CN102283995A - Chinese medicinal preparation for treating diabetes mellitus and preparation method thereof - Google Patents
Chinese medicinal preparation for treating diabetes mellitus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating diabetes mellitus and a preparation method thereof. The Chinese medicinal preparation is prepared from lucid ganoderma serving as a main medicine, dwarf lilyturf root and rhizoma anemarrhenae which serve as deputy medicines, and ginseng which serves as an adjuvant medicine. The preparation method for the Chinese medicinal preparation comprises the following steps of: crushing lucid ganoderma, adding water, extracting, and mixing filtrate; heating and concentrating filtrate until the filtrate becomes fluid extract; standing, centrifuging, taking precipitates, drying and then crushing into fine power for later use; breaking dwarf lilyturf root, rhizoma anemarrhenae and lily, mixing and adding water, extracting and mixing filtrate; heating and concentrating the filtrate until the filtrate becomes fluid extract; standing, centrifuging, taking precipitates, drying and crushing into fine power; and mixing fine powder uniformly to obtain the Chinese medicinal preparation. The Chinese medicinal preparation has a good curative effect, is high in cure rate, and does not contain toxic matter, or have a side effect; and through clinical use, the Chinese medicinal preparation has an obvious effect on type 2 diabetes mellitus, and is short in a treatment course and healthy. The Chinese medicinal preparation can be loaded into a capsule No.1 for use and is convenient to carry. The cure rate is 86.7 percent and the effective rate is 100 percent.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof.
Background technology
China the earliest the medical book Plain Questions of Huangdi's Internal Classic and Miraculous Pivot in just put down in writing " diabetes " this name of disease.The piece of writing of quenching one's thirst of Han dynasty well-known doctor's Zhang Zhongjing " Medical Treasures of the Golden Chamber " is also on the books to " more than three " symptom.The first years of a historical period Tang Dynasty, the famous Zhen Liyan of doctor family of China points out that at first diabetes patient's urine is sweet.
Diabetes (Diabetes) are divided type 1 diabetes and type 2 diabetes mellitus.In diabetics, the shared ratio of type 2 diabetes mellitus is about 95%.Wherein the type 1 diabetes pilosity is born in teenager, because of insulin secretion lacks, relies on exogenous insulin and replenishes to earn a bare living.
During type 2 diabetes mellitus is more common in, the old people, its secretion of insulin amount is not low, even also higher, it is responsive inadequately to insulin that clinical manifestation is a body, promptly insulin resistant (Insulin Resistance, IR).Insulin is the interior unique blood sugar lowering hormone of the health of human pancreas β emiocytosis.Insulin resistant is meant that surrounding tissue is to the sensitivity reduction of insulin in the body, and peripheral tissues such as muscle, fat promote absorption, conversion, the utilization of glucose that opposing has taken place to insulin.The clinical observation insulin resistant is prevalent in the type 2 diabetes mellitus, up to about 90%.
Chinese medicine thinks it mainly is owing to the plain body deficiency of YIN, and the five internal organs weakness is multiple because of eating and drinking without temperance, the surfeit delicious food, and disorder of emotion, labor is desired excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; The pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, scorchingly is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and the bright liquid in consumption Tianjin makes blood viscous, the capable not smooth stasis of blood that forms of blood; Deficiency of YIN affecting YANG, the yang deficiency cold coagulation, thus can cause sun in the blood stasis.
At present, a lot of Chinese medicine or Chinese patent medicines about the treatment diabetes are arranged also on the market, but curative effect is still unstable.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of diabetes and preparation method thereof, is principal agent with the Ganoderma, and Radix Ophiopogonis, the Rhizoma Anemarrhenae are ministerial drug, and Radix Ginseng is an adjuvant drug.Its compatibility is simple, evident in efficacy, safe and reliable and have no side effect, and has supplementing QI and nourishing YIN, the effect of clearing away heat and promoting production of body fluid.
The present invention treats the Chinese medicine preparation of diabetes and is made by 3～10 portions of Ganodermas, 1～4 part of Radix Ophiopogonis, 1～4 part of Rhizoma Anemarrhenae and 2～7 portions of Bulbus Liliies by ratio of weight and the number of copies.
