CN104547530A - Chinese medicinal composition for treating diabetes - Google Patents
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Abstract
The invention belongs to the field of traditional Chinese medicines and aims to provide a Chinese medicinal composition for treating diabetes according to the mechanism on the Chinese medical understanding of diabetes. The Chinese medicinal composition is characterized by comprising the following Chinese medicinal raw materials in parts by weight: 12-18 parts of red paeony roots, 3-9 parts of liquorice roots, 9-15 parts of milkvetch roots, 9-15 parts of ground beetles, 28-32 parts of rehmannia roots, 12-18 parts of twotooth achyranthes roots, 18-25 parts of coptis roots, 28-32 parts of Danshen roots, 9-15 parts of earthworms, 28-32 parts of Chinese angelica, 18-25 parts of cassia seeds, 9-15 parts of leeches, 9-15 parts of peach seeds, 12-18 parts of gynostemma pentaphyllum, 12-18 parts of safflowers, 28-32 parts of suberect spatholobus stems, 9-15 parts of white silkworms, 28-32 parts of cochinchinese asparagus roots and 28-32 parts of dwarf lilyturf tubers. The Chinese medicinal raw materials in the Chinese medicinal composition are conventional medicinal herbs, but the conventional medicinal herbs are combined reasonably and well-weighed by analyzing the symptoms of diabetes dialectically, so that the Chinese medicinal composition can achieve a satisfactory treatment effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to a kind of Chinese medicine composition for the treatment of diabetes.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature.Hyperglycemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.
Summary of the invention
The object of the invention is understanding mechanism diabetes one demonstrate,proved according to the traditional Chinese medical science, and then a kind of Chinese medicine composition for the treatment of this disease is provided.
For realizing above-mentioned technical purpose, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 12-18 part, Radix Glycyrrhizae 3-9 part, Radix Astragali 9-15 part, Eupolyphaga Seu Steleophaga 9-15 part, Radix Rehmanniae 28-32 part, Radix Achyranthis Bidentatae 12-18 part, Rhizoma Coptidis 18-25 part, Radix Salviae Miltiorrhizae 28-32 part, Pheretima 9-15 part, Radix Angelicae Sinensis 28-32 part, Semen Cassiae 18-25 part, Hirudo 9-15 part, Semen Persicae 9-15 part, Herb Gynostemmae Pentaphylli 12-18 part, Flos Carthami 12-18 part, Caulis Spatholobi 28-32 part, Bombyx Batryticatus 9-15 part, Radix Asparagi 28-32 part, Radix Ophiopogonis 28-32 part.
The optimum weight proportioning of above-mentioned raw materials medicine is: Radix Paeoniae Rubra 15 parts, 6 parts, Radix Glycyrrhizae, the Radix Astragali 12 parts, Eupolyphaga Seu Steleophaga 12 parts, Radix Rehmanniae 30 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Coptidis 22 parts, Radix Salviae Miltiorrhizae 30 parts, Pheretima 12 parts, Radix Angelicae Sinensis 30 parts, Semen Cassiae 20 parts, Hirudo 12 parts, 12 parts, Semen Persicae, Herb Gynostemmae Pentaphylli 15 parts, 15 parts, Flos Carthami, Caulis Spatholobi 30 parts, Bombyx Batryticatus 12 parts, Radix Asparagi 30 parts, Radix Ophiopogonis 30 parts.
The instructions of taking of Chinese medicine composition provided by the present invention is: adopt the method for conventional fried Chinese medicine to get its medicine juice 300-500ml by after the mixing of the material medicine of above-mentioned weight proportion, every day takes for twice sooner or later, and every day one is secondary.
