CN103316124A - Application of raw rhubarb composition in bowel relaxing, qi regulating, and intestinal recovery - Google Patents
Application of raw rhubarb composition in bowel relaxing, qi regulating, and intestinal recovery Download PDFInfo
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- CN103316124A CN103316124A CN2013101910993A CN201310191099A CN103316124A CN 103316124 A CN103316124 A CN 103316124A CN 2013101910993 A CN2013101910993 A CN 2013101910993A CN 201310191099 A CN201310191099 A CN 201310191099A CN 103316124 A CN103316124 A CN 103316124A
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Abstract
The invention relates to an application of a raw rhubarb composition in bowel relaxing, qi regulating, and intestinal recovery. The raw rhubarb composition comprises, by weight, 8-10 parts of raw rhubarb, 4-6 parts of stir-fried immature bitter orange, 4-6 parts of officinal magnolia bark, 3-5 parts of swordlike atractylodes rhizome, 4-6 parts of tangerine peel, 4-6 parts of immature tangerine fruit, 4-6 parts of coked hawthorn fruit, and 4-6 parts of medicated leaven. With bowel relaxing and qi regulating functions, rat small intestine and colon movements can be enhanced, and defaecation can be accelerated. An in-vitro experiment result is completely opposite to an in-vivo experiment. The result of the in-vitro experiment shows that with the bowel relaxing and qi regulating functions, normal rat ileum and colon movements can be inhibited, and the excitation effect of acetylcholine upon small intestine can be significantly inhibited.
Description
One, technical field
The present invention relates to medicine, especially Radix Et Rhizoma Rhei compositions that the postoperative intestinal recovers in purging FU-organs is regulated the flow of vital energy and intestinal recovers purposes.
Two, background technology
Xiao Chengqi Tang is ancient prescription, and by Radix Et Rhizoma Rhei (five money) Cortex Magnoliae Officinalis (three money) Fructus Aurantii Immaturus (two money) compatibility, medicine-feeding three flavors with 800 milliliters in water, boil and get 400 milliliters, go dregs, divide the secondary decoction being taken warmly.Radix Et Rhizoma Rhei purging heat to relax the bowels in the Xiao Chengqi Tang side, Cortex Magnoliae Officinalis circulation of qi promoting loose full, the Fructus Aurantii Immaturus dispelling the stagnated QI painful abdominal mass that disappears, and all medicines share, and can gently descend accumulation of heat, remove the painful abdominal mass that completely disappears.Also be used for the delirium hectic fever, constipation, yellow fur, slippery and rapid pulse, dysentery from the beginning of, pestilence pain in the abdomen, or distension and fullness in the abdomen, tenesmus person.
But the curative effect of recovery that does not have the postoperative function of intestinal canal of modern clinical needs is in body, the pharmacological action of the laboratory observation internal organs side of regulating the flow of vital energy of external two aspects.
Three, summary of the invention
The present invention seeks to: propose a kind of Radix Et Rhizoma Rhei compositions in purging FU-organs is regulated the flow of vital energy and intestinal recovers purposes.The clinical recovery that is mainly used in the postoperative function of intestinal canal.
The Radix Et Rhizoma Rhei compositions is in purging FU-organs is regulated the flow of vital energy and intestinal recovers purposes, described Radix Et Rhizoma Rhei compositions, mainly by Radix Et Rhizoma Rhei 8-10, Fructus Aurantii Immaturus (parched) 4-6, Cortex Magnoliae Officinalis 4-6, Rhizoma Atractylodis 3-5, Pericarpium Citri Reticulatae 4-6, Pericarpium Citri Reticulatae Viride 4-6, Fructus Crataegi (parched to brown) 4-6, Massa Medicata Fermentata 4-6 form, and compositions is weight portion.Weight portion unit is gram, can be used as once or one day decoction amount.
