CN102274273A - Topical Chinese patent medicine for treating nasal polyps and preparation method and application thereof - Google Patents
Topical Chinese patent medicine for treating nasal polyps and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a topical Chinese patent medicine for treating nasal polyps and a preparation method and an application thereof, belonging to the technical field of treatment of ear-nose-throat diseases. The topical Chinese patent medicine is characterized in that the medicine comprises the following medicinal materials: leech, white alum, Chinese honeylocust fruits, sal-ammoniac, dahurian angelica roots, mirabilite, Java brucea fruits and depositum urinae praeparatum. The topical Chinese patent medicine is prepared by the following steps: selecting and weighing the medicinal materials, vacuum-drying at room temperature, pulverizing, sieving with a 60-mesh sieve, pulverizing at low temperature, sieving with a 320-mesh sieve, collecting sieved matters, and packaging. Compared with the prior art, the topical Chinese patent medicine disclosed by the invention can eliminate diseases of patients and promote physical and mental health, has the advantages of convenience for administration of patients, quick action and no adverse effect, and has prominent substantive features and notable progress.
Description
Technical field
The present invention relates to otorhinolaryngology disease treatment technology field, relate in particular to a kind of technical field that is used for the treatment of polypous external Chinese patent medicine, preparation method and application.
Background technology
Nasal polyp: with nasal obstruction with the passing of time, see in the nose key smooth surface is arranged, translucent, softness touched and bitterly vegetation is not hindered the disease of breath for main performance, the genus otorhinolaryngology disease.Nasal polyp is common clinical, frequently-occurring disease, sees " General Treatise on the Cause and Symptoms of Diseases " the earliest, is meant the living vegetation of nasal cavity.Chinese medicine is referred to as " nasal polyp, nose young pilose antler, nose ligusticumic " again.How to eat the pungent Bo of processing savoury, accumulate living damp and hot because of having a liking for usually; On steam in lung the knot nose key that stagnates; Or wind-heat evil toxin invasion and attack lung meridian, lung qi must not be declared freely, gathers the nose key and causes.Western medicine thinks that nasal polyp is the superfluous lump of being born in nasal cavity or nasal sinuses mucosa upper process.Good sending out in the lateral wall and the nose top of nasal cavity.Nasal polyp is not a true neoplasm, the nasal mucosa that causes of allergy and nasal sinuses chronic inflammation edema extremely often, sinunasal mucosa sagging gradually and result of forming under action of gravity.Divide three types: (1) anaphylaxis polyp.(2) struvite polyp.(3) choanal polyps.This sick sickness rate improves year by year now, various operations by doctor trained in Western medicine to treatment-resistant as can be seen, nasal polyp is easy to recurrence after operation, and unusual misery after the corrective surgery, though it is little that reason is exactly the nose organ, construct but very complicatedly, general operation can not be deep into all gaps nasal polyp is cut off totally, so, remaining nasal polyp is constantly growth just, several years have an operation once more with regard to returning to the symptom before performing the operation, and make the patient forbidding, agonizing.The cryogenic ablation art is ripe under the scope at present, damage advantages such as little, that curative effect is lacked, should not recur in a organized way with the traditional surgical approaches ratio, but operation to the requirement of surgical staff and equipment than higher; the more high shortcoming of hands art Charges, be not suitable for the use of basic hospital and nasal polyp early, mid-term the patient treatment.Therefore, seek that a kind of patient's of having medication is convenient, curative effect is fast, the polypous external Chinese patent medicine of treatment, preparation method that have no side effect are still the problem that those skilled in the art need to be resolved hurrily.
Summary of the invention
The misery that technical problem to be solved by this invention provides a kind of illness that can eliminate the patient, exempts the nasal polyp operation promotes physically and mentally healthyly, has the polypous external Chinese patent medicine of treatment that patient's medication is convenient, curative effect is fast, price is low, have no side effect simultaneously.
Another technical problem to be solved by this invention provides the method that a kind of method novelty, simple and reliable preparation are treated polypous external Chinese patent medicine.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: the polypous external Chinese patent medicine of a kind of treatment, its special character are that the medication preparation by following weight parts forms: Hirudo 10-50 part, Alumen 10-50 part, Fructus Gleditsia 10-50 part, Sal Ammoniacus 5-30 part, Radix Angelicae Dahuricae 10-50 part, Natrii Sulfas 10-50 part, Fructus Bruceae 5-30 part, depositum urinae praeparatum 10-50 part.
For further solving the problems of the technologies described above, the present invention adopts the medication preparation of following preferred weight part to form: Hirudo 20-40 part, Alumen 20-40 part, Fructus Gleditsia 20-40 part, Sal Ammoniacus 10-25 part, Radix Angelicae Dahuricae 20-40 part, Natrii Sulfas 20-40 part, Fructus Bruceae 10-25 part, depositum urinae praeparatum 20-40 part.