Prescription analysis: the traditional Chinese medical science is thought, the pathogenesis of diabetes is mainly YIN fluid deficiency, scorching inclined Sheng, and take the deficiency of YIN as this, and scorching is mark, both reciprocal causations, and more void is then scorching more contains for the moon, and scorching more to contain then the moon more empty.The internal organs of diabetes pathological changes, mainly at lung, stomach, kidney, are key with kidney especially.With the passing of time simultaneously ill, then easily generation deficiency of YIN affecting YANG and disease enter the pathological changes of network for a long time, and deficiency of YIN affecting YANG is deficiency in both YIN and YANG then, and disease enters network for a long time, and then the blood vessels stasis of blood is stagnant.When treating based on above-mentioned cognition should with nourishing YIN, moisturize for wanting, hold concurrently kidney-replenishing, removing blood stasis simultaneously, live and become silted up, especially will take into account removing blood stasis and live and become silted up, notice blood foot of invigorating blood circulation then dryly goes.Therefore in Chinese medicine composition provided by the present invention, increase Radix Rehmanniae, Radix Angelicae Sinensis, Radix Asparagi, the consumption proportion of Radix Ophiopogonis get the effect that its nourishing YIN is moisturized, get the effect of Herb Gynostemmae Pentaphylli, Pheretima, Rhizoma Coptidis, Semen Cassiae heat clearing away, with the broken silt of Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, Hirudo, Semen Persicae, Flos Carthami, Caulis Spatholobi, the effect of invigorating blood circulation, more get the logical loose effect of Bombyx Batryticatus to help blood.Owing to being full of cool, cold, bitter, salty thing in prescription, be anti-negative electrode impairment of YANG, be also the changed situation of the deficiency of YIN affecting YANG of prolonged illness appearance, with Radix Achyranthis Bidentatae, the Radix Astragali, kidney-replenishing and whole body yang-energy simultaneously.Above-mentioned all medicines share, and cloudy liquid must be mended, and cloudy liquid must be capable, and the dryness of the lung removes to the greatest extent all cloth of then whole body body fluid, and diabetes one card is explained by oneself.Although this Chinese medicine composition is common drug on choice of drug, by disease dialectical Analyses accurately, conventional medicine is carried out reasonable compatibility, consideration consumption, it can obtain gratifying therapeutic effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 18g, Radix Glycyrrhizae 9g, Radix Astragali 15g, Eupolyphaga Seu Steleophaga 15g, Radix Rehmanniae 32g, Radix Achyranthis Bidentatae 18g, Rhizoma Coptidis 25g, Radix Salviae Miltiorrhizae 32g, Pheretima 15g, Radix Angelicae Sinensis 32g, Semen Cassiae 25g, Hirudo 15g, Semen Persicae 15g, Herb Gynostemmae Pentaphylli 18g, Flos Carthami 18g, Caulis Spatholobi 32g, Bombyx Batryticatus 15g, Radix Asparagi 32g, Radix Ophiopogonis 32g.
In the present embodiment, for carrying out toxicity test to medicine, the weight portion of each material medicine is got its maximum weight part and is tested, and toxicity test is divided into acute toxicity testing and long term toxicity test, and result is as follows:
Acute toxicity test: for convenience of carrying out dispensing feeding to white mice, the Chinese medicine decoction embodiment of the present invention 1 prepared carries out concentrated atomization pelletize and obtains Chinese medicinal granule.Chinese medicinal granule is dissolved in distilled water, with 195 of clinical consumption per day times to white mice dispensing feeding, observes 7.The activity of all white mice of result, diet, hair no abnormality seen, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test: the Chinese medicinal granule prepared in this embodiment of the invention is dissolved in water to mice by 20.15g crude drug/kg, to mice continuous use 16 weeks, every day 2 times, and drug withdrawal is after 2 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to test white mice all has no significant effect, and internal organs naked eyes do not find difference change.Employing histological indications shows, medication 16 weeks and drug withdrawal are after 2 weeks, and Organs of Mice is all without obviously changing.
Embodiment 2
A kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 15g, Radix Glycyrrhizae 6g, Radix Astragali 12g, Eupolyphaga Seu Steleophaga 12g, Radix Rehmanniae 30g, Radix Achyranthis Bidentatae 15g, Rhizoma Coptidis 22g, Radix Salviae Miltiorrhizae 30g, Pheretima 12g, Radix Angelicae Sinensis 30g, Semen Cassiae 20g, Hirudo 12g, Semen Persicae 12g, Herb Gynostemmae Pentaphylli 15g, Flos Carthami 15g, Caulis Spatholobi 30g, Bombyx Batryticatus 12g, Radix Asparagi 30g, Radix Ophiopogonis 30g.
In the present embodiment, adopt the material medicine of above-mentioned weight proportion to carry out clinical trial, test as follows:
Diabetics 58 example, wherein male patient 32 example, female patient 2 example, the mean age 48.6, symptom: polydipsia, polyuria, to become thin, on an empty stomach average blood sugar value 10.4, urine band foam, diet does not subtract the increase of some patients dietary amount.