The Radix Et Rhizoma Rhei compositions is the purging FU-organs side of regulating the flow of vital energy, and is made up of Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus (parched), Cortex Magnoliae Officinalis, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Fructus Crataegi (parched to brown), Massa Medicata Fermentata, and this side is that end sanction forms with Xiao Chengqi Tang, has the effect of dampness dissipating, QI regulating, purging FU-organs.The clinical recovery that is mainly used in the postoperative function of intestinal canal is in body, the pharmacological action of the laboratory observation internal organs side of regulating the flow of vital energy of external two aspects, for the clinical practice of the internal organs side of regulating the flow of vital energy provides foundation.
Beneficial effect of the present invention is: the purging FU-organs side of the regulating the flow of vital energy medicinal liquid according to embodiment 1 carries out tests such as animal, gets supernatant and is concentrated into 190ml, be i.e. 380g/190ml, 2g crude drug/ml.Fructus Cannabis Bolus (60g/ bottle) Nanjing Tongrentang Pharmaceutical Co., Ltd..R-1132 (DC, 2.5mg/ sheet) Changzhou Kang Pu pharmaceutcal corporation, Ltd.Azovan blue is gone up sea blue season development in science and technology company limited import packing.Tyrode's solution is prepared according to document.
Animal KM mice, body weight 18～25g is provided by Nanjing University of Traditional Chinese Medicine's Experimental Animal Center.
Instrument multiple tracks bio signal analytical system (Shanghai Alcott bio tech ltd), routine operation apparatus.
Obtain following result:
1.1 the purging FU-organs side of regulating the flow of vital energy is to the mouse small intestine motion effects
Get 50 of the mices of fasting 20h, be divided into five groups, 10 every group.Normal saline group, purging FU-organs regulate the flow of vital energy 5g/kg, 10g/kg, 20g/kg, Fructus Cannabis Bolus group 2.4g/kg.Behind the ig30min, ig0.5% azovan blue 0.1ml/10g again.Take off cervical vertebra behind the 10min and put to death mice, open the abdominal cavity, separate mesentery, take off the intestinal tube of upper end to stomach, lower end to ileocecus, measure small intestinal total length (pylorus is to ileocecus), azovan blue in enteral advance distance (pyloric part is to the azovan blue forward position), calculate the propelling rate, the comparable group differences.
The table 1 purging FU-organs side of regulating the flow of vital energy is to the influence of mouse small intestine motion
Compare with the blank group: * p＜0.05
Experimental result shows, the ahead running of its reinforcement small intestinal is pointed out to the be significantly increased intestinal propulsion rate of AZO-blue of heavy dose group (20g/kg) by the purging FU-organs side of regulating the flow of vital energy.The results are shown in Table 1.
1.2 the purging FU-organs side of regulating the flow of vital energy is to the influence of mice defecation time and quantity
1.2.1 the purging FU-organs side of regulating the flow of vital energy is to the influence (carbon powder method) of healthy mice defecation time and quantity
Get 40 of the mices of fasting 12h, be divided into 4 groups, 10 every group, the male and female dual-purpose.Normal saline group, purging FU-organs regulate the flow of vital energy 10g/kg, 20g/kg, Fructus Cannabis Bolus group 2.4g/kg, every kind of medicinal liquid comprises that normal saline contains carbon powder (active carbon) 0.1g/ml.Press the 0.1ml/10g body weight and irritate stomach, each Mus is placed separately in the mouse cage, give normal diet, drinking-water.Time, the number of record mice row melena were observed 8 hours continuously, relatively, the results are shown in Table 2 between organizing.
The table 2 purging FU-organs side of regulating the flow of vital energy is to the influence of healthy mice defecation
Experimental result shows, the purging FU-organs side of regulating the flow of vital energy to little, in, heavy dose of three dosage group head just time and 8h just the grain number do not have significant difference with matched group, point out its gastrointestinal motility to healthy mice not have to influence.
1.2.1 the purging FU-organs side of regulating the flow of vital energy is to the influence of mice constipation model
Get 60 of male mices, behind the fasting 12h, be divided into 6 groups at random, every group 10, except normal group, all the other each groups give DC40mg/kg, behind the 1h, each group gives corresponding medicine, divide to go into separately in the 1000ml beaker of back-off after the administration, give normal diet, drinking-water, the head of interior every the animal of record 8h, 10h is the feces number of time, discharge just, beginning 10min is the laundering period, does not count.The results are shown in Table 3.