The preparation method of treatment diabetes Chinese medicine preparation of the present invention is as follows: step 1: give Ganoderma as one thinks fit fragmentation, add 12 times of water gagings, extract 2 times, and each 3h, gradation filters, and filtrate merges; The filtrate heating is concentrated into flowing soaking paste, and making its relative density is 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 2h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder standby under 70 ℃ of conditions; Step 2: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Bulbus Lilii are given as one thinks fit cataclasm, mix and to add 8 times of water gagings, extracts 2 times, each 1.5h, gradation filters, the filtrate merging; Heating is concentrated into flowing soaking paste, and to make its relative density be 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 24h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder under 70 ℃ of conditions; Step 3: promptly with the fine powder mixing of step 1 and step 2.
The fine powder of mix homogeneously appends sterilization (6KGY radiation sterilization) in the described step 3, the capsule of packing into No. 1; Wherein, every capsules contains polysaccharide and is not less than 0.2g in anhydrous glucose.
Chinese medicine preparation good effect of the present invention, cure rate height, do not contain Toxic matter, have no side effect,, diabetes 2 type diseases are had significant curative effect by clinical use.
The present invention has good hypoglycemic activity, can repair β-islet cells, strengthen insulin secretion, and blood glucose is converted into the effect of glycogen in the promotion liver.
Chinese medicine preparation of the present invention can be packed into and be used in No. 1 capsule, and is easy to carry.Cure rate 86.7% of the present invention; Effective percentage is 100%.
The preparation method of Chinese medicine preparation of the present invention is simple, can guarantee that the medical material active ingredient is not destroyed, the medicine long shelf-life.
Chinese crude drug Ganoderma of the present invention---sweet, flat.GUIXIN, lung, liver, kidney channel.Effect with invigorating QI and tranquilization, relieving cough and asthma.Function cures mainly: asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor.
Radix Ophiopogonis---sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Function cures mainly: dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
The Rhizoma Anemarrhenae---bitter, sweet, cold.Return lung, stomach, kidney channel.Function cures mainly: clearing away heat-fire, promote the production of body fluid and moisturize.
Bulbus Lilii---sweet in the mouth, cold nature.GUIXIN, lung meridian.Function cures mainly: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.Be used for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.
Figure of description
Fig. 1 treats the preparation method flow chart of diabetes Chinese medicine preparation for the present invention.
The specific embodiment:
The specific embodiment one: the Chinese medicine of present embodiment treatment diabetes is made by 3～10 portions of Ganodermas, 1～4 part of Radix Ophiopogonis, 1～4 part of Rhizoma Anemarrhenae and 2～7 portions of Bulbus Liliies by ratio of weight and the number of copies.
The treatment diabetes Chinese medicine preparation of present embodiment is that theoretical basis is organized medicine with supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid.
Chinese medicine preparation of the present invention, for oral administration, every day three times, each 4～6,2 months is 1 course of treatment.
The present invention is forbidden for the anemia of pregnant woman.
The specific embodiment two: the Chinese medicine preparation of present embodiment treatment diabetes is made by 4～9 portions of Ganodermas, 1.5～3 parts of Radix Ophiopogonis, 1.5～3 parts of Rhizoma Anemarrhenaes and 3～6 portions of Bulbus Liliies by ratio of weight and the number of copies.
The specific embodiment three: the Chinese medicine preparation of present embodiment treatment diabetes is made by 8 portions of Ganodermas, 2 parts of Radix Ophiopogonis, 2 parts of Rhizoma Anemarrhenaes and 4 portions of Bulbus Liliies by ratio of weight and the number of copies.
The specific embodiment four: the Chinese medicine preparation of present embodiment treatment diabetes is made by 7 portions of Ganodermas, 2.5 parts of Radix Ophiopogonis, 2.5 parts of Rhizoma Anemarrhenaes and 5 portions of Bulbus Liliies by ratio of weight and the number of copies.
The specific embodiment five: the preparation method of present embodiment treatment diabetes Chinese medicine preparation is as follows:
Step 1: give Ganoderma as one thinks fit fragmentation, add 12 times of water gagings, extract 2 times, each 3h, gradation filters, and filtrate merges; The filtrate heating is concentrated into flowing soaking paste, and making its relative density is 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 2h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder standby under 70 ℃ of conditions; Step 2: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Bulbus Lilii are given as one thinks fit cataclasm, mix and to add 8 times of water gagings, extracts 2 times, each 1.5h, gradation filters, the filtrate merging; Heating is concentrated into flowing soaking paste, and to make its relative density be 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 24h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder under 70 ℃ of conditions; Step 3: promptly with the fine powder mixing of step 1 and step 2.