For further solving the problems of the technologies described above, the present invention adopts the medication preparation of following optimum weight part to form: 30 parts of Hirudos, 30 parts of Alumens, 30 parts of Fructus Gleditsia, 18 parts of Sal Ammoniacuss, 30 parts of the Radixs Angelicae Dahuricae, 30 parts in Natrii Sulfas, 18 parts of Fructus Bruceaes, 30 parts of depositum urinae praeparatum.
Above-mentioned described external Chinese patent medicine is externally-applied powder, dropping liquid or the spray-type of making according to the conventional technology of preparing of Chinese medicine.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: above-mentioned described external Chinese patent medicine is to be prepared from by following preparation method: the selected medical material of weighing, vacuum normal temperature drying, pulverized 60 mesh sieves, pulverize at low temperature, crossed 320 mesh sieves, the extracting screen underflow packing.
Above-mentioned described vacuum normal temperature drying is that Chinese medicine is placed the inherent vacuum of vacuum drying oven is 0.08-0.1Mpa room temperature drying under reduced pressure 10-12h.
Above-mentioned described pulverize at low temperature is to pulverize 30-40min with low temperature vibration super micron mill, and its powder body microstructure analysis particle diameter is less than 15 μ m.
Above-mentioned described external Chinese patent medicine is as the polypous application of treatment.
Above-mentioned described external Chinese patent medicine is as the application of treatment acute and chronic rhinitis, sinusitis, allergic rhinitis.
The principles of formulating prescriptions of external Chinese patent medicine of the present invention are: be guidance with the theory of Chinese medical science, to reach blood circulation promoting and blood stasis dispelling, dampness detumescence, anti-inflammation, improve the nasal mucosa congestion and edema, the treatment nasal conchae hypertrophy, nasal polyp is eliminated the effect of clinical symptoms, plays treatment and prevents polypous purpose.The present invention has proper, the reasonable recipe of compatibility of drugs, and the effect of its described each herbal medicine is:
Hirudo: another name: Hirudo, leech, meat awl; Character: be flat spindle, most links are arranged, long 4～10cm, wide 0.5～2cm.Back pitchy or dark brown swells slightly, and after water logging, the visible black color speckle is lined up 5 longitudinal grins; Matter is crisp, frangibility, section colloidal substance.The feeble QI raw meat; The property salty, bitter in the mouth, flat; Slightly poisonous; Return Liver Channel; Effect: removing blood stasis, removing blood stasis stimulates the menstrual flow; Be used for the lump in the abdomen mass in the abdomen, blood stasis amenorrhea, the treatment of injury from falling down.
Alumen: another name: Alumen, Alumen, for refining through processing, makes Sulfates mineral alunite; Character is an irregular bulk or granular, and colourless or yellowish white is transparent or semitransparent, and the surface is slightly level and smooth or uneven, and the fine and closely woven vertical rib of tool has hyaloid gloss, and matter is hard and crisp.Cold in nature, sour in the mouth, puckery are returned lung, spleen, liver, large intestine channel; Function: external detoxifcation parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration is dispeled wind-phlegm; Cure mainly: external treatment is used for eczema, scabies, Ting discharging ear, pudendal pruritus leukorrhagia, epistaxis bleeding from the gum, nose Xi meat; For oral administration be used for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy is gone mad.
Fructus Gleditsia: another name: day fourth, soap fourth are the dry Spina jujubae of leguminous plant Fructus Gleditsia; All can gather the whole year, drying, or take advantage of fresh slices, drying; Warm in nature, acrid in the mouth are returned liver, stomach warp; Effect: detumescence detoxification, evacuation of pus, parasite killing; Be used for carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.
Sal Ammoniacus: other title: northern front yard sand, red sand, yellow ground are the crystal of halogenide class mineral Sal Ammoniacus; Chemical analysis: SALMIACUM mainly contains ammonium chloride (NH4CI); Warm in nature, salty in the mouth, hardship, suffering, poisonous; Effect: removing food stagnancy softening the hard mass, drastically removing blood stasis and resolving static blood; Cure mainly: control the lump in the abdomen mass beside the umbilicus, dysphagia and regurgitation, phlegm retention, sore throat, long-pending dysentery, amenorrhea, corneal nebula, polyp, warty vegetation is treated skin ulcer, scrofula, carbuncle, malignant boil.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, return stomach, large intestine, lung meridian.Effect: the wind dehumidifying of loosing, understand things pain-stopping, detumescence and apocenosis.Be mainly used in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection treatment of diseases such as swell and ache.
Natrii Sulfas: cold in nature, salty in the mouth, hardship, return stomach, large intestine channel.Effect: purging heat to relax the bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat.Be mainly used in the excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache; The external treatment acute mastitis, the treatment of swelling and pain of hemorrhoid.
Fructus Bruceae: cold in nature, bitter in the mouth, slightly poisonous, return large intestine, Liver Channel; Effect: heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving, corrosion wart.Be mainly used in dysentery, malaria; The external treatment wart, the treatment of clavus.