The table 3 purging FU-organs side of regulating the flow of vital energy causes the influence of mice with constipation defecation to DC
Compare with the blank group: ##p＜0.01; Compare with model group: * p＜0.05, * * p＜0.01
Experimental result shows, compare with model group, the purging FU-organs side of regulating the flow of vital energy little, in, big three dosage groups can significantly shorten mice head just the time (* p＜0.05), increase the just grain number (* * p＜0.01) in the 8h, in the purging FU-organs side of regulating the flow of vital energy, heavy dose of group remarkable just number in the 10h also, the prompting purging FU-organs is regulated the flow of vital energy and can significantly be strengthened the gastrointestinal motility of mice with constipation, accelerates defecation.
1.3 the purging FU-organs side of regulating the flow of vital energy is to the stripped colonic smooth muscle motion effects of mice
Get mice, cut the abdominal cavity after shooting dead immediately open, take out downwards the colon that a segment length is about 5～6cm along ileocecus, put into immediately and fill the tyrode's solution plate, wash away the enteral food debris with syringe, change fresh tyrode's solution after, 4 ℃ of refrigerators storages, standby.Get on the lateral bending hook that is fixed in the bath bottom in 2cm intestinal tube lower end, the upper end links to each other with transducer, puts into 37 ℃ of tyrode's solution baths (bath tyrode's solution 30ml), passes to 95%O
2And 5%CO
2, stable about 30min, (1) record normal tension curve 15min, the purging FU-organs side of regulating the flow of vital energy adds 0.1ml/ time, and continuous 5 times (being accumulate to 0.5ml) record 5min at every turn.(2) record normal tension curve 15min adds Ach0.2ml, and record 10min adds the purging FU-organs side of regulating the flow of vital energy 0.1ml/ time, continuous 2 times, records 10min at every turn.Observe and compare the situation of the stripped colonic smooth muscle motion of mice in each section 10min.The results are shown in Table 4,5.
The table 4 purging FU-organs side of regulating the flow of vital energy medicinal liquid is to the influence of the stripped colon of mice
Compare with the blank group: * * p＜0.01
Experimental result shows, compares with the blank group, and the purging FU-organs side of regulating the flow of vital energy water extract all has significant inhibitory effect (* * p＜0.01) to minima, maximum, absolute area and the contraction frequency of the stripped ileum tension force of mice.
The table 5 purging FU-organs side of regulating the flow of vital energy water extract causes the influence of the stripped colon excitement of mice to Ach
Compare with the blank group: ##p＜0.01; Compare with the Ach group: * * p＜0.01
Experimental result shows, compare with the blank group, acetylcholine (Ach) has significant excitation to the mice colon that exsomatizes, and the exsomatize raising of minima, maximum, absolute area and contraction frequency of ileum tension force of the mice that the purging FU-organs side of regulating the flow of vital energy water extract causes Ach all has powerful antagonism (* * p＜0.01).
1.4 the purging FU-organs side of regulating the flow of vital energy is to the stripped ileum smooth muscle motion effects of mice
Get mice, cut the abdominal cavity after shooting dead immediately open, upwards take out the small intestinal that a segment length is about 5～6cm along ileocecus, put into immediately and fill the tyrode's solution plate, wash away the enteral food debris with syringe, change fresh tyrode's solution after, the storage of 4 ℃ of refrigerators, standby.Get on the lateral bending hook that is fixed in the bath bottom in 2cm intestinal tube lower end, the upper end links to each other with transducer, puts into 37 ℃ of tyrode's solution baths (bath tyrode's solution 30ml), passes to 95%O
2And 5%CO
2, stable about 30min.Record normal tension curve 10min adds Ach0.2ml, and record 10min adds the purging FU-organs side of regulating the flow of vital energy 0.1ml/ time, adds 2 times, records 5min at every turn.Observe and compare the situation of the stripped ileum smooth muscle motion of mice in each section 5min.The results are shown in Table 6.
