CN109512988A - The Chinese medicine compound prescription and preparation method thereof for treating coronary heart disease - Google Patents
The Chinese medicine compound prescription and preparation method thereof for treating coronary heart disease Download PDFInfo
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Abstract
The Chinese medicine compound prescription and preparation method thereof for treating coronary heart disease.A kind of Chinese medicine compound prescription for treating coronary heart disease, its composition includes: Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata, the parts by weight of Radix Salviae Miltiorrhizae are 10-20, the parts by weight of ginseng are 20-30, the parts by weight of semen trichosanthis are 10-20, the parts by weight of Radix Notoginseng are 10-20, the parts by weight of pinellia are 3-15, the parts by weight of Rhizoma Atractylodis Macrocephalae are 5-15, the parts by weight of dried orange peel are 5-15, the parts by weight of Yun Ling are 5-15, the parts by weight of the dried immature fruit of citron orange are 5-15, the parts by weight of Exocarpium Citri Rubrum are 5-15, the parts by weight of Longstamen Onion Bulb are 5-15, the parts by weight of ginger are 5-15, the parts by weight of arisaema cum bile are 2-8, the parts by weight of radix glycyrrhizae preparata are 2-8.The present invention is for treating coronary heart disease.
Description
Technical field:
The present invention relates to a kind of Chinese medicine compound prescriptions and preparation method thereof for treating coronary heart disease.
Background technique:
The present people for obtaining coronary heart disease has very much, and most people is all hospitalize, but has many treatment methods all
Be it is palliative, only Chinese medicine is treated can treat thorough, Chinese medicine medical expense during treatment sometimes
Also relatively low.
Summary of the invention:
Coronary heart disease can be treated well the object of the present invention is to provide one kind, in the good treatment coronary heart disease of therapeutic effect
Medicine compound and preparation method thereof.
Above-mentioned purpose is realized by following technical scheme:
A kind of Chinese medicine compound prescription for treating coronary heart disease, composition includes: Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, white
Art, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata, the parts by weight of the Radix Salviae Miltiorrhizae are 10-20, institute
The parts by weight for the ginseng stated are 20-30, and the parts by weight of the semen trichosanthis are 10-20, the parts by weight of the Radix Notoginseng
For 10-20, the parts by weight of the pinellia are 3-15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 5-15, the dried orange peel
Parts by weight are 5-15, and the parts by weight of the cloud Siberian cocklebur are 5-15, and the parts by weight of the dried immature fruit of citron orange are 5-15, the tangerine
Red parts by weight are 5-15, and the parts by weight of the Longstamen Onion Bulb are 5-15, and the parts by weight of the ginger are 5-15, described
The parts by weight of arisaema cum bile be 2-8, the parts by weight of the radix glycyrrhizae preparata are 2-8.
The Chinese medicine compound prescription of the treatment coronary heart disease, the parts by weight of the Radix Salviae Miltiorrhizae are 10, the weight of the ginseng
Number is 20, and the parts by weight of the semen trichosanthis are 10, and the parts by weight of the Radix Notoginseng are 10, the weight of the pinellia
Measuring number is 5, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 5, and the parts by weight of the dried orange peel are 5, the parts by weight of the cloud Siberian cocklebur
Number is 5, and the parts by weight of the dried immature fruit of citron orange are 5, and the parts by weight of the Exocarpium Citri Rubrum are 5, and the parts by weight of the Longstamen Onion Bulb are
5, the parts by weight of the ginger are 5, and the parts by weight of the arisaema cum bile are 2, and the parts by weight of the radix glycyrrhizae preparata are
2。
The Chinese medicine compound prescription of the treatment coronary heart disease, the parts by weight of the Radix Salviae Miltiorrhizae are 20, the weight of the ginseng
Number is 30, and the parts by weight of the semen trichosanthis are 20, and the parts by weight of the Radix Notoginseng are 20, the weight of the pinellia
Measuring number is 15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 15, and the parts by weight of the dried orange peel are 15, the weight of the cloud Siberian cocklebur
Number is 15, and the parts by weight of the dried immature fruit of citron orange are 15, and the parts by weight of the Exocarpium Citri Rubrum are 15, the parts by weight of the Longstamen Onion Bulb
Number is 15, and the parts by weight of the ginger are 15, and the parts by weight of the arisaema cum bile are 8, the weight of the radix glycyrrhizae preparata
Number is 8.
