute gastroenteritis.Outpatient's 224 examples, inpatient's 15 examples.
Comparability detects and shows before the treatment, two groups of sexes, age, the course of disease, previously treatment, gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache, aspects such as stool antibacterial culturing situation, total mark, body of the tongue, tongue fur, pulse condition relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.
Treat that the curative effect of disease result of study shows after 3 days: treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group curative effect of disease is better than matched group, and significant difference is arranged.
Treat that Syndrome in TCM marquis effectiveness study result shows after 3 days: treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group Syndrome in TCM marquis curative effect is better than matched group, and significant difference is arranged.
Treat back 3 days symptoms relatively for two groups, treatment group breast gastral cavity feeling of distension and oppression, nausea and vomiting, diet reduce, the order of severity of loose stool is lighter than matched group, significant difference are arranged, there was no significant differences such as all the other belch acid regurgitations.
In sum, Drug therapy acute gastroenteritis of the present invention (dyspepsia dampness) has obvious curative effects, and its clinical recommended dose is safe.
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1:
A. write out a prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 50%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 75% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 88～92 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing, in 88～92 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol, make ball according to the pill preparation method.
Embodiment 2:
A. write out a prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;
B. above 16 flavor Chinese crude drugs are ground into fine powder, make pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly.
Embodiment 3:
A. write out a prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and 3 hours for the first time, 0.5 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 65% alcohol heating reflux respectively, and 3 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 75% alcohol heating reflux, and 3 hours for the first time, 1 hour for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 11% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80～85 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 80～85 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 70～75 ℃ of dryings, promptly.
Embodiment 4:
Prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 50%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and 1 hour for the first time, 0.5 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and 1 hour for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 65% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 60% alcohol heating reflux, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 9% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 70～72 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 70～72 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 70～72 ℃ of dryings, promptly.
Embodiment 5:
Prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2 times, and each 1 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 60% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 75% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 70 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 70 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 6
(a.) prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 60%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and 3 hours for the first time, 2 hours for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 85% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 90 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 7
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. above 16 flavor Chinese crude drugs are ground into fine powder, make pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly.
Embodiment 8
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. above 16 flavor Chinese crude drugs become superfine medicated powder through micronizing, make pill.
Embodiment 9
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. above 16 flavor Chinese crude drugs are made the nanometer medical material, make pill according to the pill preparation method then.
Embodiment 10
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. above 16 flavor Chinese crude drugs, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 11
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. manufacture method: Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 60 ℃ of dryings, promptly.
Embodiment 12
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. manufacture method: Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 13
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrate are concentrated in right amount, add ethanol and make and contain alcohol amount and reach 60%, standing over night, filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and 1 hour for the first time, 0.5 hour for the second time, 0.2 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and 2 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 60% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 60% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, filter, filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～70 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 60～70 ℃ of dryings, promptly.
Embodiment 14
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2 times, and 1.5 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2 times, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 85% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 70～80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～70 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 70～80 ℃ of dryings, promptly.
Embodiment 15
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, and 3 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate, filtrate are concentrated in right amount, add ethanol and make and contain alcohol amount and reach 50%～55%, standing over night, filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and 2 hours for the first time, 1 hour for the second time, 0.2 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and 3 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 60%～65% alcohol heating reflux respectively, and 3 hours for the first time, 1 hour for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 70%～75% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 0.5 hour for the third time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, filter, filtrate is concentrated into the thick paste shape with 8%～10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 70～80 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 16
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 3 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 85% alcohol heating reflux respectively, and each 1 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 1 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 85～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 85～90 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 17
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 50%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 75% alcohol heating reflux respectively, and each 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 85% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 88～92 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, fully mixing, in 88～92 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil with an amount of dissolve with ethanol, make ball according to the pill preparation method.