58 routine patients are divided into treatment group and matched group at random, each group 29 example, treatment group on an empty stomach average blood sugar value is 10.6, and matched group is average blood sugar value 10.2 on an empty stomach, treatment group adopts oral Chinese medicine composition provided by the present invention to treat, and matched group adopts oral administration of metformin treatment.
Diagnostic criteria:
Often treat 1 week, adopt and detect fasting blood sugar and carry out therapeutic effect and compare, treatment end drug withdrawal again detects fasting blood sugar for 2 weeks and carries out therapeutic effect and compare.
Therapeutic outcome is as follows:
After treating 1 week, surveying matched group empty stomach average blood sugar value is 9.5, on average declines 1.1, wherein the fasting blood sugar of 29 routine patients all has certain decline, surveying treatment group empty stomach average blood sugar value is 9.6, and on average decline 0.6, wherein the fasting blood sugar of 27 routine patients has certain decline.Continual cure 1 week, surveying matched group empty stomach average blood sugar value is 9.3, average decline 0.2, the fasting blood sugar of 5 routine patients is wherein only had to have certain decline relative to treatment at the end of 1 week, surveying treatment group empty stomach average blood sugar value is 8.3, average decline 1.3, wherein the fasting blood sugar of 29 routine patients has certain decline relative to treatment at the end of 1 week.Continue to take medicine one week, matched group on an empty stomach average blood sugar value is substantially unchanged, and only have 2 routine patients to occur less reduction, treatment group on an empty stomach average blood sugar value is 7.5, and on average decline 0.8, wherein the fasting blood sugar of 24 routine patients is down to less than 7.Drug withdrawal is after 2 weeks, and the fasting blood sugar of matched group generally occurs raising phenomenon, and treatment group has 5 routine patient blood glucose to be worth rising, and the patient populations wherein maintaining less than 7 is 23 examples.
Known by therapeutic outcome, first week therapeutic effect that matched group is starting to treat is better than treatment group, but continual cure effect is poor, and radical cure effect is substantially without possibility.And the curative effect continuous and effective for the treatment of group, curative effect is obviously better than matched group, and relative to thing that matched group is taken medicine, this Chinese medicine composition shows fairly obvious advantage.
Model case:
Female, 52 years old, diabetes medical history half a year, total feel thirst with desire to drink, every day amount of drinking water more than 3 liters, frequent micturition is anxious, every day more than 10 time, urine band foam not easily leaves, and the bodily form is become thin, dietary amount does not subtract, and both legs are unable, and head dusk rises, survey fasting blood sugar 11.8, oral administration of metformin blood glucose value slightly declines, doctor advised hormone insulin, because this patient has a fainting spell during acupuncture treatment for a long time, refuse always.
Rear employing is taken Chinese medicine composition provided by the present invention and is treated, after taking medicine one week, the thirsty symptom of self-induction alleviates, and surveys fasting blood sugar and drops to 9.3, continue to take this Chinese medicine composition 2 weeks, fasting blood sugar is down to 7.3, thirsty, frequent micturition emergency case shape disappears substantially, is consolidate curative effect, continues to take medicine 1 week, fasting blood sugar is down to 6.9, drug withdrawal.So far March, then occur without thirsty, the anxious phenomenon of frequent micturition, daily measurement fasting blood sugar maintains about 7 substantially, though a little more than blood glucose level normal, substantially belongs to treatment recovery from illness.
Embodiment 3
A kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 12g, Radix Glycyrrhizae 9g, Radix Astragali 9g, Eupolyphaga Seu Steleophaga 15g, Radix Rehmanniae 28g, Radix Achyranthis Bidentatae 18g, Rhizoma Coptidis 18g, Radix Salviae Miltiorrhizae 32g, Pheretima 9g, Radix Angelicae Sinensis 32g, Semen Cassiae 18g, Hirudo 15g, Semen Persicae 9g, Herb Gynostemmae Pentaphylli 18g, Flos Carthami 12g, Caulis Spatholobi 32g, Bombyx Batryticatus 9g, Radix Asparagi 32g, Radix Ophiopogonis 28g.