Depositum urinae praeparatum: cold in nature, salty in the mouth, effect: nourishing YIN for decreasing fever; Mainly be applicable to the hectic fever due to YIN-deficiency consumptive fever, pharyngalgia, aphtha, the cold disease of asthenia, frequent micturition is leaked the turbid grade of pure white disease.
The traditional Chinese medical science is thought: nasal polyp is many because of having a liking for the pungent Bo of the processing savoury of food usually, accumulates living damp and hot; On steam in lung the knot nose key that stagnates; Or wind-heat evil toxin invasion and attack lung meridian, lung qi must not be declared freely, gathers the nose key and causes.So suitable lung heat clearing a surname gas rushes down wet eliminating stagnation aspect treatment.In addition because nasal polyp and allergic rhinitis, chronic rhinitis and sinusitis are in close relations, thus to prevent nasal polyp to take place, will the active treatment chronic rhinitis, sinusitis, with the minimizing odds.Aspect prevention, should eat a little foods that can the above-mentioned disease of treatment more, the thing of greasy plumpness that consume oil is less avoided the thing of raw meat meat or fish such as eating cold and uncooked food excessively, fish and shrimp, the withdrawal tobacco and wine, the irritable food that avoids pungent food is eaten foods such as vegetable, fruit, animal livers more.For this reason,
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", all composition comes from the 5th edition medicine that records of China's " pharmacopeia ", all medicines and usefulness, play blood circulation promoting and blood stasis dispelling, Tong Jing Xiao wei, dampness detumescence, anti-inflammation, detoxifcation parasite killing altogether, have one's ideas straightened out logical close, the merit of removing food stagnancy knot, putrefaction-removing granulation-promoting, corrosion wart, reach treatment and prevention nasal polyp disease, and determined curative effect, cheap, have no side effect, external is convenient.
The clinical use result of external Chinese patent medicine of the present invention shows to have following advantage:
1, the selected Chinese medicine of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention nasal polyp disease of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Acute toxicity test and accumulation toxicity test through white mice and rat show that underproof animal does not see any toxic reaction, compare zero difference through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group, prove that its safety of medicine is reliable.
2, rich in proteins, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid in the external Chinese patent medicine powder of the present invention, also contain various trace elements such as Saponin, plant sterol, calcium, help the absorption at human nasal polyp position, removing blood stasis with potent drugs removing food stagnancy, softening the hard mass knot, putrefaction-removing granulation-promoting, and external is convenient.
3, external Chinese patent medicine of the present invention not only can effectively be treated the nasal polyp disease, and it is also very obvious to acute and chronic rhinitis, sinusitis, allergic rhinitis treatment of diseases preventive effect, particularly share by all medicines, play antiallergic, antifungal, antibacterial, antiviral, anti-inflammation hemostasia altogether, improve the nasal mucosa congestion and edema, the treatment nasal conchae hypertrophy, nasal polyp, acute and chronic rhinitis, sinusitis, allergic rhinitis are eliminated the effect of clinical symptoms.To treat irritated nasal polyp early, mid-term the patient better curative effect is arranged, method is that nasal cavity directly sucks Chinese medicine, makes medicine directly enter lesions position, make the death of nasal cavity pathogenic bacteria rapidly, nasal polyp comes off automatically, thoroughly solves the problem that nasal polyp shows effect repeatedly, reaches comparatively ideal healing rehabilitation efficacy.
Further specify the effect of external Chinese patent medicine of the present invention below by clinical practice to treatment nasal polyp disease.
One. the clinical diagnosis standard
Common sympton:
1. persistence is had a stuffy nose, and the nasal obstruction reason is because the circulation of nasal cavity blood capillary is not smooth, causes capillary dilation to cause nasal obstruction, hyposmia, and closed rhinolalia, sleep is snored and mouth breathing.
2. fibrous polyp is canescence, smooth surface, and being difficult in fact of touching is hemorrhage.
3. polyposis is often from the sieve hole, and single polyp is many to grow in maxillary sinus, crashes into choana and claims " choanal polyp.”
4. nasal polyp increases and becomes big, will not treat for a long time, can cause bridge of the nose broadening and form " frog nose ".
5. the patient can judge tentatively whether doubtful polypous possibility oneself is arranged by above common sympton, but, had better in time make a definite diagnosis Xiang the doctor to hospital after finding doubtful nasal polyp symptom.
6. watery nasal discharge can be arranged, headache, tinnitus, ear is vexed and auditory dysesthesia.
7. mucus polyp, quite like peeling botryoidalis or fresh litchi meat shape, smooth surface is translucent, and pinkiness has faciola many from the middle nasal meatus, the softness activity of touching.
8. bleeding polyp smooth surface, hyperemia, that touches is soft and easily hemorrhage.