The table 6 purging FU-organs side of regulating the flow of vital energy medicinal liquid is to the influence of the stripped ileum motion of mice
Compare with the blank group: ##p＜0.01; Compare with the Ach group: * * p＜0.01
Experimental result shows, compare with the blank group, acetylcholine (Ach) has significant excitation to the mice colon that exsomatizes, and the exsomatize raising of minima, maximum, absolute area and contraction frequency of ileum tension force of the mice that the purging FU-organs side of regulating the flow of vital energy water extract causes Ach all has powerful antagonism (* * p＜0.01).
Intestinal is pith of human body, plays a part digest food, absorbs nutrition.Cause restoration of gastrointestinal function slower because of anesthesia and factor such as have a delicate constitution after surgery the clinical patient that quite a few abdominal operation arranged, produced the constipation phenomenon, therefore this integral body that has had a strong impact on patient's postoperative is recovered, sometimes even also can cause the adhesion of abdominal tissues.The traditional Chinese medical science thinks that all diseases are affection of wind all, and dirty thing is not if go, and then mechanism of qi is dull, and the capable then blood of gas is capable, and QI and blood is unobstructed then normal, and the QI and blood stagnation of QI and blood may bring about pain is positive so-called: " stagnation of QI and blood may bring about pain, general rule are not bitterly ".The purging FU-organs side of regulating the flow of vital energy is made up of Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus (parched), Cortex Magnoliae Officinalis etc., is that end sanction forms with Xiao Chengqi Tang, has the effect of dampness dissipating, QI regulating, purging FU-organs, but efficient solution is accelerated the gastrointestinal motility of postoperative.
Experimental result shows that the purging FU-organs side of regulating the flow of vital energy can significantly improve the intestinal propulsion rate of AZO-blue when heavy dose; The head of shortening DC mice with constipation is the time just, significantly increases the just grain number of DC mice with constipation, and defecation is accelerated in small intestinal and colon motion that the prompting purging FU-organs is regulated the flow of vital energy and can effectively be strengthened mice.Yet the result of in vitro tests is opposite fully with the in vivo test result, and in vitro results demonstration purging FU-organs is regulated the flow of vital energy and can be suppressed the motion of normal mouse ileum, colon forcefully, significantly to the excitation of anti-acetylcholine to small intestinal.The present invention has done other sampling clinically, and effect is also obvious.In a word, the present invention provides theoretical foundation preferably for the purging FU-organs side of regulating the flow of vital energy in the clinical treatment intestinal tract disease to a certain extent.
Four, the specific embodiment
Embodiment 1: the purging FU-organs side of regulating the flow of vital energy (Radix Et Rhizoma Rhei compositions) is in purging FU-organs is regulated the flow of vital energy and intestinal recovers purposes, the described purging FU-organs side of regulating the flow of vital energy is made up of for 5 parts Radix Et Rhizoma Rhei 9, Fructus Aurantii Immaturus (parched) 5, Cortex Magnoliae Officinalis 5, Rhizoma Atractylodis 4, Pericarpium Citri Reticulatae 5, Pericarpium Citri Reticulatae Viride 5, Fructus Crataegi (parched to brown) 5, Massa Medicata Fermentata, and compositions is weight portion (gram).Above-mentioned formulation becomes decocting or granular preparation.
According to the above-mentioned purging FU-organs side of regulating the flow of vital energy, the amount of getting 5 pairs of square medicines adds 10 times of water yields, soaks 30min, decocts 1h, filter, decoct the 2nd time with method, (decoct 15min) down behind the Radix Et Rhizoma Rhei when decocting for the second time, merging filtrate, 4 ℃ of refrigerator overnight are got supernatant and are concentrated into 190ml, i.e. 380g/190ml, 2g crude drug/ml.