Embodiment 4
A kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 18g, Radix Glycyrrhizae 3g, Radix Astragali 15g, Eupolyphaga Seu Steleophaga 9g, Radix Rehmanniae 32g, Radix Achyranthis Bidentatae 12g, Rhizoma Coptidis 25g, Radix Salviae Miltiorrhizae 28g, Pheretima 15g, Radix Angelicae Sinensis 28g, Semen Cassiae 25g, Hirudo 9g, Semen Persicae 15g, Herb Gynostemmae Pentaphylli 12g, Flos Carthami 18g, Caulis Spatholobi 28g, Bombyx Batryticatus 15g, Radix Asparagi 28g, Radix Ophiopogonis 32g.
Claims (2)
1. treat the Chinese medicine composition of diabetes for one kind, it is characterized in that, this Chinese medicine composition adopts the raw material Chinese medicine of a little row weight proportion to make: Radix Paeoniae Rubra 12-18 part, Radix Glycyrrhizae 3-9 part, Radix Astragali 9-15 part, Eupolyphaga Seu Steleophaga 9-15 part, Radix Rehmanniae 28-32 part, Radix Achyranthis Bidentatae 12-18 part, Rhizoma Coptidis 18-25 part, Radix Salviae Miltiorrhizae 28-32 part, Pheretima 9-15 part, Radix Angelicae Sinensis 28-32 part, Semen Cassiae 18-25 part, Hirudo 9-15 part, Semen Persicae 9-15 part, Herb Gynostemmae Pentaphylli 12-18 part, Flos Carthami 12-18 part, Caulis Spatholobi 28-32 part, Bombyx Batryticatus 9-15 part, Radix Asparagi 28-32 part, Radix Ophiopogonis 28-32 part.
2. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterized in that, the optimum weight proportioning of described material medicine is: Radix Paeoniae Rubra 15 parts, 6 parts, Radix Glycyrrhizae, the Radix Astragali 12 parts, Eupolyphaga Seu Steleophaga 12 parts, Radix Rehmanniae 30 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Coptidis 22 parts, Radix Salviae Miltiorrhizae 30 parts, Pheretima 12 parts, Radix Angelicae Sinensis 30 parts, Semen Cassiae 20 parts, Hirudo 12 parts, 12 parts, Semen Persicae, Herb Gynostemmae Pentaphylli 15 parts, 15 parts, Flos Carthami, Caulis Spatholobi 30 parts, Bombyx Batryticatus 12 parts, Radix Asparagi 30 parts, Radix Ophiopogonis 30 parts.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748855A (en) * | 2016-05-09 | 2016-07-13 | 林荣波 | Traditional Chinese medicine composition used for treating diabetes |
| CN105749064A (en) * | 2016-05-09 | 2016-07-13 | 林荣波 | Traditional Chinese medicine composition with blood glucose reduction function |
| CN105902850A (en) * | 2016-05-09 | 2016-08-31 | 林荣波 | Traditional Chinese medicine composition for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745022A (en) * | 2008-12-12 | 2010-06-23 | 北京中科仁和科技有限公司 | Chinese pharmaceutical composition for treatment of diabetes and preparation method thereof |
| CN101766752A (en) * | 2008-12-26 | 2010-07-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine combination for treating diabetes mellitus and preparation method thereof |
| CN103610769A (en) * | 2013-09-24 | 2014-03-05 | 陆群英 | Diabetic peripheral neuropathy treatment traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101745022A (en) * | 2008-12-12 | 2010-06-23 | 北京中科仁和科技有限公司 | Chinese pharmaceutical composition for treatment of diabetes and preparation method thereof |
| CN101766752A (en) * | 2008-12-26 | 2010-07-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine combination for treating diabetes mellitus and preparation method thereof |
| CN103610769A (en) * | 2013-09-24 | 2014-03-05 | 陆群英 | Diabetic peripheral neuropathy treatment traditional Chinese medicine composition |
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| 周世钟: "糖尿病慢性并发症辨治体会", 《实用中医药杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748855A (en) * | 2016-05-09 | 2016-07-13 | 林荣波 | Traditional Chinese medicine composition used for treating diabetes |
| CN105749064A (en) * | 2016-05-09 | 2016-07-13 | 林荣波 | Traditional Chinese medicine composition with blood glucose reduction function |
| CN105902850A (en) * | 2016-05-09 | 2016-08-31 | 林荣波 | Traditional Chinese medicine composition for treating diabetes |
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