Work up:
The visible one or more smooth surfaces of rhinoscopy, Lycoperdon polymorphum Vitt or pink as Fructus Litchi shape, translucent swollen thing, the soft feel of touching, not bitterly, removable, generally be difficult for hemorrhage.Early stage polyp is little because of its bodily form, so can find after must concha nasalis inferior being shunk with 1% ephedrine normal saline sometimes.
Nasendoscopy is significant to clear and definite polypous position and scope; The film making of x line nasal sinuses also belongs to necessary.
(1) nasal septum pachymucosa or middle nasal concha hypertrophy: be polypoid change person and all can be nasal polyp by mistaken diagnosis.The former surface color is redder, the substrate broad and be difficult for movable, harder during palpation.
(2) meninges-brain bulging: can do skull side position or cranium base position X line is taken the photograph sheet, also can do X line forehead tomography and take the photograph sheet, visible defect of skull.
(3) inverted papilloma, profile such as polyposis, rough surface, color is greyish white or light red.Characteristics are turning over property growths in the basad direction of epithelium is on the histopathology.Easily hemorrhage during operation, postoperative easily recurs, and can cancerate.
(4) angiofibroma fibrohemangioma of nasopharynx: often betide young male nasal cavity back segment and nasopharynx part, substrate is wide, the red or Lycoperdon polymorphum Vitt of color depth, rounded or nodositas or lobulated, and to around diffusion, epistaxis repeatedly, even bleed profusely.
(5) nose malignant tumor: all one-sided carrying out property nasal obstructions, nasal mucus band blood and with severe headache, facial numbness person, all should consider the possibility of nose malignant tumor, must implement biopsy and clarify a diagnosis.
Diagnosis basis:
1. be common in allergic rhinitis and chronic sinusitis patient.
2. above sings and symptoms is arranged.
Can find nasal cavity soft tissue shadow 3.X line is taken the photograph sheet, increase in density in the nasal sinuses, mucosa thicken.No bone destruction and basis cranii are damaged.
Typing:
The visible polypous organizational structure of test under microscope is incomplete same, can be divided into three types:
The anaphylaxis polyp:
Normal be that bilateral is multiple, as not removing anaphylactogen because of, the resident recurrence after the polypectomy.Pathological changes except that edema obviously, a large amount of intiltration of acidophilic leukocyte are arranged, basement membrane has obviously and thickens (hyaloid variation) under the mucous epithelium, last having of micromicro given birth to.
Struvite polyp:
One-sided or single polyp forms, and how to be caused by local infection that edema is slight, and the struvite cell that oozes out is mainly neutrophil and mononuclear cell.Epithelial metaplasia and basement membrane thickened are more rare, can distinguish mutually with the anaphylaxis polyp.
Choanal polyps:
This is a clinical name, stretches into nasopharynx part from nasal cavity through metapore because of polyp has a long base of a fruit.Sharp in fact or allergy nasal mucosa edema does not heal for a long time, and pathological changes is based on inflammation edema and inflammatory infiltration, and the phenomenon of qualitative change hypertrophy continuously is so nasal polyp belongs to struvite pathological changes.But,, generally can not cancerate in fact so often be called " tumor-like lesion " because nasal polyp forms lump.
Nasal polyp volume sometimes is very big, even reaches several centimetres of sizes and fill nasal cavity and cause nasal obstruction, breathe obstructedly, or is the flap valve sample and opens and closes.Nasal polyp is also often with olfactory disorder, headache, symptom such as Hypernasality when speaking.Nasal obstruction causes secretions to be detained, and can bring out sinusitis, and this moment, secretions was many and be purulence.Huge nasal polyp can fill up nasal cavity fully, even nasal bone is extrapolated, changes the profile of nose.
Two. case selection
Selected 113 examples observe patients be the outpatient service in 2009 to 2010 of my institute early, mid-term nasal polyp disease patient case, diagnostic criteria meets the diagnostic criteria that Chinese national otorhinolaryngology of Chinese medicine can be worked out in 1991, man's 72 examples, woman's 41 examples, age 10-62 year, 36.2 years old mean age, the course of disease is the shortest 1 year, and is the longest 20 years.Anaphylaxis polyp 37 examples wherein, struvite polyp 53 examples, choanal polyps 23 examples.
Three, clinical application method
Observation group's 57 examples, 2 times on the 1st, each 0.5g directly delivers to diseased region or patient's nasal cavity by the intranasal mirror with external Chinese patent medicine of the present invention and directly sucks and suffer from the cacorhinia kitchen range, and 21 days is a course of treatment;
Matched group 56 examples, 2 times on the 1st, with Sweden's Rhinocort (budesonide) spray preparation, 2 times on the 1st, 1 time 1 spray (64 μ g) sprays into and suffers from the nose.
Four. curative effect determinate standard:
1. recovery from illness: clinical symptom disappearance, nasal meatus NIP secretions, the nasal endoscopy nasal mucosa is normal, does not have recurrence in 1 year;
2. produce effects: symptom disappears substantially, but still has recurrence in 1 year or have mild, nasal mucosa not to have the pale or rheuminess thing of obvious edema;
3. take a turn for the better: before treatment back symptom is treated is light, and nasal obstruction alleviates, the nasal mucosa Mild edema, and polyp diminishes;
4. invalid: no significant change person before and after the treatment.