Embodiment 18
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 4 times, and each 3 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 60%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 4 times, and each 3.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 50%, and standing over night filters, and recovery ethanol also is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 4 times, each 2 hours, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 60%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 4 times, each 3.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 80%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 19
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 1 time, extract 0.5 hour, and collecting decoction filters, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 30%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 1 time, extract 0.5 hour, and collecting decoction filters, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 30%, and standing over night filters, and recovery ethanol also is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 1 time, extracts 2 hours, collecting decoction filters, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 20%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 1 time, extracted 0.2 hour, collecting decoction filters, and filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 20
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 3 times, and each 2 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 50%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 3 times, and each 3 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol also is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 3 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 50%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 3 times, each 3 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 70%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 20
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water 2 times, and each 1 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 40%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water 2 times, and each 1 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 35%, and standing over night filters, and recovery ethanol also is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water 2 times, each 0.5 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 30%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water 2 times, each 0.5 hour, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, added ethanol and made and contain the alcohol amount and reach 50%, and standing over night filters, and reclaims ethanol, is concentrated in right amount, and is standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 21
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis vapor distillation, and it is standby to collect volatile oil; Medicinal residues decoct with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate is concentrated in right amount, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, and standing over night filters, and recovery ethanol is concentrated into certain volume, and is standby; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 40%, standing over night filters, and reclaims ethanol and is concentrated into certain volume, and is standby; Get Semen Coicis, Fructus Oryzae Germinatus decocts with water secondary, each 1 hour, collecting decoction filtered, filtrate is concentrated in right amount, puts coldly, add ethanol and make and contain the alcohol amount and reach 45%, standing over night, recovery ethanol is concentrated into certain volume, and is standby; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated in right amount, puts coldly, adds ethanol and makes and contain alcohol and measure and reach 60%, standing over night, filter, reclaim ethanol, be concentrated into an amount of, standby; Said extracted liquid is mixed drying; Use water pill, when a certain amount of, add volatile oil with an amount of dissolve with ethanol at general ball, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 22
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 10 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 100 ℃ with 12 times of water gagings, and each 5 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 12 times of amount ethanol of 80%, and each 5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 80 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, makes ball according to the pill preparation method.
Embodiment 23
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 35 ℃ with 2 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 2 times at 100 ℃ with 2 times of amount ethanol of 30%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 70～75 ℃ of dryings, promptly.
Embodiment 24
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 6 times of water gagings, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 8 times of amount ethanol of 50%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 70 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds the required adjuvant of micropill, according to microsphere and its preparation, makes micropill.
Embodiment 25
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 90 ℃ with 8 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2～3 times at 80 ℃ with 8 times of amount ethanol of 70%, and each 3 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 70 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds Mel, according to the honeyed pill method, makes honeyed pill.
Embodiment 26
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 50 ℃ with 3 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 3 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is used water pill, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 27
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 60 ℃ with 7 times of water gagings, and 2.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 4 times of amount ethanol of 60%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 60 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is made pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly.
Embodiment 28
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 65 ℃ with 3 times of water gagings, and 1.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 65 ℃; Medicinal residues after the extraction extract 2 times at 59 ℃ with 4 times of amount ethanol of 65%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, adds pill adjuvant commonly used, according to the pill conventional method, makes pill.
Embodiment 29
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying, with the cyclodextrin clathrate mix homogeneously, water is made pill.
Embodiment 30
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 9 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 100 ℃ with 10 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 5 times of amount ethanol of 80%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 80%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 20000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 5 times of column volumes 3 times, and 80% ethanol elution of 8 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 10 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 80% ethanol elution 3 times, eluting ethanol is 10 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing.
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, make active component of the present invention, use water pill, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
Embodiment 31
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1 time at 35 ℃ with 2 times of water gagings, extracted 5 hours, and the merge extractive liquid, filtration, relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 1 time at 100 ℃ with 2 times of amount ethanol of 30%, extract 5 hours, and merge extractive liquid, filters, extracting solution recovery ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 50%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 5000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 2 times, and 20% ethanol elution of 3 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I;
C. dry extract I, clear paste II are merged, concentrate, drying adds sucrose, according to the pill conventional method, makes pill.
Embodiment 32
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 55 ℃ with 5.5 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 55 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 5.5 times of amount ethanol of 55%, and each 2.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5.5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. clear paste I, dry extract II are merged, concentrate, drying is mixed with lactose, according to the pill conventional method, makes pill.
Embodiment 33
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 85 ℃ with 3 times of water gagings, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 75 ℃; Medicinal residues after the extraction extract 2 times at 75 ℃ with 7 times of amount ethanol of 75%, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 75 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 60%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 10000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2 times of column volumes 3 times, and 70% ethanol elution of 6 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 8 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 70% ethanol elution 3 times, eluting ethanol is 8 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, starch is made pill with 5% starch slurry.