In the present embodiment, the fine powder of mix homogeneously in the described step 3 can be appended sterilization, after the 6KGY radiation sterilization, the capsule of packing into No. 1; Wherein, every capsules contains polysaccharide and is not less than 0.2g in anhydrous glucose.
In the present embodiment, add fluid extract state before alcohol is handled and should guarantee the denseness that both reached certain, save ethanol again, also will certain fluidity be arranged so that alcohol is deposited to best condition.Through The effects, it is concentrated into every ml fluid extract is equivalent to the 2g raw medicinal herbs, promptly 1: 2 is better, and this moment, its relative density was about 1.15, and heat is surveyed 80 ℃.
The pharmacodynamics summary:
1, the standard of case selection:
Select clinical manifestation to discuss at random and be divided into six kinds of diabeticss totally 30 people, wherein 36 years old of the age minimum, maximum 73 years old, 50 years old mean age.The shortest three months of the course of disease, the longest 10 years.Wherein 28 people have the treatment history.
2, the diagnostic criteria of disease
Main performance polyphagia, polydipsia, polyuria, symptom such as become thin.
3, administrated method:
Chinese medicine preparation of the present invention, for oral administration, every day three times, each 4～6,2 months is 1 course of treatment.
4, medication composition:
8 portions of Ganodermas, 2 parts of Radix Ophiopogonis, 2 parts of Rhizoma Anemarrhenaes and 4 portions of Bulbus Liliies.
5, the criterion of curative effect:
1. cure: transference cure is fully recovered, is not rebounded, and symptom is observed does not continuously have the recidivist half a year;
2. produce effects: symptom obviously disappears;
3. effective: doing well,improving, other objective determinations take an evident turn for the better;
4. invalid: symptom and objective determination do not have improvement, or only have short-term to improve.
6, efficacy result analysis:
Pairs 30 example ages of table 1 treat in the sufferer of the diabetes in 36-73 year, and the survey report that regular hospital provides is accepted and believed in state of an illness diagnosis.
Table 1 (unit: the people)
| Sequence number | Age | Sex | Disease or symptom | Medication (course of treatment) | Therapeutic effect |
| 1 | 45 | The man | Thirsty, polyuria | 1 | Cure |
| 2 | 42 | The woman | Thirsty, polyuria | 1 | Cure |
| 3 | 36 | The man | Thirsty, polyuria | 2 | Cure |
| 4 | 39 | The man | Thirsty, polyuria | 2 | Cure |
| 5 | 38 | The man | Thirsty, polyuria | 1 | Cure |
| 6 | 56 | The woman | Eyestrain, visual deterioration | 1 | Cure |
| 7 | 60 | The man | Eyestrain, visual deterioration | 3 | Effectively |
| 8 | 48 | The man | Eyestrain, visual deterioration | 1 | Cure |
| 9 | 60 | The woman | Eyestrain, visual deterioration | 3 | Effectively |
| 10 | 58 | The woman | Eyestrain, visual deterioration | 2 | Cure |
| 11 | 49 | The man | Hunger and polyphagia | 2 | Cure |
| 12 | 49 | The woman | Hunger and polyphagia | 1 | Cure |
| 13 | 50 | The man | Hunger and polyphagia | 1 | Cure |
| 14 | 56 | The woman | Hunger and polyphagia | 2 | Cure |
| 15 | 44 | The man | Hunger and polyphagia | 1 | Cure |
| 16 | 48 | The man | Hand and foot numbness, shake | 3 | Cure |
| 17 | 44 | The man | Hand and foot numbness, shake | 1 | Cure |
| 18 | 38 | The woman | Hand and foot numbness, shake | 1 | Cure |
| 19 | 58 | The man | Hand and foot numbness, shake | 3 | Cure |
| 20 | 54 | The man | Hand and foot numbness, shake | 1 | Cure |
| 21 | 55 | The man | Hand and foot numbness, shake | 1 | Cure |
| 22 | 51 | The man | Fatigue, hypertension, urine are turned white | 1 | Cure |
| 23 | 49 | The man | Fatigue, hypertension, urine are turned white | 1 | Cure |
| 24 | 53 | The man | Fatigue, hypertension, urine are turned white | 1 | Cure |
| 25 | 53 | The woman | Fatigue, hypertension, urine are turned white | 2 | Cure |
| 26 | 73 | The man | Fatigue, hypertension, urine are turned white | 2 | Effectively |
| 27 | 49 | The man | Fatigue and weakness, bradykinesia | 3 | Cure |
| 28 | 47 | The woman | Fatigue and weakness, bradykinesia | 2 | Cure |
| 29 | 62 | The woman | Fatigue and weakness, bradykinesia | 1 | Effectively |
| 30 | 42 | The man | Fatigue and weakness, bradykinesia | 1 | Cure |
After 1-3 the course of treatment, cure 26 people, account for 86.7%; Effective percentage is 100%.