Five, clinical treatment result
1. clinical treatment result: see following table for details
Observation group's matched group clinical statistics table
2. statistical analysis
Observation group, totally 57 examples.11 days recovery from illness 3 examples, cure rate 5.26%; 17 days recovery from illness 12 examples, cure rate 21.05%; 21 days recovery from illness 21 examples, cure rate 36.84% adds up to recovery from illness 36 examples, and cure rate is 63.15%; Produce effects 13 examples, 5 examples that take a turn for the better, invalid 3 examples.Total effectively example 54 examples, total effective rate 94.73%, total cure rate 63.15%.Observation group does not have 1 example untoward reaction is arranged except that 3 examples are invalid, and recovery from illness patient clinical symptom disappearance does not have recurrence in 1 year, and observation group morning, mid-term, the patient accounted for 68.3%.
Matched group, totally 56 examples.11 days recovery from illness 1 examples, cure rate 1.79%; 17 days recovery from illness 2 examples, cure rate 3.57%; 21 days recovery from illness 4 examples, cure rate 7.14% adds up to recovery from illness 7 examples, and cure rate is 12.5%; Produce effects 28 examples, 15 examples that take a turn for the better, invalid 6 examples.Total effectively example 50 examples, total effective rate 89.28.%, total cure rate 12.5%.Matched group patient effective time is short, and remission is obvious, but 60% patient has untoward reaction such as dryness in the nasal cavity, epistaxis, sneeze, dermoreaction in various degree, and rate is higher repeatedly, the 7 routine patients that only fully recover, matched group early, mid-term the patient account for 67.7%.
Two groups of patients are carried out statistical procedures, adopt SPSS18.0 software to carry out data statistic analysis.Owing to occurring the situation of grid number in the effective percentage contingency table, so adopt gauged χ less than 5
2Check is carried out contingency table analysis to data, and the result shows efficient does not have significant difference (to proofread and correct χ
2=0.522, P=0.47); Cure rate is adopted the Pearson X 2 test, and the result shows that cure rate has notable difference (Pearson χ
2=30.752, P＜0.001).
3. special case
1. Xing, the man, 21 years old, the student, 8: 20 on the 27th April in 2009 went to a doctor, 1 year cause of patient is had a bath and is caused aversion to cold and cold limbs, sneeze repeatedly, the thin nasal discharge amount is many, does not give and comprehending, after, bad during fashion, intermittently have a stuffy nose in hyposmia, right nostril, closed rhinolalia, the sleep snoring.Recently PD, nose stream yellow thick nasal discharge, nasal obstruction increases the weight of, brains dusk pain, red tip of the tongue yellow and greasy fur, forceful pulse.Rhinoscopy: single struvite polyp, quite like peeling botryoidalis or fresh litchi meat shape, smooth surface is translucent, edema is slight, the nasal mucosa color is red thicken not obvious.Diagnosis: one-sided struvite polyp (lung meridian damp-heat type), treatment: Chinese patent medicine powder preparation of the present invention, every day 2 times, each 0.5g sends into focus in the nose with the intranasal mirror.Or in the suction nose.All cards takes a turn for the better after 5 days, and further consultation is breathed unimpededly after 11 days, and the watery nasal discharge nasal obstruction disappears, and concha nasalis swelling, polyp disappear and fully recover.
2 Mas, the woman, 24 years old, the student went to a doctor 9: 40 on the 21st June in 2009, over 3 years carrying out property nasal obstruction, clear rare nasal mucus increase, the headache of olfactory disorder companion paroxysmal, increased the weight of 20 days, companion's fatigue and weakness, easy catching a cold, pale tongue with white fur is a little less than the moderate pulse.Rhinoscopy: the bilateral polyposis, the pathological changes local edema is obvious, and polyp is light white; Pathologic finding: a large amount of intiltration of acidophilic leukocyte are arranged, and basement membrane has obviously and thickens (hyaloid variation) under the mucous epithelium.Diagnosis: anaphylaxis polyp (asthenia of pulmonosplenic qi type), treatment: Chinese patent medicine drop preparation of the present invention, every day 2 times, each 0.5g sends in the nose in focus or the suction nose with the intranasal mirror.All cards takes a turn for the better after 5 days, and further consultation is breathed unimpededly after 11 days, and the watery nasal discharge nasal obstruction disappears, and concha nasalis swelling, polyp disappear and fully recover.