Embodiment 34
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 7 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 7 times of water gagings, and each 2.5 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 4 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 70%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 40～70% ethanol elution of 5 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 60% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, dextrin is made pill with 8% starch slurry.
Embodiment 35
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 4.5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 80 ℃ with 4.5 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 7.5 times of amount ethanol of 45%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 75%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 12000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 1 time, and 60% ethanol elution of 6 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 7 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of steviosin, use water pill, make pill according to the pill preparation method.
Embodiment 36
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 65%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously, add an amount of crospovidone, use water pill, make pill according to the pill preparation method.
Embodiment 37 active component preparation methoies of the present invention
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Get part clear paste I and add ethanol and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃; Get part clear paste II and add water to that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II with the cyclodextrin clathrate mix homogeneously, is made active component of the present invention.
Embodiment 38
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. clear paste I, the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 1g, dry extract I 1g, clear paste II 1g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add crospovidone, mixing is granulated drying, granulate; Use water pill, make pill according to the pill preparation method.
Embodiment 39
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. clear paste I, the dry extract I, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 15g, dry extract I 0.5g, dry extract II 0.5g and cyclodextrin clathrate mix homogeneously, add 50g starch, use water pill, make pill according to the pill preparation method.
Embodiment 40
A. get prescription, it is standby with embodiment 3 to write out a prescription;
B. dry extract I, the clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with dry extract I 20g, clear paste II 2g, dry extract II 3g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 250g hydroxypropyl cellulose, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
Embodiment 41
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. clear paste I, the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 3g, dry extract I 1g, clear paste II 8g, dry extract II 1g and cyclodextrin clathrate mix homogeneously, add the 65g micropowder silica gel, use water pill, make pill according to the pill preparation method.
Embodiment 42
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the clear paste I, the clear paste II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, use water pill, make pill according to the pill preparation method.
Embodiment 43
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the dry extract I, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with dry extract I 15g, dry extract II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, mixing is used water pill, makes pill according to the pill preparation method.
Embodiment 44
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the clear paste I, the clear paste II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, mixing with the general ball of ethanol, is made pill according to the pill preparation method.
Embodiment 45
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the dry extract I, the clear paste II that get the acquisition of embodiment 37 methods are standby;
C. with dry extract I 15g, clear paste II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose, use water pill, make pill according to the pill preparation method.
Embodiment 46
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the clear paste I that gets the acquisition of embodiment 37 methods is standby;
C. with clear paste I 100g and cyclodextrin clathrate mix homogeneously, add the 100g sodium carboxymethyl cellulose, use water pill, make pill according to the pill preparation method.
Embodiment 47
A. get prescription, it is standby with embodiment 2 to write out a prescription;
B. the dry extract I that gets the acquisition of embodiment 37 methods is standby;
C. with dry extract I 15g and cyclodextrin clathrate mix homogeneously, add proper honey, make pill according to the pill preparation method.
Embodiment 48
A. get prescription, it is standby with embodiment 6 to write out a prescription;
B. the dry extract II that gets the acquisition of embodiment 37 methods is standby;
C. with dry extract II 4g and cyclodextrin clathrate mix homogeneously, add 30g starch, proper honey, mixing is made pill according to the pill preparation method.
Embodiment 49
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. the clear paste II that gets the acquisition of embodiment 37 methods is standby;
C. with clear paste II 13g and cyclodextrin clathrate mix homogeneously, add an amount of sucrose, the 150g hydroxypropyl cellulose is used water pill, makes pill according to the pill preparation method.
Embodiment 50
A. get prescription, it is standby with embodiment 4 to write out a prescription;
B. the clear paste I, the dry extract I that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 15g, dry extract I 2g and cyclodextrin clathrate mix homogeneously, add the 30g dextrin, mixing is used water pill, makes pill according to the pill preparation method.
Embodiment 51
A. get prescription, it is standby with embodiment 5 to write out a prescription;
B. the clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste II 3g, dry extract II 25g and cyclodextrin clathrate mix homogeneously, add 240g starch, mixing is used water pill, makes pill according to the pill preparation method.
