CN102283991A

CN102283991A - Medicament for treating acute urinary system infection and preparation method thereof

Info

Publication number: CN102283991A
Application number: CN2011102114253A
Authority: CN
Inventors: 张秀兰
Original assignee: Individual
Current assignee: Lan Hengzhi
Priority date: 2011-07-27
Filing date: 2011-07-27
Publication date: 2011-12-21
Anticipated expiration: 2031-07-27
Also published as: CN102283991B

Abstract

The invention discloses a medicament for treating acute urinary system infection and a preparation method thereof. The medicament is prepared from indigowoad leaf, Mongolian dandelion herb, weeping forsythia, yerbadetajo herba ecliptae, dipsacus asper, chaff flower root, phellodendron and Japanese climbing fern spore in a certain weight mixing ratio. The medicament has the effect of clearing heat, promoting diuresis and combining recuperation and treatment, is used for treating acute and chronic urinary system infection, and is quick in a curative effect and high in cure rate.

Description

A kind of medicine for the treatment of acute urinary system infection and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of acute urinary system infection and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Acute urinary system infection is urethra and bladder infection, urinary tract infection regular meeting up initiation bladder inflammation.By antibacterial (only a few can by fungus, protozoon, virus) directly invasion and attack institute caused.Common paruria is frequent micturition, urgent micturition, dysurea, also can see urinary incontinence and urine retention.Sometimes also with symptoms such as the soreness of waist, lumbago, heatings.Primary disease is sent out in the women well, especially the marriage and childbirth period women.After the people entered the geratic period, the chance of suffering from urinary tract infection all can increase.According to statistics, 70 years old can be up to 50% with the upper urinary tract infection sickness rate up to the old man more than 33.3%, 80 years old.In a single day the old people suffers from urinary tract infection, and often touching not going is difficult for curing, and severe patient also can cause serious consequences such as renal failure, uremia.And at present, it is main treatment that the doctor trained in Western medicine medication mostly is the antibiotic Western medicine, and effect is fast but toxic and side effects is big, takes easy generation drug resistance for a long time, adds to the difficulties for treatment from now on.As curing, easy infection recurs or protracted course of disease, and then transfers to chronic.

Summary of the invention

Therefore there is great demand in people to the Chinese medicine of special effect.The inventor has found the medicine of the acute urinary system infection of quick curing finally, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provide a kind of can treat acute urinary system infection composition of medicine.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicament selection Folium Isatidis of the present invention, Herba Taraxaci, Fructus Forsythiae, Herba Ecliptae, Radix Dipsaci, Radix Achyranthis Bidentatae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae and Spora Lygodii make up, make each efficacy of drugs produce synergism these drug regimens, thereby the enough effects of energy are treated the infection of acute urinary system.Wherein select for use Folium Isatidis to be because its nature and flavor hardship is cold, go into liver, the heart, stomach warp, heat clearing away is arranged, detoxifcation, removing heat from blood, the hemostatic function is controlled epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select for use Herba Taraxaci to be because its property bitter but sweet flavor is cold, go into liver, stomach warp, heat-clearing and toxic substances removing is arranged, the function of diuresis eliminating stagnation is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Selecting Fructus Forsythiae for use is because its nature and flavor hardship, and the heart, liver, gallbladder meridian are gone in cold, and heat clearing away is arranged, detoxifcation, eliminating stagnation, detumescence, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Selecting Herba Ecliptae for use is that liver, kidney channel are gone in cold, and removing heat from blood is arranged because of its nature and flavor picric acid, hemostasis, and the kidney invigorating, the function of tonifying YIN is controlled haematemesis, hemoptysis, epistaxis, hematuria is had blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Selecting Radix Dipsaci for use is that tepor is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of its nature and flavor toil, reuniting the fractured tendons and bones, and the function of blood circulation regulating is controlled aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, the carbuncle skin ulcer is swollen.Select for use Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, go into liver, kidney channel, give birth to and use dissipating blood stasis blood, subduing inflammation is controlled gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury is ripely used invigorating the liver and kidney, and bone and muscle strengthening is controlled waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Select for use Cortex Phellodendri to be because its nature and flavor hardship is cold, go into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select for use the Rhizoma Anemarrhenae to be because its nature and flavor hardship is cold, go into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select for use Talcum to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, inducing diuresis for treating stranguria syndrome is arranged, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat is controlled pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select for use Fructus Gardeniae to be because its nature and flavor hardship is trembled with fear, GUIXIN, lung, tri-jiao channel have the pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, and the function of removing pathogenic heat from blood and toxic substance from the body, it is existing vexed to control heat, the jaundice dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription is processed with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Give birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select for use Spora Lygodii to be because its property slightly sweet flavor is cold, go into small intestinal, urinary bladder channel, heat-clearing and toxic substances removing is arranged, the function of relieving stranguria by diuresis is controlled urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.