3 Jiangs, man, 23 years old, the senior, 9: 10 on the 12nd May in 2010 went to a doctor, and private prosecution is aversion to cold and cold limbs usually, suffered from allergic rhinitis 4 years, when season alternation or when meeting penetrating odor, the state of an illness breaks out at every turn, the paroxysmal intranasal is very itched, and sneeze has a large amount of watery secretion repeatedly, the headache of nearly 1 year olfactory disorder companion paroxysmal, the paroxysmal nasal obstruction increased the weight of 20 days, companion's fatigue and weakness, pale tongue with white fur has indentation, a little less than the moderate pulse.Rhinoscopy: the bilateral polyposis, hypertrophic inferior turbinate, the pathological changes local edema is obvious, and polyp is light white; Pathologic finding: eosinophilic granulocyte is arranged in the secretions.Diagnosis: anaphylaxis polyp (asthenia of pulmonosplenic qi type), treatment: Chinese patent medicine spray agent of the present invention, every day 2 times, each 0.5g sends in the nose in focus or the suction nose with the intranasal mirror.All cards takes a turn for the better after 11 days, and further consultation is breathed unimpededly after 17 days, and the watery nasal discharge nasal obstruction disappears rhinoscopy: concha nasalis swelling, nasal polyp disappear clinical recovery.
4, Zhang, man, 46 years old, teacher, went to a doctor 8: 15 on the 22nd April in 2010, patient's private prosecution, frequent flu over 6 years, each flu cause that rhinitis shows effect repeatedly, intermittent or property nasal obstruction alternately, it is heavy to meet cold rnning, Wen Zehuan, a little mucus and purulence nasal mucus are arranged, slight headache of companion and olfactory disorder, the nasal obstruction snoring increases the weight of closely over the past half year, hypopnea, with rhinophonia, hypomnesis, fatigue and weakness, thin white fur of tongue, thready pulse is tight.Rhinoscopy: tunica mucosa nasi swelling, single polyp grows in maxillary sinus, crashes into the choana nasopharynx part, and pathological changes is based on inflammation edema and inflammatory infiltration, the phenomenon of qualitative change hypertrophy continuously.Diagnosis: choanal polyp (asthenia of pulmonosplenic qi type), treatment: Chinese patent medicine powder preparation of the present invention, every day 2 times, each 0.5g sends in the nose in focus or the suction nose with the intranasal mirror.All cards takes a turn for the better after 11 days, and further consultation is breathed unimpededly after 17 days, and the watery nasal discharge nasal obstruction disappears, and concha nasalis swelling, polyp disappear and fully recover.
5, Zhang, the man, 62 years old, the retired cadre, prescription on individual diagnosis 8: 20 on the 29th March in 2009, patient's paroxysmal is had a stuffy nose stench for many years, and is bad during fashion, and increase the weight of nearly half a year, nose stream yellow thick nasal discharge, amount is many, and nasal obstruction is smelt and is subtracted, and brains is lost consciousness bitterly, red tip of the tongue yellow and greasy fur, forceful pulse.Control suitable clearing away and dispersing lung-heat, damp eliminating eliminating stagnation nasal obstruction olfactory disorder.Rhinoscopy: single polyp, the nasal mucosa color is red to be thickened, and edema is slight, a small amount of crust and purulent secretion is arranged, frowziness.Pathologic finding: be mainly neutrophil and mononuclear cell in the secretions.Diagnosis: struvite polyp (lung meridian damp-heat type), treatment: Chinese patent medicine powder preparation of the present invention, every day 2 times, each 0.5g sends in the nose in focus or the suction nose with the intranasal mirror.All cards takes a turn for the better after 11 days, and further consultation is breathed unimpededly after 21 days, and the watery nasal discharge nasal obstruction disappears rhinoscopy: concha nasalis swelling, nasal polyp disappear clinical recovery.
6, grandson so-and-so, woman, 31 years old, family members, December was gone to a doctor in 9: 24 on the 8th in 2010, and patient's snivel amount is many, meet cold abnormal flavour and increased the weight of 6 years, patient's lazy speech of breathing hard at ordinary times, aversion to cold and cold limbs, shallow complexion, paroxysmal sneeze is more than, nearly 2 years olfactory disordeies, nasal obstruction obviously, paroxysmal is vexed to expand fatigue and weakness, pale tongue with white fur is thick, weak pulse.Rhinoscopy: the bilateral polyposis, the greyish white edema of nasal mucosa, polyp is light white; Pathologic finding: mainly be eosinophilic granulocyte in the nasal discharge.Diagnosis: anaphylaxis polyp (asthenia of pulmonosplenic qi type), treatment: Chinese patent medicine drop preparation of the present invention, every day 2 times, each 0.5g sends in the nose in focus or the suction nose with the intranasal mirror.All cards takes a turn for the better after 11 days, and further consultation is breathed unimpededly after 21 days, and the watery nasal discharge nasal obstruction disappears rhinoscopy: concha nasalis swelling, nasal polyp disappear clinical recovery.