The Chinese medicine compound prescription of the treatment coronary heart disease, the parts by weight of the Radix Salviae Miltiorrhizae are 15, the weight of the ginseng
Number is 25, and the parts by weight of the semen trichosanthis are 15, and the parts by weight of the Radix Notoginseng are 15, the weight of the pinellia
Measuring number is 10, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 10, and the parts by weight of the dried orange peel are 10, the weight of the cloud Siberian cocklebur
Number is 10, and the parts by weight of the dried immature fruit of citron orange are 10, and the parts by weight of the Exocarpium Citri Rubrum are 10, the parts by weight of the Longstamen Onion Bulb
Number is 10, and the parts by weight of the ginger are 10, and the parts by weight of the arisaema cum bile are 6, the weight of the radix glycyrrhizae preparata
Number is 6.
A kind of preparation method of Chinese medicine powder that treating coronary heart disease, this preparation method include six steps, the first step weigh Radix Salviae Miltiorrhizae,
Ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata weight
Number is measured, second step is by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, life
Ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step is crushed Chinese medicine is mixed, and the traditional Chinese medicine powder crushed is crossed 200 by the 4th step
The traditional Chinese medicine powder of excessively complete sieve is divided into 2 grams every part by mesh sieve, the 5th step, and the 6th step packs traditional Chinese medicine powder, is taken daily 3 times.
A kind of preparation method of Chinese medicinal aqua that treating coronary heart disease, this preparation method include six steps, the first step weigh Radix Salviae Miltiorrhizae,
Ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata weight
Number is measured, second step is by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, life
Ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step will mix the water of 3 times of Chinese medicine addition, and the 4th step is impregnated 3-6 hours, the 5th step
High fire is boiled, and to remaining 1/3 liquid medicine, the 6th step, which is dried in the air to room temperature, is drunk for small fire tanning.
The utility model has the advantages that
1. the Radix Salviae Miltiorrhizae that the present invention uses can treat sternal rib hypochondriac pain, rheumatic arthralgia, abdominal mass caking, sore swell and ache curative, fall servant's wound
Bitterly, irregular menstruation, amenorrhea and algomenorrhea, postpartum stasis caused pain etc.；Treat sternal rib pain, abdominal mass caking and irregular menstruation, menostasis dysmenorrhoea tool
There is good effect.
It reinforces vital energy 2. the ginseng that the present invention uses has, prevent prolapse and engender liquid is calmed the nerves；It is deficient that internal lesion caused by overexertion can be controlled, deficiency of food is tired
Idle, regurgitation and emesis, stool slide-lets out, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, amnesia, dizziness and headache, sun-impotence, and frequent micturition is quenched one's thirst, woman
Female's metrorrhagia and metrostaxis, infantile chronic fright and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.
3. the semen trichosanthis that the present invention uses has the function of that clearing heat and eliminating phlegm, the wide chest of sharp gas, dissipating bind disappear carbuncle, can moistening lung dryness,
Fall fire controls cough, wash phlegm knot, only quenches one's thirst, benefit stool, subduing inflammation sore.
4. the Radix Notoginseng that the present invention uses have the function of hemostasis enrich blood, antithrombotic, enhancing it is immune, can treat to fall and flutter the stasis of blood
It is swollen, thoracic obstruction colic pain, abdominal mass, blood stasis, dysmenorrhea, postpartum stasis of blood yin abdominal pain, sore, carbuncle and painful swelling.
5. the pinellia that the present invention uses has eliminating dampness and eliminating phlegm, anti-vomiting, for treating many coughs of phlegm: pinellia is dry
Can resolving sputum, the phlegm changed gathers into based on phlegm person with spleen not dampness elimination.
6. the Rhizoma Atractylodis Macrocephalae that the present invention uses has strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention；For spleen eating less, abdominal distension is let out
It rushes down, the diseases such as threatened abortion.