The specific embodiment

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range:

Folium Isatidis 25-32 gram Herba Taraxaci 12-16 gram Fructus Forsythiaes 8-12 grams

Herba Ecliptae 12-18 gram Radix Dipsacis 10-15 gram Radix Achyranthis Bidentataes 10-15 grams

Cortex Phellodendri 8-12 gram Rhizoma Anemarrhenaes 8-12 gram Talcums 8-15 grams

Fructus Gardeniae 3-5 gram Radix Glycyrrhizaes 2-4 gram Spora Lygodii 2-5 grams

Be preferably:

Folium Isatidis 30 gram Herba Taraxacis 15 gram Fructus Forsythiaes 10 grams

Herba Ecliptae 15 gram Radix Dipsacis 12 gram Radix Achyranthis Bidentataes 12 grams

The Cortex Phellodendri 10 gram Rhizoma Anemarrhenaes 10 gram Talcums 10 grams

Fructus Gardeniae 4.5 gram Radix Glycyrrhizaes 3 gram Spora Lygodii 3 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Folium Isatidis: choose decontamination and dead leaf, clean, moisten slightly, cutting is dried;

2, Herba Taraxaci: choose decontamination, clean earth, cutting is dried;

3, Fructus Forsythiae: choose clean impurity, stranding is opened, and removes discarding stalk;

4, Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;

5, Radix Dipsaci: clean silt, remove the retained root head, run through the back section and dry, sieve anti-dandruff;

6, Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

7, Cortex Phellodendri: get crude drug, remove impurity, clean cutting, drying;

8, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;

9, Talcum: get crude drug, remove impurity, cleaning, drying;

10, Fructus Gardeniae: get crude drug, remove impurity, the time spent smashs to pieces;

11, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through section, dry;

12, Spora Lygodii: get crude drug, remove impurity, cleaning, drying.

Two, preparation

1, Folium Isatidis, Herba Taraxaci, Fructus Forsythiae, Herba Ecliptae, Radix Dipsaci, Radix Achyranthis Bidentatae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae, the Spora Lygodii with described weight decocts with water, add for the first time 3 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 25 minutes in the reuse slow fire boiling.

2, will filter for the first time the back medicinal residues and add 2 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient.

Medicine of the present invention has the effect of clearing away heat-damp and promoting diuresis, has the cure combination, is fit to the advantage of taking for a long time.Below further set forth the beneficial effect of medicine of the present invention by testing example, these tests comprise that the animal toxicity test of medicine of the present invention and clinical observation test.

The animal toxicity test report of [test example 1] medicine of the present invention:

Treating excess syndrome is tested with 50 of rabbits, the male and female dual-purpose, and body weight 2.0-2.5kg divides two groups, and 25 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is

40ml/kg, normal amount is 20ml/kg, and administering mode is the administration by gavage administration, and every day, secondary serve on 7 days, observed administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, medicine does not have bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention:

1, physical data:

Accept out-patient's 298 examples for medical treatment, 35-40 years old 100 age example, 41-50 years old 98 example, 50-70 examples, 100 examples.