Embodiment 52
A. get prescription, it is standby with embodiment 1 to write out a prescription;
B. clear paste I, the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 37 methods are standby;
C. with clear paste I 14g, dry extract I 3g, clear paste II 5g, dry extract II 29g and cyclodextrin clathrate mix homogeneously, add 1000g starch, mixing is used water pill, makes pill according to the pill preparation method.
Claims (16)
1. a Chinese medicine composition for the treatment of gastrointestinal disease is characterized in that it is to be made by following weight portion proportioning raw material: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.
2. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim is characterized in that comprising the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs are ground into fine powder, make pill, with the mixture coating of oil stone dust, carmine and red ferric oxide, 60 ℃ of dryings, promptly.
3. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 1 is characterized in that comprising the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs become superfine medicated powder through micronizing, make pill.
4. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 1 is characterized in that comprising the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs are made the nanometer medical material, make pill according to the pill preparation method then.
5. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 1 is characterized in that comprising the steps:
A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;
B. above 16 flavor Chinese crude drugs, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
6. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 1 is characterized in that comprising the steps:
A. get 15.50～55.80 parts of recipe quantity Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～3 time, and each 1～2 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%～60%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～3 time, and each 0.2～1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～3 time, and each 1～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 50～90 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 50～80 ℃ of dryings, promptly.
7. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 6 is characterized in that comprising the steps:
A. it is standby to get 34.10 parts of recipe quantity Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when general ball is extremely a certain amount of, add volatile oil, with the mixture coating of oil stone dust, carmine and red ferric oxide with an amount of dissolve with ethanol, 60 ℃ of dryings, promptly.
8. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 1 is characterized in that comprising the steps:
A. get 15.50～55.80 parts of recipe quantity Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～3 time, and each 0.5～3 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 40%～60%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～3 time, and each 0.2～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～3 time, and each 0.5～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～3 time with 60%～85% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～3 time with 60%～85% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8%～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 50～90 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
9. the preparation method of the Chinese medicine composition of treatment gastrointestinal disease as claimed in claim 8 is characterized in that comprising the steps:
A. it is standby to get 34.10 parts of recipe quantity Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, abundant mixing, in 60～80 ℃ of oven dry, pulverize, sieve, use water pill, when a certain amount of, add volatile oil at general ball with an amount of dissolve with ethanol, make pill according to the pill preparation method after, carry out film coating with macromolecular material and pigment, make coated pill.
10. a preparation method for the treatment of the gastrointestinal disease Chinese medicine composition comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; The paste ring spermatophore that volatile oil is added 1～10 times of extract amount closes, and gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate mix homogeneously are made medicine activity component of the present invention.
11. the preparation method as treatment gastrointestinal disease Chinese medicine composition as described in the claim 10 is characterized in that comprising the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is made active component of the present invention.
12. the preparation method as treatment gastrointestinal disease Chinese medicine composition as described in the claim 11 is characterized in that comprising the steps:
A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
C. qinghuo reagent I, clear paste II, cyclodextrin clathrate, mix homogeneously is made active component of the present invention.
13. a preparation method for the treatment of the gastrointestinal disease Chinese medicine composition comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;
Adding ethanol to clear paste I makes and contains alcohol amount and reach 50～80%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.01～1.15, rotating speed with 5000～20000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～10 times distilled water eluting of first usefulness column volume 1～3 time, and water liquid discards, reuse 50～80% ethanol elutions 1～3 time, eluting ethanol is 2～10 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
14. the preparation method as treatment gastrointestinal disease Chinese medicine composition as described in the claim 13 is characterized in that comprising the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;
Adding ethanol to clear paste I makes and contains alcohol amount and reach 60～70%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.02～1.10, rotating speed with 10000～15000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～8 times distilled water eluting of first usefulness column volume 2～3 times, and water liquid discards, reuse 60～70% ethanol elutions 2～3 times, eluting ethanol is 2～8 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
15. the preparation method as treatment gastrointestinal disease Chinese medicine composition as described in the claim 14 is characterized in that comprising the steps:
A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II mixes with cyclodextrin clathrate, makes active component of the present invention.
16. as claim 10～15 arbitrary as described in the preparation method of treatment gastrointestinal disease Chinese medicine composition, wherein the adjuvant that the medicine activity component that makes among the step c and pill are commonly used mixes, makes pill according to pill routine preparation method.
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