7. the dried orange peel that the present invention uses has regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, and the effect of resolving sputum, for treating spleen deficiency diet
The diseases such as reduction, indigestion and nausea and vomiting.
8. the cloud Siberian cocklebur that the present invention uses has eliminating dampness and diuresis, the effect of strengthening the spleen and stomach, for treating reduction blood glucose, having invigorating heart
The effect of dirty, antitumor, anticancer, air making-up and spleen enlivening.
9. the dried immature fruit of citron orange that the present invention uses has the function of relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass, damp and hot to let out for treating gastrointestinal retention
Dysentery；Thoracic obstruction, accumulation of pathogens in chest；Stagnation of the circulation of vital energy pain in chest and hypochondrium, postpartum abdominal pain, still with controlling the internal organs such as dilatation of the stomach, gastroptosis, uterine prolapse, rectal prolapse
Sagging illness.
10. the Exocarpium Citri Rubrum that the present invention uses has regulating the flow of QI to ease the stomach, eliminating dampness and eliminating phlegm effect, for treating coughing with a lot of sputum, dyspepsia
It gets sick from drinking too much wine, evil of vomitting ruffian is bored.
11. the Longstamen Onion Bulb that the present invention uses has middle benefit gas stomach invigorating, activate yang and remove abstruction, the wide chest of qi-regulating, promoting digestion, activate yang and remove abstruction,
The effect of promoting the circulation of qi promoting, for treating thoracic obstruction card, it can also be used to which the abdominal pain of epigastric abdominal fullness, the tenesmus of dysentery wait diseases.
12. the ginger that the present invention uses has the function of improving a poor appetite, town is spat, promoting blood circulation is warded off the cold, for treating swollen blister, adenopathy
The diseases such as matter, morbilli, chronic enteritis, rheumatism.
13. the arisaema cum bile that the present invention uses has eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating, the effect of Southern Star, for stupid
The diseases such as productive cough coughs, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm.
14. the radix glycyrrhizae preparata that the present invention uses has tonifying spleen stomach function regulating, Yiqi and vein recovery, antitussive and antiasthmatic, analgesic effect, can mend
Spleen QI invigorating, expelling phlegm and arresting coughing, relieving spasm to stop pain, clearing heat and detoxicating, coordinating the drug actions of a prescription.
Specific embodiment:
Embodiment 1:
A kind of Chinese medicine compound prescription for treating coronary heart disease, composition includes: Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, white
Art, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata, the parts by weight of the Radix Salviae Miltiorrhizae are 10-20, institute
The parts by weight for the ginseng stated are 20-30, and the parts by weight of the semen trichosanthis are 10-20, the parts by weight of the Radix Notoginseng
For 10-20, the parts by weight of the pinellia are 3-15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 5-15, the dried orange peel
Parts by weight are 5-15, and the parts by weight of the cloud Siberian cocklebur are 5-15, and the parts by weight of the dried immature fruit of citron orange are 5-15, the tangerine
Red parts by weight are 5-15, and the parts by weight of the Longstamen Onion Bulb are 5-15, and the parts by weight of the ginger are 5-15, described
The parts by weight of arisaema cum bile be 2-8, the parts by weight of the radix glycyrrhizae preparata are 2-8.
Embodiment 2:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, composition includes: Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, ginger
The parts by weight of the tuber of pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata, the Radix Salviae Miltiorrhizae are
15, the parts by weight of the ginseng are 20, and the parts by weight of the semen trichosanthis are 10, and the parts by weight of the Radix Notoginseng are
15, the parts by weight of the pinellia are 3, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 10, and the parts by weight of the dried orange peel are
10, the parts by weight of the cloud Siberian cocklebur are 10, and the parts by weight of the dried immature fruit of citron orange are 5, and the parts by weight of the Exocarpium Citri Rubrum are 5,
The parts by weight of the Longstamen Onion Bulb are 5, and the parts by weight of the ginger are 5, and the parts by weight of the arisaema cum bile are 5, institute
The parts by weight for the radix glycyrrhizae preparata stated are 8.