The specific embodiment
Embodiment 1
Press row weight portion (0.5 kilogram/part) and take by weighing each Chinese crude drug: 10 parts of Hirudos, 10 parts of Alumens, 10 parts of Fructus Gleditsia, 5 parts of Sal Ammoniacuss, 10 parts of the Radixs Angelicae Dahuricae, 10 parts in Natrii Sulfas, 5 parts of Fructus Bruceaes, 10 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is as the polypous powder external used medicine of treatment, is the externally-applied powder dosage form of making according to the conventional powder technology of preparing of Chinese medicine by with above-mentioned each medicinal raw material.
Embodiment 2
Press row weight portion (0.5 kilogram/part) and take by weighing each medical material: 50 parts of Hirudos, 50 parts of Alumens, 50 parts of Fructus Gleditsia, 30 parts of Sal Ammoniacuss, 50 parts of the Radixs Angelicae Dahuricae, 50 parts in Natrii Sulfas, 30 parts of Fructus Bruceaes, 50 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is the external dropping liquid medicine as the treatment sinusitis, is the external dropping liquid dosage form of making according to the conventional dropping liquid dosage form of Chinese medicine technology of preparing by with above-mentioned each medicinal raw material.
Embodiment 3
Press row weight portion (1 kilogram/part) and take by weighing each medical material: 45 parts of Hirudos, 45 parts of Alumens, 45 parts of Fructus Gleditsia, 25 parts of Sal Ammoniacuss, 45 parts of the Radixs Angelicae Dahuricae, 45 parts in Natrii Sulfas, 25 parts of Fructus Bruceaes, 45 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is as the polypous externally applied spray medicine of treatment, is the externally applied spray dosage form of making according to the conventional spray dosage form of Chinese medicine technology of preparing by with above-mentioned each medicinal raw material.
Embodiment 4
Press the row weight portion and take by weighing each medical material: 20 parts of Hirudos, 20 parts of Alumens, 20 parts of Fructus Gleditsia, 10 parts of Sal Ammoniacuss, 20 parts of the Radixs Angelicae Dahuricae, 20 parts in Natrii Sulfas, 10 parts of Fructus Bruceaes, 20 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is the powder external used medicine as the treatment acute or chronic rhinitis, its preparation technology is: above-mentioned each medicinal raw material is prepared from by following preparation method: the selected and medical material of weighing according to 1 kilogram/part weight portion, place in the vacuum drying oven dry under the decompression of vacuum room temperature, this gets final product through pulverize at low temperature, mistake 320 mesh sieves, extracting screen underflow packing after pulverizer was pulverized 60 mesh sieves again.
Embodiment 5
Press the row weight portion and take by weighing each medical material: 40 parts of Hirudos, 40 parts of Alumens, 40 parts of Fructus Gleditsia, 25 parts of Sal Ammoniacuss, 40 parts of the Radixs Angelicae Dahuricae, 40 parts in Natrii Sulfas, 25 parts of Fructus Bruceaes, 40 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is as the polypous powder external used medicine of treatment, its preparation technology is: above-mentioned each medicinal raw material is prepared from by following preparation method: the selected and medical material of weighing according to 2 kilograms/part weight portion, it is room temperature drying under reduced pressure 10h among the 0.08-0.09Mpa that mixing is placed on the inherent vacuum of vacuum drying oven, this is after pulverizer carries out just pulverizing 60 mesh sieves, reuse low temperature vibration super micron mill is pulverized 30min, cross 320 mesh sieves, extracting screen underflow, reach powder body microstructure analysis particle diameter less than 15 μ m, get final product according to outer the packing with Chinese patent medicine powder packaging standard.
Embodiment 6
Press the row weight portion and take by weighing each medical material: 30 parts of Hirudos, 30 parts of Alumens, 30 parts of Fructus Gleditsia, 18 parts of Sal Ammoniacuss, 30 parts of the Radixs Angelicae Dahuricae, 30 parts in Natrii Sulfas, 18 parts of Fructus Bruceaes, 30 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is the powder external used medicine as the treatment allergic rhinitis, its preparation technology is: above-mentioned each medicinal raw material is prepared from by following preparation method: the selected and medical material of weighing according to 1 kilogram/part weight portion, it is room temperature drying under reduced pressure 11h among the 0.09-0.1Mpa that mixing is placed on the inherent vacuum of vacuum drying oven, this is after pulverizer carries out just pulverizing 60 mesh sieves, reuse low temperature vibration super micron mill is pulverized 35min, cross 320 mesh sieves, extracting screen underflow, reach powder body microstructure analysis particle diameter less than 15 μ m, get final product according to outer the packing with Chinese patent medicine powder packaging standard.
Embodiment 7
Press the row weight portion and take by weighing 25 parts of each medical material Hirudos, 25 parts of Alumens, 25 parts of Fructus Gleditsia, 10 parts of Sal Ammoniacuss, 25 parts of the Radixs Angelicae Dahuricae, 30 parts in Natrii Sulfas, 10 parts of Fructus Bruceaes, 30 parts of depositum urinae praeparatum.