Through clinical proof, Chinese medicine preparation good effect of the present invention, cure rate height, do not contain Toxic matter, have no side effect, by clinical use, diabetes 2 type diseases there is significant curative effect, short treating period of the present invention, health.Chinese medicine preparation of the present invention can be packed into and be used in No. 1 capsule, and is easy to carry.
In the present embodiment, concrete production technology is as follows:
One, the Ganoderma extraction process is preferred
To extract ganoderan is that target is carried out optimal process, adopts L9 (34) Orthogonal Experiment and Design, and four factors, three levels specifically see Table 2.
Table 2 Ganoderma extraction factor and water-glass
Concrete operations are as follows:
By the Orthogonal Experiment and Design table, each sample is got Ganoderma 50g, adopts the water extraction alcohol sedimentation method to extract ganoderan.In the precipitate with ethanol operation, 95% ethanol limit edged is stirred rapidly until the alcohol precipitation concentration that reaches its requirement, centrifugal after static 24 hours, get precipitation, in 70 ℃ of dryings, dry thing claims in the rearmounted exsiccator standby; Polyoses content adopts spectrophotometry, and concrete operations are seen Appendix.
Orthogonal experiment sees Table 3 by row and experimental result.
Table 3 ganoderan extracts orthogonal experiment design and experimental result
*Content (%) is to the medical material total weight.
By extreme difference R4＞R3＞R1＞R2 as can be known, the factor that has the greatest impact is an extraction time, secondly is ethanol; In the alcohol table data as can be seen, the optimised process A3B1C3D2 that ganoderan extracts, promptly amount of water is that 12 times, extraction time 2 times, each 2 hours, alcohol precipitation concentration measure 85% for containing alcohol.Because it is target that this technology is investigated with the polyoses content, thus not with the solid content amount in advance with integrated survey.
Two, the extraction process optimization of Radix Ophiopogonis, the Rhizoma Anemarrhenae, Radix Ginseng complex polysaccharide
To extract three's total polysaccharides is that target is carried out optimal process, adopts L9 (34) Orthogonal Experiment and Design, and four factors, three levels specifically see Table 4.
Table 4 mixing polysaccharide extraction factor and water-glass
Concrete operations are as follows:
By the Orthogonal Experiment and Design table, each sample is got 25g Radix Ophiopogonis, Rhizoma Anemarrhenae 25g, Radix Ginseng 50g,, adopt the water extraction alcohol sedimentation method to extract mixing polysaccharide.In the precipitate with ethanol operation, the limit adds 95% ethanol limit stirs rapidly until the alcohol precipitation concentration that reaches its requirement, centrifugal after static 24 hours, gets precipitation, in 70 ℃ of dryings, standby in the rearmounted exsiccator of weighing dry substances; Determination of polysaccharide adopts spectrophotometry, and concrete operations are seen Appendix.
Orthogonal experiment arrangement and experimental result see Table 5.
Table 5 mixing polysaccharide extracts orthogonal experiment design and experimental result
*Content (%) is to the medical material total weight.
By range analysis, R3＞R1＞R2＞R4, what have the greatest impact is extraction time, secondly is concentration of alcohol; In the table data as can be seen, the optimised process that mixing polysaccharide extracts is A3B1C3D3, promptly adds 8 times of amounts of water, extracts 3 times, each 1.5 hours, alcohol precipitation concentration is 85%.The extreme difference (R4) of considering extraction time only is 1.66, and K3 and K2 differ and have only 0.18, so for reducing cost, reduce operation, changes extraction time into secondary by 3 times.Consideration about the solid content amount is ditto analyzed.