Embodiment 3:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, the parts by weight of the Radix Salviae Miltiorrhizae are 20, the ginseng
Parts by weight be 30, the parts by weight of the semen trichosanthis are 20, and the parts by weight of the Radix Notoginseng are 20, the ginger half
The parts by weight in summer are 15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 15, and the parts by weight of the dried orange peel are 15, the cloud Siberian cocklebur
Parts by weight be 15, the parts by weight of the dried immature fruit of citron orange are 15, and the parts by weight of the Exocarpium Citri Rubrum are 15, the Longstamen Onion Bulb
Parts by weight are 15, and the parts by weight of the ginger are 15, and the parts by weight of the arisaema cum bile are 8, the radix glycyrrhizae preparata
Parts by weight be 8.
Embodiment 4:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, the parts by weight of the Radix Salviae Miltiorrhizae are 15, the ginseng
Parts by weight be 25, the parts by weight of the semen trichosanthis are 15, and the parts by weight of the Radix Notoginseng are 15, the ginger half
The parts by weight in summer are 10, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 10, and the parts by weight of the dried orange peel are 10, the cloud Siberian cocklebur
Parts by weight be 10, the parts by weight of the dried immature fruit of citron orange are 10, and the parts by weight of the Exocarpium Citri Rubrum are 10, the Longstamen Onion Bulb
Parts by weight are 10, and the parts by weight of the ginger are 10, and the parts by weight of the arisaema cum bile are 6, the radix glycyrrhizae preparata
Parts by weight be 6.
Embodiment 5:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, the parts by weight of the Radix Salviae Miltiorrhizae are 18, the ginseng
Parts by weight be 28, the parts by weight of the semen trichosanthis are 18, and the parts by weight of the Radix Notoginseng are 18, the ginger half
The parts by weight in summer are 11, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 11, and the parts by weight of the dried orange peel are 11, the cloud Siberian cocklebur
Parts by weight be 11, the parts by weight of the dried immature fruit of citron orange are 11, and the parts by weight of the Exocarpium Citri Rubrum are 11, the Longstamen Onion Bulb
Parts by weight are 11, and the parts by weight of the ginger are 11, and the parts by weight of the arisaema cum bile are 7, the radix glycyrrhizae preparata
Parts by weight be 7.
Embodiment 6:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, the parts by weight of the Radix Salviae Miltiorrhizae are 13, the ginseng
Parts by weight be 23, the parts by weight of the semen trichosanthis are 13, and the parts by weight of the Radix Notoginseng are 13, the ginger half
The parts by weight in summer are 7, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 7, and the parts by weight of the dried orange peel are 7, the cloud Siberian cocklebur
Parts by weight are 7, and the parts by weight of the dried immature fruit of citron orange are 7, and the parts by weight of the Exocarpium Citri Rubrum are 7, the weight of the Longstamen Onion Bulb
Number is 7, and the parts by weight of the ginger are 7, and the parts by weight of the arisaema cum bile are 4, the weight of the radix glycyrrhizae preparata
Number is 4.
Embodiment 7:
The Chinese medicine compound prescription for the treatment of coronary heart disease described in embodiment 1, the parts by weight of the Radix Salviae Miltiorrhizae are 17, the ginseng
Parts by weight be 27, the parts by weight of the semen trichosanthis are 17, and the parts by weight of the Radix Notoginseng are 17, the ginger half
The parts by weight in summer are 9, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 9, and the parts by weight of the dried orange peel are 9, the cloud Siberian cocklebur
Parts by weight are 9, and the parts by weight of the dried immature fruit of citron orange are 9, and the parts by weight of the Exocarpium Citri Rubrum are 9, the weight of the Longstamen Onion Bulb
Number is 9, and the parts by weight of the ginger are 9, and the parts by weight of the arisaema cum bile are 6, the weight of the radix glycyrrhizae preparata
Number is 6.
Embodiment 8:
A kind of preparation method of Chinese medicine powder that treating coronary heart disease, this preparation method include six steps, the first step weigh Radix Salviae Miltiorrhizae,
Ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata weight
Number is measured, second step is by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, life
Ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step is crushed Chinese medicine is mixed, and the traditional Chinese medicine powder crushed is crossed 200 by the 4th step
The traditional Chinese medicine powder of excessively complete sieve is divided into 2 grams every part by mesh sieve, the 5th step, and the 6th step packs traditional Chinese medicine powder, is taken daily 3 times.
Embodiment 9:
A kind of preparation method of Chinese medicinal aqua that treating coronary heart disease, this preparation method include six steps, the first step weigh Radix Salviae Miltiorrhizae,
Ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata weight
Number is measured, second step is by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, life
Ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step will mix the water of 3 times of Chinese medicine addition, and the 4th step is impregnated 3-6 hours, the 5th step
High fire is boiled, and to remaining 1/3 liquid medicine, the 6th step, which is dried in the air to room temperature, is drunk for small fire tanning.
Embodiment 10:
A kind of complementary therapy of Chinese medicine that treating coronary heart disease, needs to be subject to dietotherapy when taking Chinese medicine, medication while takes
Rice is cooked into congee, and haw pulp, chrysanthemum crystals is added, in each one spoon of addition congee of honeysuckle, takes daily 3 times.
Embodiment 11:
1.1 case sources
Collect 75 Treating Stable Angina Pectoris of Coronary Artery Disease patients.75 patients were according to Chinese Medical Association's angiocardiology in 2007
The diagnostic criteria that branch formulates, clarifies a diagnosis as Treating Stable Angina Pectoris of Coronary Artery Disease patient.Then it is randomly divided by its medical sequence
Two groups, i.e. treatment group, control a group, control b group, wherein the embodiment of the present invention 3 is taken by 25 treatment groups records prescription, wherein 25
Example control a group takes compound danshen dripping pills, wherein 25 control b groups, which take the embodiment of the present invention 2, records prescription.
Male patient 15, female patient 10 in 25 control a groups；Age 40-86 years old, average age be 62.96 ±
10.41 years old；The course of disease is 0.8-9, and average course of disease is 4.57 ± 2.22 years；Body mass index is 21.4-26.3Kg/m2, average body
Weight index is 24.42 ± 1.42Kg/m2。
Male patient 16, female patient 9 in 25 control b groups；Age 42-83 years old, average age be 62.85 ±
11.36 years old；The course of disease is 0.7-8, and average course of disease is 4.55 ± 2.32 years；Body mass index is 21.7-26.6Kg/m2, average body
Weight index is 24.35 ± 1.41Kg/m2。
Male patient 15, female patient 10 in 25 treatment groups；Age 42-86 years old, average age be 62.96 ±
12.41 years old；The course of disease is 0.8-8, and average course of disease is 4.66 ± 2.18 years；Body mass index is 21.8-26.5Kg/m2, average body
Weight index is 24.29 ± 1.39Kg/m2。
Two groups of research objects either gender, in terms of no significant difference (P > 0.05), therefore have it is comparable
Property.
1.2 diagnostic criteria
Referring to Chinese Medical Association's angiocardiology branch, Chinese Journal of Cardiology editorial board in publication in 2007
" chronic stable angina pectoris Clinics and Practices guide ":
1. the course of disease was at 1 month or more；2. based on old and middle-aged patients, or having familial inheritance medical history；3. position is in chest
After bone or left front chest, range are not often limited to, can emit to neck, song portion, pharyngeal, shoulder back, left arm and left hand refer to inside, on
Abdomen, also radiation to other positions.Clinical research often each angina pectoris attacks when position can be close；4. pain is often in
Girdle sensation, burn feeling, twists and squeezes sense, uncomfortable in chest or sensation of asphyxia, sense of heaviness constriction, and some shows as out of strength, shortness of breath ,-a little patients
Only chest is uncomfortable, and individual difference is larger, and wherein prickling-like pain seldom occurs；5. breaking out in paroxysmal, several points can be continued
Clock, but tend not to more than 10 minutes, will not be written in water or lasts for hours；6. risk factor and alleviation mode: chronic
The breaking-out of stable angina cordis often with it is excited or overworked related, such as the quick building Zou Huopa, climbing when can induce, this
When stop and take a momentary rest to can be relieved immediately, be frequently experienced in labour carry out when rather than later.Contain immediately sublingual at this time
Taking nitroglycerin symptom can be eased rapidly in 2-5 minutes；7. ECG examination has ischemic change；8. excluding other originals
The angina pectoris because caused by.