2, diagnostic criteria:

Light-duty urinary tract infection: fell ill for 1 week, symptoms such as frequent micturition, urgent micturition, dysurea, the discomfort of urinating appear in the patient.

Heavy urinary tract infection: medical history is more than 1 week, and the patient more has lumbago except that with the above-mentioned symptom, and the whole body poisoning symptom is as heating, shiver with cold, headache etc.The routine blood test leukocyte slightly raises, the urine positive bacterial culture.

3, Therapeutic Method:

Select above-mentioned medicament for use, take, take 400ml at every turn to the patient, every day early, respectively obey 1 time evening, 30 days is a course of treatment, takes two courses of treatment continuously.

4, efficacy assessment standard:

Produce effects: light, heavy urinary system infection after treatment, patient's transference cure, it is normal that patient's body constitution is recovered.Follow up a case by regular visits to unmanned recurrence in 1-3 years.

Take a turn for the better: patient's symptom progressively alleviates, and feels good, and it is normal that body constitution is recovered substantially.

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In the treatment of a course of treatment, with light-duty urinary system infection patient 198 examples of Drug therapy of the present invention, produce effects 190 examples, 8 examples that take a turn for the better, total effective rate 100%; In the treatment of two courses of treatment, with the heavy urinary tract infection patient of Drug therapy of the present invention 100 examples, produce effects 96 examples, 2 examples that take a turn for the better, total effective rate 98%.

Claims

One kind the treatment acute urinary system infection medicine, it is characterized in that: it is to be made by the crude drug in the following weight range:

Folium Isatidis 25-32 gram Herba Taraxaci 12-16 gram Fructus Forsythiaes 8-12 grams

Herba Ecliptae 12-18 gram Radix Dipsacis 10-15 gram Radix Achyranthis Bidentataes 10-15 grams

Cortex Phellodendri 8-12 gram Rhizoma Anemarrhenaes 8-12 gram Talcums 8-15 grams

Fructus Gardeniae 3-5 gram Radix Glycyrrhizaes 2-4 gram Spora Lygodii 2-5 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:

Folium Isatidis 30 gram Herba Taraxacis 15 gram Fructus Forsythiaes 10 grams

Herba Ecliptae 15 gram Radix Dipsacis 12 gram Radix Achyranthis Bidentataes 12 grams

The Cortex Phellodendri 10 gram Rhizoma Anemarrhenaes 10 gram Talcums 10 grams

Fructus Gardeniae 4.5 gram Radix Glycyrrhizaes 3 gram Spora Lygodii 3 grams.
3. the preparation method of medicine as claimed in claim 1 or 2, it comprises the following steps:

(1) gets the raw materials ready

(1) Folium Isatidis: choose decontamination and dead leaf, clean, moisten slightly, cutting is dried;

(2) Herba Taraxaci: choose decontamination, clean earth, cutting is dried;

(3) Fructus Forsythiae: choose clean impurity, stranding is opened, and removes discarding stalk;

(4) Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;

(5) Radix Dipsaci: clean silt, remove the retained root head, run through the back section and dry, sieve anti-dandruff;

(6) Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

(7) Cortex Phellodendri: get crude drug, remove impurity, clean cutting, drying;

(8) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;

(9) Talcum: get crude drug, remove impurity, cleaning, drying;

(10) Fructus Gardeniae: get crude drug, remove impurity, the time spent smashs to pieces;

(11) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through section, dry;

(12) Spora Lygodii: get crude drug, remove impurity, cleaning, drying;

Two, preparation

(1) Folium Isatidis, Herba Taraxaci, Fructus Forsythiae, Herba Ecliptae, Radix Dipsaci, Radix Achyranthis Bidentatae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Talcum, Fructus Gardeniae, Radix Glycyrrhizae, the Spora Lygodii with described weight decocts with water, add for the first time 3 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 25 minutes in the reuse slow fire boiling;

(2) will filter for the first time the back medicinal residues and add 2 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient.