CN103142843B - Medicinal composition for nursing or preventing and treating tristimania - Google Patents
Medicinal composition for nursing or preventing and treating tristimania Download PDFInfo
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Abstract
The invention discloses a medicinal composition for nursing or preventing and treating tristimania, which relates to the field of a traditional Chinese medicine technology. The medicinal composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 18-25 parts of radix bupleuri, 25-35 parts of fructus aurantii immaturus, 25-35 parts of semen ziziphi spinosae, 25-35 parts of folium mori, 15-22 parts of radix ophiopogonis, 15-22 parts of fructus gardeniae and 6-12 parts of polygala tenuifolia. The medicinal composition provided by the invention is capable of soothing liver-qi stagnation and dredging effects of the heart and the kidney by bringing a multi-target effect into play, and the clinical application effect is obvious.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of pharmaceutical composition of preventing and treating depression.
Background technology
Depression belongs to affective disorders, is a kind of take the low psychiatric syndrome as principal character of mood.Clinical manifestation is that depressed, depressed, bradyphrenia, bulesis go down, indifferent pessimism, sleep disorder, self evaluation reduce, often there are sense of uselessness, hopeless sense, helplessness, valueless sense, thought or behavior passiveness, also the emotion symptom having is also not obvious, show as the discomfort of various healths, as symptom of digestive tract, uncomfortable in chest, headache etc.Patient usually tangles in a certain health main suit and produces hypochondriacal idea, but checks the large problem, the not obvious hypochondriasis etc. that increased the weight of again of corresponding treatment do not found.
Depression can betide all age group, has become so far global main spirits hygienic issues.According to WHO statistics, the prevalence of depression of all categories has accounted for 3%～5% of population in the world, to the year two thousand twenty, depression may become and is only second to cardiopathic second largest disease, within 2002, its disability rate is 12%, is one of disease the most easily disabling in the world, and its medical treatment cost accounts for 4.5% of global health economy.Bearing the even very big misery of body of spirit in the patient of depressive state, severe patient can have suicidal tendency, has a strong impact on its quality of worklife, very large to family and even social danger.
The pathogenesis of depression is not yet completely clear and definite at present, also without significantly sign and lab testing are abnormal.Saying of summarizing is hereditary, biology, psychology, the result of society's (culture) factor interaction.1. inherited genetic factors: the investigation of large sample crowd genetic epidemiology shows with the nearer P of patient's blood relationship higher.2. biochemical factors: catecholamine theory thinks that the generation of depression may be relevant with the lowering of concentration of the monoamine neurotransmitter receptors such as brain synaptic space neurotransmitter serotonin (5-HT) and norepinephrine (NE); The antidepressant drug of developing at present mainly with monoamine neurotransmitter as action target spot, as stung in fluorine west." the cytokine hypothesis " of depression emphasizes that depression is a kind of psychological nerve immunity irregularity obstacle in addition; In recent years, neural plasticity (Neuroplasticity), neural occur (Neurogeuesis) of Hippocampus, endocrine and immune system are subject to larger attention in the morbidity of depression; 3. a psychological social factor: various momentous life events occur suddenly, or sustainable existence can cause strong or lasting depression experience for a long time, causes the generation of depression.
Chinese medicine is for the understanding of depression, sporadically appears in categories such as " strongly fragrant disease, hysteria, Bulbus Lilii syndromes, be insomnia ", originates from Qin Han, developed in the Tang and Song Dynasty, ripe in gold dollar, prosperous in bright clear, improved the present age, and ancient Chinese medicine doctor is discussed a lot of to depression etiology and pathogenesis and treatment.Depression mechanism is complicated, relate to multiple systems and link, and the antidepressant multi-target effect of Chinese medicine compound illustrates that Chinese medicine compound has very large advantage and good prospect in treating depression.
Summary of the invention
The object of the invention is to by prescription again after conventional medicament pharmacology is studied, the pharmaceutical composition of a kind of good effect, instant effect, depression that cost is few is provided.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition of preventing and treating depression of the present invention, is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Bupleuri 18-25 part, Fructus Aurantii Immaturus 25-35 part, Semen Ziziphi Spinosae 25-35 part, Folium Mori 25-35 part, Radix Ophiopogonis 15-22 part, Fructus Gardeniae 15-22 part, Radix Polygalae 6-12 part.
The pharmaceutical composition of above-mentioned control depression, is preferably prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 22 parts of Radix Bupleuri, 30 parts of Fructus Aurantii Immaturuss, 30 parts of Semen Ziziphi Spinosaes, 30 parts, Folium Mori, 18 parts of Radix Ophiopogonis, 18 parts of Fructus Gardeniaes, 9 parts of Radix Polygalaes.
Preferably, the pharmaceutical composition of above-mentioned control depression is oral formulations.
Again further preferably, the pharmaceutical composition of above-mentioned control depression is granule.
According to Chinese medicine Historical Data Data About, the pharmacologically active of said medicine material is as follows:
Radix Bupleuri: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cure mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Select the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..