1.3 are included in standard
1. being issued referring to Chinese Medical Association's angiocardiology branch, Chinese Journal of Cardiology editorial board in 2007
The diagnostic criteria of " chronic stable angina pectoris Clinics and Practices guide " be diagnosed as the patient of coronary disease and angina pectoris: 2. medical history
More than three months, attack times >=2 time weekly.
1.4 groupings and treatment method
75 patients with stable angina cordis are randomly divided into etc. to treatment group and the control group of number of cases.
Control a group 25 gives compound danshen dripping pills daily, and 5 balls 3 times a day take orally, surrounding is as a treatment course.
Control b group 25 are being given the record prescription of the embodiment of the present invention 3, recipe composition are as follows: Radix Salviae Miltiorrhizae 20g, ginseng daily
30g, semen trichosanthis 20g, Radix Notoginseng 20g, pinellia 15g, Rhizoma Atractylodis Macrocephalae 15g, dried orange peel 15g, Yun Ling 15g, dried immature fruit of citron orange 15g, Exocarpium Citri Rubrum 15g, Longstamen Onion Bulb
15g, ginger 15g, arisaema cum bile 8g, radix glycyrrhizae preparata 8g are prepared, 1 bag every time, every bag of dose according to 8 method one~six of embodiment
2g takes orally, the four Monday courses for the treatment of 3 times a day；
The record prescription of the embodiment of the present invention 2, recipe composition are being given daily by treatment group 25 are as follows: Radix Salviae Miltiorrhizae 15g, ginseng 20g,
Semen trichosanthis 10g, Radix Notoginseng 15g, pinellia 3g, Rhizoma Atractylodis Macrocephalae 10g, dried orange peel 10g, Yun Ling 10g, dried immature fruit of citron orange 5g, Exocarpium Citri Rubrum 5g, Longstamen Onion Bulb 5g, ginger
5g, arisaema cum bile 5g, radix glycyrrhizae preparata 8g are prepared, 1 bag every time according to 8 method one~six of embodiment, every bag of dose 2g, and daily 3
It is secondary, it takes orally, the four Monday courses for the treatment of；
This time all patients in research cut out all possible drugs for influencing this experimental result, if occurring special
Different situation, such as burst severe angina pectoris can temporarily give oral nitroglycerin anti symptom treatment.It observes and analyzes to compare and control
Treat the curative effect of the two groups of conditions of patients in front and back.1.5 result
Effect in three groups of patient's surrounding therapeutic process compares and (is shown in Table 1)
Effect comparison sheet in 1 three groups of patient treatment procedures of table
Effective: the sings and symptoms such as the conscious girdle sensation of patient, uncomfortable in chest take an evident turn for the better, and electrocardiogram tends to just after medication
Often/completely normal.
Effective: the sings and symptoms such as the conscious girdle sensation of patient, uncomfortable in chest take a favorable turn, and electrocardiographic abnormality degree subtracts after medication
Gently.
Invalid: the sings and symptoms such as the conscious girdle sensation of patient, uncomfortable in chest are without improvement, and electrocardiogram still remains exception after medication
Without significant change.
Visible according to statistic analysis result: control group and treatment group are in these sides of gender, the course of disease, age and body mass index
Face is more not statistically significant (P > 0.05), and explanation can be compared.
Three groups of Patient Global's curative effects compare and (are shown in Table 2)
2 three groups of patient's surrounding comprehensive therapeutic effect comparison sheets [example (%)] of table
| Group | n | It is effective | Effectively | In vain | Efficient (%) |
| Compare a group | 25 | 9 | 10 | 6 | 76 |
| Compare b group | 25 | 9 | 9 | 7 | 72 |
| Treatment group | 25 | 14 | 11 | 0 | 100 |
Note: effective percentage=(effective number of cases+effective number of cases) ÷ n
Observation comparison is carried out to the therapeutic effect of three groups of patients after four courses for the treatment of, compares 25 patient's effective percentage 76% of a group；
Compare 25 patient's effective percentage 72% of b group；25 patient's effective percentage 100% for the treatment of group.B group is compareed compared with compareing a group, effect
Lower than control group；Treatment group is compared with compareing a group, and effective number of days is obviously shortened, and effective percentage significantly improves.Treatment group with compare b
Group is compared, and effective number of days is obviously shortened, and effective percentage significantly improves.The traditional chinese medicine composition of the invention compatibility changes, clinical therapeutic efficacy
It disappears, does not have therapeutic effect.