More than in eight flavors, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Rhizoma Atractylodis soaked 0.5 hour, added the water of 8 times of amounts of decoction pieces total amount, vapor distillation 6h collects volatile oil.Inclusion essential oil adopts ultrasonic method, volatile oil: beta-schardinger dextrin-(1: 6), add 10 times of water gagings, and enclose 60min, standby behind 40 ℃ of vacuum dryings of clathrate.Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis add 6 times of amounts of decoction pieces total amount, 70% ethanol, extract 3 times, extract 1.0h at every turn.Filter, merge extractive liquid,, decompression recycling ethanol are concentrated into does not have the alcohol flavor.Above-mentioned medicinal residues and Fructus Crataegi, Massa Medicata Fermentata merge, and add the water of 10 times of amounts of decoction pieces total amount, divide 3 decoctions (three consumptions be respectively total amount 40%, 30%, 30%), at every turn 1.5h.Filter, merge decocting liquid, it is 1.102～1.122(60 ℃ that filtrate is concentrated into relative density), cooling adds ethanol and reaches 40% to containing the alcohol amount, stirs evenly, and places 48 hours.Centrifugal (4800 rev/mins), gained clear liquor and alcohol extraction concentrated solution merge, and decompression recycling ethanol also is condensed into thick paste, 80 ℃ of drying under reduced pressure, crushed after being dried becomes fine powder.With the Benexate Hydrochloride mix homogeneously, will mix extract powder: Icing Sugar again: dextrin (1: 0.2: 0.6), with 90% ethanol wet method granule processed, 50 ℃ of dryings, granulate, namely.
Embodiment 2: Radix Et Rhizoma Rhei 8, Fructus Aurantii Immaturus (parched) 4, Cortex Magnoliae Officinalis 4, Rhizoma Atractylodis 3, Pericarpium Citri Reticulatae 4, Pericarpium Citri Reticulatae Viride 4, Fructus Crataegi (parched to brown) 4,4 parts of compositions of Massa Medicata Fermentata.
Embodiment 3: Radix Et Rhizoma Rhei 10, Fructus Aurantii Immaturus (parched) 6, Cortex Magnoliae Officinalis 6, Rhizoma Atractylodis 5, Pericarpium Citri Reticulatae 6, Pericarpium Citri Reticulatae Viride 6, Fructus Crataegi (parched to brown) 6,6 parts of compositions of Massa Medicata Fermentata.
Embodiment 2-3 uses with example 1 infusion, and its effect and embodiment 1 do not have obviously difference.
Though the present invention discloses as above with preferred embodiment, so it is not in order to limit the present invention.The persond having ordinary knowledge in the technical field of the present invention, without departing from the spirit and scope of the present invention, when being used for a variety of modifications and variations.Therefore, protection scope of the present invention is as the criterion when looking claims person of defining.
Claims (2)
1. the Radix Et Rhizoma Rhei compositions is in purging FU-organs is regulated the flow of vital energy and intestinal recovers purposes, described Radix Et Rhizoma Rhei compositions, mainly be made up of Radix Et Rhizoma Rhei 8-10, Fructus Aurantii Immaturus (parched) 4-6, Cortex Magnoliae Officinalis 4-6, Rhizoma Atractylodis 3-5, Pericarpium Citri Reticulatae 4-6, Pericarpium Citri Reticulatae Viride 4-6, Fructus Crataegi (parched to brown) 4-6, Massa Medicata Fermentata 4-6 part, compositions is weight portion.
According to claim 1 Radix Et Rhizoma Rhei compositions in the purposes that purging FU-organs is regulated the flow of vital energy and intestinal recovers, it is characterized in that being prepared into decocting or granular preparation and use.
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| CN106819436A (en) * | 2017-01-23 | 2017-06-13 | 长治市雄丰清真养殖屠宰有限公司 | A kind of fodder compound of prevention cattle and sheep taeniasis |
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| CN104398635A (en) * | 2014-11-29 | 2015-03-11 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicinal composition for treating acute ruminal tympany of sheep and preparation method thereof |
| CN106819436A (en) * | 2017-01-23 | 2017-06-13 | 长治市雄丰清真养殖屠宰有限公司 | A kind of fodder compound of prevention cattle and sheep taeniasis |
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