Three, the research of moulding process
(1) retrial of selection process and recipe quantity determines
By Orthogonal Experiment and Design preferred preparation process condition, carry out the retrial of technology by above-mentioned optimal conditions.Test recipe: Ganoderma 4000g, Radix Ophiopogonis 1000g, Rhizoma Anemarrhenae 1000g, Radix Ginseng 2000g.
Production technology: above 4 flavors, Ganoderma is given fragmentation as one thinks fit, adds 12 times of water gagings, extract secondary, each 3 hours, gradation filtered, filtrate merges, and heating is concentrated into flowing soaking paste (about relative density 1.15,80 ℃), be chilled to room temperature and add 95% ethanol, the limit edged stirs, and reaches 85% to determining alcohol, left standstill 24 hours, centrifugal, get 70 ℃ of dryings of precipitation, it is standby to be ground into fine powder; All the other Radix Ophiopogonis, the Rhizoma Anemarrhenae, Radix Ginseng give as one thinks fit cataclasm mixing to add 8 times of water gagings, extract secondary, each 1.5 hours, gradation filters, and filtrate merges, and heating is concentrated into flowing soaking paste (about relative density 1.15,80 ℃), be chilled to room temperature and add 95% ethanol, the limit edged stirs, reach 85% to determining alcohol, leave standstill 24 hours, centrifugal, get precipitation, 70 ℃ of dryings also are ground into fine powder, with Ganoderma fine powder mixing, adorn capsule No. 1, promptly.
Four Chinese medicine altogether fine powder 1083g, every capsules loading amount 0.4g, obtain 2670 altogether surplus capsules, by the conversion of 1000 capsules, preparation prescription should be: Ganoderma 1500g, Radix Ophiopogonis 375g, Rhizoma Anemarrhenae 375g, Radix Ginseng 750g.
(2) mensuration of test parameters
Through test, various technical parameters are determined as follows:
The fluid extract enrichment stage adds denseness that the fluid extract state before alcohol is handled should guarantee both to have reached certain to save ethanol, also will certain fluidity be arranged so that precipitate with ethanol reaches best condition, is the precipitation part because we need.Through The effects it is concentrated into every ml fluid extract and is equivalent to 2g raw medicinal herbs (promptly 1: 2) better, this moment, its relative density was about 1.15,80 ℃ of heat surveys, so then can relative density be measured in the production technology.
Other corresponding techniques parameter
Ganoderma: obtain the about 76g of dry thing, productive rate about 2.4%.
Radix Ophiopogonis, the Rhizoma Anemarrhenae, Radix Ginseng mixed extraction: obtain dry thing 1027g, productive rate about 25.68%.
Mixing fine powders altogether 1.83g, flour extraction is 96.35%.
Four, pilot plant test
Obtaining preparation prescription is enlarged 10 times, feed intake by 10000 capsules and carry out three batches of pilot plant tests.Production technology is undertaken by above-mentioned selection process, and various technical parameters see Table 6.
Table 6 pilot plant test tables of data
Show that by above data pilot plant test all can repeat the preferred production technology of institute, output does not have discrepancy substantially, so technology is feasible.Its character, discriminating, assay and health examination all meet quality standard draft and the " requirement of Chinese pharmacopoeia (version was an one in 2005).Testing result sees survey report for details.
Five, sterilization measure
Hygienic control is except that strict technical process, and the clean rank (guaranteeing 300,000 grades of levels) of strict control workshop condition is appended sterilization with the 6KGY radiation dose at last.
Six, assay
(1) preparation of standard curve
1. the preparation of reference substance solution: the glucose reference substance is dried to constant weight in 105 ℃, and precision takes by weighing 0.023g, with water dissolution and be settled in the 100ml measuring bottle, shakes up, as reference substance solution.
2. measure the selection of wavelength: the accurate reference substance solution 0.3ml that draws, put in the tool plug test tube, and be diluted with water to 1ml, add chromogenic reagent solution 5ml, heating is 10 minutes in boiling water bath, takes out and cools off rapidly with ice-water bath.Setting wave-length coverage 600-700nm sweep measuring, the result has absorption maximum at the 626nm place, sees accompanying drawing.