1.6 safety observations
The above results show: patients with coronary heart disease is significantly improved by using symptom is available after drug therapy of the present invention,
Treatment group does not find apparent adverse events during the entire course for the treatment of.There is no the symptoms such as patient's allergy, thus illustrate yet
Drug of the present invention is curative for effect in terms for the treatment of coronary heart disease, highly-safe, can be used as therapeutic drug of coronary heart disease.
Observation control group and treatment group check that every safety index does not occur any adverse reaction or medicine source before the treatment, afterwards
Property variation and other side effects, and treatment group patient indices in receiving prescription therapeutic process of the present invention show it is good
It is good.Occurs the phenomenon that out of strength, loss of appetite when taking in particular for arisaema cum bile patient, drug of the present invention does not have over the course for the treatment of
Out of strength, any side effect such as loss of appetite is occurred, exceeds us and expects.
Do not find that any an example patient drug induccd occurs not in treatment group and control group in this clinical research treatment
Good reaction or allergic reaction illustrate clinically both safe and effective and resistance to prescription of the present invention treatment coronary disease and angina pectoris
It is good by property.
1.7 conclusion
1. having no that toxicity or other drug induccds are bad anti-using prescription of the present invention treatment Treating Stable Angina Pectoris of Coronary Artery Disease
The generation answered, renal function etc. do not occur obvious exception, a problem that any cardiovascular unexpected do not occur in therapeutic process, and control
Treatment group is totally good to the tolerance of prescription of the present invention.
Face 2. Treating Patients of Angina Pectoris girdle sensation, uncomfortable in chest etc. can be effectively improved by clinically having using prescription of the present invention
Bed symptom.
3. clinically anginal pain degree, breaking-out frequency can be made using prescription of the present invention treatment Treating Patients of Angina Pectoris
Rate, duration are effectively reduced.
In conclusion this clinical research shows using prescription of the present invention treatment Treating Stable Angina Pectoris of Coronary Artery Disease safety, height
Effect, tolerance are good, and effectively reduce it is cardiovascular unexpected occur, in terms of have progress outstanding.
Claims (6)
1. a kind of Chinese medicine compound prescription for treating coronary heart disease, composition include: Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae,
Dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata, it is characterized in that: the parts by weight of the Radix Salviae Miltiorrhizae are
10-20, the parts by weight of the ginseng are 20-30, and the parts by weight of the semen trichosanthis are 10-20, the Radix Notoginseng
Parts by weight are 10-20, and the parts by weight of the pinellia are 3-15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 5-15, described
The parts by weight of dried orange peel be 5-15, the parts by weight of the cloud Siberian cocklebur are 5-15, and the parts by weight of the dried immature fruit of citron orange are 5-15,
The parts by weight of the Exocarpium Citri Rubrum are 5-15, and the parts by weight of the Longstamen Onion Bulb are 5-15, and the parts by weight of the ginger are
5-15, the parts by weight of the arisaema cum bile are 2-8, and the parts by weight of the radix glycyrrhizae preparata are 2-8.
2. the Chinese medicine compound prescription for the treatment of coronary heart disease according to claim 1, it is characterized in that: the parts by weight of the Radix Salviae Miltiorrhizae
It is 15, the parts by weight of the ginseng are 20, and the parts by weight of the semen trichosanthis are 10, the parts by weight of the Radix Notoginseng
It is 15, the parts by weight of the pinellia are 3, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 10, the parts by weight of the dried orange peel
It is 10, the parts by weight of the cloud Siberian cocklebur are 10, and the parts by weight of the dried immature fruit of citron orange are 5, and the parts by weight of the Exocarpium Citri Rubrum are
5, the parts by weight of the Longstamen Onion Bulb are 5, and the parts by weight of the ginger are 5, and the parts by weight of the arisaema cum bile are 5,
The parts by weight of the radix glycyrrhizae preparata are 8.