Fructus Aurantii Immaturus: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.Select rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof or Fructus Citri sinensis Citrus sinensis (L.) Osbeck dry young fruit.
Semen Ziziphi Spinosae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Select the dry mature seed of Rhamnaceae plant Ziziphi Spinosae Z iziphus psinosa Hu.
Folium Mori: there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, effect of cooling blood for hemostasis.Originally select the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L..
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Be selected from Liliaceae Ophiopogon plant Ophiopogon Radix Ophiopogonis Japonicus(Thunb.) dried root of Ker-Gawl..
Fructus Gardeniae: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Fructus Gardeniae Preparatus: cooling blood for hemostasis.Be used for the treatment of calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.Select the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.
Radix Polygalae: the function of there is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Select the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. and ovum leaf Radix Polygalae P.sibirica L..
The preparation method that above-mentioned each Chinese crude drug is prepared into compound granular agent of the present invention, comprises the steps:
The first step, prepare clear paste powder:
1) get the raw materials ready: take Radix Bupleuri 18-25 part of cleaning up, Fructus Aurantii Immaturus 25-35 part, Semen Ziziphi Spinosae 25-35 part, Folium Mori 25-35 part, Radix Ophiopogonis 15-22 part, Fructus Gardeniae 15-22 part and Radix Polygalae 6-12 part by recipe quantity, for subsequent use;
2) decoct: decoct with water, first decoct every tank add water into the 6-10 of medical material total amount doubly, after ebuillition of heated, keep 2-4 hour, extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds medical material amount 3-5 times, protects the 2-4 hour that boils, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: extracting solution precipitation 24～36 hours in settling tank, extract supernatant and be filtered in triple effect evaporator through 200 order filters, precipitate is by offal treatment;
4) concentrated: to be 1.00～1.10(40 ℃ of mensuration when supernatant is concentrated into relative density in triple effect evaporator) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in cream bucket, for subsequent use;
5) dry: wherein vacuum :-0.1MPa, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves, obtain clear paste powder;
Second step, according to clear paste powder: dextrin: the weight ratio that 55% ethanol is 1:1～3:0.1～0.3 takes clear paste powder, dextrin and 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, drops into clear paste powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol, to making soft material, granulates with 12 order stainless steel sifts, and 65～75 ℃ are dried 2 hours, take out, and cool and obtain described granule.
Chinese medicine composition of the present invention is by performance multi-target effect, and dispersing the stagnated live-QI to relieve the stagnation of QI, adjusts the grand work of merit that leads to heart kidney, and clinical application effect is obvious.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: 220 grams of Radix Bupleuri, 300 grams of Fructus Aurantii Immaturuss, 300 grams of Semen Ziziphi Spinosaes, 300 grams, Folium Mori, 180 grams of Radix Ophiopogonis, 180 grams of Fructus Gardeniaes, 90 grams of Radix Polygalaes.
Preparation technology:
The first step, prepare clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, keeps 3 hours after ebuillition of heated, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 5 times of medical material amounts, protects and boils 3 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: extracting solution precipitation 24 hours in settling tank, extract supernatant and be filtered in triple effect evaporator through 200 order filters, precipitate is by offal treatment;
4) concentrated: to be 1.10(40 ℃ of mensuration when supernatant is concentrated into relative density in triple effect evaporator) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in cream bucket, for subsequent use;
5) dry: wherein vacuum :-0.1MPa, temperature: 78～82 ℃, 20 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves, obtain clear paste powder;
Second step, according to clear paste powder: dextrin: the weight ratio that 55% ethanol is 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, drops into clear paste powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol, to making soft material, granulates with 12 order stainless steel sifts, and 70 ℃ are dried 2 hours, take out, and cool and obtain described granule, by every bag of 10g packing.
Embodiment 2
Crude drug prescription: 250 grams of Radix Bupleuri, 250 grams of Fructus Aurantii Immaturuss, 300 grams of Semen Ziziphi Spinosaes, 350 grams, Folium Mori, 220 grams of Radix Ophiopogonis, 150 grams of Fructus Gardeniaes, 120 grams of Radix Polygalaes.
Preparation technology:
The first step, prepare clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, keeps 5 hours after ebuillition of heated, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 5 times of medical material amounts, protects and boils 5 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: extracting solution precipitation 36 hours in settling tank, extract supernatant and be filtered in triple effect evaporator through 200 order filters, precipitate is by offal treatment;
4) concentrated: to be 1.10(40 ℃ of mensuration when supernatant is concentrated into relative density in triple effect evaporator) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in cream bucket, for subsequent use;
5) dry: wherein vacuum :-0.1MPa, temperature: 78～82 ℃, 24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves, obtain clear paste powder;
Second step, according to clear paste powder: dextrin: the weight ratio that 55% ethanol is 1:2.5 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, drops into clear paste powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol, to making soft material, granulates with 12 order stainless steel sifts, and 75 ℃ are dried 2 hours, take out, and cool and obtain described granule, by every bag of 10g packing.
