CN102292333B - 蛋白激酶c抑制剂及其用途 - Google Patents

蛋白激酶c抑制剂及其用途 Download PDF

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Publication number
CN102292333B
CN102292333B CN201080005581.8A CN201080005581A CN102292333B CN 102292333 B CN102292333 B CN 102292333B CN 201080005581 A CN201080005581 A CN 201080005581A CN 102292333 B CN102292333 B CN 102292333B
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fluoro
benzo
pyrimidine
alkyl
diamine
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Chinese (zh)
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CN102292333A (zh
Inventor
赵浩然
R·克鲁瑞
C·巴尔德斯
K·曹
R·辛格
J·拉姆菲尔
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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CN201080005581.8A 2009-01-15 2010-01-13 蛋白激酶c抑制剂及其用途 Expired - Fee Related CN102292333B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14502109P 2009-01-15 2009-01-15
US61/145,021 2009-01-15
US14735309P 2009-01-26 2009-01-26
US61/147,353 2009-01-26
PCT/US2010/020888 WO2010083207A2 (en) 2009-01-15 2010-01-13 Protein kinase c inhibitors and uses thereof

Publications (2)

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CN102292333A CN102292333A (zh) 2011-12-21
CN102292333B true CN102292333B (zh) 2015-05-13

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US (3) US8394951B2 (https=)
EP (1) EP2387572B1 (https=)
JP (1) JP5603881B2 (https=)
CN (1) CN102292333B (https=)
CA (1) CA2749195C (https=)
ES (1) ES2555982T3 (https=)
WO (1) WO2010083207A2 (https=)

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TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
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WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
CA3150681A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
US11851426B2 (en) 2019-10-11 2023-12-26 Incyte Corporation Bicyclic amines as CDK2 inhibitors
CN117015543A (zh) * 2020-09-14 2023-11-07 高德美控股有限公司 新型jak抑制剂化合物、其合成方法及其用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
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