3. the Chinese medicine compound prescription for the treatment of coronary heart disease according to claim 1, it is characterized in that: the parts by weight of the Radix Salviae Miltiorrhizae
It is 20, the parts by weight of the ginseng are 30, and the parts by weight of the semen trichosanthis are 20, the parts by weight of the Radix Notoginseng
It is 20, the parts by weight of the pinellia are 15, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 15, the parts by weight of the dried orange peel
It is 15, the parts by weight of the cloud Siberian cocklebur are 15, and the parts by weight of the dried immature fruit of citron orange are 15, and the parts by weight of the Exocarpium Citri Rubrum are
15, the parts by weight of the Longstamen Onion Bulb are 15, and the parts by weight of the ginger are 15, and the parts by weight of the arisaema cum bile are
8, the parts by weight of the radix glycyrrhizae preparata are 8.
4. the Chinese medicine compound prescription for the treatment of coronary heart disease according to claim 1, it is characterized in that: the parts by weight of the Radix Salviae Miltiorrhizae
It is 15, the parts by weight of the ginseng are 25, and the parts by weight of the semen trichosanthis are 15, the parts by weight of the Radix Notoginseng
It is 15, the parts by weight of the pinellia are 10, and the parts by weight of the Rhizoma Atractylodis Macrocephalae are 10, the parts by weight of the dried orange peel
It is 10, the parts by weight of the cloud Siberian cocklebur are 10, and the parts by weight of the dried immature fruit of citron orange are 10, and the parts by weight of the Exocarpium Citri Rubrum are
10, the parts by weight of the Longstamen Onion Bulb are 10, and the parts by weight of the ginger are 10, and the parts by weight of the arisaema cum bile are
6, the parts by weight of the radix glycyrrhizae preparata are 6.
5. a kind of preparation method for the Chinese medicine powder for treating coronary heart disease, it is characterized in that: this preparation method includes six steps, the first step claims
Take Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, toast sweet
The parts by weight of grass, second step is by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Chinese onion
White, ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step is crushed Chinese medicine is mixed, the traditional Chinese medicine powder that the 4th step will crush
200 mesh sieve are crossed, the traditional Chinese medicine powder of excessively complete sieve is divided into 2 grams every part by the 5th step, and the 6th step packs traditional Chinese medicine powder, is taken daily 3 times.
6. a kind of preparation method for the Chinese medicinal aqua for treating coronary heart disease, it is characterized in that: this preparation method includes six steps, the first step
Weigh Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum, Longstamen Onion Bulb, ginger, arisaema cum bile, toast
The parts by weight of Radix Glycyrrhizae, second step by Radix Salviae Miltiorrhizae, ginseng, semen trichosanthis, Radix Notoginseng, pinellia, Rhizoma Atractylodis Macrocephalae, dried orange peel, Yun Ling, the dried immature fruit of citron orange, Exocarpium Citri Rubrum,
Longstamen Onion Bulb, ginger, arisaema cum bile, radix glycyrrhizae preparata are sufficiently mixed, and third step will mix the water of 3 times of Chinese medicine addition, and it is small that the 4th step impregnates 3-6
When, the 5th step high fire is boiled, and to remaining 1/3 liquid medicine, the 6th step, which is dried in the air to room temperature, is drunk for small fire tanning.
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| CN113262262A (en) * | 2021-07-07 | 2021-08-17 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating phlegm-heat stasis type stable coronary heart disease and preparation method thereof |
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| 赵成洙: "山药补肺元汤合熊胆散治疗太阴人冠心病心绞痛的临床研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
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| CN113262262A (en) * | 2021-07-07 | 2021-08-17 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating phlegm-heat stasis type stable coronary heart disease and preparation method thereof |
| CN113262262B (en) * | 2021-07-07 | 2022-11-08 | 天津中医药大学第一附属医院 | Traditional Chinese medicine preparation for treating phlegm-heat stasis type stable coronary heart disease and preparation method thereof |
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