The described external Chinese patent medicine of present embodiment is as the polypous powder external used medicine of treatment, its preparation technology is: above-mentioned each medicinal raw material is prepared from by following preparation method: the selected and medical material of weighing according to 1.5 kilograms/part weight portion, it is room temperature drying under reduced pressure 12h among the 0.08-0.09Mpa that mixing is placed on the inherent vacuum of vacuum drying oven, this is after pulverizer carries out just pulverizing 60 mesh sieves, reuse low temperature vibration super micron mill is pulverized 40min, cross 320 mesh sieves, extracting screen underflow, reach powder body microstructure analysis particle diameter less than 15 μ m, get final product according to outer the packing with Chinese patent medicine powder packaging standard.
Claims (9)
1. the polypous external Chinese patent medicine of treatment is characterized in that being formed by the medication preparation of following weight parts: Hirudo 10-50 part, Alumen 10-50 part, Fructus Gleditsia 10-50 part, Sal Ammoniacus 5-30 part, Radix Angelicae Dahuricae 10-50 part, Natrii Sulfas 10-50 part, Fructus Bruceae 5-30 part, depositum urinae praeparatum 10-50 part.
2. the polypous external Chinese patent medicine of treatment according to claim 1 is characterized in that being formed by the medication preparation of following weight parts: Hirudo 20-40 part, Alumen 20-40 part, Fructus Gleditsia 20-40 part, Sal Ammoniacus 10-25 part, Radix Angelicae Dahuricae 20-40 part, Natrii Sulfas 20-40 part, Fructus Bruceae 10-25 part, depositum urinae praeparatum 20-40 part.
3. the polypous external Chinese patent medicine of treatment according to claim 1 is characterized in that being formed by the medication preparation of following weight parts: 30 parts of Hirudos, 30 parts of Alumens, 30 parts of Fructus Gleditsia, 18 parts of Sal Ammoniacuss, 30 parts of the Radixs Angelicae Dahuricae, 30 parts in Natrii Sulfas, 18 parts of Fructus Bruceaes, 30 parts of depositum urinae praeparatum.
4. according to the polypous external Chinese patent medicine of the described treatment of the arbitrary claim of claim 1-3, it is characterized in that described external Chinese patent medicine is externally-applied powder, dropping liquid or the spray-type of making according to the conventional technology of preparing of Chinese medicine.
5. the polypous external Chinese patent medicine of the described treatment of the arbitrary claim of claim 1-3 is characterized in that described external Chinese patent medicine is to be prepared from by following preparation method: the selected medical material of weighing, vacuum normal temperature drying, pulverized 60 mesh sieves, pulverize at low temperature, crossed 320 mesh sieves, the extracting screen underflow packing.
6. the method for polypous external Chinese patent medicine is treated in preparation according to claim 5, it is characterized in that described vacuum normal temperature drying is that Chinese medicine is placed the inherent vacuum of vacuum drying oven is 0.08-0.1Mpa room temperature drying under reduced pressure 10-12h.
7. the method for polypous external Chinese patent medicine is treated in preparation according to claim 5, it is characterized in that described pulverize at low temperature is to pulverize 30-40min with low temperature vibration super micron mill, and its powder body microstructure analysis particle diameter is less than 15 μ m.
8. the external Chinese patent medicine of the described treatment nose diseases of the arbitrary claim of claim 1-3 is characterized in that the application of described external Chinese patent medicine as treatment nasal polyp disease.
9. the external Chinese patent medicine of the described treatment nose diseases of the arbitrary claim of claim 1-3 is characterized in that the application of described external Chinese patent medicine as treatment acute and chronic rhinitis, sinusitis, allergic rhinitis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110197562A CN102274273B (en) | 2011-07-07 | 2011-07-07 | Topical Chinese patent medicine for treating nasal polyps and preparation method and application thereof |
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| CN201110197562A CN102274273B (en) | 2011-07-07 | 2011-07-07 | Topical Chinese patent medicine for treating nasal polyps and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872169A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Medicine composition for treating chronic rhinitis and preparation method of medicine composition |
| CN104546969A (en) * | 2013-10-26 | 2015-04-29 | 张福增 | Formulas and using method of drug for treating rhinopolypus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174072A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for eliminating rhinitis and nasal polyp |
-
2011
- 2011-07-07 CN CN201110197562A patent/CN102274273B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174072A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for eliminating rhinitis and nasal polyp |
Non-Patent Citations (1)
| Title |
|---|
| 《山东中医药大学学报》 20101130 王惠娟 胃息肉的中医药治疗概况和展望 552-553 1-9 第34卷, 第6期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872169A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Medicine composition for treating chronic rhinitis and preparation method of medicine composition |
| CN102872169B (en) * | 2012-10-19 | 2014-01-22 | 黄庆德 | Medicine composition for treating chronic rhinitis and preparation method of medicine composition |
| CN104546969A (en) * | 2013-10-26 | 2015-04-29 | 张福增 | Formulas and using method of drug for treating rhinopolypus |
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| Publication number | Publication date |
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| CN102274273B (en) | 2012-09-19 |
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