Embodiment 3
Crude drug prescription: 180 grams of Radix Bupleuri, 350 grams of Fructus Aurantii Immaturuss, 350 grams of Semen Ziziphi Spinosaes, 250 grams, Folium Mori, 150 grams of Radix Ophiopogonis, 220 grams of Fructus Gardeniaes, 60 grams of Radix Polygalaes.
Preparation technology:
The first step, prepare clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, for subsequent use;
2) decoct: decoct with water, first decocts 6 times that every tank adds water as medical material total amount, keeps 4 hours after ebuillition of heated, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 6 times of medical material amounts, protects and boils 4 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: extracting solution precipitation 30 hours in settling tank, extract supernatant and be filtered in triple effect evaporator through 200 order filters, precipitate is by offal treatment;
4) concentrated: to be 1.05(40 ℃ of mensuration when supernatant is concentrated into relative density in triple effect evaporator) time, rare clear paste is filtered in suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in cream bucket, for subsequent use;
5) dry: wherein vacuum :-0.1MPa, temperature: 78～82 ℃, 24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves, obtain clear paste powder;
Second step, according to clear paste powder: the weight ratio that dextrin is 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, drops into clear paste powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol, to making soft material, granulates with 12 order stainless steel sifts, and 75 ℃ are dried 2 hours, take out, and cool and obtain described granule, by every bag of 10g packing.
The experimental study of embodiment 4 Chinese medicine granules Cure of depressions
48 routine patients with depression, all meet Chinese Spirit classification of diseases side will with diagnostic criteria (CCMD-III) in criteria for depression were.Patient age, between 21-57 year, is got rid of and is had serious body illness, brain organic disease, alcohol dependence and allergic constitution patient, all patients to be divided at random test group (25 example) and matched group (23 example).Epidemiological Analysis by statistics, sex between two groups, age there was no significant difference (
p> is O.05), there is comparability.
Two groups of patients are at disposable oral 20mg fluoxetine hydrochloride capsules every morning, continuous use 5 weeks.Test group patient is at take traditional Chinese medicine 1 bag of granule (being prepared from according to the prescription of embodiment 1 and technique) of the basic upper punch of taking fluoxetine hydrochloride capsules, continuous use 5 weeks.Simultaneously, two groups of patients all adopt the methods such as psychological education treatment, cognitive behavioral therapy, family therapy, help patient to understand paathogenic factor, pathogenic process, change bad thinking and conviction, respect, understand, sympathize with patient and give supportive psychotherapy, build harmonious family atmosphere, advice, encouragement patient actively participate in suitable motion with partner treatment.
According to HAMD scale, respectively because of subclassification (emotion, sleep, anxiety, cognitive disorder), relatively each group treatment 5 weeks situation of HAMD overall score and Ge Yin subclassification afterwards, the results are shown in Table 1 respectively.
Can find out from the result of the test of table 1, two groups treatment before and after all have significant difference (
p< 0.05), after application Chinese medicine, test group the symptoms such as emotion, sleep, anxiety and overall score and matched group relatively have utmost point significant difference (
p< 0.01).
Before and after table 1 liang group treatment, (dividing) compared in the scoring of HAMD scale
Claims (4)
1. prevent and treat a pharmaceutical composition for depression, it is characterized in that being prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Bupleuri 18-25 part, Fructus Aurantii Immaturus 25-35 part, Semen Ziziphi Spinosae 25-35 part, Folium Mori 25-35 part, Radix Ophiopogonis 15-22 part, Fructus Gardeniae 15-22 part, Radix Polygalae 6-12 part.
2. the pharmaceutical composition of control depression according to claim 1, is characterized in that being prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 22 parts of Radix Bupleuri, 30 parts of Fructus Aurantii Immaturuss, 30 parts of Semen Ziziphi Spinosaes, 30 parts, Folium Mori, 18 parts of Radix Ophiopogonis, 18 parts of Fructus Gardeniaes, 9 parts of Radix Polygalaes.
3. the pharmaceutical composition of control depression according to claim 1 and 2, is characterized in that: described pharmaceutical composition is oral formulations.
4. the pharmaceutical composition of control depression according to claim 1 and 2, is characterized in that: described pharmaceutical composition is granule.
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| CN201310117254.7A CN103142843B (en) | 2013-04-07 | 2013-04-07 | Medicinal composition for nursing or preventing and treating tristimania |
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| CN201310117254.7A CN103142843B (en) | 2013-04-07 | 2013-04-07 | Medicinal composition for nursing or preventing and treating tristimania |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101168024A (en) * | 2007-10-25 | 2008-04-30 | 陈卫辉 | Proprietary Chinese medicine for treating depression and production method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101168024A (en) * | 2007-10-25 | 2008-04-30 | 陈卫辉 | Proprietary Chinese medicine for treating depression and production method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗抑郁症的研究进展;沈莉等;《辽宁中医药大学学报》;20070905;第9卷(第05期);43-45 * |
| 沈莉等.中医药治疗抑郁症的研究进展.《辽宁中医药大学学报》.2007,第9卷(第05期),43-45. |
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