3. the preparation of standard curve: accurate respectively absorption reference substance solution 0.1ml, 0.2ml, 0.3ml, 0.4ml, 0.5ml put in 5 tool plug test tubes, and add water to 1ml respectively and respectively add chromogenic reagent solution 5.0ml, heating is 10 minutes in 100 ℃ of water-baths, take out cooling rapidly in ice-water bath, measure trap in the 626nm place after being chilled to room temperature, data see Table 7.
Table 7 glucose standard curve tables of data
Data are carried out linear regression, obtain the standard curve equation and be
A＝5.53913·C+0.00120
R=0.99975 wherein, dependency is fabulous.
The result shows that glucose is good linear relationship between 0.023～0.115mg.
Certainly, above-mentioned explanation is not to be limitation of the present invention, and the present invention also is not limited in above-mentioned giving an example, and variation, remodeling, interpolation or replacement that those skilled in the art are made in essential scope of the present invention also should belong to protection scope of the present invention.
Claims (7)
1. a Chinese medicine preparation for the treatment of diabetes is characterized in that being made by 3～10 portions of Ganodermas, 1～4 part of Radix Ophiopogonis, 1～4 part of Rhizoma Anemarrhenae and 2～7 portions of Bulbus Liliies by ratio of weight and the number of copies.
2. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1 is characterized in that being made by 4～9 portions of Ganodermas, 1.5～3 parts of Radix Ophiopogonis, 1.5～3 parts of Rhizoma Anemarrhenaes and 3～6 portions of Bulbus Liliies by ratio of weight and the number of copies.
3. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1 is characterized in that being made by 8 portions of Ganodermas, 2 parts of Radix Ophiopogonis, 2 parts of Rhizoma Anemarrhenaes and 4 portions of Bulbus Liliies by ratio of weight and the number of copies.
4. a kind of Chinese medicine preparation for the treatment of diabetes according to claim 1 is characterized in that being made by 7 portions of Ganodermas, 2.5 parts of Radix Ophiopogonis, 2.5 parts of Rhizoma Anemarrhenaes and 5 portions of Bulbus Liliies by ratio of weight and the number of copies.
5. the method for preparing the described diabetes Chinese medicine preparation of claim 1, the preparation method step that it is characterized in that treating the diabetes Chinese medicine preparation is as follows: step 1: give Ganoderma as one thinks fit fragmentation, add 12 times of water gagings, extract 2 times, each 3h, gradation filters, and filtrate merges; The filtrate heating is concentrated into flowing soaking paste, and making its relative density is 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 2h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder standby under 70 ℃ of conditions; Step 2: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Bulbus Lilii are given as one thinks fit cataclasm, mix and to add 8 times of water gagings, extracts 2 times, each 1.5h, gradation filters, the filtrate merging; Heating is concentrated into flowing soaking paste, and to make its relative density be 1.14～1.16, and it is 80 ℃ that heat is surveyed; Be chilled to and add 95% ethanol after the room temperature, the limit edged stirs, and measures 85% to alcohol precipitation concentration for containing alcohol, leaves standstill 24h, and is centrifugal, gets precipitation, and crushed after being dried becomes fine powder under 70 ℃ of conditions; Step 3: promptly with the fine powder mixing of step 1 and step 2.
6. the method for diabetes Chinese medicine preparation according to claim 5 is characterized in that the fine powder of mix homogeneously in the step 3 is appended sterilization, the capsule of packing into No. 1.
7. the method for diabetes Chinese medicine preparation according to claim 6 is characterized in that every capsules contains polysaccharide and is not less than 0.2g.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106579455A (en) * | 2016-12-23 | 2017-04-26 | 盐城工学院 | Ganoderma lucidum tablets and method for preparing ganoderma lucidum tablets |
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2011
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Non-Patent Citations (1)
| Title |
|---|
| 许蕾: "复方灵芝降糖胶囊工艺及药效学研究", 《黑龙江中医药大学硕士学文论文》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106579455A (en) * | 2016-12-23 | 2017-04-26 | 盐城工学院 | Ganoderma lucidum tablets and method for preparing ganoderma lucidum tablets |
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Application publication date: 20111221 |